The role of microRNAs in liver injury at the crossroad between hepatic cell death and regeneration
Open accessAbstract
The liver fulfills critical metabolic functions, such as controlling blood sugar and ammonia levels, and is of central importance for lipid metabolism and detoxification of environmental and chemical agents, including drugs. Liver injuries of different etiology can elicit a spectrum of responses. Some hepatocytes initiate molecular programs resulting in cell death, whereas others undergo cellular divisions to regenerate the damaged organ. Interestingly, recent research indicates that microRNAs serve as very rapid as well as long-term regulators in these processes. In this review, we discuss their importance in liver disease etiology and progression as well as for therapy with particular focus on metabolic and inflammatory conditions. Furthermore, we highlight the central role of microRNAs in controlling hepatocyte differentiation and plasticity, which are required for successful regeneration, but under certain conditions, such as chronic liver insults, can result in the formation of hepatocellular carcinoma.
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Several microRNAs are involved in controlling hepatocyte regenerative identity, for example, by maintaining the hepatocyte quiescent state or promoting cell cycle entry during liver regeneration.
“As reviewed elsewhere,64,65 several microRNAs are involved in controlling hepatocyte regenerative identity, for example, by maintaining the hepatocyte quiescent state or promoting cell cycle entry during liver regeneration.”
From Distinct hepatocyte identities in liver homeostasis and regeneration (2023) · cites this paper as [64]
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Distinct hepatocyte identities in liver homeostasis and regeneration
Chen, F., Schönberger, K., & Tchorz, J. S. (2023) · JHEP Reports · doi:10.1016/j.jhepr.2023.100779 · Cited by 30 · see citing works
- Authors
- Lauschke, V. M., Mkrtchian, S., & Ingelman-Sundberg, M.
- Affiliations
- Karolinska Institutet (SE)
- Corresponding author
- Lauschke, Volker M.
- Venue
- Biochemical and Biophysical Research Communications
- Publisher
- Elsevier BV
- Published
- 2017-01
- Volume
- 482
- Issue
- 3
- Pages
- 399-407
- ISSN
- 0006-291X (ISSN-L)
- OpenAlex
- W2559892379
- Cited by
- 29
- References
- 14
- Citations by year
- 2024: 2 · 2023: 2 · 2022: 3 · 2021: 3 · 2020: 6 · 2019: 4 · 2018: 3 · 2017: 6
- FWCI
- 0.54
- Type
- journal article
- Language
- en
- Open access
- green
- zenodo.org
- Licence
- Locations
- Biochemical and Biophysical Research Communications (publishedVersion)
- PubMed (publishedVersion)
- Zenodo (CERN European Organization for Nuclear Research) (submittedVersion, other-oa)
- Funders
- European Union's Horizon 2020 research and innovation programme (668353)
- Innovative Medicine Initiative (115336)
- Topics
- Health Sciences › Medicine › Hepatology › Liver physiology and pathology
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › MicroRNA in disease regulation
- Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmacology › Drug-Induced Hepatotoxicity and Protection
- Keywords
- microRNA, liver injury, hepatocyte death, liver regeneration, hepatocyte differentiation, hepatocellular carcinoma, liver disease progression, liver inflammation, metabolic liver disease, drug-induced liver injury, liver regeneration therapy
- MeSH terms
- Animals, Humans, Liver, Liver Regeneration, Metabolic Diseases, Cell Death, Hepatocytes, MicroRNAs, Cell Proliferation
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