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Lookup table–based inverse model for determining optical properties of turbid media
Open accessAbstract
We present a lookup table (LUT)-based inverse model for determining the optical properties of turbid media from steady-state diffuse reflectance spectra that is valid for fiber-based probe geometries with close source-detector separations and tissue with low albedo. The lookup table is based solely on experimental measurements of calibration standards. We used tissue-simulating phantoms to validate the accuracy of the LUT inverse model. Our results show excellent agreement between the expected and extracted values of the optical parameters. In addition, the LUT represents a significant improvement in accuracy at short source-detector separations (300 microm) and low albedo (approximately 0.35). We also present in vivo data from clinically normal and malignant nonmelanoma skin cancers fit to the LUT-based model.
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Cited by
Cell-Phone-Based Platform for Biomedical Device Development and Education Applications
Smith, Z. J., Chu, K., Espenson, A. R., Rahimzadeh, M., Gryshuk, A., Molinaro, M., Dwyre, D. M., Lane, S., Matthews, D., & Wachsmann-Hogiu, S. (2011) · PLoS ONE · doi:10.1371/journal.pone.0017150 · Cited by 339
Optical properties of neonatal skin measured in vivo as a function of age and skin pigmentation
Bosschaart, N., Mentink, R., van Leeuwen, A. G. J. M. T., Aalders, M. C., & Kok, J. H. (2011) · Journal of Biomedical Optics · doi:10.1117/1.3622629 · Cited by 49
Metadata
- Authors
- Rajaram, N., Nguyen, T. H., & Tunnell, J. W.
- Venue
- Journal of Biomedical Optics
- Publisher
- SPIE-Intl Soc Optical Eng
- Published
- 2008
- Volume
- 13
- Issue
- 5
- Pages
- 050501
- ISSN
- 1083-3668 (ISSN-L)
- OpenAlex
- W2143353384
- Cited by
- 168
- References
- 0
- FWCI
- 8.36
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Rajaram, N., Nguyen, T. H., & Tunnell, J. W. (2008). Lookup table–based inverse model for determining optical properties of turbid media. Journal of Biomedical Optics. https://doi.org/10.1117/1.2981797
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