The DOI matches its Crossref record; 13 of the 13 references it cites were found in a registry or an index.
Functions of AMP‐activated protein kinase in adipose tissue
Open accessAbstract
AMP‐activated protein kinase (AMPK) is involved in cellular energy homeostasis. Its functions have been extensively studied in muscles and liver. AMPK stimulates pathways which increase energy production (glucose transport, fatty acid oxidation) and switches off pathways which consume energy (lipogenesis, protein synthesis, gluconeogenesis). This has led to the concept that AMPK has an interesting pharmaceutical potential in situations of insulin resistance and it is indeed the target of existing drugs and hormones which improve insulin sensitivity. Adipose tissue is a key player in energy metabolism through the release of substrates and hormones involved in metabolism and insulin sensitivity. Activation of AMPK in adipose tissue can be achieved through situations such as fasting and exercise. Leptin and adiponectin as well as hypoglycaemic drugs are activators of adipose tissue AMPK. This activation probably involves changes in the AMP/ATP ratio and the upstream kinase LKB1. When activated, AMPK limits fatty acid efflux from adipocytes and favours local fatty acid oxidation. Since fatty acids have a key role in insulin resistance, especially in muscles, activating AMPK in adipose tissue might be found to be beneficial in insulin‐resistant states, particularly as AMPK activation also reduces cytokine secretion in adipocytes.
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Cites
Role of AMP-Activated Protein Kinase in Mechanism of Metformin Action
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Self-citationLeptin stimulates fatty-acid oxidation by activating AMP-activated protein kinase
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LKB1 is the upstream kinase in the AMP-activated protein kinase cascade
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Mammalian AMP-activated protein kinase subfamily
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Characterization of AMP-activated protein kinase γ-subunit isoforms and their role in AMP binding
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Cited by
AMPK and the biochemistry of exercise: implications for human health and disease
Richter, E. A., & Ruderman, N. B. (2009) · Biochemical Journal · doi:10.1042/bj20082055 · Cited by 481
Regulation and Metabolic Significance of De Novo Lipogenesis in Adipose Tissues
Song, Z., Xiaoli, A. M., & Yang, F. (2018) · Nutrients · doi:10.3390/nu10101383 · Cited by 435
Glycerolipid Metabolism and Signaling in Health and Disease
Prentki, M., & Madiraju, S. R. M. (2008) · Endocrine Reviews · doi:10.1210/er.2008-0007 · Cited by 326
Srivastava, R. A. K., Pinkosky, S. L., Filippov, S., Hanselman, J. C., Cramer, C. T., & Newton, R. S. (2012) · Journal of Lipid Research · doi:10.1194/jlr.r025882 · Cited by 296
TBK1 at the Crossroads of Inflammation and Energy Homeostasis in Adipose Tissue
Zhao, P., Wong, K. I., Sun, X., Reilly, S. M., Uhm, M., Liao, Z., Skorobogatko, Y., & Saltiel, A. R. (2018) · Cell · doi:10.1016/j.cell.2018.01.007 · Cited by 250
Metadata
- Authors
- Daval, M., Foufelle, F., & Ferré, P.
- Venue
- The Journal of Physiology
- Publisher
- Wiley
- Published
- 2006-06-19
- Volume
- 574
- Issue
- 1
- Pages
- 55-62
- ISSN
- 0022-3751 (ISSN-L)
- 1469-7793
- OpenAlex
- W1523898198
- Cited by
- 417
- References
- 13
- FWCI
- 6.51
- Type
- journal article
- Language
- en
- Open access
- hybrid
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