CoChat
Sign Up
Cited by 38Neuroscience and Neuropharmacology ResearchHeart Rate Variability and Autonomic ControlNeuroscience of respiration and sleep

Ganglionic transmission in a vasomotor pathway studied in vivo

Open access
Bratton, Bradford, Davies, Philip, Jänig, Wilfrid, McAllen, Robin·2010·The Journal of Physiology
DOI 10.1113/jphysiol.2009.185025PMC PMC2876816
Open this paper in CoChat — free account

Abstract

Intracellular recordings were made in vivo from 40 spontaneously active cells in the third lumbar sympathetic ganglion of urethane‐anaesthetized rats. In 38/40 cells ongoing action potentials showed strong cardiac rhythmicity (93.4 ± 1.9% modulation) indicating high barosensitivity and probable muscle vasoconstrictor (MVC) function. Subthreshold excitatory postsynaptic potentials (EPSPs) showed the same pattern. The 38 barosensitive neurons fired action potentials at 2.9 ± 0.3 Hz. All action potentials were triggered by EPSPs, most of which were unitary events. Calculations indicated that <5% of action potentials were triggered by summation of otherwise subthreshold EPSPs. ‘Dominant’ synaptic inputs with a high safety factor were identified, confirming previous work. These were active in 24/38 cells and accounted for 32% of all action potentials; other (‘secondary’) inputs drove the remainder. Inputs (21 dominant, 19 secondary) attributed to single preganglionic neurons fired at 1.38 ± 0.16 Hz. An average of two to three preganglionic neurons were estimated to drive each ganglion cell's action potentials. When cells were held hyperpolarized to block spiking, a range of spontaneous EPSP amplitudes was revealed. Threshold equivalent was defined as the membrane potential value that was exceeded by spontaneous EPSPs at the same frequency as the cell's original firing rate. In 10/12 cells examined, a continuum of EPSP amplitudes overlapped threshold equivalent. Small changes in cell excitability could therefore raise or lower the percentage of preganglionic inputs triggering action potentials. The results indicate that vasoconstrictor ganglion cells in vivo mostly behave not as 1:1 relays, but as continuously variable gates.

Integrity signals

Registry

Crossref · 10.1113/jphysiol.2009.185025

Cites

45 of 45 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

We couldn’t retrieve this paper’s full text, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

  • Nerve firing salvos are most likely generated in sympathetic ganglia and are probably represented in multiple regional sympathetic outflows, including the outflow to skeletal muscle vasculature and to the heart.

    “The phenomenon of nerve firing salvos, because it is most likely generated in sympathetic ganglia, 52 is probably represented in multiple regional sympathetic outflows, including in the outflow to skeletal muscle vasculature where it can be measured, and to the heart where it can be inferred.”

    From Obesity Paradox in Hypertension: Is This Because Sympathetic Activation in Obesity-Hypertension Takes a Benign Form? (2018) · cites this paper as [52]

Cites

Flagged first, then by citations

Cited by

Sorted by citations

Related

Authors
Bratton, B., Davies, P., Jänig, W., & McAllen, R.
Affiliations
  • The University of Melbourne (AU)
  • Christian-Albrechts-Universität zu Kiel (DE)
ORCID
McAllen, Robin
Venue
The Journal of Physiology
Publisher
Wiley
Published
2010-04-30
Volume
588
Issue
9
Pages
1647-1659
ISSN
  • 0022-3751 (ISSN-L)
  • 1469-7793
DOI
10.1113/jphysiol.2009.185025
PMC
PMC2876816
OpenAlex
W1492743391
Cited by
38
References
45
Citations by year
2026: 1 · 2025: 2 · 2022: 2 · 2021: 2 · 2020: 2 · 2019: 1 · 2018: 2 · 2017: 2 · 2016: 4 · 2015: 2 · 2014: 7 · 2013: 2 · 2012: 4
FWCI
1.42
Type
journal article
Language
en
Open access
Licence
onlinelibrary.wiley.com/termsAndConditions#vor (vor)
Locations
  • The Journal of Physiology (publishedVersion)
  • PubMed Central (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • National Health and Medical Research Council
  • National Medical Research Council
Topics
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
  • Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Heart Rate Variability and Autonomic Control
  • Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Neuroscience of respiration and sleep
Keywords
ganglionic transmission, sympathetic ganglia, barosensitive neurons, excitatory postsynaptic potentials, synaptic summation, preganglionic neurons, neuronal excitability
MeSH terms
Action Potentials, Animals, Autonomic Fibers, Preganglionic, Blood Pressure, Ganglia, Sympathetic, Heart, Hindlimb, Male, Muscle, Smooth, Vascular, Synaptic Transmission, Neurons, Pressoreceptors, Regional Blood Flow, Synapses, Signal Transduction, Rats, Sprague-Dawley, Excitatory Postsynaptic Potentials, Rats

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review