The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
In vivo imaging of light-emitting probes
Abstract
In vivo imaging of cells tagged with light-emitting probes, such as firefly luciferase or fluorescent proteins, is a powerful technology that enables a wide range of biological studies in small research animals. Reporters with emission in the red to infrared (>600 nm) are preferred due to the low absorption in tissue at these wavelengths. Modeling of photon diffusion through tissue indicates that bioluminescent cell counts as low as a few hundred can be detected subcutaneously, while approximately 10(6) cells are required to detect signals at approximately 2 cm depth in tissue. Signal-to-noise estimates show that cooled back-thinned integrating charge coupled devices (CCDs) are preferred to image-intensified CCDs for this application, mainly due to their high quantum efficiency (approximately 85%) at wavelengths >600 nm where tissue absorption is low. Instrumentation for in vivo imaging developed at Xenogen is described and several examples of images of mice with bioluminescent cells are presented.
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Cites
A review of the optical properties of biological tissues
Cheong, W. F., Prahl, S. A., & Welch, A. J. (1990) · IEEE Journal of Quantum Electronics · doi:10.1109/3.64354 · Cited by 2,530
Cited by
Troy, T., Jekic-McMullen, D., Sambucetti, L., & Rice, B. (2004) · Molecular Imaging · doi:10.1162/153535004773861688 · Cited by 418
Self-citationImaging extracellular vesicles: current and emerging methods
Chuo, S. T.-Y., Chien, J. C.-Y., & Lai, C. P.-K. (2018) · Journal of Biomedical Science · doi:10.1186/s12929-018-0494-5 · Cited by 359
In Vivo mouse imaging and spectroscopy in drug discovery
Beckmann, N., Kneuer, R., Gremlich, H., Karmouty‐Quintana, H., Blé, F., & Müller, M. (2007) · NMR in Biomedicine · doi:10.1002/nbm.1153 · Cited by 118
Application of Bioluminescence Imaging for In Vivo Monitoring of Fungal Infections
Brock, M. (2012) · International Journal of Microbiology · doi:10.1155/2012/956794 · Cited by 42
Metadata
- Authors
- Rice, B. W., Cable, M. D., & Nelson, M. B.
- Venue
- Journal of Biomedical Optics
- Publisher
- SPIE-Intl Soc Optical Eng
- Published
- 2001
- Volume
- 6
- Issue
- 4
- Pages
- 432
- ISSN
- 1083-3668 (ISSN-L)
- OpenAlex
- W2035074260
- Cited by
- 493
- References
- 1
- FWCI
- 6.95
- Type
- journal article
- Language
- en
- Open access
- closed
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