Newborn granule cells in the ageing dentate gyrus
Open accessAbstract
The dentate gyrus of the hippocampus generates neurons throughout life, but adult neurogenesis exhibits a marked age‐dependent decline. Although the decrease in the rate of neurogenesis has been extensively documented in the ageing hippocampus, the specific characteristics of dentate granule cells born in such a continuously changing environment have received little attention. We have used retroviral labelling of neural progenitor cells of the adult mouse dentate gyrus to study morphological properties of neurons born at different ages. Dendritic spine density was measured to estimate glutamatergic afferent connectivity. Fully mature neurons born at the age of 2 months display ∼2.3 spines μm−1 and maintain their overall morphology and spine density in 1‐year‐old mice. Surprisingly, granule cells born in 10‐month‐old mice, at which time the rate of neurogenesis has decreased by ∼40‐fold, reach a density of dendritic spines similar to that of neurons born in young adulthood. Therefore, in spite of the sharp decline in cell proliferation, differentiation and overall neuronal number, the ageing hippocampus presents a suitable environment for new surviving neurons to reach a high level of complexity, comparable to that of all other dentate granule cells.
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It is well accepted that neurogenesis sharply decreases in the aged mammalian nervous system, with no new neurons detectable in mice by 10 months of age.
“It is well accepted that neurogenesis sharply decreases in the aged mammalian nervous system29–31, with no new neurons detectable in mice by 10 months of age29,31.”
From Therapeutically viable generation of neurons with antisense oligonucleotide suppression of PTB (2021) · cites this paper as [29]
The ‘Sharp decrease in adult neurogenesis in the ageing brain’ section reports an approximately 40-fold reduction between 2- and 10-month-old mice, supporting the decline. But it also says GFP-positive newborn neurons were observed at all time points, and the ‘Complex morphological traits’ section describes neurons born in 10-month-old mice. The claim that none were detectable by that age is therefore contradicted. (LLM, conf=0.90)
Experimental — accuracy not yet measuredThe known low rate of ongoing neurogenesis in the dentate gyrus of young adult mice.
“consistent with the known low rate of ongoing neurogenesis in the dentate gyrus of young adult mice29.”
From Therapeutically viable generation of neurons with antisense oligonucleotide suppression of PTB (2021) · cites this paper as [29]
The section “Sharp decrease in adult neurogenesis in the ageing brain” reports newly generated dentate granule cells in 2-month-old mice, supporting ongoing neurogenesis in young adults. It reports a roughly 40-fold decline by 10 months, but does not characterize the rate in young adult mice as low. (LLM, conf=0.83)
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Cites
Running increases cell proliferation and neurogenesis in the adult mouse dentate gyrus
van Praag, H., Kempermann, G., & Gage, F. H. (1999) · Nature Neuroscience · doi:10.1038/6368 · Cited by 3,880 · see citing works
Neural consequences of enviromental enrichment
van Praag, H., Kempermann, G., & Gage, F. H. (2000) · Nature Reviews Neuroscience · doi:10.1038/35044558 · Cited by 2,468 · see citing works
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Bridging animal and human models of exercise-induced brain plasticity
Voss, M. W., Vivar, C., Kramer, A. F., & van Praag, H. (2013) · Trends in Cognitive Sciences · doi:10.1016/j.tics.2013.08.001 · Cited by 1,030 · see citing works
Physical exercise, neuroplasticity, spatial learning and memory
Cassilhas, R. C., Tufik, S., & de Mello, M. T. (2016) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-015-2102-0 · Cited by 340 · see citing works
Early stem cell aging in the mature brain
Ibrayeva, A., Bay, M., Pu, E., Jörg, D. J., Peng, L., Jun, H., Zhang, N., Aaron, D., Lin, C., Resler, G., et al. (2021) · Cell Stem Cell · doi:10.1016/j.stem.2021.03.018 · Cited by 137 · see citing works
Therapeutically viable generation of neurons with antisense oligonucleotide suppression of PTB
Maimon, R., Chillon-Marinas, C., Snethlage, C. E., Singhal, S. M., McAlonis-Downes, M., Ling, K., Rigo, F., Bennett, C. F., Da Cruz, S., Hnasko, T. S., et al. (2021) · Nature Neuroscience · doi:10.1038/s41593-021-00864-y · Cited by 62 · see citing works
- Authors
- Morgenstern, N. A., Lombardi, G., & Schinder, A. F.
- Affiliations
- Consejo Nacional de Investigaciones Científicas y Técnicas (AR)
- Venue
- The Journal of Physiology
- Publisher
- Wiley
- Published
- 2008-08-15
- Volume
- 586
- Issue
- 16
- Pages
- 3751-3757
- ISSN
- 0022-3751 (ISSN-L)
- 1469-7793
- PMC
- PMC2538941
- OpenAlex
- W2169508723
- Cited by
- 104
- References
- 2
- Citations by year
- 2026: 1 · 2025: 7 · 2024: 4 · 2023: 5 · 2022: 2 · 2021: 7 · 2020: 5 · 2019: 8 · 2018: 2 · 2017: 9 · 2016: 5 · 2015: 9 · 2014: 2 · 2013: 10 · 2012: 6
- FWCI
- 2.24
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- The Journal of Physiology (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- CONICET Digital (CONICET) (submittedVersion, cc-by-nc-sa)
- Funders
- Howard Hughes Medical Institute
- American Health Assistance Foundation
- Consejo Nacional de Investigaciones Científicas y Técnicas
- Topics
- Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
- Keywords
- dentate gyrus, adult neurogenesis, dentate gyrus granule cells, dendritic spine density, neural progenitor cells, neuronal morphology
- MeSH terms
- Aging, Animals, Animals, Newborn, Cell Differentiation, Female, Mice, Inbred C57BL, Neurons, Stem Cells, Dentate Gyrus, Cell Proliferation, Mice
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