Student or educator? Sign up with your school email and get 6 months of Pro free.
CoChat
Sign Up
Cited by 42

The DOI matches its Crossref record.

Effects of Different Vitamin C–Enriched Collagen Derivatives on Collagen Synthesis

Lis, Dana M., Baar, Keith·2019·International Journal of Sport Nutrition and Exercise Metabolism
DOI 10.1123/ijsnem.2018-0385
Open this paper in CoChat — free account

Abstract

Nutritional strategies to improve connective tissue collagen synthesis have garnered significant interest, although the scientific validity of these interventions lags behind their hype. This study was designed to determine the effects of three forms of collagen on N-terminal peptide of procollagen and serum amino acid levels. A total of 10 recreationally active males completed a randomized double-blinded crossover design study consuming either placebo or 15 g of vitamin C–enriched gelatin or hydrolyzed collagen (HC), or gummy containing equal parts of gelatin and HC. Supplements were consumed 1 hr before 6 min of jump rope. Blood samples were collected immediately prior to supplement consumption and 4 hr after jump rope. A subset of blood samples (n = 4) was collected for amino acid analysis 1 hr after ingestion. Consumption of an equivalent dose of each supplement increased amino acids in the circulation similarly across all interventions. N-terminal peptide of procollagen levels tended to increase ∼20% from baseline in the gelatin and HC interventions but not the placebo or gummy. These results suggest that vitamin C–enriched gelatin and HC supplementation may improve collagen synthesis when taken 1 hr prior to exercise. However, large variability was observed, which precluded significance for any treatment.

Overview

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Integrity signals

Registry

Crossref · 10.1123/ijsnem.2018-0385

Cites

Statistics

Verification

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Citations

Cites

No references could be resolved yet.

Research works printed but not linked: 20

  1. Clark, K.L., Sebastianelli, W., Flechsenhar, K.R., Aukermann, D.F., Meza, F., Millard, R.L., … Albert, A. (2008). 24-Week study on the use of collagen hydrolysate as a dietary supplement in athletes with activity-related joint pain. Current Medical Research and Opinion, 24(5), 1485–1496. PubMed ID: 18416885 doi:10.1185/030079908X29196710.1185/030079908X291967 · DOI
  2. Daniel, H. (2004). Molecular and integrative physiology of intestinal peptide transport. Annual Review of Physiology, 66, 361–384. PubMed ID: 14977407 doi:10.1146/annurev.physiol.66.032102.14414910.1146/annurev.physiol.66.032102.144149 · DOI · Paper page
  3. Eastoe, J.E. (1955). The amino acid composition of mammalian collagen and gelatin. Biochemical Journal, 61(4), 589–600. PubMed ID: 13276342 doi:10.1042/bj061058910.1042/bj0610589 · DOI · Paper page
  4. Gómez-Guillén, M.C., Giménez, B., López-Caballero, M.E., & Montero, M.P. (2011). Functional and bioactive properties of collagen and gelatin from alternative sources: A review. Food Hydrocolloids, 25(8), 1813–1827. doi:10.1016/j.foodhyd.2011.02.00710.1016/j.foodhyd.2011.02.007 · DOI · Paper page
  5. Hansen, M., Kongsgaard, M., Holm, L., Skovgaard, D., Magnusson, S.P., Qvortrup, K., … Kjaer, M. (2009). Effect of estrogen on tendon collagen synthesis, tendon structural characteristics, and biomechanical properties in postmenopausal women. Journal of Applied Physiology, 106(4), 1385–1393. doi:10.1152/japplphysiol.90935.200810.1152/japplphysiol.90935.2008 · DOI
  6. Igwemmarm, N.C., Kolawole, S.A., & Imran, I.A. (2013). Effect of heating on vitamin C content of some selected vegetables. International Journal of Scientific & Technology Research, 2(11), 209–212.
  7. Iwai, K., Hasegawa, T., Taguchi, Y., Morimatsu, F., Sato, K., Nakamura, Y., … Ohtsuki, K. (2005). Identification of food-derived collagen peptides in human blood after oral ingestion of gelatin hydrolysates. Journal of Agricultural and Food Chemistry, 53(16), 6531–6536. PubMed ID: 16076145 doi:10.1021/jf050206p10.1021/jf050206p · DOI · Paper page
  8. Jaques, T. (2008). When an icon stumbles: The Ribena issue mismanaged. Corporate Communications: An International Journal, 13(4), 394–406. doi:10.1108/1356328081091482910.1108/13563280810914829 · DOI
  9. Kjaer, M. (2004). Role of extracellular matrix in adaptation of tendon and skeletal muscle to mechanical loading. Physiological Reviews, 84(2), 649–698. PubMed ID: 15044685 doi:10.1152/physrev.00031.200310.1152/physrev.00031.2003 · DOI · Paper page
  10. Matsuda, N., Koyama, Y., Hosaka, Y., Ueda, H., Watanabe, T., Araya, T., … Takehana, K. (2006). Effects of ingestion of collagen peptide on collagen fibrils and glycosaminoglycans in the dermis. Journal of Nutritional Science and Vitaminology, 52(3), 211–215. PubMed ID: 16967766 doi:10.3177/jnsv.52.21110.3177/jnsv.52.211 · DOI
  11. McAlindon, T.E., Nuite, M., Krishnan, N., Ruthazer, R., Price, L.L., Burstein, D., … Flechsenhar, K. (2011). Change in knee osteoarthritis cartilage detected by delayed gadolinium enhanced magnetic resonance imaging following treatment with collagen hydrolysate: A pilot randomized controlled trial. Osteoarthritis Cartilage, 19(4), 399–405. PubMed ID: 21251991 doi:10.1016/j.joca.2011.01.00110.1016/j.joca.2011.01.001 · DOI
  12. Meng, Q.H., Irwin, W.C., Fesser, J., & Massey, K.L. (2005). Interference of ascorbic acid with chemical analytes. Annals of Clinical Biochemistry, 42(Pt 6), 475–477. PubMed ID: 16259800 doi:10.1258/00045630577453827410.1258/000456305774538274 · DOI
  13. Oesser, S., Adam, M., Babel, W., & Seifert, J. (1999). Oral administration of (14)C labeled gelatin hydrolysate leads to an accumulation of radioactivity in cartilage of mice (C57/BL). Journal of Nutrition, 129(10), 1891–1895. PubMed ID: 10498764 doi:10.1093/jn/129.10.189110.1093/jn/129.10.1891 · DOI
  14. Ohara, H., Matsumoto, H., Ito, K., Iwai, K., & Sato, K. (2007). Comparison of quantity and structures of hydroxyproline-containing peptides in human blood after oral ingestion of gelatin hydrolysates from different sources. Journal of Agricultural and Food Chemistry, 55(4), 1532–1535. PubMed ID: 17253720 doi:10.1021/jf062834s10.1021/jf062834s · DOI
  15. Orum, O., Hansen, M., Jensen, C.H., Sørensen, H.A., Jensen, L.B., Hørslev-Petersen, K., & Teisner, B. (1996). Procollagen type I N-terminal propeptide (PINP) as an indicator of type I collagen metabolism: ELISA development, reference interval, and hypovitaminosis D induced hyperparathyroidism. Bone, 19(2), 157–163. PubMed ID: 8853860 doi:10.1016/8756-3282(96)00165-210.1016/8756-3282(96)00165-2 · DOI
  16. Parry, D.A. (1988). The molecular and fibrillar structure of collagen and its relationship to the mechanical properties of connective tissue. Biophysical Chemistry, 29(1–2), 195–209. doi:10.1016/0301-4622(88)87039-X10.1016/0301-4622(88)87039-X · DOI · Paper page
  17. Peleg, M. (2017). Theoretical study of aerobic vitamin C loss kinetics during commercial heat preservation and storage. Food Research International, 102, 246–255. PubMed ID: 29195945 doi:10.1016/j.foodres.2017.10.00810.1016/j.foodres.2017.10.008 · DOI
  18. Shaw, G., Lee-Barthel, A., Ross, M.L., Wang, B., & Baar, K. (2017). Vitamin C-enriched gelatin supplementation before intermittent activity augments collagen synthesis. American Journal of Clinical Nutrition, 105(1), 136–143. PubMed ID: 27852613 doi:10.3945/ajcn.116.13859410.3945/ajcn.116.138594 · DOI · Paper page
  19. Shigemura, Y., Akaba, S., Kawashima, E., Park, E.Y., Nakamura, Y., & Sato, K. (2011). Identification of a novel food-derived collagen peptide, hydroxyprolyl-glycine, in human peripheral blood by pre-column derivatisation with phenyl isothiocyanate. Food Chemistry, 129(3), 1019–1024. PubMed ID: 25212331 doi:10.1016/j.foodchem.2011.05.06610.1016/j.foodchem.2011.05.066 · DOI
  20. West, D.W., Lee-Barthel, A., McIntyre, T., Shamim, B., Lee, C.A., & Baar, K. (2015). The exercise-induced biochemical milieu enhances collagen content and tensile strength of engineered ligaments. The Journal of Physiology, 593(20), 4665–4675. PubMed ID: 26282066 doi:10.1113/JP27073710.1113/JP270737 · DOI

Cited by

See all 42

Metadata

Authors
Lis, D. M., & Baar, K.
Venue
International Journal of Sport Nutrition and Exercise Metabolism
Publisher
Human Kinetics
Published
2019-09-01
Volume
29
Issue
5
Pages
526-531
ISSN
  • 1526-484X
  • 1543-2742
DOI
10.1123/ijsnem.2018-0385
Cited by
42
References
0

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

How to cite

Cite CoChat for the checks on this page, and the paper for its own findings.

This page
CoChat. (2026). Citation check: Effects of Different Vitamin C–Enriched Collagen Derivatives on Collagen Synthesis. https://app.cochat.ai/papers/10.1123/ijsnem.2018-0385
The paper
Lis, D. M., & Baar, K. (2019). Effects of Different Vitamin C–Enriched Collagen Derivatives on Collagen Synthesis. International Journal of Sport Nutrition and Exercise Metabolism. https://doi.org/10.1123/ijsnem.2018-0385

Data sources

Bibliographic data: Semantic Scholar, OpenAlex, Crossref.

Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.