Calmodulin-dependent protein kinase kinase-β is an alternative upstream kinase for AMP-activated protein kinase

AMP-activated protein kinase: ancient energy gauge provides clues to modern understanding of metabolism

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Evidence that metformin exerts its anti-diabetic effects through inhibition of complex 1 of the mitochondrial respiratory chain

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The tumor suppressor LKB1 kinase directly activates AMP-activated kinase and regulates apoptosis in response to energy stress

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Complexes between the LKB1 tumor suppressor, STRADα/β and MO25α/β are upstream kinases in the AMP-activated protein kinase cascade

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LKB1 is the upstream kinase in the AMP-activated protein kinase cascade

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Dimethylbiguanide inhibits cell respiration via an indirect effect targeted on the respiratory chain complex I

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LKB1 is a master kinase that activates 13 kinases of the AMPK subfamily, including MARK/PAR‐1

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The specificities of protein kinase inhibitors: an update

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Characterization of the AMP-activated Protein Kinase Kinase from Rat Liver and Identification of Threonine 172 as the Major Site at Which It Phosphorylates AMP-activated Protein Kinase

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The AMP-activated protein kinase pathway – new players upstream and downstream

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The AMP-activated protein kinase cascade – a unifying system for energy control

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The Anti-diabetic Drugs Rosiglitazone and Metformin Stimulate AMP-activated Protein Kinase through Distinct Signaling Pathways

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Management of cellular energy by the AMP‐activated protein kinase system

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Inactivation of acetyl-CoA carboxylase and activation of AMP-activated protein kinase in muscle during exercise

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AMP‐activated protein kinase: the energy charge hypothesis revisited

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CBS domains form energy-sensing modules whose binding of adenosine ligands is disrupted by disease mutations

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The antidiabetic drug metformin activates the AMP-activated protein kinase cascade via an adenine nucleotide-independent mechanism

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Calcium promotes cell survival through CaM-K kinase activation of the protein-kinase-B pathway

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Activation of yeast Snf1 and mammalian AMP-activated protein kinase by upstream kinases

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The structure of a domain common to archaebacteria and the homocystinuria disease protein.

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Deficiency of LKB1 in skeletal muscle prevents AMPK activation and glucose uptake during contraction

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5′-AMP Activates the AMP-activated Protein Kinase Cascade, and Ca2+/Calmodulin Activates the Calmodulin-dependent Protein Kinase I Cascade, via Three Independent Mechanisms

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Tissue distribution of the AMP‐activated protein kinase, and lack of activation by cyclic‐AMP‐dependent protein kinase, studied using a specific and sensitive peptide assay

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AMPK β Subunit Targets Metabolic Stress Sensing to Glycogen

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[37] Protein phosphatase-1 and protein phosphatase-2A from rabbit skeletal muscle

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AMP-Activated Protein Kinase: An Ultrasensitive System for Monitoring Cellular Energy Charge

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AMP-Activated Protein Kinase is Highly Expressed in Neurons in the Developing Rat Brain and Promotes Neuronal Survival Following Glucose Deprivation

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A novel domain in AMP-activated protein kinase causes glycogen storage bodies similar to those seen in hereditary cardiac arrhythmias

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Growth suppression by Lkb1 is mediated by a G 1 cell cycle arrest

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STO-609, a Specific Inhibitor of the Ca2+/Calmodulin-dependent Protein Kinase Kinase

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Activation of GLUT1 by metabolic and osmotic stress: potential involvement of AMP-activated protein kinase (AMPK)

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Elm1p Is One of Three Upstream Kinases for the Saccharomyces cerevisiae SNF1 Complex

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The α1 and α2 isoforms of the AMP‐activated protein kinase have similar activities in rat liver but exhibit differences in substrate specificity in vitro

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Components of a Calmodulin-dependent Protein Kinase Cascade

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Regulation of spinach SNF1‐related (SnRK1) kinases by protein kinases and phosphatases is associated with phosphorylation of the T loop and is regulated by 5′‐AMP

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Protein kinase substrate recognition studied using the recombinant catalytic domain of AMP-activated protein kinase and a model substrate

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Bateman domains and adenosine derivatives form a binding contract

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AICA riboside both activates AMP‐activated protein kinase and competes with adenosine for the nucleoside transporter in the CA1 region of the rat hippocampus

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Ionizing radiation induces ataxia telangiectasia mutated kinase (ATM)-mediated phosphorylation of LKB1/STK11 at Thr-366

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Myocardial Ischemia Differentially Regulates LKB1 and an Alternate 5′-AMP-activated Protein Kinase Kinase

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Multiple Ca2+-Calmodulin-dependent Protein Kinase Kinases from Rat Brain

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AMP-Activated Protein Kinase: A New Beta-Cell Glucose Sensor?

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Differential Regulatory Mechanism of Ca 2+ /Calmodulin-Dependent Protein Kinase Kinase Isoforms

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Towards the molecular basis for the regulation of mitochondrial dehydrogenases by calcium ions

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Homeostatic Effects of Depolarization on Ca2+Influx, Synaptic Signaling, and Survival

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A Calmodulin-Regulated Protein Kinase Linked to Neuron Survival Is a Substrate for the Calmodulin-Regulated Death-Associated Protein Kinase

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Identification and characterization of novel components of a Ca2+/calmodulin‐dependent protein kinase cascade in HeLa cells

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Block of neuronal apoptosis by a sustained increase of steady-state free Ca2+ concentration

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AMPK: a nutrient and energy sensor that maintains energy homeostasis

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AMPK: guardian of metabolism and mitochondrial homeostasis

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The AMPK signalling pathway coordinates cell growth, autophagy and metabolism

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The selectivity of protein kinase inhibitors: a further update

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AMP-activated/SNF1 protein kinases: conserved guardians of cellular energy

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Butyrate enhances the intestinal barrier by facilitating tight junction assembly via activation of AMP-activated protein kinase in Caco-2 cell monolayers

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AMPK: Mechanisms of Cellular Energy Sensing and Restoration of Metabolic Balance

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The Kinase LKB1 Mediates Glucose Homeostasis in Liver and Therapeutic Effects of Metformin

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The LKB1-AMPK pathway: metabolism and growth control in tumour suppression

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AMP-activated protein kinase: an energy sensor that regulates all aspects of cell function

Hardie, D. G. (2011) · Genes & Development · doi:10.1101/gad.17420111 · Cited by 1,638 · see citing works

AMPK in Health and Disease

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Role of AMPK-mTOR-Ulk1/2 in the regulation of autophagy: cross talk, shortcuts, and feedbacks

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Exercise, GLUT4, and skeletal muscle glucose uptake

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The GLUT4 Glucose Transporter

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Resveratrol Ameliorates Aging-Related Metabolic Phenotypes by Inhibiting cAMP Phosphodiesterases

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Metformin—mode of action and clinical implications for diabetes and cancer

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AMP-Activated Protein Kinase in Metabolic Control and Insulin Signaling

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Metformin Inhibits Hepatic Gluconeogenesis in Mice Independently of the LKB1/AMPK Pathway via a Decrease in Hepatic Energy State

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AMPK: Sensing Glucose as well as Cellular Energy Status

Lin, S., & Hardie, D. G. (2017) · Cell Metabolism · doi:10.1016/j.cmet.2017.10.009 · Cited by 1,177 · see citing works

Regulation and function of AMPK in physiology and diseases

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AMP-activated protein kinase signaling in metabolic regulation

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Tumor suppressors and cell metabolism: a recipe for cancer growth

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Control of Macroautophagy by Calcium, Calmodulin-Dependent Kinase Kinase-β, and Bcl-2

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New insights into activation and function of the AMPK

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Adiponectin and AdipoR1 Regulate PGC-1α and Mitochondria by Ca2+ and AMPK/SIRT1

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AMPK and SIRT1: a long-standing partnership?

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AMPK: An Energy-Sensing Pathway with Multiple Inputs and Outputs

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The Energy Sensor AMP-activated Protein Kinase Directly Regulates the Mammalian FOXO3 Transcription Factor

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AMP-Activated Protein Kinase – Development of the Energy Sensor Concept

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An AMPK-FOXO pathway mediates longevity induced by a novel method of dietary restriction in C. elegans

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AMPK and TOR: The Yin and Yang of Cellular Nutrient Sensing and Growth Control

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AMPK signalling in health and disease

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LKB1-Dependent Signaling Pathways

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SIRT1 Regulates Hepatocyte Lipid Metabolism through Activating AMP-activated Protein Kinase

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Use of Cells Expressing γ Subunit Variants to Identify Diverse Mechanisms of AMPK Activation

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Membrane Fatty Acid Transporters as Regulators of Lipid Metabolism: Implications for Metabolic Disease

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AMP-activated protein kinase: the current landscape for drug development

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The Molecular Bases of Training Adaptation

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Resveratrol stimulates AMP kinase activity in neurons

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AMPK: a key regulator of energy balance in the single cell and the whole organism

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Investigating the mechanism for AMP activation of the AMP-activated protein kinase cascade

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ATP synthesis and storage

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AMPK—Sensing Energy while Talking to Other Signaling Pathways

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Resistance exercise increases AMPK activity and reduces 4E-BP1 phosphorylation and protein synthesis in human skeletal muscle

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Cancer Metabolism: Phenotype, Signaling and Therapeutic Targets

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