The DOI matches its Crossref record; 43 of the 43 references it cites were found in a registry or an index.
Primary structure and functional expression from cDN A of the cardiac ryanodine receptor/calcium release channel
Open accessAbstract
The sequence of 4968 (or 4976 with an insertion) amino acids composing the ryanodine receptor from rabbit cardiac sarcoplasmic reticulum has been deduced by cloning and sequencing the cDNA. This protein is homologous in amino acid sequence and shares characteristic structural features with the skeletal muscle ryanodine receptor. Xenopus oocytes injected with mRNA derived from the cardiac ryanodine receptor cDNA exhibit Ca 2+‐dependent Cl− current in response to caffeine, which indicates the formation of functional calcium release channels. RNA blot hybridization analysis with a probe specific for the cardiac ryanodine receptor mRNA shows that the stomach and brain contain a hybridizable RNA species with a size similar to that of the cardiac mRNA. This result, in conjunction with cloning and analysis of partial cDNA sequences, suggests that the brain contains a cardiac type of ryanodine receptor mRNA.
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Cited by
Activation of the Cardiac Calcium Release Channel (Ryanodine Receptor) by Poly-S-Nitrosylation
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Ryanodine Receptors: Structure, Expression, Molecular Details, and Function in Calcium Release
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Structure and function of ryanodine receptors
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The control of neuronal Ca2+ homeostasis
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The brain ryanodine receptor: A caffeine-sensitive calcium release channel
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Metadata
- Authors
- Nakai, J., Imagawa, T., Hakamata, Y., Shigekawa, M., Takeshima, H., & Numa, S.
- Venue
- FEBS Letters
- Publisher
- Wiley
- Published
- 1990-10
- Volume
- 271
- Issue
- 1-2
- Pages
- 169-177
- ISSN
- 0014-5793 (ISSN-L)
- 1873-3468
- OpenAlex
- W2067297047
- Cited by
- 360
- References
- 43
- FWCI
- 4.46
- Type
- journal article
- Language
- en
- Open access
- bronze
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- The paper
- Nakai, J., Imagawa, T., Hakamata, Y., Shigekawa, M., Takeshima, H., & Numa, S. (1990). Primary structure and functional expression from cDN A of the cardiac ryanodine receptor/calcium release channel. FEBS Letters. https://doi.org/10.1016/0014-5793(90)80399-4
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
