Altered Subthreshold Sodium Currents and Disrupted Firing Patterns in Purkinje Neurons of Scn8a Mutant Mice

Raman, Indira M; Sprunger, Leslie K; Meisler, Miriam H; Bean, Bruce P

doi:10.1016/s0896-6273(00)80969-1

Cited by 390Ion channel regulation and functionCardiac electrophysiology and arrhythmiasIon Transport and Channel Regulation

Altered Subthreshold Sodium Currents and Disrupted Firing Patterns in Purkinje Neurons of Scn8a Mutant Mice

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Raman, Indira M, Sprunger, Leslie K, Meisler, Miriam H, Bean, Bruce P·1997·Neuron

DOI 10.1016/s0896-6273(00)80969-1

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Abstract

Sodium currents and action potentials were characterized in Purkinje neurons from ataxic mice lacking expression of the sodium channel Scn8a. Peak transient sodium current was approximately 60% of that in normal mice, but subthreshold sodium current was affected much more. Steady-state current elicited by voltage ramps was reduced to approximately 30%, and resurgent sodium current, an unusual transient current elicited on repolarization following strong depolarizations, was reduced to 8%-18%. In jolting mice, with a missense mutation in Scn8a, steady-state and resurgent current were also reduced, with altered voltage dependence and kinetics. Both spontaneous firing and evoked bursts of spikes were diminished in cells from null and jolting mice. Evidently Scn8a channels carry most subthreshold sodium current and are crucial for repetitive firing.

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From The neurogenetics of alternative splicing (2016) · cites this paper as [141]

Ionic channels of excitable membranes
(1985) · General Pharmacology The Vascular System · doi:10.1016/0306-3623(85)90172-7 · Cited by 7,133 · see citing works
The Intrinsic Electrophysiological Properties of Mammalian Neurons: Insights into Central Nervous System Function
Llinás, R. R. (1988) · Science · doi:10.1126/science.3059497 · Cited by 2,285 · see citing works
Electrophysiological properties of in vitro Purkinje cell dendrites in mammalian cerebellar slices.
Llinas, R. H., & Sugimori, M. (1980) · The Journal of Physiology · doi:10.1113/jphysiol.1980.sp013358 · Cited by 1,758 · see citing works
The Ionic Channels in Excitable Membranes
Keynes, R. D. (1975) · Novartis Foundation symposium · doi:10.1002/9780470720134.ch11 · Cited by 1,671 · see citing works
Electrophysiological properties of in vitro Purkinje cell somata in mammalian cerebellar slices.
Llinas, R. H., & Sugimori, M. (1980) · The Journal of Physiology · doi:10.1113/jphysiol.1980.sp013357 · Cited by 1,061 · see citing works
A cluster of hydrophobic amino acid residues required for fast Na(+)-channel inactivation.
West, J. W., Patton, D. E., Scheuer, T., Wang, Y., Goldin, A. L., & Catterall, W. A. (1992) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.89.22.10910 · Cited by 829 · see citing works
P-type calcium channels in rat central and peripheral neurons
Mintz, I. M., Adams, M. E., & Bean, B. P. (1992) · Neuron · doi:10.1016/0896-6273(92)90223-z · Cited by 788 · see citing works
Self-citation
Conformation-sensitive gel electrophoresis for rapid detection of single-base differences in double-stranded PCR products and DNA fragments: evidence for solvent-induced bends in DNA heteroduplexes.
Ganguly, A. A., Rock, M. J., & Prockop, D. J. (1993) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.90.21.10325 · Cited by 678 · see citing works
Persistent Sodium Current in Mammalian Central Neurons
Crill, W. E. (1996) · Annual Review of Physiology · doi:10.1146/annurev.ph.58.030196.002025 · Cited by 634 · see citing works
Resurgent Sodium Current and Action Potential Formation in Dissociated Cerebellar Purkinje Neurons
Raman, I. M., & Bean, B. P. (1997) · The Journal of Neuroscience · doi:10.1523/jneurosci.17-12-04517.1997 · Cited by 568 · see citing works
Self-citation
Differential subcellular localization of the RI and RII Na+ channel subtypes in central neurons
Westenbroek, R. E., Merrick, D., & Catterall, W. A. (1989) · Neuron · doi:10.1016/0896-6273(89)90238-9 · Cited by 477 · see citing works
A voltage-dependent persistent sodium current in mammalian hippocampal neurons.
French, C. R., Sah, P., Buckett, K. J., & Gage, P. W. (1990) · The Journal of General Physiology · doi:10.1085/jgp.95.6.1139 · Cited by 374 · see citing works
Differential regulation of three sodium channel messenger RNAs in the rat central nervous system during development.
Beckh, S., Noda, M., Lübbert, H., & Numa, S. (1989) · The EMBO Journal · doi:10.1002/j.1460-2075.1989.tb08534.x · Cited by 361 · see citing works
Sodium channel α-subunit mRNAs I, II, III, NaG, Na6 and hNE (PN1): different expression patterns in developing rat nervous system
Felts, P. A., Yokoyama, S., Dib‐Hajj, S. D., Black, J. A., & Waxman, S. G. (1997) · Molecular Brain Research · doi:10.1016/s0169-328x(96)00241-0 · Cited by 333 · see citing works
Mutation of a new sodium channel gene, Scn8a, in the mouse mutant ‘motor endplate disease’
Burgess, D. L., Kohrman, D. C., Galt, J., Plummer, N. W., Jones, J. M., Spear, B. T., & Meisler, M. H. (1995) · Nature Genetics · doi:10.1038/ng0895-461 · Cited by 307 · see citing works
Self-citation
The inactivation gate of the Shaker K+ channel behaves like an open-channel blocker
Demo, S. D., & Yellen, G. (1991) · Neuron · doi:10.1016/0896-6273(91)90277-7 · Cited by 306 · see citing works
Modal gating of Na+ channels as a mechanism of persistent Na+ current in pyramidal neurons from rat and cat sensorimotor cortex
Alzheimer, C., Schwindt, P. C., & Crill, W. E. (1993) · Journal of Neuroscience · doi:10.1523/jneurosci.13-02-00660.1993 · Cited by 300 · see citing works
A novel, abundant sodium channel expressed in neurons and glia
Schaller, K., Krzemien, D., Yarowsky, P., Krueger, B., & Caldwell, J. (1995) · Journal of Neuroscience · doi:10.1523/jneurosci.15-05-03231.1995 · Cited by 231 · see citing works
A sodium channel gating model based on single channel, macroscopic ionic, and gating currents in the squid giant axon
Vandenberg, C. A., & Bezanilla, F. (1991) · Biophysical Journal · doi:10.1016/s0006-3495(91)82186-5 · Cited by 204 · see citing works
The adult rat brain beta 1 subunit modifies activation and inactivation gating of multiple sodium channel alpha subunits
Patton, D. E., Isom, L. L., Catterall, W. A., & Goldin, A. L. (1994) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(17)32490-0 · Cited by 201 · see citing works
Voltage-dependent calcium currents in Purkinje cells from rat cerebellar vermis
Regan, L. J. (1991) · Journal of Neuroscience · doi:10.1523/jneurosci.11-07-02259.1991 · Cited by 196 · see citing works
Two modes of gating during late Na+ channel currents in frog sartorius muscle.
Patlak, J. B., & Ortiz, M. (1986) · The Journal of General Physiology · doi:10.1085/jgp.87.2.305 · Cited by 180 · see citing works
Ligand- and voltage-gated ion channels
North, R. A. (1995) · CRC Press eBooks · Cited by 176 · see citing works
Restoration of inactivation and block of open sodium channels by an inactivation gate peptide
Eaholtz, G., Scheuer, T., & Catterall, W. A. (1994) · Neuron · doi:10.1016/0896-6273(94)90312-3 · Cited by 171 · see citing works
Na+ currents that fail to inactivate
Taylor, C. P. (1993) · Trends in Neurosciences · doi:10.1016/0166-2236(93)90077-y · Cited by 160 · see citing works
Alternative Splicing of the Sodium Channel SCN8A Predicts a Truncated Two-domain Protein in Fetal Brain and Non-neuronal Cells
Plummer, N. W., McBurney, M. W., & Meisler, M. H. (1997) · Journal of Biological Chemistry · doi:10.1074/jbc.272.38.24008 · Cited by 155 · see citing works
Self-citation
Mutation Detection in the and Alleles of the Sodium Channel
Kohrman, D. C., Harris, J. B., & Meisler, M. H. (1996) · Journal of Biological Chemistry · doi:10.1074/jbc.271.29.17576 · Cited by 140 · see citing works
Self-citation
A Missense Mutation in the Sodium Channel Scn8a Is Responsible for Cerebellar Ataxia in the Mouse Mutant jolting
Kohrman, D. C., Smith, M. R., Goldin, A. L., Harris, J. B., & Meisler, M. H. (1996) · Journal of Neuroscience · doi:10.1523/jneurosci.16-19-05993.1996 · Cited by 132 · see citing works
Self-citation
Morphological and physiological differentiation of Purkinje neurons in cultures of rat cerebellum
Gruol, D. L., & Franklin, C. (1987) · Journal of Neuroscience · doi:10.1523/jneurosci.07-05-01271.1987 · Cited by 118 · see citing works
Modulation of sodium channels of rat cerebellar Purkinje neurons by the pyrethroid tetramethrin.
Song, J.-H., & Narahashi, T. (1996) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(25)12842-5 · Cited by 110 · see citing works
Sodium channel mRNAs I, II and III in the CNS: cell-specific expression
Black, J. A., Yokoyama, S., Higashida, H., Ransom, B. R., & Waxman, S. G. (1994) · Molecular Brain Research · doi:10.1016/0169-328x(94)90056-6 · Cited by 106 · see citing works
Electrophysiological studies of neuromuscular transmission in hereditary ‘motor end‐plate disease’ of the mouse
Duchen, L. W., & Stefani, E. (1971) · The Journal of Physiology · doi:10.1113/jphysiol.1971.sp009340 · Cited by 94 · see citing works
Molecular characterization of the sodium channel subunits expressed in mammalian cerebellar Purkinje cells
de Miera, E. V., Rudy, B., Sugimori, M., & Llinás, R. (1997) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.94.13.7059 · Cited by 90 · see citing works
Different voltage dependence of transient and persistent Na+ currents is compatible with modal-gating hypothesis for sodium channels
Brown, A. M., Schwindt, P. C., & Crill, W. E. (1994) · Journal of Neurophysiology · doi:10.1152/jn.1994.71.6.2562 · Cited by 80 · see citing works
Hereditary motor end-plate disease in the mouse: light and electron microscopic studies.
Duchen, L. W. (1970) · Journal of Neurology Neurosurgery & Psychiatry · doi:10.1136/jnnp.33.2.238 · Cited by 79 · see citing works
Distribution of I, II and III subtypes of voltage-sensitive Na+ channel mRNA in the rat brain
Furuyama, T., Morita, Y., Inagaki, S., & Takagi, H. (1993) · Molecular Brain Research · doi:10.1016/0169-328x(93)90087-6 · Cited by 59 · see citing works
Differential expression of sodium channel mRNAs in rat peripheral nervous system and innervated tissues
Beckh, S. (1990) · FEBS Letters · doi:10.1016/0014-5793(90)80218-8 · Cited by 55 · see citing works
Insertional mutation of the motor endplate disease (med) locus on mouse chromosome 15
Kohrman, D. C., Plummer, N. W., Schuster, T. G., Jones, J. M., Jang, W., Burgess, D. L., Galt, J., Spear, B. T., & Meisler, M. H. (1995) · Genomics · doi:10.1016/0888-7543(95)80198-u · Cited by 49 · see citing works
Self-citation
Ion Channel Mutations in Mouse Models of Inherited Neurological Disease
Meisler, M. H., Sprunger, L. K., Plummer, N. W., Escayg, A., & Jones, J. M. (1997) · Annals of Medicine · doi:10.3109/07853899709007484 · Cited by 34 · see citing works
Self-citation
A CEREBELLAR ABNORMALITY IN THE MOUSE WITH MOTOR END‐PLATE DISEASE
Boakes, R. J., Harris, J. B., & DICK, D. K. (1985) · Neuropathology and Applied Neurobiology · doi:10.1111/j.1365-2990.1985.tb00011.x · Cited by 31 · see citing works
R56865 and flunarizine as Na+-channel blockers in isolated Purkinje neurons of rat cerebellum
Kiskin, N. I., Chizhmakov, I. V., Tsyndrenko, A. Y., Krishtal, O., & Tegtmeier, F. (1993) · Neuroscience · doi:10.1016/0306-4522(93)90229-9 · Cited by 28 · see citing works
Neuromuscular transmission in the murine mutants “motor end-plate disease” and “jolting”
Harris, J. B., & Pollard, S. (1986) · Journal of the Neurological Sciences · doi:10.1016/0022-510x(86)90172-3 · Cited by 28 · see citing works
Physiological and biochemical studies on the cerebellar cortex of the murine mutants “jolting” and “motor end-plate disease”
Harris, J. B., Boakes, R. J., & COURT, J. A. (1992) · Journal of the Neurological Sciences · doi:10.1016/0022-510x(92)90027-i · Cited by 25 · see citing works
Cerebellar structure and function in the murine mutant “jolting”
Dick, D. J., Boakes, R. J., Candy, J. M., Harris, J. B., & Cullen, M. J. (1986) · Journal of the Neurological Sciences · doi:10.1016/0022-510x(86)90173-5 · Cited by 22 · see citing works
Pacemaker properties of mammalian Purkinje cells
Hounsgaard, J. (1979) · Acta Physiologica Scandinavica · doi:10.1111/j.1748-1716.1979.tb06375.x · Cited by 19 · see citing works

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Catterall, W. A., Goldin, A. L., & Waxman, S. G. (2005) · Pharmacological Reviews · doi:10.1124/pr.57.4.4 · Cited by 2,259 · see citing works
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Goldin, A. L. (2001) · Annual Review of Physiology · doi:10.1146/annurev.physiol.63.1.871 · Cited by 688 · see citing works
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Caldwell, J. H., Schaller, K. L., Lasher, R. S., Peles, E., & Levinson, S. R. (2000) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.090034797 · Cited by 649 · see citing works
The NaV1.7 sodium channel: from molecule to man
Dib‐Hajj, S. D., Yang, Y., Black, J. A., & Waxman, S. G. (2012) · Nature reviews. Neuroscience · doi:10.1038/nrn3404 · Cited by 613 · see citing works
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Zhou, D., Lambert, S., Malen, P. L., Carpenter, S., Boland, L. M., & Bennett, V. (1998) · The Journal of Cell Biology · doi:10.1083/jcb.143.5.1295 · Cited by 568 · see citing works
Voltage-Gated Ion Channels and Hereditary Disease
Lehmann‐Horn, F., & Jurkat‐Rott, K. (1999) · Physiological Reviews · doi:10.1152/physrev.1999.79.4.1317 · Cited by 548 · see citing works
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Kumar, P., & Prabhakar, N. R. (2012) · Comprehensive physiology · doi:10.1002/cphy.c100069 · Cited by 532 · see citing works
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Meisler, M. H. (2005) · Journal of Clinical Investigation · doi:10.1172/jci25466 · Cited by 512 · see citing works
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Vacher, H., Mohapatra, D. P., & Trimmer, J. S. (2008) · Physiological Reviews · doi:10.1152/physrev.00002.2008 · Cited by 488 · see citing works
The roles of sodium channels in nociception: Implications for mechanisms of pain
Cummins, T., Sheets, P. L., & Waxman, S. G. (2007) · Pain · doi:10.1016/j.pain.2007.07.026 · Cited by 484 · see citing works
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Sterling, P., & Laughlin, S. (2015) · doi:10.7551/mitpress/9780262028707.001.0001 · Cited by 482 · see citing works
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Raman, I. M., & Bean, B. P. (1999) · Journal of Neuroscience · doi:10.1523/jneurosci.19-05-01663.1999 · Cited by 456 · see citing works
Self-citation
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Jenkins, S. M., & Bennett, V. (2001) · The Journal of Cell Biology · doi:10.1083/jcb.200109026 · Cited by 446 · see citing works
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Trimmer, J. S., & Rhodes, K. J. (2004) · Annual Review of Physiology · doi:10.1146/annurev.physiol.66.032102.113328 · Cited by 442 · see citing works
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Boiko, T., Rasband, M., Levinson, S., Caldwell, J., Mandel, G., Trimmer, J. S., & Matthews, G. (2001) · Neuron · doi:10.1016/s0896-6273(01)00265-3 · Cited by 434 · see citing works
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Escayg, A., WAARD, M. M. D., Lee, D. D., Bichet, D., Wolf, P., Mayer, T., Johnston, J. L., Baloh, R. W., Sander, T., & Meisler, M. H. (2000) · The American Journal of Human Genetics · doi:10.1086/302909 · Cited by 422 · see citing works
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Lorincz, A., & Nusser, Z. (2008) · The Journal of Neuroscience · doi:10.1523/jneurosci.4833-08.2008 · Cited by 382 · see citing works
Slow Closed-State Inactivation: A Novel Mechanism Underlying Ramp Currents in Cells Expressing the hNE/PN1 Sodium Channel
Cummins, T., Howe, J. R., & Waxman, S. G. (1998) · Journal of Neuroscience · doi:10.1523/jneurosci.18-23-09607.1998 · Cited by 382 · see citing works
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Eijkelkamp, N., Linley, J. E., Baker, M. D., Minett, M. S., Cregg, R., Werdehausen, R., Rugiero, F., & Wood, J. (2012) · Brain · doi:10.1093/brain/aws225 · Cited by 359 · see citing works
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Herzog, R. I., Cummins, T., Ghassemi, F., Dib‐Hajj, S. D., & Waxman, S. G. (2003) · The Journal of Physiology · doi:10.1113/jphysiol.2003.047357 · Cited by 318 · see citing works
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Raman, I. M., & Bean, B. P. (2001) · Biophysical Journal · doi:10.1016/s0006-3495(01)76052-3 · Cited by 209 · see citing works
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Martin, M. S., Tang, B., Papale, L. A., Yu, F. H., Catterall, W. A., & Escayg, A. (2007) · Human Molecular Genetics · doi:10.1093/hmg/ddm248 · Cited by 202 · see citing works
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Royeck, M., Horstmann, M., Remy, S., Reitze, M., Yaari, Y., & Beck, H. (2008) · Journal of Neurophysiology · doi:10.1152/jn.90332.2008 · Cited by 204 · see citing works
Robustness of burst firing in dissociated purkinje neurons with acute or long-term reductions in sodium conductance
Swensen, A. M., & Bean, B. P. (2005) · The Journal of Neuroscience · doi:10.1523/jneurosci.3929-04.2005 · Cited by 197 · see citing works
Self-citation
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Taylor, A. L., Goaillard, J.-M., & Marder, E. (2009) · The Journal of Neuroscience · doi:10.1523/jneurosci.4438-08.2009 · Cited by 202 · see citing works
Evolution and Diversity of Mammalian Sodium Channel Genes
Plummer, N. W., & Meisler, M. H. (1999) · Genomics · doi:10.1006/geno.1998.5735 · Cited by 202 · see citing works
Self-citation
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Meisler, M. H., Hill, S. F., & Yu, W. (2021) · Nature reviews. Neuroscience · doi:10.1038/s41583-020-00418-4 · Cited by 202 · see citing works
Self-citation
Where is the trace in trace conditioning?
Woodruff‐Pak, D. S., & Disterhoft, J. F. (2008) · Trends in Neurosciences · doi:10.1016/j.tins.2007.11.006 · Cited by 188 · see citing works
Heterozygosity for a protein truncation mutation of sodium channel SCN8A in a patient with cerebellar atrophy, ataxia, and mental retardation
Trudeau, M., Dalton, J. C., Day, J., Ranum, L. P. W., & Meisler, M. H. (2005) · Journal of Medical Genetics · doi:10.1136/jmg.2005.035667 · Cited by 187 · see citing works
Self-citation
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Craner, M. J. (2003) · Brain · doi:10.1093/brain/awg153 · Cited by 187 · see citing works
Diversity of Mammalian Voltage‐Gated Sodium Channels
Goldin, A. L. (1999) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.1999.tb11272.x · Cited by 186 · see citing works
Where Is the Spike Generator of the Cochlear Nerve? Voltage-Gated Sodium Channels in the Mouse Cochlea
Hossain, W., Antic, S., Yang, Y., Rasband, M., & Morest, D. (2005) · Journal of Neuroscience · doi:10.1523/jneurosci.0123-05.2005 · Cited by 177 · see citing works
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Aman, T. K., Grieco‐Calub, T. M., Chen, C., Rusconi, R., Slat, E. A., Isom, L. L., & Raman, I. M. (2009) · Journal of Neuroscience · doi:10.1523/jneurosci.4531-08.2009 · Cited by 171 · see citing works
Self-citation
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Ogata, N., & Ohishi, Y. (2002) · The Japanese Journal of Pharmacology · doi:10.1254/jjp.88.365 · Cited by 170 · see citing works
Neuronal Death and Perinatal Lethality in Voltage-Gated Sodium Channel αII-Deficient Mice
Planells‐Cases, R., Caprini, M., Zhang, J., Rockenstein, E. M., Rivera, R. R., Murre, C., Masliah, E., & Montal, M. (2000) · Biophysical Journal · doi:10.1016/s0006-3495(00)76829-9 · Cited by 168 · see citing works
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Khaliq, Z. M., & Raman, I. M. (2005) · Journal of Neuroscience · doi:10.1523/jneurosci.3045-04.2005 · Cited by 167 · see citing works
Self-citation
Cell‐attached measurements of the firing threshold of rat hippocampal neurones
Fricker, D., Verheugen, J. A. H., & Miles, R. (1999) · The Journal of Physiology · doi:10.1111/j.1469-7793.1999.0791s.x · Cited by 160 · see citing works
Spike Encoding of Neurotransmitter Release Timing by Spiral Ganglion Neurons of the Cochlea
Rutherford, M. A., Chapochnikov, N. M., & Moser, T. (2012) · Journal of Neuroscience · doi:10.1523/jneurosci.4511-11.2012 · Cited by 160 · see citing works
Sodium channel SCN8A (Nav1.6): properties and de novo mutations in epileptic encephalopathy and intellectual disability
O’Brien, J. E., & Meisler, M. H. (2013) · Frontiers in Genetics · doi:10.3389/fgene.2013.00213 · Cited by 158 · see citing works
Self-citation
Relative Contributions of Axonal and Somatic Na Channels to Action Potential Initiation in Cerebellar Purkinje Neurons
Khaliq, Z. M., & Raman, I. M. (2006) · Journal of Neuroscience · doi:10.1523/jneurosci.4664-05.2006 · Cited by 157 · see citing works
Self-citation
The Making of a Complex Spike: Ionic Composition and Plasticity
SCHMOLESKY, M. T., Weber, J. T., Zeeuw, C. I. D., & Hansel, C. (2002) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2002.tb07581.x · Cited by 149 · see citing works
Presynaptic Na + Channels: Locus, Development, and Recovery from Inactivation at a High-Fidelity Synapse
Leão, R. M., Kushmerick, C., Pinaud, R., Renden, R., Li, G., Taschenberger, H., Spirou, G. A., Levinson, S. R., & von Gersdorff, H. (2005) · Journal of Neuroscience · doi:10.1523/jneurosci.3983-04.2005 · Cited by 148 · see citing works
Marshall Syndrome Associated with a Splicing Defect at the COL11A1 Locus
Griffith, A. J., Sprunger, L. K., Sirko-Osadsa, D. A., Tiller, G. E., Meisler, M. H., & Warman, M. L. (1998) · The American Journal of Human Genetics · doi:10.1086/301789 · Cited by 145 · see citing works
Self-citation
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Kay, A. R., Sugimori, M., & Llinás, R. (1998) · Journal of Neurophysiology · doi:10.1152/jn.1998.80.3.1167 · Cited by 140 · see citing works
Functional reciprocity between Na + channel Na v 1.6 and β1 subunits in the coordinated regulation of excitability and neurite outgrowth
Brackenbury, W. J., Calhoun, J. D., Chen, C., Miyazaki, H., Nukina, N., Oyama, F., Ranscht, B., & Isom, L. L. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0909434107 · Cited by 139 · see citing works
Impaired Motor Function in Mice With Cell-Specific Knockout of Sodium Channel Scn8a (Na V 1.6) in Cerebellar Purkinje Neurons and Granule Cells
Levin, S. I., Khaliq, Z. M., Aman, T. K., Grieco, T. M., Kearney, J. A., Raman, I. M., & Meisler, M. H. (2006) · Journal of Neurophysiology · doi:10.1152/jn.01193.2005 · Cited by 138 · see citing works
Self-citation
Human voltage-gated sodium channel mutations that cause inherited neuronal and muscle channelopathies increase resurgent sodium currents
Jarecki, B. W., Piekarz, A. D., Jackson, J. O., & Cummins, T. (2010) · Journal of Clinical Investigation · doi:10.1172/jci40801 · Cited by 137 · see citing works
Dysregulation of sodium channel expression in cortical neurons in a rodent model of absence epilepsy
Klein, J. P., Khera, D. S., Nersesyan, H., Kimchi, E. Y., Waxman, S. G., & Blumenfeld, H. (2003) · Brain Research · doi:10.1016/j.brainres.2003.11.051 · Cited by 137 · see citing works
Sodium channel Na(v)1.6 is expressed along nonmyelinated axons and it contributes to conduction.
Black, J., Renganathan, M., & Waxman, S. (2002) · Brain Research. Molecular Brain Research · doi:10.1016/s0169-328x(02)00385-6 · Cited by 142 · see citing works
Regulation of Neuronal Excitability through Pumilio-Dependent Control of a Sodium Channel Gene
Mee, C., Pym, E. C. G., Moffat, K. G., & Baines, R. (2004) · Journal of Neuroscience · doi:10.1523/jneurosci.2282-04.2004 · Cited by 137 · see citing works
Functional Analysis of the Rat I Sodium Channel inXenopusOocytes
Smith, R. D., & Goldin, A. L. (1998) · Journal of Neuroscience · doi:10.1523/jneurosci.18-03-00811.1998 · Cited by 136 · see citing works
A Gain-of-Function Mutation in Nav1.6 in a Case of Trigeminal Neuralgia
Tanaka, B. S., Zhao, P., Dib-Hajj, F. B., Morisset, V., Tate, S., Waxman, S. G., & Dib‐Hajj, S. D. (2016) · Molecular Medicine · doi:10.2119/molmed.2016.00131 · Cited by 134 · see citing works
Expression and distribution of voltage-gated sodium channels in the cerebellum
Schaller, K., & Caldwell, J. H. (2003) · The Cerebellum · doi:10.1080/14734220309424 · Cited by 134 · see citing works
Functional properties and differential neuromodulation of Nav1.6 channels
Chen, Y., Yu, F. H., Sharp, E. M., Beacham, D., Scheuer, T., & Catterall, W. A. (2008) · Molecular and Cellular Neuroscience · doi:10.1016/j.mcn.2008.05.009 · Cited by 128 · see citing works
Sodium channelopathies of skeletal muscle and brain
Mantegazza, M., Cestèle, S., & Catterall, W. A. (2021) · Physiological Reviews · doi:10.1152/physrev.00025.2020 · Cited by 133 · see citing works
Impaired Firing and Cell-Specific Compensation in Neurons Lacking Na v 1.6 Sodium Channels
Wart, A. V., & Matthews, G. (2006) · Journal of Neuroscience · doi:10.1523/jneurosci.1101-06.2006 · Cited by 132 · see citing works
FGF14 Regulates the Intrinsic Excitability of Cerebellar Purkinje Neurons
Shakkottai, V., Xiao, M.-L., Xu, L., Wong, M., Nerbonne, J., Ornitz, D., & Yamada, K. A. (2008) · Neurobiology of Disease · doi:10.1016/j.nbd.2008.09.019 · Cited by 130 · see citing works
Interaction of Kv3 Potassium Channels and Resurgent Sodium Current Influences the Rate of Spontaneous Firing of Purkinje Neurons
Akemann, W., & Knöpfel, T. (2006) · Journal of Neuroscience · doi:10.1523/jneurosci.5204-05.2006 · Cited by 129 · see citing works
Autonomous pacemakers in the basal ganglia: who needs excitatory synapses anyway?
Surmeier, D. J., Mercer, J. N., & Chan, C. S. (2005) · Current Opinion in Neurobiology · doi:10.1016/j.conb.2005.05.007 · Cited by 128 · see citing works
Heterozygous mutations of the voltage-gated sodium channel SCN8A are associated with spike-wave discharges and absence epilepsy in mice
Papale, L. A., Beyer, B., Jones, J. M., Sharkey, L. M., Tufik, S., Epstein, M., Letts, V. A., Meisler, M. H., Frankel, W. N., & Escayg, A. (2009) · Human Molecular Genetics · doi:10.1093/hmg/ddp081 · Cited by 127 · see citing works
Self-citation
Transfection of rat or mouse neurons by biolistics or electroporation
Dib‐Hajj, S. D., Choi, J., Macala, L. J., Tyrrell, L., Black, J. A., Cummins, T., & Waxman, S. G. (2009) · Nature Protocols · doi:10.1038/nprot.2009.90 · Cited by 127 · see citing works
Sensory neuron-specific sodium channel SNS is abnormally expressed in the brains of mice with experimental allergic encephalomyelitis and humans with multiple sclerosis
Black, J. A., Dib‐Hajj, S. D., Baker, D., Newcombe, J., Cuzner, M. L., & Waxman, S. G. (2000) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.97.21.11598 · Cited by 127 · see citing works
Transcriptional channelopathies: An emerging class of disorders
Waxman, S. G. (2001) · Nature reviews. Neuroscience · doi:10.1038/35090026 · Cited by 127 · see citing works
Resurgent current of voltage‐gated Na + channels
Lewis, A. H., & Raman, I. M. (2014) · The Journal of Physiology · doi:10.1113/jphysiol.2014.277582 · Cited by 122 · see citing works
Self-citation
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Bant, J. S., & Raman, I. M. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1005633107 · Cited by 123 · see citing works
Self-citation
Acquired channelopathies in nerve injury and MS
Waxman, S. G. (2001) · Neurology · doi:10.1212/wnl.56.12.1621 · Cited by 122 · see citing works
Regulation of Thalamic and Cortical Network Synchrony by Scn8a
Makinson, C. D., Tanaka, B. S., Sorokin, J. M., Wong, J. C., Christian, C. A., Goldin, A. L., Escayg, A., & Huguenard, J. R. (2017) · Neuron · doi:10.1016/j.neuron.2017.01.031 · Cited by 117 · see citing works
Voltage‐gated Sodium Channels in Epilepsy
Köhling, R. (2002) · Epilepsia · doi:10.1046/j.1528-1157.2002.40501.x · Cited by 117 · see citing works
Functional profiles of SCN9A variants in dorsal root ganglion neurons and superior cervical ganglion neurons correlate with autonomic symptoms in small fibre neuropathy
Han, C., Hoeijmakers, J. G. J., Liu, S., Gerrits, M. M., Morsche, R. H. M. T., Lauria, G., Dib‐Hajj, S. D., Drenth, J. P. H., Faber, C. G., Merkies, I. S. J., et al. (2012) · Brain · doi:10.1093/brain/aws187 · Cited by 116 · see citing works
Functional Analysis of a Voltage‐Gated Sodium Channel and Its Splice Variant from Rat Dorsal Root Ganglia
Dietrich, P. S., McGivern, J. G., Delgado, S. G., Koch, B., Eglen, R. M., Hunter, J. C., & Sangameswaran, L. (1998) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.1998.70062262.x · Cited by 115 · see citing works
Voltage-clamp and current-clamp recordings from mammalian DRG neurons
Cummins, T., Rush, A. M., Estación, M., Dib‐Hajj, S. D., & Waxman, S. G. (2009) · Nature Protocols · doi:10.1038/nprot.2009.91 · Cited by 114 · see citing works
Nav1.6 channels generate resurgent sodium currents in spinal sensory neurons
Cummins, T., Dib‐Hajj, S. D., Herzog, R. I., & Waxman, S. G. (2005) · FEBS Letters · doi:10.1016/j.febslet.2005.03.009 · Cited by 112 · see citing works
Evidence for a role of Na v 1.6 in facilitating increases in neuronal hyperexcitability during epileptogenesis
Hargus, N. J., Nigam, A., Bertram, E. H., & Patel, M. K. (2013) · Journal of Neurophysiology · doi:10.1152/jn.00383.2013 · Cited by 110 · see citing works
The axon initial segment in nervous system disease and injury
Buffington, S. A., & Rasband, M. N. (2011) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2011.07875.x · Cited by 108 · see citing works
A novel de novo mutation of SCN8A (Nav1.6) with enhanced channel activation in a child with epileptic encephalopathy
Estación, M., O’Brien, J. E., Conravey, A., Hammer, M. F., Waxman, S. G., Dib‐Hajj, S. D., & Meisler, M. H. (2014) · Neurobiology of Disease · doi:10.1016/j.nbd.2014.05.017 · Cited by 105 · see citing works
Self-citation
Molecular and pathological effects of a modifier gene on deficiency of the sodium channel Scn8a (Nav1.6)
Kearney, J. A. (2002) · Human Molecular Genetics · doi:10.1093/hmg/11.22.2765 · Cited by 104 · see citing works
Ion Channels Set Spike Timing Regularity of Mammalian Vestibular Afferent Neurons
Kalluri, R., Xue, J., & Eatock, R. A. (2010) · Journal of Neurophysiology · doi:10.1152/jn.00396.2010 · Cited by 102 · see citing works

The absence of resurgent sodium current in mouse spinal neurons
Pan, F., & Beam, K. G. (1999) · Brain Research · doi:10.1016/s0006-8993(99)02060-0 · Cited by 38 · see citing works
Functional Analysis of the Mouse Scn8a Sodium Channel
Smith, M. R., Smith, R. D., Plummer, N. W., Meisler, M. H., & Goldin, A. L. (1998) · Journal of Neuroscience · doi:10.1523/jneurosci.18-16-06093.1998 · Cited by 248 · see citing works
Self-citation
Impaired Motor Function in Mice With Cell-Specific Knockout of Sodium Channel Scn8a (Na V 1.6) in Cerebellar Purkinje Neurons and Granule Cells
Levin, S. I., Khaliq, Z. M., Aman, T. K., Grieco, T. M., Kearney, J. A., Raman, I. M., & Meisler, M. H. (2006) · Journal of Neurophysiology · doi:10.1152/jn.01193.2005 · Cited by 138 · see citing works
Self-citation
The Contribution of Resurgent Sodium Current to High-Frequency Firing in Purkinje Neurons: An Experimental and Modeling Study
Khaliq, Z. M., Gouwens, N. W., & Raman, I. M. (2003) · Journal of Neuroscience · doi:10.1523/jneurosci.23-12-04899.2003 · Cited by 308 · see citing works
Self-citation
Cerebellum-Related Characteristics of Scn8a-Mutant Mice
Chen, K., Godfrey, D. A., Ilyas, O., Xu, J., & Preston, T. W. (2009) · The Cerebellum · doi:10.1007/s12311-009-0110-z · Cited by 18 · see citing works

Authors: Raman, I. M., Sprunger, L. K., Meisler, M. H., & Bean, B. P.
Affiliations: Harvard University (US)
University of Michigan (US)
Corresponding author: Raman, Indira M
ORCID: Raman, Indira M
Meisler, Miriam H
Bean, Bruce P
Venue: Neuron
Publisher: Elsevier BV
Published: 1997-10
Volume: 19
Issue: 4
Pages: 881-891
ISSN: 0896-6273 (ISSN-L)
DOI: 10.1016/s0896-6273(00)80969-1
OpenAlex: W2090477486
Cited by: 390
References: 45
Citations by year: 2026: 4 · 2025: 7 · 2024: 9 · 2023: 14 · 2022: 14 · 2021: 10 · 2020: 11 · 2019: 11 · 2018: 11 · 2017: 16 · 2016: 14 · 2015: 11 · 2014: 14 · 2013: 10 · 2012: 21
FWCI: 4.39
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/open-access/userlicense/1.0/ (vor, 5768 d)
Locations: Neuron (publishedVersion)
PubMed (publishedVersion)
Funders: Vedecká Grantová Agentúra MŠVVaŠ SR a SAV
National Institutes of Health
National Institute of Neurological Disorders and Stroke (R01NS036855, F32-NS10396, R01-NS34059, R01NS36855, F32NS010396)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Ion channel regulation and function
Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiac electrophysiology and arrhythmias
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Ion Transport and Channel Regulation
Keywords: SCN8A, sodium channels, Purkinje cells, resurgent sodium current, missense mutations, ataxia, repetitive firing, action potential, cerebellum
MeSH terms: Animals, Calcium, Crosses, Genetic, Evoked Potentials, Genotype, Heterozygote, Kinetics, Membrane Potentials, Mice, Inbred C3H, Mice, Inbred C57BL, Nerve Tissue Proteins, Purkinje Cells, Time Factors, Sodium Channels, Polymerase Chain Reaction, Mice, Knockout, Patch-Clamp Techniques, Mice, NAV1.6 Voltage-Gated Sodium Channel, In Vitro Techniques

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Altered Subthreshold Sodium Currents and Disrupted Firing Patterns in Purkinje Neurons of Scn8a Mutant Mice

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