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Trimethylamine and Trimethylamine N-Oxide, a Flavin-Containing Monooxygenase 3 (FMO3)-Mediated Host-Microbiome Metabolic Axis Implicated in Health and Disease
Open accessAbstract
Flavin-containing monooxygenase 3 (FMO3) is known primarily as an enzyme involved in the metabolism of therapeutic drugs. On a daily basis, however, we are exposed to one of the most abundant substrates of the enzyme trimethylamine (TMA), which is released from various dietary components by the action of gut bacteria. FMO3 converts the odorous TMA to nonodorous TMA N-oxide (TMAO), which is excreted in urine. Impaired FMO3 activity gives rise to the inherited disorder primary trimethylaminuria (TMAU). Affected individuals cannot produce TMAO and, consequently, excrete large amounts of TMA. A dysbiosis in gut bacteria can give rise to secondary TMAU. Recently, there has been much interest in FMO3 and its catalytic product, TMAO, because TMAO has been implicated in various conditions affecting health, including cardiovascular disease, reverse cholesterol transport, and glucose and lipid homeostasis. In this review, we consider the dietary components that can give rise to TMA, the gut bacteria involved in the production of TMA from dietary precursors, the metabolic reactions by which bacteria produce and use TMA, and the enzymes that catalyze the reactions. Also included is information on bacteria that produce TMA in the oral cavity and vagina, two key microbiome niches that can influence health. Finally, we discuss the importance of the TMA/TMAO microbiome-host axis in health and disease, considering factors that affect bacterial production and host metabolism of TMA, the involvement of TMAO and FMO3 in disease, and the implications of the host-microbiome axis for management of TMAU.
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“Approximately 50% of the ingested TMAO is absorbed unchanged and then excreted in urine. The remaining 50% is converted into TMA in the gut by the action of TMAO reductase [19].”
From Implication of Trimethylamine N-Oxide (TMAO) in Disease: Potential Biomarker or New Therapeutic Target (2018) · cites this paper as [19]
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“The degradation of ergothioneine by the enzyme ergothionase produces TMA [19]”
From Implication of Trimethylamine N-Oxide (TMAO) in Disease: Potential Biomarker or New Therapeutic Target (2018) · cites this paper as [19]
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Human gut microbes associated with obesity
Ley, R. E., Turnbaugh, P. J., Klein, S., & Gordon, J. I. (2006) · Nature · doi:10.1038/4441022a · Cited by 8,785
A JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS
Lindemann, L., Jaeschke, G., Michalon, A., Vieira, E., Honer, M., Spooren, W., Porter, R., Hartung, T., Kolczewski, S., Büttelmann, B., et al. (1909) · JAMA · doi:10.1001/jama.1909.02550020033007 · Cited by 7,889
Human gut microbiome viewed across age and geography
Yatsunenko, T., Rey, F. E., Manary, M. J., Trehan, I., Dominguez-Bello, M. G., Contreras, M., Magris, M., Hidalgo, G., Baldassano, R. N., Anokhin, A. P., et al. (2012) · Nature · doi:10.1038/nature11053 · Cited by 7,815
Gut flora metabolism of phosphatidylcholine promotes cardiovascular disease
Wang, Z., Klipfell, E., Bennett, B. J., Koeth, R., Levison, B. S., DuGar, B., Feldstein, A. E., Britt, E. B., Fu, X., Chung, Y.-M., et al. (2011) · Nature · doi:10.1038/nature09922 · Cited by 5,597
Host-gut microbiota metabolic interactions
Nicholson, J. K., Holmes, E., Kinross, J., Burcelin, R., Gibson, G., Jia, W., & Pettersson, S. (2012) · Science · doi:10.1126/science.1223813 · Cited by 4,760
Intestinal microbiota metabolism of l-carnitine, a nutrient in red meat, promotes atherosclerosis
Koeth, R. A., Wang, Z., Levison, B. S., Buffa, J. A., Org, E., Sheehy, B. T., Britt, E. B., Fu, X., Wu, Y., Li, L., et al. (2013) · Nature Medicine · doi:10.1038/nm.3145 · Cited by 4,386
Intestinal microbial metabolism of phosphatidylcholine and cardiovascular risk
Tang, W. H. W., Wang, Z., Levison, B. S., Koeth, R. A., Britt, E. B., Fu, X., Wu, Y., & Hazen, S. L. (2013) · New England Journal of Medicine · doi:10.1056/nejmoa1109400 · Cited by 3,400
Caspi, R., Billington, R., Ferrer, L., Foerster, H., Fulcher, C. A., Keseler, I. M., Kothari, A., Krummenacker, M., Latendresse, M., Mueller, L. A., et al. (2016) · Nucleic Acids Research · doi:10.1093/nar/gkv1164 · Cited by 3,395
Drug Metabolism and Disposition
(2014) · Basic & Clinical Pharmacology & Toxicology · doi:10.1111/bcpt.12259_4 · Cited by 2,518
Wang, Z., Roberts, A. B., Buffa, J. A., Levison, B. S., Zhu, W., Org, E., Gu, X., Huang, Y., Zamanian-Daryoush, M., Culley, M. K., et al. (2015) · Cell · doi:10.1016/j.cell.2015.11.055 · Cited by 1,317
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- Kleber H-P, 1977, [Utilization of trimethylammonium-compounds by Acinetobacter calcoaceticus (author’s transl)], Arch Microbiol, 112, 201
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Items 201–300 of 355
Ji, L., Deng, H., Xue, H., Wang, J., Hong, K., Gao, Y., Kang, X., Fan, G., Huang, W., Zhan, J., et al. (2023) · Comprehensive Reviews in Food Science and Food Safety · doi:10.1111/1541-4337.13106 · Cited by 16
Kalnins, G., Sevostjanovs, E., Hartmane, D., Grı̄nberga, S., & Tārs, K. (2017) · Journal of Basic Microbiology · doi:10.1002/jobm.201700428 · Cited by 15
Chang, D., Xu, X., Yang, Z., Ma, T., Nie, J., & Dong, J. (2021) · Peritoneal Dialysis International · doi:10.1177/08968608211051809 · Cited by 15
Kramer, D. J., Wang, W., Loque, I. C., Walters-Laird, C. J., Morisseau, C. H. P., Xiao, X., Nearing, M., Rocha, C. S., Dandekar, A. M., Hammock, B. G., et al. (2025) · mBio · doi:10.1128/mbio.01718-25 · Cited by 18
Zhang, S., Feng, H., Jiang, J., Feng, S., Jiang, Y., Chen, G., Wu, Y., Liu, R., Ma, Y., Ma, Y., et al. (2025) · Phytomedicine · doi:10.1016/j.phymed.2025.157318 · Cited by 14
Christodoulou, P., Vlassopoulou, M., Zervoú, M., Xanthakos, E., Moulos, P., Koutrotsios, G., Zervakis, G. I., Kerezoudi, E. N., Mitsou, E. K., Saxami, G., et al. (2023) · Journal of Fungi · doi:10.3390/jof9010128 · Cited by 16
Emerging roles of low-molecular-weight thiols at the host–microbe interface
Dumitrescu, D. G., & Hatzios, S. K. (2023) · Current Opinion in Chemical Biology · doi:10.1016/j.cbpa.2023.102322 · Cited by 13
He, L., Zuo, Q., Ma, S., Zhang, G., Wang, Z., Zhang, T., Zhai, J., & Guo, Y. (2024) · Renal Failure · doi:10.1080/0886022x.2023.2300314 · Cited by 14
Murtazina, R. Z., Zhukov, I. S., Korenkova, O. M., Popova, E., Kuvarzin, S. R., Efimova, E. V., Кубарская, Л. Г., Геннадьевна, Б. Е., Zolotoverkhaya, E. A., Vaganova, A. N., et al. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22062942 · Cited by 16
Yang, M. J., Khoukaz, L., Qi, X., Kimchi, E. T., Staveley-O’Carroll, K. F., & Li, G. (2021) · Biomedicines · doi:10.3390/biomedicines9121893 · Cited by 17
Microbiome and Diet in Colon Cancer Development and Treatment
Kato, I., & Sun, J. (2023) · The Cancer Journal · doi:10.1097/ppo.0000000000000649 · Cited by 14
Shimizu, M., Yoda, H., Igarashi, N., Makino, M., Tokuyama, E., & Yamazaki, H. (2018) · Xenobiotica · doi:10.1080/00498254.2018.1539279 · Cited by 14
A direct time-based ITC approach for substrate turnover measurements demonstrated on human FMO3
Catucci, G., Sadeghi, S. J., & Gilardi, G. (2019) · Chemical Communications · doi:10.1039/c9cc01356c · Cited by 14
Zheng, X., Huang, Y., Yang, M., Jin, L., Zhang, X., Zhang, R., Wu, Y., Yan, C., Gao, Y., Zeng, M., et al. (2024) · Nutrition and Diabetes · doi:10.1038/s41387-024-00297-z · Cited by 14
van den Berg, E. H., Flores-Guerrero, J. L., Garcia, E., Connelly, M. A., de Meijer, V. E., TransplantLines Investigators, Bakker, S. J. L., Blokzijl, H., & Dullaart, R. P. F. (2022) · Liver International · doi:10.1111/liv.15310 · Cited by 13
Sohouli, M. H., Lozovanu, O. D., Fatahi, S., & Hekmatdoost, A. (2022) · Clinical Nutrition ESPEN · doi:10.1016/j.clnesp.2022.06.006 · Cited by 13
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Salazar, J., Morillo, V., Suarez, M., Castro, A. V., Ramírez, P., Rojas, M., Áñez, R., D’Marco, L., Chacín, M., & Bermúdez, V. (2023) · Current Cardiology Reviews · doi:10.2174/1573403x19666230202164524 · Cited by 17
Hampel, D., Shahab‐Ferdows, S., Nguyen, N. T., Kac, G., & Allen, L. H. (2021) · Frontiers in Nutrition · doi:10.3389/fnut.2020.604570 · Cited by 12
Zou, H., Huang, C., Zhou, L., Lu, R., Zhang, Y., & Lin, D. (2022) · Biomolecules · doi:10.3390/biom12091288 · Cited by 12
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Asija, K., Sutter, M., & Kerfeld, C. A. (2021) · Frontiers in Microbiology · doi:10.3389/fmicb.2021.669024 · Cited by 12
Gut Microbiota and Atherosclerosis: Integrative Multi-Omics and Mechanistic Insights
He, J. H., Wang, H., Qiu, E., Qi, Q., & Wang, Z. (2025) · Current Atherosclerosis Reports · doi:10.1007/s11883-025-01371-2 · Cited by 14
Xin, L., Ren, M., Lou, Y., Yin, H., Qin, F., & Xiong, Z. (2024) · Journal of Pharmaceutical and Biomedical Analysis · doi:10.1016/j.jpba.2024.116062 · Cited by 11
Kittithaworn, A., Dogra, P., Saini, J., Gruppen, E. G., Atkinson, E. J., Achenbach, S. J., Yu, K., Thangamuthu, K., Connelly, M. A., Dullaart, R. P. F., et al. (2024) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/clinem/dgae204 · Cited by 11
Xie, L., Li, P., Liu, B., Cheng, H., & Mao, X. (2023) · Postgraduate Medical Journal · doi:10.1093/postmj/qgad133 · Cited by 13
Zhou, Z., Yao, Y., Sun, Y., Wang, X., Huang, S., Hou, J., Wang, L., & Wei, F. (2024) · Endocrine · doi:10.1007/s12020-024-03732-4 · Cited by 10
Gao, C., Wei, J., Lu, C., Wang, L., Dong, D. F., & Sun, M. (2024) · Gut Microbes · doi:10.1080/19490976.2024.2404141 · Cited by 11
Mak, I. E. K., Yao, Y., Ng, M. T. T., & Kim, J. E. (2025) · Critical Reviews in Food Science and Nutrition · doi:10.1080/10408398.2025.2452362 · Cited by 13
Qin, Z., Wu, W., Yang, X., Wang, X., Ding, A., Huang, Y., Tang, J., Jiang, S., Zhang, P., Qian, C., et al. (2025) · Frontiers in Pharmacology · doi:10.3389/fphar.2025.1592524 · Cited by 13
Mazzini, L., Marchi, F. D., Niccolai, E., Mandrioli, J., & Amedei, A. (2021) · Exon Publications eBooks · doi:10.36255/exonpublications.amyotrophiclateralsclerosis.microbiota.2021 · Cited by 10
Li, X., Li, S., & Kellermann, G. H. (2017) · Journal of Chromatography B · doi:10.1016/j.jchromb.2017.09.049 · Cited by 10
Shimizu, M., Suemizu, H., Mizuno, S., Kusama, T., Miura, T., Uehara, S., & Yamazaki, H. (2018) · The Journal of Toxicological Sciences · doi:10.2131/jts.43.387 · Cited by 9
Prospects of Using Microbiota Correction Methods in the Treatment of Inflammatory Bowel Disease
Akinshina, A. I., Smirnova, D. V., Zagaynova, A. V., Makarov, V. V., & Yudin, S. M. (2019) · Russian Journal of Gastroenterology Hepatology Coloproctology · doi:10.22416/1382-4376-2019-29-2-12-22 · Cited by 9
Gabashvili, I. S. (2020) · JMIR Dermatology · doi:10.2196/10508 · Cited by 9
Living with trimethylaminuria and body and breath malodour: personal perspectives
Flaherty, C. C., Phillips, I. R., Janmohamed, A., & Shephard, E. A. (2024) · BMC Public Health · doi:10.1186/s12889-024-17685-w · Cited by 9
Self-citationXu, H., Bian, X., Wang, H., Huang, L., & Chen, X. (2024) · Applied Biological Chemistry · doi:10.1186/s13765-024-00905-7 · Cited by 9
Dimethylamine enhances platelet hyperactivity in chronic kidney disease model
Gao, Y., Zhang, J., Chen, H., Wang, Z., Hou, J., & Wang, L. (2021) · Journal of Bioenergetics and Biomembranes · doi:10.1007/s10863-021-09913-4 · Cited by 9
The Gut Axis Involvement in Heart Failure
Salzano, A., Cassambai, S., Yazaki, Y., Israr, M. Z., Bernieh, D., Wong, M., & Suzuki, T. (2022) · Cardiology Clinics · doi:10.1016/j.ccl.2021.12.004 · Cited by 9
Human microbiome and cardiovascular diseases
Alam, J., Puppala, V., Uppulapu, S. K., Das, B., & Banerjee, S. (2022) · Progress in molecular biology and translational science · doi:10.1016/bs.pmbts.2022.07.012 · Cited by 11
Beaumont, M., Lencina, C., Bertide, A., Gallo, L., Barilly, C., Marrauld, C., Cauquil, L., Samson, A., & Combes, S. (2023) · Microbiology Spectrum · doi:10.1128/spectrum.00694-23 · Cited by 11
A Novel Dried Blood Spot Detection Strategy for Characterizing Cardiovascular Diseases
Liu, L., Jin, X., Wu, Y.-F., Yang, M., Xu, T., Li, X., Ren, J., & Yan, L. L. (2020) · Frontiers in Cardiovascular Medicine · doi:10.3389/fcvm.2020.542519 · Cited by 11
Role of drug-metabolizing enzymes in biotransformation of drugs
Yaqoob, A., Rehman, Q., Rehman, K., Akash, M. S. H., Hussain, I., & Ahmad, R. (2022) · Elsevier eBooks · doi:10.1016/b978-0-323-95120-3.00013-0 · Cited by 8
Karaağaç, Y. (2023) · Eurasian Journal of Medicine · doi:10.5152/eurasianjmed.2023.23070 · Cited by 9
Taurine and proline promote lung tumour growth by co-regulating Azgp1/mTOR signalling pathway
Liang, T.-L., Chen, Y., Zhou, N.-J., Shu, X., Mi, J., Ma, G.-Y., Xiao, Y., Yang, X., Huang, C., Li, J., et al. (2025) · npj Precision Oncology · doi:10.1038/s41698-025-00872-2 · Cited by 8
Wang, S., Ma, G., Qi, C., Cheng, S., Lai, H., Zhou, L., Wu, G., Chen, Z., Mao, X., Jing, T., et al. (2025) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2025.11.052 · Cited by 9
Scimone, C., Alibrandi, S., Donato, L., Giofrè, S. V., Rao, G., Sidoti, A., & D’Angelo, R. (2020) · Journal of Clinical Pharmacy and Therapeutics · doi:10.1111/jcpt.13315 · Cited by 8
The Correlation Between Heart Failure and Gut Microbiome Metabolites
Chen, L., Li, S., Ai, L., Zhou, J., Huang, J., Xu, F. H., Zeng, X., Han, J., Yin, F., Zhu, Y., et al. (2020) · Infectious Microbes & Diseases · doi:10.1097/im9.0000000000000042 · Cited by 9
Baginski, A. M., Farmer, N. M., Baumer, Y., Wallen, G. R., & Powell‐Wiley, T. M. (2022) · Metabolites · doi:10.3390/metabo12121196 · Cited by 7
Zhu, K.-X., Song, P.-Y., Heli, Li, M.-P., Du, Y., Ma, Q., Peng, L., & Chen, X. (2020) · European Journal of Clinical Pharmacology · doi:10.1007/s00228-020-03024-6 · Cited by 9
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Huguenard, C. J. C., Cseresznye, A., Darcey, T. S., Nkiliza, A., Evans, J. E., Hazen, S. L., MULLAN, M. J., Crawford, F., & Abdullah, L. I. (2023) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2022.1059017 · Cited by 9
Arya, C. K., Maurya, S., & Ramanathan, G. (2023) · Environmental Science and Pollution Research · doi:10.1007/s11356-023-30858-1 · Cited by 8
Flavin-containing monooxygenases: new structures from old proteins
Phillips, I. R., & Shephard, E. A. (2019) · Nature Structural & Molecular Biology · doi:10.1038/s41594-019-0356-1 · Cited by 8
Self-citationA normative microbiome is not restored following kidney transplantation
Craven, H., Erlandsson, H., McGuinness, D., McGuinness, D. H., Mafra, D., Ijaz, U. Z., Bergman, P., Shiels, P. G., & Stenvinkel, P. (2023) · Clinical Science · doi:10.1042/cs20230779 · Cited by 7
MacCann, R., Ghosh, T. S., Léon, A., Li, J., Negi, R., Gaillard, C. M., Saini, G., Tinago, W., Feeney, E. R., Yousif, O., et al. (2023) · Microbes and Infection · doi:10.1016/j.micinf.2023.105247 · Cited by 6
Dual Regulation Mechanism of Obesity: DNA Methylation and Intestinal Flora
Ren, Y., Huang, P., Zhang, L., Tang, Y.-F., Luo, S., She, Z., Peng, H., Chen, Y.-Q., Luo, J., Duan, W.-X., et al. (2024) · Biomedicines · doi:10.3390/biomedicines12081633 · Cited by 8
de Beer, D., Mels, C. M. C., Schutte, A. E., Louw, R., Delles, C., & Kruger, R. (2020) · Nutrition Metabolism and Cardiovascular Diseases · doi:10.1016/j.numecd.2020.06.004 · Cited by 7
Seth, M., Mondal, P., Ghosh, D., Biswas, R., Chatterjee, S., & Mukhopadhyay, S. K. (2024) · Archives of Microbiology · doi:10.1007/s00203-024-03931-7 · Cited by 6
Wang, R., Li, J., Li, X., Guo, Y., Chen, P., & Tian, P. (2025) · Reviews in the Neurosciences · doi:10.1515/revneuro-2025-0013 · Cited by 7
Morvaridzadeh, M., Alami, M., Berrougui, H., Boumezough, K., Sidibé, H., Salih, I., Sadki, K., & Khalil, A. (2025) · Nutrients · doi:10.3390/nu17233784 · Cited by 8
Yao, M., Xiao, Y., Sun, Y., Zhang, B., Ding, Y., Ma, Q., Liang, F., Yang, Z., Ge, W., Liu, S., et al. (2024) · European Journal of Clinical Nutrition · doi:10.1038/s41430-024-01502-z · Cited by 6
Sidoti, A., D’Angelo, R., Castagnetti, A., Viciani, E., Scimone, C., Alibrandi, S., & Giannini, G. (2024) · Biology · doi:10.3390/biology13120961 · Cited by 6
Understanding the Relationship Between Cerebrovascular Disease and the Gut Microbiome
Roth, W., Lo, E., DeLeon, O., Suriya, S. S., Fakhri, F., Brorson, J. R., Polster, S. P., Kass‐Hout, T., Prabhakaran, S., & Siegler, J. E. (2024) · Stroke Vascular and Interventional Neurology · doi:10.1161/svin.124.001272 · Cited by 7
Alibrandi, S., Nicita, F., Donato, L., Scimone, C., Rinaldi, C., D’Angelo, R., & Sidoti, A. (2021) · Molecules · doi:10.3390/molecules26227045 · Cited by 6
Laugwitz, L., Zizmare, L., Santhanakumaran, V., Cannet, C., Böhringer, J., Okun, J. G., Spraul, M., Krägeloh‐Mann, I., Groeschel, S., & Trautwein, C. (2022) · JIMD Reports · doi:10.1002/jmd2.12273 · Cited by 5
Circulating molecules that control brown/beige adipocyte differentiation and thermogenic capacity
Ludwig, R. G., Rocha, A. L. S., & Mori, M. A. (2018) · Cell Biology International · doi:10.1002/cbin.10946 · Cited by 6
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Sun, S., & Bakkeren, G. (2024) · Frontiers in Plant Science · doi:10.3389/fpls.2024.1369299 · Cited by 5
Calvillo, L., Vanoli, E., Ferrara, F., & Caradonna, E. (2025) · International Journal of Molecular Sciences · doi:10.3390/ijms27010203 · Cited by 7
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Almanza, M. C. T., Chvatal‐Medina, M., Connelly, M. A., Moshage, H. J., TransplantLines Investigators, Bakker, S. J. L., de Meijer, V. E., Blokzijl, H., & Dullaart, R. P. F. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms25116031 · Cited by 5
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Amato, B., Novellino, E., Morlando, D., Vanoli, C., Vanoli, E., Ferrara, F., Difruscolo, R., Goffredo, V. M., Compagna, R., Tenore, G. C., et al. (2024) · Journal of Cardiovascular Development and Disease · doi:10.3390/jcdd11060174 · Cited by 5
Deciphering the role of dietary modifications and gut dysbiosis in Non-Alcoholic Fatty Liver Disease
Vachher, M., Kaur, K., Marothia, M., Burman, A., Deepanjana, & Bansal, S. (2025) · Human Nutrition & Metabolism · doi:10.1016/j.hnm.2025.200305 · Cited by 7
Fang, L., Yang, T., Nijiati, Y., Shahanati, D., Abudukeremu, A., Li, J., Shi, W., Maimaitiyiming, D., & Aikemu, A. (2025) · Phytomedicine · doi:10.1016/j.phymed.2025.157069 · Cited by 9
Drug Metabolism: Other Phase I Enzymes
Catucci, G., Gilardi, G., & Sadeghi, S. J. (2021) · Elsevier eBooks · doi:10.1016/b978-0-12-820472-6.00106-7 · Cited by 5
Microbiota and detrimental protein derived metabolites in colorectal cancer
González, A., Odriozola, I., Fullaondo, A., & Odriozola, A. (2024) · Advances in genetics · doi:10.1016/bs.adgen.2024.06.001 · Cited by 7
Bai, H., Zhang, Y., Tian, P., Wu, Y., Peng, R., Liang, B., Ruan, W., Cai, E., Lu, Y., Ma, M., et al. (2024) · Frontiers in Nutrition · doi:10.3389/fnut.2024.1461942 · Cited by 5
Shimizu, M., & Yamazaki, H. (2017) · The Journal of Toxicological Sciences · doi:10.2131/jts.42.485 · Cited by 5
Valenbreder, I., Balăn, S., Breuer, M., & Adriaens, M. E. (2023) · Frontiers in Systems Biology · doi:10.3389/fsysb.2023.1074749 · Cited by 4
Alzughayyar, D., Weber, R.-M., Husain, S., Schoch, N., & Englert, H. S. (2025) · Nutrients · doi:10.3390/nu17020298 · Cited by 4
Gut microbiota and risk of coronary heart disease: a two-sample Mendelian randomization study
Hu, X.-Z., Fu, L.-L., Ye, B., Ao, M., Yan, M., & Feng, H.-C. (2024) · Frontiers in Cardiovascular Medicine · doi:10.3389/fcvm.2024.1273666 · Cited by 6
Shi, F., Liu, Q., Yue, D., Zhang, Y., Wei, X., Wang, Y., & Ma, W. (2024) · Nutrition & Metabolism · doi:10.1186/s12986-024-00787-y · Cited by 4
Yang, X., Zhang, X., Sun, C., Zhao, C., Kong, X., Zhao, M., Ji, L., & Li, Y. (2025) · Frontiers in Endocrinology · doi:10.3389/fendo.2025.1575087 · Cited by 4
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Park, J., Park, I.-H., Kim, J., Noh, J. Y., Kim, K., & Park, J. Y. (2021) · Molecular Medicine Reports · doi:10.3892/mmr.2021.12564 · Cited by 4
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Stoian, D. L., Pescari, D., Bena, A., Paul, C., & Mihuta, S. (2026) · Frontiers in Clinical Diabetes and Healthcare · doi:10.3389/fcdhc.2026.1765794 · Cited by 3
Xu, H., Fang, C., Wang, C., Gan, X., & He, S. (2024) · Water Biology and Security · doi:10.1016/j.watbs.2024.100295 · Cited by 3
Din, A. U., Sweet, M. G., McAmis, A. M., Ratliff, J. G., Babu, P. V. A., & Neilson, A. P. (2025) · The Journal of Nutritional Biochemistry · doi:10.1016/j.jnutbio.2025.109905 · Cited by 3
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AL-Jabri, Z., Al‐Reesi, I., Shizawi, N. A., Al-Balushi, M. S., Al-Jabri, A. A., & Said, E. A. (2021) · Endocrine Metabolic & Immune Disorders - Drug Targets · doi:10.2174/1871530321666211119150231 · Cited by 3
Song, J., Shi, X., Li, X., Liang, Q., Zeng, L., Li, G., Yan, Y., Xu, G., & Zheng, J. (2022) · Frontiers in Veterinary Science · doi:10.3389/fvets.2022.868602 · Cited by 4
Flavin-containing Monooxygenases in the Brain and their Involvement in Neurodegeneration and Aging
Li, B., & An, Z. (2023) · Journal of Exploratory Research in Pharmacology · doi:10.14218/jerp.2022.00067 · Cited by 4
Fu, Y., Hou, X., Feng, Z., Feng, H., & Li, L. (2024) · PubMed Central · doi:10.11817/j.issn.1672-7347.2024.230427 · Cited by 4
Xu, J., Zhang, Y., Liao, J., Le, W., Wu, G., & Zhang, W. (2025) · Phytotherapy Research · doi:10.1002/ptr.70012 · Cited by 3
Chen, B., Chen, M., Pan, X., Bai, M., Sun, D., Jiang, H., Lin, N., & Ma, Z. (2025) · Drug Metabolism and Disposition · doi:10.1016/j.dmd.2025.100133 · Cited by 3
Giannini, G., Soldi, S., Elli, M., Sagheddu, V., Castagnetti, A., Viciani, E., Salvini, L., Battistuzzi, G., Milazzo, F. M., Alibrandi, S., et al. (2025) · Frontiers in Pharmacology · doi:10.3389/fphar.2025.1591825 · Cited by 2
Zheng, B., Xiaoming, S. H. E. N., Han, N., Guo, X. D., & Wan, S. (2026) · Frontiers in Medicine · doi:10.3389/fmed.2026.1778348 · Cited by 4
Kurhaluk, N., Mazur, Z., Kołodziejska, R., & TKACZENKO, H. (2026) · International Journal of Molecular Sciences · doi:10.3390/ijms27083511 · Cited by 5
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Dysbiosis–epigenetics–immune system interaction and ageing health problems
Eshkoor, S. A., & Fanijavadi, S. (2024) · Journal of Medical Microbiology · doi:10.1099/jmm.0.001921 · Cited by 2
Cardiometabolic disease risk in gorillas is associated with altered gut microbial metabolism
Davison, S., Mascellani, A., Ward, Z., Sackett, A., Stryková, A., Jaimes, J. D. C., Travis, D. A., Clayton, J. B., Murphy, H. W., Danforth, M. D., et al. (2025) · npj Biofilms and Microbiomes · doi:10.1038/s41522-025-00664-3 · Cited by 3
Relationship of TMAO levels with vascular function in patients with hypertension
Yamaji, T., Takaeko, Y., Yusoff, F. M., Kishimoto, S., Kajikawa, M., Nakano, Y., Harada, T., Harada, T., Mizobuchi, A., Saito, Y., et al. (2025) · Hypertension Research · doi:10.1038/s41440-025-02346-1 · Cited by 2
Lyu, H., Li, T., Chen, Y., Xue, Y., Liu, W., Yuan, Y., Chen, S., Lu, D., Ren, Y., Wang, H., et al. (2025) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2025.120648 · Cited by 2
Effects of Serum Metabolites on the Pancreatic Transcriptome in Acute Acalculous Cholecystitis
Sun, Y., Wang, Q., Hao, C., & Xue, D. (2021) · Gastroenterology Research and Practice · doi:10.1155/2021/2368571 · Cited by 2
Zhang, W., Gao, Y., Song, S., & Gao, F. (2022) · Soft Computing · doi:10.1007/s00500-022-07368-2 · Cited by 2
Applications of Metabolic Phenotyping in Pharmaceutical Research and Development
Everett, J. R. (2018) · Elsevier eBooks · doi:10.1016/b978-0-12-812293-8.00014-1 · Cited by 2
Metadata
- Authors
- Fennema, D., Phillips, I. R., & Shephard, E. A.
- Affiliations
- Queen Mary University of London (GB)
- Corresponding author
- Shephard, Elizabeth A
- Venue
- Drug Metabolism and Disposition
- Publisher
- Elsevier BV
- Published
- 2016-11
- Volume
- 44
- Issue
- 11
- Pages
- 1839-1850
- ISSN
- 0090-9556 (ISSN-L)
- PMC
- PMC5074467
- OpenAlex
- W2397682060
- Cited by
- 355
- References
- 192
- Citations by year
- 2026: 22 · 2025: 39 · 2024: 48 · 2023: 30 · 2022: 36 · 2021: 56 · 2020: 52 · 2019: 36 · 2018: 20 · 2017: 15
- FWCI
- 2.14
- Type
- journal article
- Language
- en
- Update notices
- erratum (2016-12-01)
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Drug Metabolism and Disposition (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by-nc)
- PubMed (publishedVersion)
- UCL Discovery (University College London) (submittedVersion)
- Funders
- Medical Research Council (MR/K015494/1)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
- Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmacology › Pharmacogenetics and Drug Metabolism
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Polyamine Metabolism and Applications
- Keywords
- trimethylamine, trimethylamine N-oxide, FMO3, trimethylaminuria, gut microbiota, dietary precursors, oral microbiota, vaginal microbiota, cardiovascular disease, reverse cholesterol transport, glucose and lipid homeostasis
- MeSH terms
- Gastrointestinal Microbiome, Animals, Cardiovascular Diseases, Humans, Methylamines, Oxygenases, Host-Pathogen Interactions
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