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Cited by 408

The DOI matches its Crossref record; 50 of the 50 references it cites were found in a registry or an index.

Smooth muscle cell calcium activation mechanisms

Open access
Berridge, Michael J.·2008·The Journal of Physiology
DOI 10.1113/jphysiol.2008.160440
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Abstract

Smooth muscle cell (SMC) contraction is controlled by the Ca 2+and Rho kinase signalling pathways. While the SMC Rho kinase system seems to be reasonably constant, there is enormous variation with regard to the mechanisms responsible for generating Ca 2+signals. One way of dealing with this diversity is to consider how this system has been adapted to control different SMC functions. Phasic SMCs (vas deferens, uterus and bladder) rely on membrane depolarization to drive Ca 2+influx across the plasma membrane. This depolarization can be induced by neurotransmitters or through the operation of a membrane oscillator. Many tonic SMCs (vascular, airway and corpus cavernosum) are driven by a cytosolic Ca 2+oscillator that generates periodic pulses of Ca 2+. A similar oscillator is present in pacemaker cells such as the interstitial cells of Cajal (ICCs) and atypical SMCs that control other tonic SMCs (gastrointestinal, urethra, ureter). The changes in membrane potential induced by these cytosolic oscillators does not drive contraction directly but it functions to couple together individual oscillators to provide the synchronization that is a characteristic feature of many tonic SMCs.

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Metadata

Authors
Berridge, M. J.
Venue
The Journal of Physiology
Publisher
Wiley
Published
2008-10-30
Volume
586
Issue
21
Pages
5047-5061
ISSN
  • 0022-3751 (ISSN-L)
  • 1469-7793
DOI
10.1113/jphysiol.2008.160440
OpenAlex
W2167060203
Cited by
408
References
50
FWCI
8.07
Type
journal article
Language
en
Open access
green

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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.

Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.