COMPARISON OF MOUSE AND RAT CYTOCHROME P450-MEDIATED METABOLISM IN LIVER AND INTESTINE

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Interspecies variation in phase I metabolism of bufalin in hepatic microsomes from mouse, rat, dog, minipig, monkey, and human

Ning, J., Hou, J., Wang, P., Wu, J., Dai, Z., Zou, L., Li, W., Ge, G., Ma, X., & Yang, L. (2015) · Xenobiotica · doi:10.3109/00498254.2015.1035359 · Cited by 12 · see citing works

Natural Product Diversification by One‐Step Biocatalysis using Human P450 3A4

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Age-related changes in the mRNA levels of CYP1A1, CYP2B1/2 and CYP3A1 isoforms in rat small intestine

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Relationship between low midazolam metabolism by cytochrome P450 3A in mice and the high incidence of birth defects

Kitaoka, S., Hatogai, J., Iimura, R., Yamamoto, Y., Oba, K., Nakai, M., Kusunoki, Y., Ochiai, W., & Sugiyama, K. (2018) · The Journal of Toxicological Sciences · doi:10.2131/jts.43.65 · Cited by 11 · see citing works

Tissue Distribution and Gender-Specific Protein Expression of Cytochrome P450 in five Mouse Genotypes with a Background of FVB

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Theoretical consideration of the properties of intestinal flow models on route‐dependent drug removal: Segregated Flow (SFM) vs. Traditional (TM)

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The effect of chronic kidney disease on CYP 2B expression and activity in male Wistar rats

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Extrahepatic Drug‐Metabolizing Enzymes and Their Significance

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A meta-analysis of randomized controlled studies on the hepatoxicity induced by polybrominated diphenyl ethers (PBDEs) in rats and mice

Robledo, D. A., Prudente, M. S., Aguja, S. E., & Iwata, H. (2023) · Current Research in Toxicology · doi:10.1016/j.crtox.2023.100131 · Cited by 8 · see citing works

Comparative analysis of sex-based, vendor-based, and species differences in cytochrome P450 metabolism

Kinatukara, N., Xu, X., & Shah, P. (2026) · Scientific Reports · doi:10.1038/s41598-025-34936-x · Cited by 8 · see citing works

Cysteine effects on the pharmacokinetics of etoposide in protein–calorie malnutrition rats: increased gastrointestinal absorption by cysteine

Suh, J. H., Kang, H. E., Yoon, I., Yang, S., Kim, S. H., Lee, H., Shim, C., & Lee, M. G. (2011) · Xenobiotica · doi:10.3109/00498254.2011.585186 · Cited by 8 · see citing works

Contribution of rat intestinal metabolism to the xenobiotics clearance

Kajbaf, M., Ricci, R., Zambon, S., & Fontana, S. (2012) · European Journal of Drug Metabolism and Pharmacokinetics · doi:10.1007/s13318-012-0098-5 · Cited by 8 · see citing works

Lack of ABC transporter autoinduction in mice following long-term exposure to imatinib

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CYP 450 Enzymes in Drug Discovery and Development: An Overview

Xu, L. S., Das, B., & Prakash, C. (2012) · Encyclopedia of Drug Metabolism and Interactions · doi:10.1002/9780470921920.edm117 · Cited by 7 · see citing works

Effects of cysteine on metformin pharmacokinetics in rats with protein-calorie malnutrition: partial restoration of some parameters to control levels

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Effects of cysteine on the pharmacokinetics of tamoxifen in rats with protein-calorie malnutrition

Lee, Y. K., Yoon, I., Lee, M. G., & Choi, Y. H. (2012) · Xenobiotica · doi:10.3109/00498254.2012.683498 · Cited by 6 · see citing works

The HepG2 Cell Line as a Model for Studying Metabolic Dysfunction-Associated Steatotic Liver Disease

Kotlyarova, A., Iskrina, A., & Kotlyarov, S. (2026) · International journal of molecular sciences · doi:10.3390/ijms27083399 · Cited by 5 · see citing works

Evaluation of Violacein Metabolic Stability and Metabolite Identification in Human, Mouse, and Rat Liver Microsomes

Calemi, D. B. D. A., Godoi, A. B., Minuti, G., Neto, F. C., Hispagnol, G. F., Pilon, A. C., Costa, J. L., Hyslop, S., & Antunes, N. D. J. (2025) · Pharmaceutics · doi:10.3390/pharmaceutics17050601 · Cited by 5 · see citing works

The “false-positive” conundrum in the NTP 2-year rodent cancer study database

Smith, C. J., & Perfetti, T. A. (2018) · Toxicology Research and Application · doi:10.1177/2397847318772839 · Cited by 5 · see citing works

Ambient tonicity and intestinal cytochrome CYP3A

Chuang, A. I., & Ito, S. (2010) · Expert Opinion on Drug Metabolism & Toxicology · doi:10.1517/17425251003781912 · Cited by 4 · see citing works

Pharmacokinetic characterization of anhuienoside C and its deglycosylated metabolites in rats

Sun, H., Liu, H., Zhao, H., Wang, Y., Li, Y.-L., Ye, W., & Wu, B. (2016) · Xenobiotica · doi:10.1080/00498254.2016.1241452 · Cited by 4 · see citing works

Metabolic Disposition of Triazolam and Clobazam in Humanized CYP3A Mice with a Double-Knockout Background of Mouse Cyp2c and Cyp3a Genes

Kobayashi, K., Minegishi, G., Kuriyama, N., Miyajima, A., Abe, S., Kazuki, K., & Kazuki, Y. (2022) · Drug Metabolism and Disposition · doi:10.1124/dmd.122.001087 · Cited by 4 · see citing works

Effect of isavuconazole on the pharmacokinetics of sunitinib and its mechanism

Hu, J., Xia, H., Chen, X., Xu, X., Wu, H.-L., Shen, Y., Xu, R.-A., & Wu, W. (2024) · BMC Cancer · doi:10.1186/s12885-024-12904-4 · Cited by 3 · see citing works

Ninjurin-1 mediates hepatic ischemia-reperfusion injury

Mossemann, J., Martins, B. X., Zhao, Y., Aguilar, F., Taskina, D., Hur, J. C., Nakib, D., Volchuk, A., Ye, G., Ali, D., et al. (2025) · Zeitschrift für Gastroenterologie · doi:10.1055/s-0045-1810803 · Cited by 2 · see citing works

A Study of Serum Levels of Select Heavy Metals and Histology of Brain, Lung, Heart and Ileum of Rats Chronically Exposed to Kerosene

Iyanda, A. A. (2014) · Journal of Pharmaceutical Research International · doi:10.9734/bjpr/2014/2983 · Cited by 2 · see citing works

Bronchioloalveolar lung tumors induced in “mice only” by non-genotoxic chemicals are not useful for quantitative assessment of pulmonary adenocarcinoma risk in humans

Smith, C. J., Perfetti, T. A., & King, J. A. (2018) · Toxicology Research and Application · doi:10.1177/2397847318816617 · Cited by 2 · see citing works

Human Cytomegalovirus-IE1 induces neonate liver injury in transgenic mouse

Song, G., Han, S., & Zhang, X. (2025) · Microbial Pathogenesis · doi:10.1016/j.micpath.2025.107750 · Cited by 1 · see citing works

Hepatocyte Models for Metabolic Dysfunction-Associated Steatotic Liver Disease: A Comparative Analysis of Non-HepG2 Cell Models

Котлярова, А. А., & Kotlyarov, S. N. (2026) · International Journal of Molecular Sciences · doi:10.3390/ijms27104453 · Cited by 1 · see citing works

Comparable efficacy of oral bendamustine versus intravenous administration in treating hematologic malignancies

Cracchiolo, M. J., Davis, L. E., Matiatos, A. P., Davini, D. W., Husnain, M., Simpson, R. J., Voudouris, V., & Katsanis, E. (2024) · Cancer Chemotherapy and Pharmacology · doi:10.1007/s00280-024-04688-y · Cited by 1 · see citing works

Metabolic Stability and Metabolite Identification of CYP450 Probe Substrates in Ferret Hepatocytes

Pu, J., & Feng, W. (2024) · Current Drug Metabolism · doi:10.2174/0113892002302675240903075500 · Cited by 1 · see citing works

ALTERATION OF CYP3A1 mRNA LEVEL IN PRIMARY RAT HEPATOCYTES IN RESPONSE TO AMPK ACTIVE ATOR AICAR

Lee, B.-S., Kim, J., & So, W.-Y. (2019) · Journal of Men s Health · doi:10.22374/jomh.v15i1.113 · Cited by 1 · see citing works

A novel Css-MRTpo approach to simulate oral plasma concentration–time profiles of the partial glucokinase activator PF-04937319 and its disproportionate N-demethylated metabolite in humans using chimeric mice with humanized livers

Kamimura, H., Uehara, S., & Suemizu, H. (2019) · Xenobiotica · doi:10.1080/00498254.2019.1693082 · Cited by 1 · see citing works

Drug metabolism in human and rat intestine: an 'in vitro' approach

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Precision‐Cut Tissue Slices: A SuitableIn VitroSystem for the Study of the Induction of Drug‐Metabolizing Enzyme Systems

Ioannides, C., & Lake, B. G. (2012) · Encyclopedia of Drug Metabolism and Interactions · doi:10.1002/9780470921920.edm064 · Cited by 1 · see citing works

The Interplay Between Drug Release and Intestinal Gut‐Wall Metabolism

Darwich, A. S., Hatley, O. J. D., Olivares‐Morales, A., Salem, F., Margolskee, A., & Rostami‐Hodjegan, A. (2022) · doi:10.1002/9781119772729.ch4 · Cited by 1 · see citing works

Avaliação do potencial efeito antipsicótico da miricitrina em modelos animais

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HER2 Targeted Therapy‐Induced Gastrointestinal Toxicity: From the Clinical Experience to Possible Molecular Mechanisms

Al‐Dasooqi, N., Gibson, R. J., Bowen, J. M., & Keefe, D. M. K. (2012) · doi:10.1002/9781119967309.ch3

Intestinal Perfusion Methods for Oral Drug Absorptions

Zhu, W., & Jeong, E. J. (2011) · doi:10.1002/9781118067598.ch29

Biotransformation of carbamazepine and nicotine in juvenile American alligator (Alligator mississippiensis) in vitro hepatic S9 vs. in situ perfused liver

Umeki, Y., Hala, D. N., & Petersen, L. H. (2024) · Comparative Biochemistry and Physiology Part C Toxicology & Pharmacology · doi:10.1016/j.cbpc.2024.110015

Comparison of mouse and rat cytochrome P450mediated metabolism in liver and intestine. Drug Metab Dispos

Martignoni, M., Groothuis, G., & de Kanter, R. (2016)

How important is intestinal cytochrome P450 3A metabolism?

van Herwaarden, A. E., van Waterschoot, R. A. B., & Schinkel, A. H. (2009) · Trends in Pharmacological Sciences · doi:10.1016/j.tips.2009.02.003 · Cited by 54 · see citing works

Poor Correlation Between Intestinal and Hepatic Metabolic Rates of CYP3A4 Substrates in Rats

Aiba, T., Takehara, Y., Okuno, M., & Hashimoto, Y. (2003) · Pharmaceutical Research · doi:10.1023/a:1023429401738 · Cited by 30 · see citing works

Species Differences in In Vitro and In Vivo Small Intestinal Metabolism of CYP3A Substrates

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Prediction of intestinal first-pass effect of phenacetin in the rat from enzyme kinetic data — correlation with in in vivo data using mucosal blood flow

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