The DOI matches its Crossref record; 265 of the 277 references it cites were found in a registry or an index.
Polarized light interaction with tissues
Abstract
This tutorial-review introduces the fundamentals of polarized light interaction with biological tissues and presents some of the recent key polarization optical methods that have made possible the quantitative studies essential for biomedical diagnostics. Tissue structures and the corresponding models showing linear and circular birefringence, dichroism, and chirality are analyzed. As the basis for a quantitative description of the interaction of polarized light with tissues, the theory of polarization transfer in a random medium is used. This theory employs the modified transfer equation for Stokes parameters to predict the polarization properties of single- and multiple-scattered optical fields. The near-order of scatterers in tissues is accounted for to provide an adequate description of tissue polarization properties. Biomedical diagnostic techniques based on polarized light detection, including polarization imaging and spectroscopy, amplitude and intensity light scattering matrix measurements, and polarization-sensitive optical coherence tomography are described. Examples of biomedical applications of these techniques for early diagnostics of cataracts, detection of precancer, and prediction of skin disease are presented. The substantial reduction of light scattering multiplicity at tissue optical clearing that leads to a lesser influence of scattering on the measured intrinsic polarization properties of the tissue and allows for more precise quantification of these properties is demonstrated.
Overview
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“In addition, changes in the polarisation state of light can be used to provide information about tissues, including the superficial layers of the skin, by characterising the depolarisation of light as it propagates [88,89].”
From Relevance and utility of the in-vivo and ex-vivo optical properties of the skin reported in the literature: a review [Invited] (2023) · cites this paper as [89]
Citations
Cites
Items 201–265 of 265
Maksimova, I. L., Romanov, S. V., & Izotova, V. F. (2002) · Optics and Spectroscopy · doi:10.1134/1.1490031 · Cited by 23
Quantitative analysis of light scattering in polarization-resolved nonlinear microscopy
de Aguiar, H. B., Gąsecka, P., & Brasselet, S. (2015) · Optics Express · doi:10.1364/oe.23.008960 · Cited by 22
Shyu, J., Chan, C.-H., Hsiung, M.-W., Yang, P.-N., Chen, H., & Kuo, W. (2009) · Electromagnetic waves · doi:10.2528/pier09022602 · Cited by 22
Sun, P., Ma, Y., Liu, W., Yang, Q., & Jia, Q. (2014) · Journal of Biomedical Optics · doi:10.1117/1.jbo.19.4.046015 · Cited by 21
Spectral Imaging With Scattered Light: From Early Cancer Detection to Cell Biology
Qiu, L., Turzhitsky, V. M., Chuttani, R., Pleskow, D. K., Goldsmith, J. D., Guo, L., Vitkin, E. I., Itzkan, I., Hanlon, E. B., & Perelman, L. T. (2011) · IEEE Journal of Selected Topics in Quantum Electronics · doi:10.1109/jstqe.2011.2161575 · Cited by 21
A new approach for optical assessment of directional anisotropy in turbid media
Ghassemi, P., Moffatt, L. T., Shupp, J. W., & Ramella‐Roman, J. C. (2015) · Journal of Biophotonics · doi:10.1002/jbio.201400124 · Cited by 21
Polarized Light Imaging of Biological Tissues
Jacques, S. L. (2011) · CRC Press eBooks · doi:10.1201/b10951-34 · Cited by 21
Ding, Z., Liang, C.-P., & Chen, Y. (2015) · Frontiers of Optoelectronics · doi:10.1007/s12200-015-0475-1 · Cited by 20
Hemoglobin polymerization in sickle cells studied by circular polarized light scattering
Gross, C. T., Salamon, H., Hunt, A. J., Macey, R. I., Orme, F. W., & Quintanilha, A. T. (1991) · Biochimica et Biophysica Acta (BBA) - Protein Structure and Molecular Enzymology · doi:10.1016/0167-4838(91)90120-o · Cited by 20
NEW PARAMETER FOR DESCRIBING AND ANALYZING THE OPTICAL-ANISOTROPIC PROPERTIES OF BIOLOGICAL TISSUES
Ushenko, Y., Telenga, O. I., Peresunko, O. P., & Numan, O. K. (2011) · Journal of Innovative Optical Health Sciences · doi:10.1142/s1793545811001496 · Cited by 20
Puhakka, P. H., Moller, N. C. R. T., Afara, I. O., Mäkelä, J. T. A., Tiitu, V., Korhonen, R. K., Brommer, H., Virén, T., Jurvelin, J. S., & Töyräs, J. (2015) · Osteoarthritis and Cartilage · doi:10.1016/j.joca.2015.05.034 · Cited by 19
Optical clearing at cellular level
Kinnunen, M. T., Bykov, A. V., Tuorila, J., Haapalainen, T., Karmenyan, A., & Tuchin, V. V. (2014) · Journal of Biomedical Optics · doi:10.1117/1.jbo.19.7.071409 · Cited by 19
Self-citationBiophysical and Biomedical Applications of Nonspherical Scattering
Hoekstra, A. G., & Sloot, P. M. A. (2000) · Elsevier eBooks · doi:10.1016/b978-012498660-2/50047-1 · Cited by 19
Monte Carlo modeling of polarized light propagation: Stokes vs Jones Part I
Akarçay, H. G., Hohmann, A., Kienle, A., Frenz, M., & Rička, J. (2014) · Applied Optics · doi:10.1364/ao.53.007576 · Cited by 18
On the birefringence of healthy and malaria-infected red blood cells
Dharmadhikari, A. K., Basu, H., Dharmadhikari, J. A., Sharma, S., & Mathur, D. (2013) · Journal of Biomedical Optics · doi:10.1117/1.jbo.18.12.125001 · Cited by 17
Wang, G., Zhao, T., Song, X., Zhong, W., Yu, L., Hua, W., Xing, M. M. Q., & Qiu, X. (2014) · Polymer Chemistry · doi:10.1039/c4py01161a · Cited by 16
Near real-time polarimetric imaging system
Buscemi, I. C., & Guyot, S. (2013) · Journal of Biomedical Optics · doi:10.1117/1.jbo.18.11.116002 · Cited by 16
Optical Tissue Clearing to Enhance Imaging Performance for OCT
Wang, R. K., & Tuchin, V. V. (2008) · Biological and medical physics series · doi:10.1007/978-3-540-77550-8_28 · Cited by 15
Self-citationMonte Carlo modeling of polarized light propagation: Stokes vs Jones Part II
Akarçay, H. G., Hohmann, A., Kienle, A., Frenz, M., & Rička, J. (2014) · Applied Optics · doi:10.1364/ao.53.007586 · Cited by 15
Optical properties of the sclera
Fine, I., Loewinger, E., Weinreb, A., & Weinberger, D. (1985) · Physics in Medicine and Biology · doi:10.1088/0031-9155/30/6/006 · Cited by 15
Banerjee, P., Soni, J., Purwar, H., Ghosh, N., & Sengupta, T. K. (2013) · Journal of Biomedical Optics · doi:10.1117/1.jbo.18.3.035003 · Cited by 15
Light Scattering Spectroscopy of Epithelial Tissues: Principles and Applications
Perelman, L. T., & Backman, V. (2017) · doi:10.1117/3.2219608.ch2 · Cited by 14
Hong, Y.-J., Makita, S., Sugiyama, S., & Yasuno, Y. (2014) · Biomedical Optics Express · doi:10.1364/boe.6.000225 · Cited by 14
In vivo spectroscopic ellipsometry measurements on human skin
Chan, D., Schulz, B., Gloystein, K., Müller, H., & Rübhausen, M. (2007) · Journal of Biomedical Optics · doi:10.1117/1.2435703 · Cited by 14
Jones Matrix Based Polarization Sensitive Optical Coherence Tomography
Yasuno, Y., Ju, M. J., Hong, Y. J., Makita, S., Lim, Y., & Yamanari, M. (2015) · Springer eBooks · doi:10.1007/978-3-319-06419-2_36 · Cited by 14
Refractive index changes in the ocular lens result from increased light scatter
Hemenger, R. P. (1996) · Journal of Biomedical Optics · doi:10.1117/12.242695 · Cited by 13
Introduction to Light Scattering by Biological Objects
Khlebtsov, N. G., Maksimova, I. L., Meglinski, I. V., Wang, L. V., & Tuchin, V. V. (2017) · doi:10.1117/3.2219603.ch1 · Cited by 13
Self-citationFeng, X. G., Doherty, S. T., Yaroslavsky, I. V., Altshuler, G. B., & Yaroslavsky, A. N. (2015) · Lasers in Surgery and Medicine · doi:10.1002/lsm.22390 · Cited by 12
Effect of gold nanoparticles on depolarization characteristics of Intralipid tissue phantom
Swami, M. K., Patel, H. S., Geethu, P. M., Uppal, A., Kushwaha, P. K., & Gupta, P. K. (2013) · Optics Letters · doi:10.1364/ol.38.002855 · Cited by 12
Zhang, P., Mehta, K. B., Rehman, S., & Chen, N. (2014) · Scientific Reports · doi:10.1038/srep04979 · Cited by 12
Sviridov, А. P., Chernomordik, V., Hassan, M., Boccara, C., Russo, A., Smith, P. D., & Gandjbakhche, A. (2005) · Journal of Biomedical Optics · doi:10.1117/1.2073727 · Cited by 12
Size-dependent patterns in depolarization maps from turbid medium and tissue
Swami, M. K., Patel, H., Somyaji, M. R., Kushwaha, P. K., & Gupta, P. K. (2014) · Applied Optics · doi:10.1364/ao.53.006133 · Cited by 12
Study on retardance due to well-ordered birefringent cylinders in anisotropic scattering media
Guo, Y., Liu, C., Zeng, N., He, H., Du, E., He, Y., & Ma, H. (2014) · Journal of Biomedical Optics · doi:10.1117/1.jbo.19.6.065001 · Cited by 12
Monte Carlo modeling of polarized light propagation in biological tissues.
Gangnus, S. V., Matcher, S. J., & Meglinski, I. V. (2004) · CERES (Cranfield University) · Cited by 12
Simonenko, G. V., Tuchin, V. V., & Lakodina, N. A. (2000) · Journal of Optical Technology · doi:10.1364/jot.67.000559 · Cited by 11
Self-citationMeasurement of an optical anisotropy of biotissues
Валентинович, С. Г., Denisova, T. P., Lakodina, N. A., & Tuchin, V. V. (2000) · Proceedings of SPIE, the International Society for Optical Engineering/Proceedings of SPIE · doi:10.1117/12.384167 · Cited by 11
Self-citationFluorescent Mueller matrix analysis of a highly scattering turbid media
Satapathi, S., Soni, J., & Ghosh, N. (2014) · Applied Physics Letters · doi:10.1063/1.4869475 · Cited by 11
Characterization of layered scattering media using polarized light measurements and neural networks
Yong, K. Y., Morgan, S. P., Stockford, I. M., & Pitter, M. C. (2003) · Journal of Biomedical Optics · doi:10.1117/1.1578090 · Cited by 11
Polarized Raman spectroscopic investigations on hemoglobin ordering in red blood cells
Ahlawat, S., Chowdhury, A., Kumar, N., Uppal, A., Verma, R. S., & Gupta, P. K. (2014) · Journal of Biomedical Optics · doi:10.1117/1.jbo.19.8.087002 · Cited by 11
Impact of wave polarization on long-range intensity correlations in a disordered medium
Gorodnichev, E. E., Kuzovlev, A. I., & Rogozkin, D. B. (2015) · Journal of the Optical Society of America A · doi:10.1364/josaa.33.000095 · Cited by 11
Pavone, F. S., & Campagnola, P. J. (2016) · CRC Press eBooks · doi:10.1201/b15039-17 · Cited by 11
Diffusion of light by the human sclera
Bakutkin, V. V., Maksimova, I. L., Saprykin, P. I., Tuchin, V. T., & Shubochkin, L. P. (1987) · Journal of Applied Spectroscopy · doi:10.1007/bf00660291 · Cited by 10
Self-citationTheoretical and numerical analysis of polarization for time-dependent radiative transfer equations
Bal, G., & Moscoso, M. (2001) · Journal of Quantitative Spectroscopy and Radiative Transfer · doi:10.1016/s0022-4073(00)00124-2 · Cited by 10
Polarimetric Measurement of Jones Matrix of a Twisted Nematic Liquid Crystal Spatial Light Modulator
Khos-Ochir, T., Munkhbaatar, P., Yang, B. K., Kim, H., Kim, J. S., & Myung-Whun, K. (2012) · Journal of the Optical Society of Korea · doi:10.3807/josk.2012.16.4.443 · Cited by 10
Sinichkin, Y. P., Zimnyakov, D. A., Yakovlev, D. A., Ovchinnikova, I. A., Spivak, A. V., & Ushakova, O. V. (2006) · Optics and Spectroscopy · doi:10.1134/s0030400x06110221 · Cited by 10
Toward Noninvasive Glucose Sensing Using Polarization Analysis of Multiply Scattered Light
Ghosh, N., Vitkin, I. A., Wood, M., & Esenaliev, R. O. (2008) · Series in medical physics and biomedical engineering · doi:10.1201/9781584889755.ch17 · Cited by 10
Farrell, R. A., Freund, D., & McCally, R. L. (1990) · Cited by 10
A Noninvasive Glucose Sensor Based on Polarimetric Measurements Through the Aqueous Humor of the Eye
Coté, G. L., & Ansari, R. R. (2008) · Series in medical physics and biomedical engineering · doi:10.1201/9781584889755.ch15 · Cited by 9
Svaasand, L. O. (1989) · Proceedings of SPIE, the International Society for Optical Engineering/Proceedings of SPIE · doi:10.1117/12.2283591 · Cited by 9
Polarization Sensitive Optical Coherence Tomography
Park, B. H., & de Boer, J. F. (2015) · Springer eBooks · doi:10.1007/978-3-319-06419-2_34 · Cited by 9
Dispersion dependence of the optical anisotropy and the degree of depolarization of fibrous tissues
Zimnyakov, D. A., Simonenko, G. V., & Tuchin, V. V. (2010) · Journal of Optical Technology · doi:10.1364/jot.77.000577 · Cited by 8
Self-citationPolarization reflectance spectroscopy of biological tissues: Diagnostic applications
Zimnyakov, D. A., Sinichkin, Y. P., & Tuchin, V. V. (2004) · Radiophysics and Quantum Electronics · doi:10.1007/s11141-005-0025-6 · Cited by 8
Self-citationTuchin, V. V., & Altshuler, G. B. (2006) · Series on biomaterials and bioengineering · doi:10.1142/9781860948831_0009 · Cited by 6
Self-citationTransillumination of highly scattering media by polarized light
Gorodnichev, E. E., Ivliev, S. V., Kuzovlev, A. I., & Rogozkin, D. B. (2013) · Springer eBooks · doi:10.1007/978-3-642-32106-1_7 · Cited by 4
OCT Fundamentals and Clinical Applications of Endoscopic OCT
Dolin, L. S., Gelikonov, G. V., Gelikonov, V. M., Gladkova, N. D., Iksanov, R. R., Kamensky, V. A., Kuranov, R. V., Sergeev, A. M., Shakhova, N. M., & Turchin, I. V. (2012) · Springer eBooks · doi:10.1007/978-1-4614-5176-1_24 · Cited by 4
Scattering of radiation by regular and random systems comprised of parallel long cylindrical rods
Maksimova, I. L. (2002) · Optics and Spectroscopy · doi:10.1134/1.1517088 · Cited by 4
Swami, M. K., Patel, H. S., Uppal, A., Kushwaha, P. K., & Gupta, P. K. (2013) · Optics Communications · doi:10.1016/j.optcom.2013.06.016 · Cited by 4
Optical Tissue Clearing to Enhance Imaging Performance for OCT
Wang, R. K., & Tuchin, V. V. (2015) · Springer eBooks · doi:10.1007/978-3-319-06419-2_49 · Cited by 4
Self-citationLight-scattering matrices for a close-packed binary system of hard spheres
Maksimova, I. L., & Shibochkin, L. P. (1991) · Optics and Spectroscopy · Cited by 3
- Quantitative Polarimetry for Tissue Characterization and Diagnosis
Wang, R. K., & Tuchin, V. V. (2013) · CRC Press eBooks · doi:10.1201/b15256-6 · Cited by 3
Self-citationHyperspectral polarized light scattering to study tumor cells in in-vitro samples
Rivière, N., Ceolato, R., Lorenzo, C., Jorand, R., & Ducommun, B. (2012) · Proceedings of SPIE, the International Society for Optical Engineering/Proceedings of SPIE · doi:10.1117/12.929826 · Cited by 2
Polarization Sensitive Optical Coherence Tomography
de Boer, J. F. (2004) · Springer eBooks · doi:10.1007/0-387-29989-0_18 · Cited by 1
Izotova, V. F., Maksimova, I. L., & Romanov, S. V. (1999) · Optics and Spectroscopy · Cited by 1
Analysis of errors of a laser polarization nephelometer
Izotova, V. F., Maksimova, I. L., & Romanov, S. V. (1996) · Optics and Spectroscopy · Cited by 1
Hitzenberger, C. K. F., & Pircher, M. (2015) · Springer eBooks · doi:10.1007/978-3-319-06419-2_35 · Cited by 1
Flagged first, then by citations
12 of the 277 references couldn’t be matched to a known paper.
Research works printed but not linked: 10
Cited by
Sorted by citations
Multifunctional materials for implantable and wearable photonic healthcare devices
Lee, G., Moon, H., Kim, H., Lee, G. H., Kwon, W., Yoo, S., Myung, D. J., Yun, S. H., Bao, Z., & Hahn, S. K. (2020) · Nature Reviews Materials · doi:10.1038/s41578-019-0167-3 · Cited by 683
Polarisation optics for biomedical and clinical applications: a review
He, C., He, H., Chang, J., Chen, B., Ma, H., & Booth, M. J. (2021) · Light Science & Applications · doi:10.1038/s41377-021-00639-x · Cited by 649
He, H., Liao, R., Zeng, N., Li, P., Chen, Z., Liu, X., & Ma, H. (2018) · Journal of Lightwave Technology · doi:10.1109/jlt.2018.2868845 · Cited by 205
Polarization Sensitive Optical Coherence Tomography: A Review of Technology and Applications
Baumann, B. (2017) · Applied Sciences · doi:10.3390/app7050474 · Cited by 173
Measurement of tissue optical properties in the context of tissue optical clearing
Bashkatov, A. N., Berezin, K. V., Dvoretski, K. N., Chernavina, M. L., Genina, E. A., Genin, V. D., Kochubey, V. I., Lazareva, E. N., Pravdin, A. B., Shvachkina, M. E., et al. (2018) · Journal of Biomedical Optics · doi:10.1117/1.jbo.23.9.091416 · Cited by 148
Self-citation
Metadata
- Authors
- Tuchin, V. V.
- Affiliations
- Saratov State University (RU)
- Corresponding author
- Tuchin, Valery V.
- ORCID
- Tuchin, Valery V.
- Venue
- Journal of Biomedical Optics
- Publisher
- SPIE-Intl Soc Optical Eng
- Published
- 2016-04-28
- Volume
- 21
- Issue
- 07
- Pages
- 1-37
- ISSN
- 1083-3668 (ISSN-L)
- 1560-2281
- OpenAlex
- W2343259352
- Cited by
- 384
- References
- 277
- Citations by year
- 2026: 27 · 2025: 43 · 2024: 48 · 2023: 51 · 2022: 62 · 2021: 41 · 2020: 35 · 2019: 34 · 2018: 23 · 2017: 10 · 2016: 3
- FWCI
- 11.23
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of Biomedical Optics (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Government of the Russian Federation (14.Z50.31.0004)
- Russian Government (14.Z50.31.0004)
- Russian Governmental (14.Z50.31.0004)
- RF Government (14.Z50.31.0004)
- Russian Science Foundation (14-15-00186)
- Russian Science (14-15-00186)
- Wuhan National Laboratory for Optoelectronics, and the Russian Science Foundation (14-15-00186)
- Topics
- Physical Sciences › Physics and Astronomy › Atomic and Molecular Physics, and Optics › Optical Polarization and Ellipsometry
- Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Optical Imaging and Spectroscopy Techniques
- Physical Sciences › Engineering › Biomedical Engineering › Optical Coherence Tomography Applications
- Keywords
- polarized light, tissue optical properties, birefringence, dichroism, chirality, polarization transfer, Stokes parameters, multiple scattering, polarization imaging, polarization spectroscopy, polarization-sensitive optical coherence tomography, cataract diagnosis, precancer detection, skin disease prediction, tissue clearing, biomedical diagnostics
- MeSH terms
- Birefringence, Diagnostic Imaging, Light, Nephelometry and Turbidimetry, Spectrum Analysis, Biomedical Technology, Tomography, Optical Coherence
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
