Marginal effects of a large caffeine dose on heat balance during exercise‐heat stress
Abstract
The use of caffeine supplements in athletic and military populations has increased in recent years. Excessive caffeine consumption in conjunction with exercise in a hot environment may predispose individuals to heat illness. Purpose: To examine heat balance induced by a large dose of caffeine during exercise in a hot environment. Methods: Ten men, not heat acclimated and not habitual caffeine users, consumed either caffeine (CAF; 9 mg/kg) or placebo (PLA) before performing cycle-ergometer exercise for 30 min at 50% VO 2peak in a 40 °C, 25% relative humidity environment while body temperature (core and skin) and ratings of thermal comfort (TC) were monitored. Heat-exchange variables were calculated using partitional calorimetry and thermometry. Results: Mean body temperature (T b) was higher (p < .05) with CAF (37.18 ± 0.15 °C) than with PLA (36.93 ± 0.15 °C) at the start of exercise. Heat production was slightly higher (~8 W, p < .05) with CAF. There were no differences in heat storage, dry heat gains, TC, or T b during exercise. Conclusions: A caffeine dose of 9 mg/kg does not appreciably alter heat balance during work in a hot environment. The small increase in T b observed with CAF was undetected by the participants and is unlikely to increase physiological strain sufficiently to affect endurance performance or risk of heat illness.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In a study using the same caffeine dose, mean body temperature was significantly higher by 0.27 degrees Celsius one hour after caffeine consumption than with placebo only at the beginning of exercise, whereas no differences between caffeine and placebo were observed with respect to core, skin or mean temperature during exercise.
“Conversely, in another study using the same caffeine dose, mean body temperature was significantly higher (by 0.27 C) one hour after caffeine consumption than with placebo only at the beginning of the exercise (cycling for 30 minutes at 50 % of VO 2peak in a 40 °C and 25 % relative humidity environment), whereas no differences between caffeine and placebo were observed with respect to core, skin”
From Scientific Opinion on the safety of caffeine (2015) · cites this paper as Ely et al., 2011
Cites
Plum, F. (1960) · Archives of Neurology · doi:10.1001/archneur.1960.03840090124020 · Cited by 10,388 · see citing works
Fredholm, B. B., Bättig, K., Holmén, J., Nehlig, A., & Zvartau, E. E. (1999) · Pharmacological Reviews · doi:10.1016/s0031-6997(24)01396-6 · Cited by 2,624 · cited 1× · see citing works
“…caffeine necessary to produce these effects varies with an individual’s size, metabolism, and urine output (Birkett & Miners, 1991) but is in the range of 10 mg/kg (Fredholm et al., 1999; International Journal of Sport Nutrition and Exercise Metabolism, 21, 2011, 65-70 © 2011 Human Kinetics, Inc.”
BackgroundACSM Position Stand: Exercise and Fluid Replacement
Convertino, V. A., Armstrong, L. E., Coyle, E. F., Mack, G. W., Sawka, M. N., Senay, L. C., & Sherman, W. M. (1996) · Medicine & Science in Sports & Exercise · doi:10.1097/00005768-199610000-00045 · Cited by 1,977 · see citing works
A new weighting system for mean surface temperature of the human body
Ramanathan, N. (1964) · Journal of Applied Physiology · doi:10.1152/jappl.1964.19.3.531 · Cited by 1,892 · see citing works
Effects of Caffeine on Plasma Renin Activity, Catecholamines and Blood Pressure
Robertson, D., Frölich, J. C., Carr, R. K., Watson, J. T., Hollifield, J. W., Shand, D. G., & Oates, J. A. (1978) · New England Journal of Medicine · doi:10.1056/nejm197801262980403 · Cited by 757 · cited 2× · see citing works
“…nervous activity (evidenced by elevated epinephrine levels after caffeine administration) may account for the increased REE, the 2% increase in VO2, and the increased ventilatory response with caffeine (Acheson et al., 2004; Powers, Dodd, Woodyard, & Mangum, 1986; Robertson et al., 1978).”
BackgroundPhysiological measurements of metabolic functions in man.
(1963) · JAMA · doi:10.1001/jama.1963.03700260090052 · Cited by 636 · see citing works
The physiology, pharmacology, and biochemistry of the eccrine sweat gland
Sato, K. (1977) · Reviews of Physiology, Biochemistry and Pharmacology · doi:10.1007/bfb0037089 · Cited by 384 · see citing works
The use of dietary supplements by athletes
Maughan, R. J., Depiesse, F., & Geyer, H. (2007) · Journal of Sports Sciences · doi:10.1080/02640410701607395 · Cited by 311 · see citing works
Acheson, K. J., Zahorska‐Markiewicz, B., Pittet, P., Anantharaman, K., & Jéquier, E. (1980) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/33.5.989 · Cited by 307 · see citing works
Epidemiology of Hospitalizations and Deaths from Heat Illness in Soldiers
Carter, R., Cheuvront, S. N., Williams, J. O., Kolka, M. A., Stephenson, L. A., Sawka, M. N., & Amoroso, P. J. (2005) · Medicine & Science in Sports & Exercise · doi:10.1249/01.mss.0000174895.19639.ed · Cited by 299 · see citing works
Self-citationMechanisms of Heat Exchange: Biophysics and Physiology
Gagge, A. P., & Gonzalez, R. R. (1996) · Comprehensive physiology · doi:10.1002/cphy.cp040104 · Cited by 272 · see citing works
Heat-Related Illness in Athletes
Howe, A. S., & Boden, B. P. (2007) · The American Journal of Sports Medicine · doi:10.1177/0363546507305013 · Cited by 257 · see citing works
Metabolic Effects of Caffeine in Humans: Lipid Oxidation or Futile Cycling?
Acheson, K. J., Gremaud, G., Meirim, I., Montigon, F., Krebs, Y., Fay, L. B., Gay, L.-J., Schneiter, P., Schindler, C., & Tappy, L. (2004) · The American Journal of Clinical Nutrition · doi:10.1093/ajcn/79.1.40 · Cited by 239 · see citing works
Knight, C. A., Knight, I., Mitchell, D. C., & Zepp, J. E. (2004) · Food and Chemical Toxicology · doi:10.1016/j.fct.2004.05.002 · Cited by 189 · see citing works
Daniels, J. W., Molé, P. A., Shaffrath, J. D., & Stebbins, C. L. (1998) · Journal of Applied Physiology · doi:10.1152/jappl.1998.85.1.154 · Cited by 130 · see citing works
Fluid, electrolyte, and renal indices of hydration during 11 days of controlled caffeine consumption
Armstrong, L. E., Pumerantz, A. C., Roti, M. W., Judelson, D. A., Watson, G., Dias, J. C., Sökmen, B., Casa, D. J., Maresh, C. M., Lieberman, H., et al. (2005) · International Journal of Sport Nutrition and Exercise Metabolism · doi:10.1123/ijsnem.15.3.252 · Cited by 112 · see citing works
Caffeinated Sports Drink: Ergogenic Effects and Possible Mechanisms
Cureton, K. J., Warren, G. L., Millard-Stafford, M. L., Wingo, J. E., Trilk, J., & Buyckx, M. (2007) · International Journal of Sport Nutrition and Exercise Metabolism · doi:10.1123/ijsnem.17.1.35 · Cited by 109 · see citing works
Mean body temperature and the control of thermal sweating.
Snellen, J. W. (1966) · PubMed · Cited by 107 · see citing works
Caffeine effects on short‐term performance during prolonged exercise in the heat
DEL COSO, J., ESTEVEZ, E., & MORA-RODRIGUEZ, R. (2008) · Medicine & Science in Sports & Exercise · doi:10.1249/mss.0b013e3181621336 · Cited by 85 · see citing works
Effects of caffeine ingestion on body fluid balance and thermoregulation during exercise
Falk, B., Burstein, R., Rosenblum, J., Shapiro, Y., Zylber-Katz, E., & Bashan, N. (1990) · Canadian Journal of Physiology and Pharmacology · doi:10.1139/y90-135 · Cited by 84 · cited 2× · see citing works
“5 mg/kg did not produce significant changes in core body temperature during exercise when the air temperature was less than 30 °C (Andersen & Hickey, 1994; Daniels, Mole, Shaffrath, & Stebbins, 1998; Dunagan, Greenleaf, & Cisar, 1998; Falk et al., 1990).”
BackgroundInfluentialJay, O., Reardon, F. D., Webb, P. W., Ducharme, M. B., Ramsay, T., Nettlefold, L., & Kenny, G. P. (2007) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00117.2007 · Cited by 79 · see citing works
Birkett, D., & Miners, J. O. (1991) · British Journal of Clinical Pharmacology · doi:10.1111/j.1365-2125.1991.tb05553.x · Cited by 77 · see citing works
Influence of Caffeine on Exercise Performance in Habitual Caffeine Users
Fisher, S., McMurray, R., Berry, M., Mar, M., & Forsythe, W. (1986) · International Journal of Sports Medicine · doi:10.1055/s-2008-1025774 · Cited by 75 · see citing works
Heatstroke and other heat-related illnesses
Lee-Chiong, T. L., & Stitt, J. T. (1995) · Postgraduate Medicine · doi:10.1080/00325481.1995.11946015 · Cited by 57 · see citing works
Estimating Sample Size in Repeated-Measures Analysis of Variance
Tran, Z. V. (1997) · Measurement in Physical Education and Exercise Science · doi:10.1207/s15327841mpee0101_6 · Cited by 47 · see citing works
Engels, H.-J., Wirth, J. C., Celik, S., & Dorsey, J. L. (1999) · International Journal of Sport Nutrition · doi:10.1123/ijsn.9.4.361 · Cited by 46 · see citing works
Lin, M. T., Chandra, A., & Liu, G. G. (1980) · Journal of Pharmacy and Pharmacology · doi:10.1111/j.2042-7158.1980.tb12891.x · Cited by 39 · see citing works
Stebbins, C. L., Daniels, J. W., & Lewis, W. R. (2001) · Clinical Physiology · doi:10.1046/j.1365-2281.2001.00365.x · Cited by 36 · see citing works
Kenefick, R. W., Ely, B. R., Cheuvront, S. N., Palombo, L. J., Goodman, D. A., & Sawka, M. N. (2009) · Medicine & Science in Sports & Exercise · doi:10.1249/mss.0b013e3181988c14 · Cited by 34 · see citing works
Self-citationEffects of caffeine on the metabolic and catecholamine responses to exercise in 5 and 28??C
Anderson, D. E., & Hickey, M. S. (1994) · Medicine & Science in Sports & Exercise · doi:10.1249/00005768-199404000-00009 · Cited by 26 · see citing works
Selected health and behavioral effects related to the use of caffeine
Lamarine, R. J. (1994) · Journal of Community Health · doi:10.1007/bf02260326 · Cited by 23 · see citing works
Caffeine alters ventilatory and gas exchange kinetics during exercise
Powers, S. K., DODD, S. L., WOODYARD, J., & Mangum, M. (1986) · Medicine & Science in Sports & Exercise · doi:10.1249/00005768-198602000-00017 · Cited by 21 · see citing works
Thermoregulatory effects of caffeine ingestion during submaximal exercise in men.
Dunagan, N. A., Greenleaf, J. E., & CISAR, C. J. (1998) · PubMed · Cited by 14 · see citing works
EFFICACY OF NUTRITIONAL ERGOGENIC AIDS IN HOT ENVIRONMENTS
Ely, B. R., & Cheuvront, S. N. (2010) · Current Topics in Nutraceutical Research · Cited by 9 · see citing works
Self-citation
Flagged first, then by citations
Cited by
Sorted by citations
A Review of Caffeine’s Effects on Cognitive, Physical and Occupational Performance
McLellan, T. M., Caldwell, J. A., & Lieberman, H. R. (2016) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2016.09.001 · Cited by 840 · see citing works
International society of sports nutrition position stand: caffeine and performance
Goldstein, E. R., Ziegenfuss, T., Kalman, D., Kreider, R., Campbell, B., Wilborn, C., Taylor, L., Willoughby, D., Stout, J., Graves, B. S., et al. (2010) · Journal of the International Society of Sports Nutrition · doi:10.1186/1550-2783-7-5 · Cited by 686 · see citing works
International Society of Sports Nutrition Position Stand: Caffeine and Exercise Performance
Guest, N. S., VanDusseldorp, T. A., Nelson, M. T., Grgic, J., Schoenfeld, B. J., Jenkins, N. D. M., Arent, S. M., Antonio, J., Stout, J. R., Trexler, E. T., et al. (2021) · Journal of the International Society of Sports Nutrition · doi:10.1186/s12970-020-00383-4 · Cited by 665 · see citing works
Scientific Opinion on the safety of caffeine
EFSA Panel on Dietetic Products, N. A. A. (. (2015) · EFSA Journal · doi:10.2903/j.efsa.2015.4102 · Cited by 613 · see citing works
“27 C) one hour after caffeine consumption than with placebo only at the beginning of the exercise (cycling for 30 minutes at 50 % of VO2peak in a 40 °C and 25 % relative humidity environment), whereas no differences between caffeine and placebo were observed with respect to core, skin or mean temperature during exerc…”
BackgroundACSM and CHAMP Summit on Sickle Cell Trait
O’Connor, F. G., Bergeron, M. F., Cantrell, J. A., Connes, P., Harmon, K. G., Ivy, E. D., Kark, J. A., KLOSSNER, D., Lisman, P. J., MEYERS, B. K., et al. (2012) · Medicine & Science in Sports & Exercise · doi:10.1249/mss.0b013e31826851c2 · Cited by 100 · see citing works
MacRae, B. A., Annaheim, S., Spengler, C. M., & Rossi, R. M. (2018) · Frontiers in Physiology · doi:10.3389/fphys.2018.00029 · Cited by 100 · see citing works
Brain temperature and exercise performance
Nybo, L. (2011) · Experimental Physiology · doi:10.1113/expphysiol.2011.062273 · Cited by 86 · see citing works
Lam, M. S. N., Krenz, J. E., Palmández, P., Negrete, M., Perla, M. E., Murphy-Robinson, H., & Spector, J. T. (2013) · BMC Public Health · doi:10.1186/1471-2458-13-1004 · Cited by 85 · see citing works
Performance outcomes and unwanted side effects associated with energy drinks
Mora‐Rodríguez, R., & Pallarés, J. G. (2014) · Nutrition Reviews · doi:10.1111/nure.12132 · Cited by 56 · see citing works
António, J., Newmire, D. E., Stout, J. R., Antonio, B. B., Gibbons, M., Lowery, L. M., Harper, J., Willoughby, D. S., Evans, C., Anderson, D., et al. (2024) · Journal of the International Society of Sports Nutrition · doi:10.1080/15502783.2024.2323919 · Cited by 48 · see citing works
Effect of caffeine on cycling time-trial performance in the heat
Pitchford, N. W., Fell, J. W., LEVERITT, M. D., Desbrow, B., & Shing, C. M. (2013) · Journal of science and medicine in sport · doi:10.1016/j.jsams.2013.07.004 · Cited by 38 · see citing works
Hydration and thermal strain during tennis in the heat
Bergeron, M. F. (2014) · British Journal of Sports Medicine · doi:10.1136/bjsports-2013-093256 · Cited by 36 · see citing works
Beaumont, R. E., & James, L. J. (2017) · Journal of science and medicine in sport · doi:10.1016/j.jsams.2017.03.017 · Cited by 29 · see citing works
Heat Stress and Thermal Strain Challenges in Running
Bergeron, M. F. (2014) · Journal of Orthopaedic & Sports Physical Therapy · doi:10.2519/jospt.2014.5500 · Cited by 28 · see citing works
Summit on Exercise Collapse Associated with Sickle Cell Trait: Finding the “Way Ahead”
O’Connor, F. G., Franzos, M. A., Nye, N. S., Nelson, D. A., Shell, D., Voss, J. D., Anderson, S. A., Coleman, N. J., Thompson, A. A., Harmon, K. G., et al. (2021) · Current Sports Medicine Reports · doi:10.1249/jsr.0000000000000801 · Cited by 24 · see citing works
Naulleau, C., Jeker, D., Pancrate, T., Claveau, P., Deshayes, T. A., Burke, L. M., & Goulet, E. D. B. (2022) · Sports Medicine · doi:10.1007/s40279-022-01692-1 · Cited by 24 · see citing works
Hunt, L. A., Hospers, L., Smallcombe, J. W., Mavros, Y., & Jay, O. (2021) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00172.2021 · Cited by 24 · see citing works
Willson, C. (2018) · Toxicology Reports · doi:10.1016/j.toxrep.2018.11.013 · Cited by 18 · see citing works
Yu, P., Fan, Y., & Wu, H. (2024) · Sports Health A Multidisciplinary Approach · doi:10.1177/19417381241231627 · Cited by 15 · see citing works
Fujii, N., Fujimoto, T., Cao, Y., Dobashi, K., Matsutake, R., Amano, T., Watanabe, K., & Nishiyasu, T. (2020) · Medicine & Science in Sports & Exercise · doi:10.1249/mss.0000000000002537 · Cited by 14 · see citing works
Predisposing Factors for Exertional Heat Illness
Pryor, J. L., Périard, J. D., & Pryor, R. R. (2019) · Springer eBooks · doi:10.1007/978-3-030-27805-2_3 · Cited by 14 · see citing works
Nye, N. S., Grubic, T., Kim, M. S., O’Connor, F., & Deuster, P. A. (2022) · Journal of Athletic Training · doi:10.4085/1062-6050-0400.21 · Cited by 13 · see citing works
John, K., Kathuria, S., Peel, J., Page, J., Aitkenhead, R., Felstead, A., Heffernan, S. M., Jeffries, O., Tallent, J., & Waldron, M. (2024) · European Journal of Applied Physiology · doi:10.1007/s00421-024-05460-z · Cited by 11 · see citing works
Peel, J., McNarry, M. A., Heffernan, S. M., Nevola, V. R., Kilduff, L. P., & Waldron, M. (2025) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00186.2024 · Cited by 6 · see citing works
Nutrition for Tactical Athletes: Insights, Applications and Research Gaps
Lye, J. C. T., & LEE, J. K. W. (2025) · Sports Medicine · doi:10.1007/s40279-025-02363-7 · Cited by 3 · see citing works
The Effects of Caffeine on Exercise in Hot Environments: A Bibliometric Study
Li, H., Yang, Y., Liu, Q., Liu, L., Zhang, G., Zhang, X., Yin, M., & Cao, Y. (2024) · Nutrients · doi:10.3390/nu16213692 · Cited by 3 · see citing works
Bergeron, M. F. (2019) · Springer eBooks · doi:10.1007/978-3-319-93515-7_11 · Cited by 2 · see citing works
Karesya, M. F., & Ramdhan, D. H. (2022) · PREPOTIF Jurnal Kesehatan Masyarakat · doi:10.31004/prepotif.v6i2.4472
Bartman, N. E., Temple, J. L., Hess, H. W., Colburn, D., & Hostler, D. P. (2025) · The Journal of Strength and Conditioning Research · doi:10.1519/jsc.0000000000005138
Katagiri, A., OTSUKA, R., Nishiyasu, T., & Fujii, N. (2025) · Medicine & Science in Sports & Exercise · doi:10.1249/mss.0000000000003792
- Authors
- Ely, B. R., Ely, M. R., & Cheuvront, S. N.
- Affiliations
- U.S. Army Research Institute of Environmental Medicine (US)
- Venue
- International Journal of Sport Nutrition and Exercise Metabolism
- Publisher
- Human Kinetics
- Published
- 2011-02
- Volume
- 21
- Issue
- 1
- Pages
- 65-70
- ISSN
- 1526-484X (ISSN-L)
- 1543-2742
- OpenAlex
- W2146917559
- Semantic Scholar
- 749ab70663f7df5e0d89480575a9a0546d7586f2
- Cited by
- 33
- References
- 34
- Citations by year
- 2025: 4 · 2024: 5 · 2022: 3 · 2021: 3 · 2020: 1 · 2019: 2 · 2018: 2 · 2017: 1 · 2016: 2 · 2015: 2 · 2014: 3 · 2013: 2 · 2012: 1
- FWCI
- 1.53
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- International Journal of Sport Nutrition and Exercise Metabolism (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Physiology › Thermoregulation and physiological responses
- Health Sciences › Medicine › Pharmacology › Coffee research and impacts
- Health Sciences › Medicine › Rehabilitation › Exercise and Physiological Responses
- Keywords
- caffeine, heat balance, heat stress, exercise in the heat, heat-related illness, body temperature, thermogenesis, thermal energy storage, thermal comfort, military personnel, endurance performance
- MeSH terms
- Adolescent, Adult, Body Temperature Regulation, Caffeine, Central Nervous System Agents, Double-Blind Method, Hot Temperature, Humans, Male, Oxygen Consumption, Stress, Physiological, Exercise, Young Adult
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review