The Dose–Response Association Between Reported Moderate to Vigorous Intensity Physical Activity and Atherogenic Index of Plasma: NHANES, 1999–2006
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Objective: Atherogenic index of plasma (AIP), calculated as LOG10 (triglycerides/high-density lipoprotein-cholesterol), may be utilized to predict risk for cardiovascular disease. Physical activity has been shown to have a favorable association with triglycerides and high-density lipoprotein-cholesterol. The dose–response association between moderate to vigorous physical activity (MVPA) and AIP has yet to be determined in a nationally representative sample of US adults, which was the purpose of this study. Methods: Data from the 1999–2006 National Health and Nutrition Examination Survey were used (N = 6694 adults aged 20–85 y). Leisure-time physical activity over the previous 30 days was self-reported, whereas AIP was calculated from a venous blood sample. Multivariable linear and logistic regression tested the independent association between MVPA and AIP. Results: The authors observed a significant inverse, graded association between quantile of MVPA and the AIP (Ptrend < .001). Conclusion: Engaging in MVPA may attenuate the risk for cardiovascular disease via improvements in AIP. More longitudinal research is necessary to confirm these cross-sectional findings.
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Trials reporting the effects of exercise on apolipoproteins and lipid ratios suggest that exercise training exerts a positive effect on these biomarkers.
“Trials reporting the effects of exercise on apolipoproteins and lipid ratios suggest that exercise training exerts a positive effect on these biomarkers [23–25]”
From Estimating the Effect of Aerobic Exercise Training on Novel Lipid Biomarkers: A Systematic Review and Multivariate Meta-Analysis of Randomized Controlled Trials (2023) · cites this paper as [24]
The paper’s Abstract reports that some aerobic exercise interventions reduced the atherogenic index of plasma, a lipid ratio, but also says intervention results were mixed: interval and resistance training showed no significant change. It does not report effects on apolipoproteins, and its own NHANES analysis was observational rather than a trial. (LLM, conf=0.88)
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Cites
Physical Activity and Reduced Risk of Cardiovascular Events: Potential Mediating Mechanisms
Mora, S., Cook, N., Buring, J. E., Ridker, P. M., & Lee, I.-M. (2007) · Circulation · doi:10.1161/circulationaha.107.729939 · Cited by 1,000 · see citing works
Watt, M. J., Heigenhauser, G. J. F., Dyck, D. J., & Spriet, L. L. (2002) · The Journal of Physiology · doi:10.1113/jphysiol.2002.018820 · Cited by 201 · see citing works
Earnest, C. P., Artero, E. G., Sui, X., Lee, D.-C., Church, T. S., & Blair, S. N. (2013) · Mayo Clinic Proceedings · doi:10.1016/j.mayocp.2012.11.006 · Cited by 170 · see citing works
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Research works printed but not linked: 16
- Dobiasova M, Frohlich J. The plasma parameter log (TG/HDL-C) as an atherogenic index: correlation with lipoprotein particle size and esterification rate in apoB-lipoprotein-depleted plasma (FER(HDL)). Clin Biochem. 2001;34(7):583-588. PubMed ID: 11738396 doi:10. 1016/S0009-9120(01)00263-6 · DOI
- Dobiasova M. AIP-atherogenic index of plasma as a significant predictor of cardiovascular risk: from research to practice. Vnitr Lek. 2006;52(1):64-71. PubMed ID: 16526201
- Bhardwaj S, Bhattacharjee J, Bhatnagar M, Tyagi S. Atherogenic index of plasma, castelli risk index and atherogenic coefficient: new parameters in assessing cardiovascular risk. Int J Pharm Biol Sci. 2013;3(3):359-364.
- Essiarab F, Taki H, Lebrazi H, Sabri M, Saile R. Usefulness of lipid ratios and atherogenic index of plasma in obese Moroccan women with or without metabolic syndrome. Ethn Dis. 2014;24(2):207-212. PubMed ID: 24804368
- Tan MH, Johns D, Glazer NB. Pioglitazone reduces atherogenic index of plasma in patients with type 2 diabetes. Clin Chem. 2004;50(7):1184- 1188. PubMed ID:15117857 doi:10.1373/clinchem.2004.031757 · DOI
- Kokkinos PF, Fernhall B. Physical activity and high density lipopro- tein cholesterol levels: what is the relationship? Sports Med. 1999;28(5):307-314. PubMed ID: 10593643 doi:10.2165/ 00007256-199928050-00002 · DOI
- Skoumas J, Pitsavos C, Panagiotakos DB, et al. Physical activity, high density lipoprotein cholesterol and other lipids levels, in men and women from the ATTICA study. Lipids Health Dis. 2003;2:3. PubMed ID: 12852790 doi:10.1186/1476-511X-2-3 · DOI
- Warburton DE, Nicol CW, Bredin SS. Health benefits of physical activity: the evidence. CMAJ. 2006;174(6):801-809. PubMed ID: 16534088 doi:10.1503/cmaj.051351 · DOI · Paper page
- Stranska Z, Matoulek M, Vilikus Z, Svacina S, Stransky P. Aerobic exercise has beneficial impact on atherogenic index of plasma in sedentary overweight and obese women. Neuro Endocrinol Lett. 2011;32(1):102-108. PubMed ID: 21407166
- Ezeukwu AO, Agwubike EO, Uadia PO. Differential effects of continuous and interval exercise training on the atherogenic index of plasma in the non-obese young male. Zhonghua Minguo Xin Zang Xue Hui Za Zhi. 2015;31(4):337-344.
- Venojarvi M, Korkmaz A, Wasenius N, et al. 12 weeks' aerobic and resistance training without dietary intervention did not influence oxidative stress but aerobic training decreased atherogenic index in middle-aged men with impaired glucose regulation. Food Chem Toxicol. 2013; 61:127-135. PubMed ID: 23623841 doi:10.1016/j.fct.2013.04.015 · DOI
- Loprinzi PD. Dose-response association of moderate-to-vigorous physical activity with cardiovascular biomarkers and all-cause mor- tality: considerations by individual sports, exercise and recreational physical activities. Prev Med. 2015;81:73-77. PubMed ID: 26307435 doi:10.1016/j.ypmed.2015.08.014 · DOI
- Ainsworth BE, Haskell WL, Herrmann SD, et al. 2011 Compendium of physical activities: a second update of codes and MET values. Med Sci Sports Exercise. 2011;43(8):1575-1581. doi:10.1249/MSS. 0b013e31821ece12 · DOI · Paper page
- Ainsworth BE, Haskell WL, Whitt MC, et al. Compendium of physical activities: an update of activity codes and MET intensities. Med Sci Sports Exercise. 2000;32(9 suppl):S498-S516. doi:10.1097/ 00005768-200009001-00009 · DOI · Paper page
- Dobiasova M. Atherogenic index of plasma [log(triglycerides/HDL- cholesterol)]: theoretical and practical implications. Clin Chem. 2004;50(7):1113-1115. PubMed ID: 15229146 doi:10.1373/ clinchem.2004.033175 · DOI
- Dobiasova M, Frohlich J, Sedova M, Cheung MC, Brown BG. Choles- terol esterification and atherogenic index of plasma correlate with lipoprotein size and findings on coronary angiography. J Lipid Res. 2011;52(3):566-571. PubMed ID: 21224290 doi:10.1194/jlr.P011668 · DOI
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Wood, G., Taylor, E., Ng, V., Murrell, A., Patil, A., van der Touw, T., Wolden, M., Andronicos, N., & Smart, N. A. (2023) · Sports Medicine · doi:10.1007/s40279-023-01817-0 · Cited by 31 · see citing works
- Authors
- Edwards, M., & Loprinzi, P.
- ORCID
- Loprinzi, Paul
- Venue
- Journal of Physical Activity and Health
- Publisher
- Human Kinetics
- Published
- 2019-05
- Volume
- 16
- Issue
- 5
- Pages
- 368-370
- ISSN
- 1543-3080 (ISSN-L)
- 1543-5474
- OpenAlex
- W2924883678
- Cited by
- 16
- References
- 3
- Citations by year
- 2026: 1 · 2025: 5 · 2024: 1 · 2023: 2 · 2022: 2 · 2021: 1 · 2020: 4
- FWCI
- 1.20
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Journal of Physical Activity and Health (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Physiology › Physical Activity and Health
- Health Sciences › Medicine › Surgery › Lipoproteins and Cardiovascular Health
- Health Sciences › Medicine › Complementary and alternative medicine › Cardiovascular and exercise physiology
- Keywords
- moderate-to-vigorous physical activity, atherogenic index of plasma, triglycerides, HDL cholesterol, cardiovascular risk, dose-response relationship, leisure-time physical activity, NHANES
- MeSH terms
- Adult, Cross-Sectional Studies, Female, Humans, Cholesterol, HDL, Male, Triglycerides, Exercise
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