The DOI matches its Crossref record; 37 of the 38 references it cites were found in a registry or an index.
Adaptations in placental nutrient transfer capacity to meet fetal growth demands depend on placental size in mice
Open accessAbstract
Experimental reduction in placental growth often leads to increased placental efficiency measured as grams of fetus produced per gram of placenta, although little is known about the mechanisms involved. This study tested the hypothesis that the smallest placenta within a litter is the most efficient at supporting fetal growth by examining the natural intra‐litter variation in placental nutrient transfer capacity in normal pregnant mice. The morphology, nutrient transfer and expression of key growth and nutrient supply genes (Igf2 P0, Grb10, Slc2a1, Slc2a3, Slc38a1, Slc38a2 and Slc38a4) were compared in the lightest and heaviest placentas of a litter at days 16 and 19 of pregnancy, when mouse fetuses are growing most rapidly in absolute terms. The data show that there are morphological and functional adaptations in the lightest placenta within a litter, which increase active transport of amino acids per gram of placenta and maintain normal fetal growth close to term, despite the reduced placental mass. The specific placental adaptations differ with age. At E16, they are primarily morphological with an increase in the volume fraction of the labyrinthine zone responsible for nutrient exchange, whereas at E19 they are more functional with up‐regulated placental expression of the glucose transporter gene, Slc2a1/GLUT1 and one isoform the System A family of amino acid transporters, Slc38a2/SNAT2. Thus, this adaptability in placental phenotype provides a functional reserve capacity for maximizing fetal growth during late gestation when placental growth is compromised.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“As a result, the naturally small placenta also supports more fetal growth per gram and maintains a normal fetal growth rate in late gestation (114).”
From Placental Origins of Chronic Disease (2016) · cites this paper as [114]
In the citing paper
“When the fetal demand and supply are mismatched in the naturally small placenta, there are changes in expression of several imprinted genes, including Igf2 in association with sparing of the labyrinth zone, increased MeAIB and glucose transport and upregulated expression of the Slc38a2 amino acid transporters (114).”
From Placental Origins of Chronic Disease (2016) · cites this paper as [114]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Developmental Origins of the Metabolic Syndrome: Prediction, Plasticity, and Programming
Mcmillen, I. C., & Robinson, J. S. (2005) · Physiological Reviews · doi:10.1152/physrev.00053.2003 · Cited by 1,910
Estimation of surface area from vertical sections
Baddeley, A. J., Gundersen, H. J. G., & Cruz-Orive, L. M. (1986) · Journal of Microscopy · doi:10.1111/j.1365-2818.1986.tb04282.x · Cited by 1,057
Placental-specific IGF-II is a major modulator of placental and fetal growth
Constância, M., Hemberger, M., Hughes, J., Dean, W., Ferguson-Smith, A., Fundele, R., Stewart, F., Kelsey, G., Fowden, A., Sibley, C., et al. (2002) · Nature · doi:10.1038/nature00819 · Cited by 1,054
Self-citationMothers, Babies, and Disease in Later Life
Gillman, M. W. (1995) · BMJ · doi:10.1136/bmj.310.6971.68a · Cited by 880
Mothers, Babies and Disease in Later Life
Barker, D. J. P., & Barker, D. J. P. (1994) · Medical Entomology and Zoology · Cited by 860
Development of Structures and Transport Functions in the Mouse Placenta
Watson, E. D., & Cross, J. C. (2005) · Physiology · doi:10.1152/physiol.00001.2005 · Cited by 580
Developmental Origins of Health and Disease: New Insights
Hanson, M. A., & Gluckman, P. D. (2008) · Basic & Clinical Pharmacology & Toxicology · doi:10.1111/j.1742-7843.2007.00186.x · Cited by 359
Programming placental nutrient transport capacity
Fowden, A. L., Ward, J. W., Wooding, F. P. B., Forhead, A. J., & Constancia, M. (2006) · The Journal of Physiology · doi:10.1113/jphysiol.2005.104141 · Cited by 334
Self-citationConstância, M., Angiolini, E., Sandovici, I., Smith, P., Smith, R., Kelsey, G., Dean, W., Ferguson-Smith, A., Sibley, C. P., Reik, W., et al. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0504468103 · Cited by 323 · cited 4×
“For example, in the small Igf2P0 mutant placenta, there is increased expression of amino acid transporters and enhanced amino acid transfer compared with the wild-type placenta (Constancia et al. 2005).”
BackgroundInfluentialSelf-citationSibley, C. P., Coan, P. M., Ferguson‐Smith, A. C., Dean, W., Hughes, J., Smith, P., Reik, W., Burton, G. J., Fowden, A. L., & Constância, M. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0402508101 · Cited by 299
Self-citation
Flagged first, then by citations
1 of the 38 references couldn’t be matched to a known paper.
Research works printed but not linked: 2
- Kelly RW, 1992, Nutrition and placental development, Proc Nutr Soc Aust, 17, 203
- 10.1111/j..2002.00085.x · DOI · Paper page
Cited by
Sorted by citations
Items 101–194 of 194
Szabo, R., Peters, D. E., Kosa, P. F., Camerer, E., & Bugge, T. H. (2014) · PLoS Genetics · doi:10.1371/journal.pgen.1004470 · Cited by 21
“5 with the radioactivelylabeled polysaccharide inulin, which can cross epithelial layers solely by a paracellular route due to lack of specific transporters [35,36].”
BackgroundDenisova, E. I., Kozhevnikova, V. V., Бажан, Н. М., & En, M. (2019) · FEBS Open Bio · doi:10.1002/2211-5463.12757 · Cited by 19
Rosales-Nieto, C. A., Ehrhardt, R., Mantey, A., Makela, B., Byrem, & Veiga‐Lopez, A. (2020) · Domestic Animal Endocrinology · doi:10.1016/j.domaniend.2020.106577 · Cited by 19
“Placental size and nutrient transfer capacity determine fetal growth and birth weight [25,26].”
BackgroundThe Primate Placenta as an Agent of Developmental and Health Trajectories Across the Life Course
Rutherford, J. N. (2012) · Springer eBooks · doi:10.1007/978-1-4614-4060-4_2 · Cited by 20
Peiris, H. N., Ponnampalam, A. P., Osepchook, C. C., Mitchell, M. D., & Green, M. P. (2010) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00673.2009 · Cited by 19
“Research into experimental reductions of placental growth resulting in changes to placental efficiency shows smaller placentae to be more efficient in transferring nutrients (10, 13).”
BackgroundCordero, M. A. O., Meza-Herrera, C. A., Vázquez-García, J. M., Stewart, C. A., Rosales-Nieto, C. A., Ochoa‐Alfaro, A. E., Purvis, I. W., Reyes, V. C., Lee-Rangel, H. A., & Martin, G. B. (2019) · Animals · doi:10.3390/ani9050214 · Cited by 19
“However, it is important to remember that the accelerated accumulation of resources, and the redistribution towards feto-placental unit(s) is not a passive process (the “sink” concept), but a controlled process that has evolved to ensure metabolic support for fetal growth and development [31,32].”
BackgroundHudson, R., Maqueda, B., Moctezuma, J. V., Miranda, A. M., & Rödel, H. G. (2011) · Physiology & Behavior · doi:10.1016/j.physbeh.2011.02.036 · Cited by 17
Caesar, G., Storey, K. M., Parmeley, L. E., & Schulz, L. C. (2021) · PLoS ONE · doi:10.1371/journal.pone.0244971 · Cited by 17
Krombeen, S. K., Shankar, V., Noorai, R. E., Saski, C. A., Sharp, J. L., Wilson, M. E., & Wilmoth, T. A. (2019) · BMC Genomics · doi:10.1186/s12864-019-5626-0 · Cited by 16
“Coan and others [3] evaluated placental nutrient transport capacity in mice with natural variations in placental size to determine if the smallest placenta in a litter of appropriately grown fetuses was the most efficient.”
BackgroundResultBloise, E., Braga, J. R. S., de Andrade, C. B. V., Império, G. E., Martinelli, L. M., Antunes, R. D. A., Silva, K. R., Nunes, C. B., Cobellis, L., Bloise, F. F., et al. (2021) · Nutrients · doi:10.3390/nu13082587 · Cited by 16
“Glucose and amino acid transport efficiency depend upon placental size and F:P weight ratio [7,18].”
BackgroundThe X-linked splicing regulator MBNL3 has been co-opted to restrict placental growth in eutherians
Spruce, T., Plass, M., Gohr, A., Ray, D., de Lagrán, M. M., Rot, G., Nóvoa, A., Burguera, D., Permanyer, J., Miret-Cuesta, M., et al. (2022) · PLoS Biology · doi:10.1371/journal.pbio.3001615 · Cited by 16
“This could be either due to a suboptimal placenta function in Mbnl3 KOs or because embryo size is already optimal under standard laboratory conditions, where mothers have ad libitum access to food; indeed, in normally gown near-term litters from WT mice, there is no correlation between placenta and fetus size [70].”
BackgroundPasha, M., Kirschenman, R. D., Wooldridge, A. L., Spaans, F., Cooke, C. M., & Davidge, S. T. (2023) · PLoS ONE · doi:10.1371/journal.pone.0282442 · Cited by 16
Adaptations in Maternofetal Calcium Transport in Relation to Placental Size and Fetal Sex in Mice
Hayward, C. E., Renshall, L. J., Sibley, C. P., Greenwood, S. L., & Dilworth, M. R. (2017) · Frontiers in Physiology · doi:10.3389/fphys.2017.01050 · Cited by 15
“In mice, the effect of placental size on maternofetal nutrient transfer can be assessed by comparing the lightest and heaviest placentas within a wild-type (WT) litter, as reported previously for System A and glucose (Coan et al., 2008).”
BackgroundResultInfluentialPijnenborg, R., Brosens, I., & Romero, R. J. (2010) · Cambridge University Press eBooks · doi:10.1017/cbo9780511750847.017 · Cited by 16
Expression profiling of autophagy associated genes in placentas of preeclampsia
Goldman‐Wohl, D., Cesla, T., Smith, Y., Greenfield, C., Dechend, R., Staff, A. C., Sugulle, M., Weedon-Fekjær, M. S., Johnsen, G. M., Yagel, S., et al. (2013) · Placenta · doi:10.1016/j.placenta.2013.07.069 · Cited by 16
Kokorudz, C., Radford, B. N., Dean, W., & Hemberger, M. (2022) · Cells · doi:10.3390/cells12010076 · Cited by 14
“The placenta had the most variability overall, regardless of maternal age, in line with the well-known extent of morphological variability that is commonly observed between placentas even in litters of inbred mouse strains [24].”
BackgroundMcIntyre, K. R., Hayward, C. E., Sibley, C. P., Greenwood, S. L., & Dilworth, M. R. (2019) · The Journal of Physiology · doi:10.1113/jp278226 · Cited by 14
“Maternofetal transport of both calcium (Hayward et al. 2017) and the non-metabolisable system A amino acid analogue methylaminoisobutyric acid (MeAIB) (Coan et al. 2008) is increased, per gram placenta, in the lightest versus heaviest placentas in a litter of wild-type C57Bl/6J (WT) mice.”
InfluentialDelivery and short-term maternal and fetal safety of vaginally administered PEG-PLGA nanoparticles
Irvin-Choy, N. S., Nelson, K. M., Gleghorn, J. P., & Day, E. S. (2023) · Drug Delivery and Translational Research · doi:10.1007/s13346-023-01369-w · Cited by 13
“:P ratio greater than one indicates an efficient placenta and adequate fetal growth [33, 34].”
BackgroundPasha, M., Kirschenman, R. D., Wooldridge, A. L., Spaans, F., Cooke, C. M., & Davidge, S. T. (2022) · Antioxidants · doi:10.3390/antiox11071275 · Cited by 13
Krombeen, S. K., Bridges, W. C., Wilson, M. E., & Wilmoth, T. A. (2018) · Journal of Animal Science · doi:10.1093/jas/sky409 · Cited by 13
Stereological study of the placental structure in abortion-prone mice model (CBA/J×DBA/2J)
Hosseini, M. S., Ali‐Hassanzadeh, M., Nadimi, E., Karbalay‐Doust, S., Noorafshan, A., & Gharesi‐Fard, B. (2020) · Annals of Anatomy - Anatomischer Anzeiger · doi:10.1016/j.aanat.2020.151508 · Cited by 13
Chronic maternal hypertension affects placental gene expression and differentiation in rabbits
McArdle, A. M., Maduwegedera, D., Moritz, K. M., Flower, R. L., Denton, K. M., & Roberts, C. T. (2010) · Journal of Hypertension · doi:10.1097/hjh.0b013e3283369f1e · Cited by 11
Growth perturbations in a phenotype with rapid fetal growth preceding preterm labor and term birth
Lampl, M., Kusanovic, J. P., Erez, O., Gotsch, F., Espinoza, J., Gonçalves, L. F., Lee, W., Gómez, R., Nien, J. K., Frongillo, E. A., et al. (2009) · American Journal of Human Biology · doi:10.1002/ajhb.20880 · Cited by 11
Assessment of Placental Transport Function in Studies of Disease Programming
Sferruzzi-Perri, A. N. (2018) · Methods in molecular biology · doi:10.1007/978-1-4939-7614-0_14 · Cited by 10
Tongpob, Y., & Wyrwoll, C. S. (2020) · Journal of Developmental Origins of Health and Disease · doi:10.1017/s2040174420000720 · Cited by 13
Deletion of the Imprinted Phlda2 Gene Increases Placental Passive Permeability in the Mouse
Angiolini, E., Sandovici, I., Coan, P. M., Burton, G. J., Sibley, C. P., Fowden, A. L., & Constância, M. (2021) · Genes · doi:10.3390/genes12050639 · Cited by 11
Self-citationPlacental Function in Maternofetal Exchange
Sibley, C. P., & Dilworth, M. R. (2020) · Elsevier eBooks · doi:10.1016/b978-0-7020-6956-7.00008-7 · Cited by 10
McArdle, A. M., Roberts, C. T., Maduwegedera, D., Flower, R. L., & Denton, K. M. (2010) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00202.2009 · Cited by 10
“Increased placental efficiency in other animal models, including sheep, rat, and mice, is thought to be caused by increased maternal nutrient availability, increased transplacental concentration gradients, and/or direct increases in the placental nutrient transfer capacity per gram of placenta, all resulting from plac…”
BackgroundElsamadicy, E. A., & Thompson, L. (2022) · Reproductive Sciences · doi:10.1007/s43032-022-00979-y · Cited by 6
“Relative placental weight was calculated (placental weight/fetal body weight) as an index of placental insufficiency [30, 31].”
BackgroundKadife, E., Harper, A. P., de Alwis, N., Chien, K., Hannan, N. J., & Brownfoot, F. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms24010403 · Cited by 10
Moorwood, K., Smith, F. M., Garfield, A. S., & Ward, A. (2024) · BMC Biology · doi:10.1186/s12915-024-01926-w · Cited by 8
Placental Evolution: Innovating How to Feed Babies
Baker, J. C. (2024) · Annual Review of Genetics · doi:10.1146/annurev-genet-111523-102135 · Cited by 8
Salazar‐Petres, E., Pereira‐Carvalho, D., López‐Tello, J., & Sferruzzi-Perri, A. N. (2023) · Cells · doi:10.3390/cells12050797 · Cited by 10
Maternal placenta modulates a deleterious fetal mutation†
Xu, H., Pausch, H., Venhoranta, H., Rutkowska, K., Wurmser, C., Rieblinger, B., Flisikowska, T., Frishman, D., Zwierzchowski, L., Fries, R., et al. (2017) · Biology of Reproduction · doi:10.1093/biolre/iox064 · Cited by 8
“Fetal growth is associated with placenta size [53], and is controlled by parent-specific monoallelic expression [54].”
BackgroundFujita, A., Noguchi, S., Hamada, R., Inoue, S., Shimada, T., Katakura, S., Maruyama, T., Sai, Y., Nishimura, T., & Tomi, M. (2022) · Pharmaceutical Research · doi:10.1007/s11095-022-03165-6 · Cited by 8
“other substances (51, 52), which would not affect the steadystate concentration determined in the present study.”
BackgroundStarr, L. M., Koski, K. G., & Scott, M. E. (2015) · International Journal for Parasitology · doi:10.1016/j.ijpara.2015.09.004 · Cited by 8
Hayward, C. E., McIntyre, K. R., Sibley, C. P., Greenwood, S. L., & Dilworth, M. (2018) · Frontiers in Endocrinology · doi:10.3389/fendo.2018.00671 · Cited by 7
Gloria, A., Veronesi, M. C., & Contri, A. (2024) · Animals · doi:10.3390/ani14030423 · Cited by 5
“The authors concluded that placentas can modify their morphology/function to normalize the neonate birthweight [15].”
BackgroundMethodA genetically small fetus impairs placental adaptations near term
Sandovici, I., Knee, O., López‐Tello, J., Shreeve, N., Fowden, A. L., Sferruzzi-Perri, A. N., & Constância, M. (2024) · Disease Models & Mechanisms · doi:10.1242/dmm.050719 · Cited by 5
“…are established mediators of placental functional adaptations to meet fetal growth requirements, both in response to genetic manipulations and altered environmental conditions in utero (Coan et al., 2008b, 2010; Constância et al., 2005; Angiolini et al., 2011; Sferruzzi-Perri et al., 2011, 2023).”
Self-citationNovel insights from fetal and placental phenotyping in 3 mouse models of Down syndrome
Adams, A. D., Hoffmann, V. J., Koehly, L. M., Guedj, F., & Bianchi, D. W. (2021) · American Journal of Obstetrics and Gynecology · doi:10.1016/j.ajog.2021.03.019 · Cited by 5
Kretschmer, T., Turnwald, E., Janoschek, R., Wohlfarth, M., Handwerk, M., Dötsch, J., Hucklenbruch‐Rother, E., & Appel, S. (2022) · American Journal of Reproductive Immunology · doi:10.1111/aji.13564 · Cited by 5
Krishnamurthy, U., Szalai, G., Shen, Y., Xu, Z., Yadav, B. K., Tarca, A. L., Chaiworapongsa, T., Hernandez‐Andrade, E. A., Than, N. G., Haacke, E. M., et al. (2015) · Gynecologic and Obstetric Investigation · doi:10.1159/000431223 · Cited by 5
Energy Supplementation during the Last Third of Gestation Improves Mother–Young Bonding in Goats
Vázquez-García, J. M., Álvarez-Fuentes, G., Orozco-Gregorio, H., García-López, J. C., González-Hernández, M., & Rosales-Nieto, C. A. (2021) · Animals · doi:10.3390/ani11020287 · Cited by 6
Widdows, K. L. (2009) · Brunel University Research Archive (BURA) (Brunel University London) · Cited by 5
Placental structure, function and mitochondrial phenotype relate to fetal size and sex in micePreprint
Salazar‐Petres, E., Carvalho, D. P., López‐Tello, J., & Sferruzzi-Perri, A. N. (2021) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2021.07.22.453249 · Cited by 5
Zhang, P. (2023) · medRxiv · doi:10.1101/2023.02.17.23286091 · Cited by 5
“Placental efficiency can be demonstrated through various animal models, but in human it is less studied during pregnancy until term or near term after delivery when fetal birth weight and placental weight can be readily measured [13, 14].”
BackgroundEffects of Quinazolinones on the Development of Balb/C Mice Embryonic Kidneys
Lahijani, M. S., Tehrani, D. M., Nohehkhan, M., & Mangual, M. (2009) · Iranian journal of basic medical sciences. · doi:10.22038/ijbms.2009.5170 · Cited by 4
“By passing through placenta (3, 4), treatments with teratogens such as alcohol, quinazolinones, etc create early death, malformations and irregularities in different parts of developing embryos (5-11).”
BackgroundBasic Structure of a Placental Villus
Burton, G. J. (2021) · Springer eBooks · doi:10.1007/978-3-030-84725-8_6 · Cited by 5
Self-citationMatsumoto, M., Tsuchiya, K. J., Yaguchi, C., Horikoshi, Y., Furuta‐Isomura, N., Oda, T., Kohmura‐Kobayashi, Y., Tamura, N., Uchida, T., & Itoh, H. (2020) · International Journal of Women’s Dermatology · doi:10.1016/j.ijwd.2020.02.009 · Cited by 5
“The placenta adapts to the maternal environment by changing its weight, structure, and/or function, thereby maintaining an optimal environment for fetal developmental (Coan et al., 2008; Fowden et al., 2009).”
BackgroundA sexually dimorphic murine model of IUGR induced by embryo transfer
Kaur, H., Care, A. S., Wilson, R. L., Piltz, S., Thomas, P. Q., Mühlhäusler, B. S., Roberts, C. T., & Gatford, K. L. (2020) · Reproduction · doi:10.1530/rep-20-0209 · Cited by 4
Lahijani, M. S., Farivar, S., Sarhady, M., & Amiri, M. (2012) · PubMed · Cited by 4
Plows, J. F., Vickers, M. H., Ganapathy, T. P., Bridge-Comer, P. E., Stanley, J. L., & Reynolds, C. M. (2019) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.201900770 · Cited by 4
Viscomi, M. P., Ziętek, M. M., & Sampino, S. (2025) · Neuroscience · doi:10.1016/j.neuroscience.2025.12.009 · Cited by 3
Nunes, L. G. A., Weingrill, R. B., Fredrick, S. B. J., Lorca, R. A., Lee, M., Atif, S. M., Chicco, A. J., Rosario, F. J., & Urschitz, J. (2025) · Acta Physiologica · doi:10.1111/apha.70012 · Cited by 4
Maternal Stress-Mediated Gene Expression Changes in the Mouse Placenta
Longo, L. D., & Goyal, R. (2013) · Elsevier eBooks · doi:10.1016/b978-0-12-394445-0.00037-0 · Cited by 3
Tinel, J. B., Veras, M. M., Waked, D., Alonso, M. A., & Fernandes, C. B. (2023) · Animal Reproduction Science · doi:10.1016/j.anireprosci.2023.107201 · Cited by 3
Diverse mechanisms underlying the fetal growth course in gastroschisis and omphalocele
Amylidi-Mohr, S. K., Wyss, M., Surbek, D., Raio, L., & Mosimann, B. (2023) · AJOG Global Reports · doi:10.1016/j.xagr.2023.100238 · Cited by 3
“Discordant birthweight: placental weight ratio placental adaptation occurs, these adaptations will affect the composition of the developing fetus.(20) The concept of BW-to-PW ratio as a marker of placental nutrient transfer efficiency is also strongly supported by studies in mice, with clear evidence of placentas adap…”
BackgroundZhong, W., Chen, Y., Zha, X., Fang, M., Feng, H., Zhang, M., & Wang, H. (2025) · Placenta · doi:10.1016/j.placenta.2025.06.022 · Cited by 2
Yıldırım, S. B., Can, Ö. K., Tekin, E., Akoğlu, H. A., & Bulut, M. (2025) · Nutrition Bulletin · doi:10.1111/nbu.70019 · Cited by 2
“Several studies have indicated that placental size plays a critical role in determining foetal growth and neo-natal birth weight (Rosales-Nieto et al. 2021; Coan et al. 2008), with a strong correlation existing between foetal birth weight and placental weight (Salafia et al. 2008).”
Conduit, S., Zhang, C. X. W., Pearce, W., Guillermet-Guibert, J., Sferruzzi-Perri, A., & Vanhaesebroeck, B. (2025) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-025-05937-w · Cited by 2
“In WT mice, naturally small placentas also exhibit a specific reduction in the junctional zone compared to large placentas within the same litter [ 4 ].”
InfluentialValidation studies of a fluorescent method to measure placental glucose transport in mice
Kaur, H., Wilson, R. L., Care, A. S., Mühlhäusler, B. S., Roberts, C. T., & Gatford, K. L. (2019) · Placenta · doi:10.1016/j.placenta.2019.01.014 · Cited by 2
Yang, Y., Hua, J. H., Liu, S., Cao, Y., Jiang, Y., Jiang, X., Li, H., Zhang, R., Wu, F., Jin, C., et al. (2025) · Journal of Animal Science · doi:10.1093/jas/skaf142 · Cited by 1
Awoke, A., Yetwale, A., Biyazin, T., Wolde, T., & Sinaga, M. (2025) · PLoS ONE · doi:10.1371/journal.pone.0332596 · Cited by 2
Afghah, M., Elkins, A. C., Powell, P. C., Mulligan, M. E., Boland, M. C., Suggs, A. P., Walker, M. A., Brenner, G. E., Johnson, L., Padgett, Z. J., et al. (2026) · Journal of the Endocrine Society · doi:10.1210/jendso/bvag010 · Cited by 2
“At mid-gestation, increased fetal weight likely results from altered placental nutrient transfer and compensatory endocrine activity, consistent with the expansion of the junctional zone in male placentas and the upregulation of metabolic pathways in female placentas (147, 148).”
Role of Amino Acid Transporters in Protein Metabolism
Taylor, P. M. (2016) · Elsevier eBooks · doi:10.1016/b978-0-12-802167-5.00005-0 · Cited by 1
Liu, Z. (2024) · Journal of Psychosomatic Research · doi:10.1016/j.jpsychores.2024.111857 · Cited by 1
Imprinted genes and placental growth
Benjamin, T., & John, R. M. (2010) · Cambridge University Press eBooks · doi:10.1017/cbo9780511933806.007 · Cited by 1
Variation in, and contributing factors of placental efficiency in swine
Wilmoth, T. A. (2009) · The Research Repository @ WVU (West Virginia University) · doi:10.33915/etd.2811 · Cited by 1
Programming of cardiovascular and metabolic functions by thyroid hormone signaling
Uhde, M. (2014) · Figshare
Abu-Amero, S. N., & Moore, G. E. (2010) · Cambridge University Press eBooks · doi:10.1017/cbo9780511750847.019
Evaluation of Placental Transport Function
Dilworth, M. R., Sibley, C. P., & Glazier, J. D. (2013) · Elsevier eBooks · doi:10.1016/b978-0-12-394445-0.00058-8
gestation is strain dependent in mice Expansion of the fetoplacental vasculature in late
Sled, J. G., Rennie, M. Y., Detmar, J., Whiteley, K. J., Jurisicova, A., & Lee, S. (2012)
Vaughan, O. R., Sferruzzi-Perri, A. N., Coan, P. M., & Fowden, A. L. (2016)
Self-citationTownley-Tilson, W. H. D. (2014)
Castro, N. (2018) · Digital Library of Theses and Dissertations (Universidade de São Paulo) · doi:10.11606/d.6.2018.tde-10102017-133047
Bonnin, A., Goeden, N., Lund, B. T., & Anderson, G. M. (2014) · doi:10.21236/ada611000
Ganguly, E. (2021) · ERA: Education and Research Archive (University of Alberta) · doi:10.7939/r3-xz0j-fs36
Zabransky, S. (2013) · doi:10.1007/978-1-908517-90-6_2
Ley, J. M. (2023) · Elsevier eBooks · doi:10.1016/b978-0-323-90541-1.00019-4
Maternal Exercise Rescues Fetal Akinesia‐Impaired Joint and Bone Development
Panebianco, C. J., Huang, Y., Khatib, N., Gottlieb, D. C., Essaidi, M., Ahmed, S., Dyment, N. A., Simmons, R. A., Boerckel, J. D., & Nowlan, N. C. (2025) · The FASEB Journal · doi:10.1096/fj.202503192r
“These findings are consistent with previous studies that found FW:PW ratio changes without significantly altered downstream measurements of placental transport [98, 99].”
MORPHOLOGICAL CHANGES OF THE LUNGS IN CHILDREN WITH CONGENITAL PNEUMONIA
Kareken, Z. T., Abibulla, B. B., Төрежан, В. Е., Кабыкенова, К. К., Dyusengazieva, N. D., Ныгызбаева, Р. Ж., & Sharafutdinova, K. N. (2025) · Medicine and ecology · doi:10.59598/me-2305-6053-2025-115-2-114-121
Feng, H., Lin, Y., Zhao, X., Ge, C., Zhong, W., Zha, X., Fang, M., Wang, H., & Zhang, M. (2025) · Reproductive Sciences · doi:10.1007/s43032-025-02006-2
“This may be due to compensatory mechanisms within the placenta, such as the upregulation of nutrient transporter proteins, which help meet the fetal demands[ 7 ].”
Vasilopoulou, E. (2010) · University of Birmingham Institutional Research Archive (University of Birmingham)
Rennie, M. Y. (2012) · TSpace (University of Toronto)
Moorwood, K., Smith, F. M., Garfield, A. S., & Ward, A. (2024) · Figshare · doi:10.6084/m9.figshare.26727838
Moorwood, K., Smith, F. M., Garfield, A. S., & Ward, A. (2024) · Figshare · doi:10.6084/m9.figshare.26727835
Narrative Review of Production Impacts of Pregnancy Shearing in Pasture-Based Systems
Corner-Thomas, R. A., Zhang, K., Fraga, F. J. R., Neimaur, K., Barbieri, I. D., & Kenyon, P. R. (2026) · Ruminants · doi:10.3390/ruminants6030061
Physiological Exchange across Mouse Placenta
Dilworth, M. R., Glazier, J. D., & Sibley, C. P. (2013) · Elsevier eBooks · doi:10.1016/b978-0-12-394445-0.00017-5
Metadata
- Authors
- Coan, P. M., Angiolini, E., Sandovici, I., Burton, G. J., Constância, M., & Fowden, A. L.
- Affiliations
- University of Cambridge (GB)
- Babraham Institute (GB)
- Corresponding author
- Coan, P. M.
- Venue
- The Journal of Physiology
- Publisher
- Wiley
- Published
- 2008-09-15
- Volume
- 586
- Issue
- 18
- Pages
- 4567-4576
- ISSN
- 0022-3751 (ISSN-L)
- 1469-7793
- PMC
- PMC2614013
- OpenAlex
- W2123416686
- Cited by
- 194
- References
- 38
- Citations by year
- 2026: 2 · 2025: 10 · 2024: 8 · 2023: 8 · 2022: 11 · 2021: 14 · 2020: 12 · 2019: 11 · 2018: 11 · 2017: 9 · 2016: 9 · 2015: 7 · 2014: 8 · 2013: 14 · 2012: 23
- FWCI
- 14.15
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- The Journal of Physiology (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Biotechnology and Biological Sciences Research Council (BB/B50118X/1, BB/C513626/1, BB/B50118X/2)
- Topics
- Health Sciences › Medicine › Obstetrics and Gynecology › Pregnancy and preeclampsia studies
- Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Birth, Development, and Health
- Life Sciences › Immunology and Microbiology › Immunology › Reproductive System and Pregnancy
- Keywords
- placental nutrient transfer, placental size, fetal growth, placental efficiency, amino acid transport, glucose transport, GLUT1, SNAT2, SLC38A2, SLC2A1, SLC38A4, SLC38A1, Grb10, placental morphology, placental development, mouse pregnancy
- MeSH terms
- Adaptation, Physiological, Animals, Female, Gestational Age, Insulin-Like Growth Factor II, Maternal-Fetal Exchange, Mice, Inbred C57BL, Organ Size, Placenta, Pregnancy, Pregnancy, Animal, Fetal Weight, Amino Acid Transport System A, Fetal Development, Glucose Transporter Type 1, Glucose Transporter Type 3, Mice, GRB10 Adaptor Protein
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
