The DOI matches its Crossref record; 44 of the 44 references it cites were found in a registry or an index.
Electrophysiological properties of two axonal sodium channels, Nav1.2 and Nav1.6, expressed in mouse spinal sensory neurones
Abstract
Sodium channels Na v 1.2 and Na v 1.6 are both normally expressed along premyelinated and myelinated axons at different stages of maturation and are also expressed in a subset of demyelinated axons, where coexpression of Na v 1.6 together with the Na+/Ca 2+ exchanger is associated with axonal injury. It has been difficult to distinguish the currents produced by Na v 1.2 and Na v 1.6 in native neurones, and previous studies have not compared these channels within neuronal expression systems. In this study, we have characterized and directly compared Na v 1.2 and Na v 1.6 in a mammalian neuronal cell background and demonstrate differences in their properties that may affect neuronal behaviour. The Na v 1.2 channel displays more depolarized activation and availability properties that may permit conduction of action potentials, even with depolarization. However, Na v 1.2 channels show a greater accumulation of inactivation at higher frequencies of stimulation (20–100 Hz) than Na v 1.6 and thus are likely to generate lower frequencies of firing. Na v 1.6 channels produce a larger persistent current that may play a role in triggering reverse Na+/Ca 2+ exchange, which can injure demyelinated axons where Na v 1.6 and the Na+/Ca 2+ exchanger are colocalized, while selective expression of Na v 1.2 may support action potential electrogenesis, at least at lower frequencies, while producing a smaller persistent current.
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Self-citationThe tetrodotoxin-resistant sodium channel SNS has a specialized function in pain pathways
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Self-citationResurgent Sodium Current and Action Potential Formation in Dissociated Cerebellar Purkinje Neurons
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Self-citationDifferential subcellular localization of the RI and RII Na+ channel subtypes in central neurons
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Cited by
Action potential generation requires a high sodium channel density in the axon initial segment
Kole, M. H. P., Ilschner, S. U., Kampa, B. M., Williams, S. R., Ruben, P. C., & Stuart, G. J. (2008) · Nature Neuroscience · doi:10.1038/nn2040 · Cited by 703
Distinct contributions of Nav1.6 and Nav1.2 in action potential initiation and backpropagation
Hu, W., Tian, C., Li, T., Yang, M., Hou, H., & Shu, Y. (2009) · Nature Neuroscience · doi:10.1038/nn.2359 · Cited by 706
Signal processing in the axon initial segment
Kole, M. H. P., & Stuart, G. J. (2012) · Neuron · doi:10.1016/j.neuron.2012.01.007 · Cited by 463
Cell-type-dependent molecular composition of the axon initial segment
Lorincz, A., & Nusser, Z. (2008) · The Journal of Neuroscience · doi:10.1523/jneurosci.4833-08.2008 · Cited by 382
Mechanisms of Neurodegeneration and Axonal Dysfunction in Progressive Multiple Sclerosis
Correale, J., Marrodan, M., & Ysrraelit, M. C. (2019) · Biomedicines · doi:10.3390/biomedicines7010014 · Cited by 167
Metadata
- Authors
- Rush, A. M., Dib‐Hajj, S. D., & Waxman, S. G.
- Venue
- The Journal of Physiology
- Publisher
- Wiley
- Published
- 2005-04-21
- Volume
- 564
- Issue
- 3
- Pages
- 803-815
- ISSN
- 0022-3751 (ISSN-L)
- 1469-7793
- OpenAlex
- W1606137504
- Cited by
- 278
- References
- 44
- FWCI
- 4.84
- Type
- journal article
- Language
- en
- Open access
- closed
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- Rush, A. M., Dib‐Hajj, S. D., & Waxman, S. G. (2005). Electrophysiological properties of two axonal sodium channels, Nav1.2 and Nav1.6, expressed in mouse spinal sensory neurones. The Journal of Physiology. https://doi.org/10.1113/jphysiol.2005.083089
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