Differentiation among prostate cancer patients with Gleason score of 7 using histopathology image and genomic data
Open accessAbstract
Prostate cancer is the most common non-skin related cancer affecting 1 in 7 men in the United States. Treatment of patients with prostate cancer still remains a difficult decision-making process that requires physicians to balance clinical benefits, life expectancy, comorbidities, and treatment-related side effects. Gleason score (a sum of the primary and secondary Gleason patterns) solely based on morphological prostate glandular architecture has shown as one of the best predictors of prostate cancer outcome. Significant progress has been made on molecular subtyping prostate cancer delineated through the increasing use of gene sequencing. Prostate cancer patients with Gleason score of 7 show heterogeneity in recurrence and survival outcomes. Therefore, we propose to assess the correlation between histopathology images and genomic data with disease recurrence in prostate tumors with a Gleason 7 score to identify prognostic markers. In the study, we identify image biomarkers within tissue WSIs by modeling the spatial relationship from automatically created patches as a sequence within WSI by adopting a recurrence network model, namely long short-term memory (LSTM). Our preliminary results demonstrate that integrating image biomarkers from CNN with LSTM and genomic pathway scores, is more strongly correlated with patients recurrence of disease compared to standard clinical markers and engineered image texture features. The study further demonstrates that prostate cancer patients with Gleason score of 4+3 have a higher risk of disease progression and recurrence compared to prostate cancer patients with Gleason score of 3+4.
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Integrating image biomarkers from CNN with an LSTM recurrence network model and genomic pathway scores is more strongly correlated with a patient's recurrence of disease compared to standard clinical markers and image-based texture features.
“The results of the study show that integrating image biomarkers from CNN with a recurrence network model, called long short-term memory LSTM and genomic pathway scores, is more strongly correlated with a patient’s recurrence of disease as compared to using standard clinical markers and image-based texture features [249].”
From AI in Medical Imaging Informatics: Current Challenges and Future Directions (2020) · cites this paper as [249]
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- Authors
- Qi, X., Karagoz, K., Ren, J., Foran, D. J., & Gatza, M.
- Affiliations
- Rutgers, The State University of New Jersey (US)
- Venue
- Medical Imaging 2018: Imaging Informatics for Healthcare, Research, and Applications
- Publisher
- SPIE
- Published
- 2018-03-06
- Volume
- 66
- Pages
- 1
- PMC
- PMC6338219
- OpenAlex
- W2794344266
- Cited by
- 11
- References
- 36
- Citations by year
- 2024: 1 · 2023: 1 · 2022: 1 · 2021: 1 · 2020: 3 · 2019: 3 · 2018: 1
- FWCI
- 0.82
- Type
- conference paper
- Language
- en
- Open access
- green
- europepmc.org
- Locations
- SPIE Medical Imaging: Imaging Informatics for Healthcare, Research, and Applications (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Cancer Institute (UG3CA225021, R01CA161375)
- U.S. National Library of Medicine (R01LM009239)
- Topics
- Physical Sciences › Computer Science › Artificial Intelligence › AI in cancer detection
- Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Radiomics and Machine Learning in Medical Imaging
- Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Prostate Cancer Diagnosis and Treatment
- Keywords
- prostate cancer, Gleason score 7, recurrence, prognostic factors, whole slide images, long short-term memory, convolutional neural networks, tumor heterogeneity
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