The DOI matches its Crossref record; 44 of the 44 references it cites were found in a registry or an index.
Electrophysiological properties of two axonal sodium channels, Nav1.2 and Nav1.6, expressed in mouse spinal sensory neurones
Abstract
Sodium channels Na v 1.2 and Na v 1.6 are both normally expressed along premyelinated and myelinated axons at different stages of maturation and are also expressed in a subset of demyelinated axons, where coexpression of Na v 1.6 together with the Na+/Ca 2+ exchanger is associated with axonal injury. It has been difficult to distinguish the currents produced by Na v 1.2 and Na v 1.6 in native neurones, and previous studies have not compared these channels within neuronal expression systems. In this study, we have characterized and directly compared Na v 1.2 and Na v 1.6 in a mammalian neuronal cell background and demonstrate differences in their properties that may affect neuronal behaviour. The Na v 1.2 channel displays more depolarized activation and availability properties that may permit conduction of action potentials, even with depolarization. However, Na v 1.2 channels show a greater accumulation of inactivation at higher frequencies of stimulation (20–100 Hz) than Na v 1.6 and thus are likely to generate lower frequencies of firing. Na v 1.6 channels produce a larger persistent current that may play a role in triggering reverse Na+/Ca 2+ exchange, which can injure demyelinated axons where Na v 1.6 and the Na+/Ca 2+ exchanger are colocalized, while selective expression of Na v 1.2 may support action potential electrogenesis, at least at lower frequencies, while producing a smaller persistent current.
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Metadata
- Authors
- Rush, A. M., Dib‐Hajj, S. D., & Waxman, S. G.
- Venue
- The Journal of Physiology
- Publisher
- Wiley
- Published
- 2005-04-21
- Volume
- 564
- Issue
- 3
- Pages
- 803-815
- ISSN
- 0022-3751 (ISSN-L)
- 1469-7793
- OpenAlex
- W1606137504
- Cited by
- 278
- References
- 44
- FWCI
- 4.84
- Type
- journal article
- Language
- en
- Open access
- closed
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