The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Molding of Deep Polydimethylsiloxane Microstructures for Microfluidics and Biological Applications
Abstract
Here we demonstrate the microfabrication of deep (>25 μm) polymeric microstructures created by replica-molding polydimethylsiloxane (PDMS) from microfabricated Si substrates. The use of PDMS structures in microfluidics and biological applications is discussed. We investigated the feasibility of two methods for the microfabrication of the Si molds: deep plasma etch of silicon-on-insulator (SOI) wafers and photolithographic patterning of a spin-coated photoplastic layer. Although the SOI wafers can be patterned at higher resolution, we found that the inexpensive photoplastic yields similar replication fidelity. The latter is mostly limited by the mechanical stability of the replicated PDMS structures. As an example, we demonstrate the selective delivery of different cell suspensions to specific locations of a tissue culture substrate resulting in micropatterns of attached cells.
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Cites
Chaudhury, M. K., & Whitesides, G. M. (1991) · Langmuir · doi:10.1021/la00053a033 · Cited by 658
Cited by
Fabrication of microfluidic systems in poly(dimethylsiloxane)
McDonald, J. C., Duffy, D. C., Anderson, J. R., Chiu, D. T., Wu, H., Schueller, O. J. A., & Whitesides, G. M. (2000) · Electrophoresis · doi:10.1002/(sici)1522-2683(20000101)21:1<27::aid-elps27>3.0.co;2-c · Cited by 3,329
Bhatia, S. N., & Ingber, D. E. (2014) · Nature Biotechnology · doi:10.1038/nbt.2989 · Cited by 3,305
Efimenko, K., Wallace, W. E., & Genzer, J. (2002) · Journal of Colloid and Interface Science · doi:10.1006/jcis.2002.8594 · Cited by 757
Chiu, D. T., Jeon, N. L., Huang, S., Kane, R. S., Wargo, C. J., Choi, I. S., Ingber, D. E., & Whitesides, G. M. (2000) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.040562297 · Cited by 526
Integration of Cell Culture and Microfabrication Technology
Park, T. H., & Shuler, M. L. (2003) · Biotechnology Progress · doi:10.1021/bp020143k · Cited by 473
Metadata
- Authors
- Folch, A., Ayon, A., Hurtado, O., Schmidt, M. A., & Toner, M.
- Venue
- Journal of Biomechanical Engineering
- Publisher
- ASME International
- Published
- 1999-02-01
- Volume
- 121
- Issue
- 1
- Pages
- 28-34
- ISSN
- 0148-0731 (ISSN-L)
- 1528-8951
- OpenAlex
- W2058238342
- Cited by
- 174
- References
- 1
- FWCI
- 10.51
- Type
- journal article
- Language
- en
- Open access
- closed
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- Folch, A., Ayon, A., Hurtado, O., Schmidt, M. A., & Toner, M. (1999). Molding of Deep Polydimethylsiloxane Microstructures for Microfluidics and Biological Applications. Journal of Biomechanical Engineering. https://doi.org/10.1115/1.2798038
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
