Transcriptional, Functional, and Mechanistic Comparisons of Stem Cell–Derived Hepatocytes, HepaRG Cells, and Three-Dimensional Human Hepatocyte Spheroids as Predictive In Vitro Systems for Drug-Induced Liver Injury
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The dose responses seen in this study are similar to doses previously used in 3D primary hepatocyte spheroids and close to in vivo levels for APAP overdosing resulting in drug induced liver injury or failure.
“The dose responses seen in this study are similar to doses previously used in 3D primary hepatocyte spheroids [40] and close to in vivo levels for APAP overdosing resulting in drug induced liver injury or failure [41] .”
From 3D microperfusion of mesoscale human microphysiological liver models improves functionality and recapitulates hepatic zonation (2023) · cites this paper as [40]
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- Authors
- Bell, C. C., Lauschke, V. M., Vorrink, S. U., Palmgren, H., Duffin, R., Andersson, T. B., & Ingelman-Sundberg, M.
- Venue
- Drug Metabolism and Disposition
- Publisher
- Elsevier BV
- Published
- 2017-04
- Volume
- 45
- Issue
- 4
- Pages
- 419-429
- ISSN
- 0090-9556
- PMC
- PMC5363699
- Cited by
- 189
- References
- 7
- Language
- en
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