The DOI matches its Crossref record; 33 of the 33 references it cites were found in a registry or an index.
Studies on expression and function of the TMEM16A calcium-activated chloride channel
Open accessAbstract
Calcium-activated chloride channels (CaCC) with similar hallmark features are present in many cell types and mediate important physiological functions including epithelial secretion, sensory signal transduction, and smooth muscle contraction. Having identified TMEM16A of the transmembrane proteins with unknown function (TMEM) 16 family as a CaCC subunit, we have developed antibodies specific for mouse TMEM16A, as evidenced by the absence of immunoreactivity in TMEM16A knockout mice. Here, we show that TMEM16A is located in the apical membranes of epithelial cells in exocrine glands and trachea. In addition, TMEM16A is expressed in airway smooth muscle cells and the smooth muscle cells of reproductive tracts, the oviduct and ductus epididymis. In the gastrointestinal (GI) tract, TMEM16A is absent from smooth muscle cells, but present in the interstitial cells of Cajal (ICC), the pacemaker cells that control smooth muscle contraction. The physiological importance of TMEM16A is underscored by the diminished rhythmic contraction of gastric smooth muscle from TMEM16A knockout mice. The TMEM16A expression pattern established in this study thus provides a roadmap for the analyses of physiological functions of calcium-activated chloride channels that contain TMEM16A subunits.
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A model for p53-induced apoptosis
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TMEM16A confers receptor-activated calcium-dependent chloride conductance
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TMEM16A, A Membrane Protein Associated with Calcium-Dependent Chloride Channel Activity
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Self-citationCALCIUM-ACTIVATED CHLORIDE CHANNELS
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INTERSTITIAL CELLS OF CAJAL AS PACEMAKERS IN THE GASTROINTESTINAL TRACT
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REGULATION OF FLUID AND ELECTROLYTE SECRETION IN SALIVARY GLAND ACINAR CELLS
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Cited by
Namkung, W., Phuan, P.-W., & Verkman, A. S. (2011) · Journal of Biological Chemistry · doi:10.1074/jbc.m110.175109 · Cited by 353
Davis, M. J., Earley, S., Li, Y.-S., & Chien, S. (2023) · Physiological Reviews · doi:10.1152/physrev.00053.2021 · Cited by 273
Expression patterns of anoctamin 1 and anoctamin 2 chloride channels in the mammalian nose
Dauner, K., Lißmann, J., Jeridi, S., Frings, S., & Möhrlen, F. (2012) · Cell and Tissue Research · doi:10.1007/s00441-012-1324-9 · Cited by 59
Metadata
- Authors
- Huang, F., Rock, J. R., Harfe, B. D., Cheng, T., Huang, X., Jan, Y. N., & Jan, L. Y.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 2009-12-15
- Volume
- 106
- Issue
- 50
- Pages
- 21413-21418
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W1987211770
- Cited by
- 310
- References
- 33
- FWCI
- 7.44
- Type
- journal article
- Language
- en
- Open access
- green
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- Huang, F., Rock, J. R., Harfe, B. D., Cheng, T., Huang, X., Jan, Y. N., & Jan, L. Y. (2009). Studies on expression and function of the TMEM16A calcium-activated chloride channel. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.0911935106
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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