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Cited by 260Neuroscience and Neuropharmacology ResearchIon channel regulation and functionNicotinic Acetylcholine Receptors Study

The DOI matches its Crossref record; 48 of the 48 references it cites were found in a registry or an index.

Non‐NMDA glutamate receptor occupancy and open probability at a rat cerebellar synapse with single and multiple release sites.

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Silver, R A, Cull-Candy, S G, Takahashi, T·1996·The Journal of Physiology
DOI 10.1113/jphysiol.1996.sp021487PMC PMC1160626
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Abstract

1. Excitatory postsynaptic currents (EPSCs) were recorded under whole-cell voltage clamp from granule cells in slices of rat cerebellum. EPSCs from individual mossy fibre inputs were identified by their all-or-none appearance in response to a graded stimulus. Excitatory synaptic transmission was investigated at room temperature (approximately 24 degrees C) and at near-physiological temperature (approximately 34 degrees C) by analysing current fluctuations in the peak and decay of the non-N-methyl-D-aspartate (non-NMDA) component of EPSCs. 2. In a subset of synapses the mean EPSC amplitude remained unchanged as the probability of transmitter release was substantially lowered by raising the extracellular [Mg2+] and lowering [Ca2+]. These synapses were considered to have only one functional release site. Single-site synapses had small EPSCs (139 +/- 16 pS, n = 5, at 24 degrees C) with a large coefficient of variation (c.v. = 0.23 +/- 0.02, n = 5) and an amplitude distribution that was well fitted by a Gaussian distribution in four out of five cases. The EPSC latency had a unimodal distribution and its standard deviation had a temperature dependence with a temperature coefficient (Q10; range, 24-35 degrees C) of 2.4 +/- 0.4 (n = 4). 3. Peak-scaled non-stationary fluctuation analysis of single-site EPSCs indicated that the mean conductance of the underlying non-NMDA channels was 12 +/- 2 pS (n = 4) at 35 degrees C. Upper and lower limits for mean channel open probability (Po), cal…

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Crossref · 10.1113/jphysiol.1996.sp021487

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Metadata

Authors
Silver, R. A., Cull-Candy, S. G., & Takahashi, T.
Affiliations
University College London (GB)
ORCID
Venue
The Journal of Physiology
Publisher
Wiley
Published
1996-07
Volume
494
Issue
1
Pages
231-250
ISSN
  • 0022-3751 (ISSN-L)
  • 1469-7793
DOI
10.1113/jphysiol.1996.sp021487
PMC
PMC1160626
OpenAlex
W2023459285
Cited by
260
References
48
Citations by year
2026: 1 · 2025: 3 · 2024: 1 · 2022: 3 · 2021: 7 · 2020: 4 · 2019: 5 · 2018: 2 · 2017: 4 · 2016: 4 · 2015: 12 · 2014: 7 · 2013: 6 · 2012: 10
FWCI
6.07
Type
journal article
Language
en
Open access
Licence
onlinelibrary.wiley.com/termsAndConditions#vor (vor)
Locations
  • The Journal of Physiology (publishedVersion)
  • PubMed Central (publishedVersion)
  • PubMed (publishedVersion)
  • UCL Discovery (University College London) (submittedVersion)
Funders
Wellcome Trust
Topics
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Ion channel regulation and function
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Nicotinic Acetylcholine Receptors Study
Keywords
non-NMDA receptors, receptor occupancy, open probability, mossy fiber synapses, granule cells, cerebellum, temperature dependence, synaptic transmission, calcium dependence, mean-variance relationship, receptor desensitization
MeSH terms
Animals, Cerebellum, Membrane Potentials, Receptors, N-Methyl-D-Aspartate, Presynaptic Terminals, Patch-Clamp Techniques, Rats

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