In Vivo mouse imaging and spectroscopy in drug discovery
Abstract
Imaging modalities such as micro‐computed tomography (micro‐CT), micro‐positron emission tomography (micro‐PET), high‐resolution MRI, optical imaging, and high‐resolution ultrasound have become invaluable tools in preclinical pharmaceutical research. They can be used to non‐invasively investigate, in vivo, rodent biology and metabolism, disease models, and pharmacokinetics and pharmacodynamics of drugs. The advantages and limitations of each approach usually determine its application, and therefore a small‐rodent imaging laboratory in a pharmaceutical environment should ideally provide access to several techniques. In this paper we aim to illustrate how these techniques may be used to obtain meaningful information for the phenotyping of transgenic mice and for the analysis of compounds in murine models of disease. Copyright © 2007 John Wiley & Sons, Ltd.
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PET imaging can detect relatively small numbers of tumor cells, requires radioactive labeling of cell populations, is only moderately sensitive, and necessitates small animal PET scanners that are not broadly available.
“PET imaging, which can detect relatively small numbers of tumor cells, requires radioactive labeling of cell populations, is only moderately sensitive, and necessitates small animal PET scanners, which are not broadly available (Beckmann et al., 2007; Tai et al., 2005”
From Transparent Adult Zebrafish as a Tool for In Vivo Transplantation Analysis (2008) · cites this paper as Beckmann et al., 2007
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Transparent Adult Zebrafish as a Tool for In Vivo Transplantation Analysis
White, R. M., Sessa, A., Burke, C., Bowman, T., LeBlanc, J., Ceol, C., Bourque, C., Dovey, M., Goessling, W., Burns, C. E., et al. (2008) · Cell Stem Cell · doi:10.1016/j.stem.2007.11.002 · Cited by 1,408 · see citing works
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- Authors
- Beckmann, N., Kneuer, R., Gremlich, H., Karmouty‐Quintana, H., Blé, F., & Müller, M.
- Affiliations
- Novartis (Switzerland) (CH)
- Corresponding author
- Beckmann, Nicolau
- Venue
- NMR in Biomedicine
- Publisher
- Wiley
- Published
- 2007-04-24
- Volume
- 20
- Issue
- 3
- Pages
- 154-185
- ISSN
- 0952-3480 (ISSN-L)
- 1099-1492
- OpenAlex
- W2056281229
- Cited by
- 118
- References
- 9
- Citations by year
- 2025: 4 · 2024: 6 · 2023: 3 · 2022: 3 · 2021: 2 · 2020: 7 · 2019: 4 · 2018: 2 · 2017: 4 · 2016: 3 · 2015: 7 · 2014: 8 · 2013: 10 · 2012: 10
- FWCI
- 1.46
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- NMR in Biomedicine (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Medical Imaging Techniques and Applications
- Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Advanced MRI Techniques and Applications
- Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Optical Imaging and Spectroscopy Techniques
- Keywords
- in vivo imaging, in vivo spectroscopy, drug discovery, micro-computed tomography, high-resolution MRI, optical imaging, high-resolution ultrasound, murine disease models, pharmacokinetics, pharmacodynamics
- MeSH terms
- Animals, Contrast Media, Disease Models, Animal, Drug Evaluation, Preclinical, Humans, Spectrum Analysis, Molecular Probes, Imaging, Three-Dimensional, Mice
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