Cited by 366Pharmacogenetics and Drug MetabolismGlutathione Transferases and PolymorphismsDrug Transport and Resistance Mechanisms

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Quantitative Evaluation of the Expression and Activity of Five Major Sulfotransferases (SULTs) in Human Tissues: The SULT “Pie”

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Riches, Zoe, Stanley, Emma L., Bloomer, Jackie C., Coughtrie, Michael W.H.·2009·Drug Metabolism and Disposition

DOI 10.1124/dmd.109.028399PMC PMC2774979

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Abstract

Expression levels of the major human sulfotransferases (SULTs) involved in xenobiotic detoxification in a range of human tissues (i.e., SULT "pies") are not available in a form allowing comparison between tissues and individuals. Here we have determined, by quantitative immunoblotting, expression levels for the five principal human SULTs-SULT1A1, SULT1A3/4, SULT1B1, SULT1E1, and SULT2A1-and determined the kinetic properties toward probe substrates, where available, for these enzymes in cytosol samples from a bank of adult human liver, small intestine, kidney, and lung. We produced new isoform-selective antibodies against SULT1B1 and SULT2A1, which were used alongside antibodies against SULT1A3 and SULT1A1 previously produced in our laboratory or available commercially (SULT1E1). Expression levels were derived using purified recombinant enzymes to construct standard curves for each individual isoform and immunoblot. Substantial intertissue and interindividual differences in expression were observed. SULT1A1 was the major enzyme (>50% of total, range 420-4900 ng/mg cytosol protein) in the liver, followed by SULT2A1, SULT1B1, and SULT1E1. SULT1A3 was completely absent from this tissue. In contrast, the small intestine contained the largest overall amount of SULT of any of the tissues, with SULT1B1 the major enzyme (36%), closely followed by SULT1A3 (31%), and SULT1A1, SULT1E1, and SULT2A1 more minor forms (19, 8, and 6% of total, respectively). The kidney and lung contained low levels of SULT. We provide a unique data set that will add value to the study of the role and contribution of sulfation to drug and xenobiotic metabolism in humans.

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PROTEIN MEASUREMENT WITH THE FOLIN PHENOL REAGENT
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“Immunochemical quantification of expression profiles has been carried out for the cytochromes P450 (P450s) in liver (Shimada et al., 1994) and intestine (Paine et al.”
BackgroundMethod
THE HUMAN INTESTINAL CYTOCHROME P450 “PIE”
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Authors: Riches, Z., Stanley, E. L., Bloomer, J. C., & Coughtrie, M. W. H.
Affiliations: University of Dundee (GB)
ORCID: Riches, Zoe
Coughtrie, Michael W.H.
Venue: Drug Metabolism and Disposition
Publisher: Elsevier BV
Published: 2009-11
Volume: 37
Issue: 11
Pages: 2255-2261
ISSN: 0090-9556 (ISSN-L)
DOI: 10.1124/dmd.109.028399
PMC: PMC2774979
OpenAlex: W2155462152
Cited by: 365
References: 51
Citations by year: 2026: 10 · 2025: 14 · 2024: 15 · 2023: 18 · 2022: 21 · 2021: 26 · 2020: 19 · 2019: 20 · 2018: 26 · 2017: 33 · 2016: 28 · 2015: 27 · 2014: 31 · 2013: 22 · 2012: 30
FWCI: 16.39
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/legal/tdmrep-license (tdm)
Locations: Drug Metabolism and Disposition (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
Discovery Research Portal (University of Dundee) (publishedVersion)
Funders: Biotechnology and Biological Sciences Research Council (BBS/S/B/2004/11767)
Topics: Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmacology › Pharmacogenetics and Drug Metabolism
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Glutathione Transferases and Polymorphisms
Health Sciences › Medicine › Oncology › Drug Transport and Resistance Mechanisms
Keywords: sulfotransferase, SULT1A1, SULT1A3, SULT1B1, SULT1E1, SULT2A1, sulfation, xenobiotic detoxification, tissue-specific enzyme expression, interindividual variability, enzyme kinetics, human liver, small intestine, kidney, lung, drug metabolism
MeSH terms: Adult, Aged, Enzyme Activation, Female, Humans, Intestine, Small, Isoenzymes, Kidney, Liver, Lung, Male, Middle Aged, Tissue Distribution, Sulfotransferases, Gene Expression Regulation, Enzymologic, Young Adult

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Quantitative Evaluation of the Expression and Activity of Five Major Sulfotransferases (SULTs) in Human Tissues: The SULT “Pie”

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