The DOI matches its Crossref record; 43 of the 43 references it cites were found in a registry or an index.
Requirement of Intact Adenosine A1 Receptors for the Diuretic and Natriuretic Action of the Methylxanthines Theophylline and Caffeine
Abstract
Although the diuretic and natriuretic effects of the methylxanthines caffeine and theophylline are well established, the mechanisms responsible for these effects are unclear and may be related to inhibition of phosphodiesterases and/or antagonism of adenosine receptors. With regard to the latter, pharmacological blockade of A1 receptors can induce diuresis and natriuresis by inhibition of proximal tubular reabsorption. To elucidate the role of the A1 receptor in renal actions of methylxanthines, experiments were performed in A1 receptor knockout (A1R-/-) and littermate wild-type (A1R+/+) mice. Urinary excretion was determined in awake mice in metabolic cages over 3 h in response to theophylline (as theophylline2/ethylenediamine, 45 mg/kg), caffeine (45 mg/kg), or vehicle (0.9 ml/30 g b.wt. of 0.85% NaCl) given by oral gavage. Theophylline and caffeine elicited a diuresis and natriuresis (in absolute terms and related to urinary creatinine excretion) in A1R+/+ but not in A1R-/- mice. In a second series, the renal effect of intravenous application of theophylline (30 mg/kg) was determined in clearance experiments under anesthesia. This study revealed that the blunted diuretic and natriuretic effect of theophylline in A1R-/- mice was not due to different responses in blood pressure or glomerular filtration rate. The data indicate that an intact A1 receptor is necessary for caffeine- and theophylline-induced inhibition of renal reabsorption causing diuresis and natriuresis. This is consistent with the assumption that A1 receptor blockade mediates these effects.
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International Union of Pharmacology: Approaches to the Nomenclature of Voltage-Gated Ion Channels
Catterall, W. A., Chandy, K. G., Clapham, D. E., Gutman, G. A., Hofmann, F., Harmar, A. J., Abernethy, D. R., & Spedding, M. (2003) · Pharmacological Reviews · doi:10.1124/pr.55.4.5 · Cited by 7,126
International Union of Pharmacology. XXV. Nomenclature and Classification of Adenosine Receptors
Fredholm, B. B., IJzerman, A. P., Jacobson, K. A., Klotz, K.-N., & Linden, J. (2001) · Pharmacological Reviews · doi:10.1016/s0031-6997(24)01511-4 · Cited by 2,585
Aggressiveness, hypoalgesia and high blood pressure in mice lacking the adenosine A2a receptor
Ledent, C. A., Vaugeois, J., Schiffmann, S. N., Pedrazzini, T., Yacoubi, M. E., Vanderhaeghen, J. J., Costentin, J., Heath, J. K., Vassart, G., & Parmentier, M. (1997) · Nature · doi:10.1038/41771 · Cited by 918
Tolerance to the humoral and hemodynamic effects of caffeine in man.
Robertson, D., Wade, D., Workman, R., Woosley, R. L., & Oates, J. A. (1981) · Journal of Clinical Investigation · doi:10.1172/jci110124 · Cited by 501 · cited 1×
“Both effects could be blocked with theophylline (Robertson et al., 1981; Fredholm, 1984).”
BackgroundSun, D., Samuelson, L. C., Yang, T., Huang, Y. G., Paliege, A., Saunders, T. L., Briggs, J., & Schnermann, J. B. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.171317998 · Cited by 402
Self-citationRenal lithium excretion in man
Thomsen, K., & Schou, M. (1968) · American Journal of Physiology-Legacy Content · doi:10.1152/ajplegacy.1968.215.4.823 · Cited by 264
Caffeine and theophylline as adenosine receptor antagonists in humans.
Biaggioni, I., Paul, S., Puckett, A. E., & Arzubiaga, C. (1991) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(25)20409-8 · Cited by 213
Adenosine formed by 5′-nucleotidase mediates tubuloglomerular feedback
Thomson, S. C., Bao, D., Deng, A., & Vallon, V. (2000) · Journal of Clinical Investigation · doi:10.1172/jci8761 · Cited by 179
Self-citationVestal, R. E., Eiriksson, C. E., Musser, B., Ozaki, L., & Halter, J. B. (1983) · Circulation · doi:10.1161/01.cir.67.1.162 · Cited by 151
Renal effects of adenosine and their inhibition by theophylline in dogs
O�wald, H. (1975) · Naunyn-Schmiedeberg s Archives of Pharmacology · doi:10.1007/bf00501815 · Cited by 147
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Scientific Opinion on the safety of caffeine
EFSA Panel on Dietetic Products, N. A. A. (. (2015) · EFSA Journal · doi:10.2903/j.efsa.2015.4102 · Cited by 613
“The diuretic activity of caffeine can be explained by an interaction with the adenosine receptor A1 in the kidney, leading to inhibition of renal re-absorption and causing diuresis and natriuresis (Rieg et al., 2005).”
BackgroundVallon, V., Mühlbauer, B., & Oßwald, H. (2006) · Physiological Reviews · doi:10.1152/physrev.00031.2005 · Cited by 450
Self-citationHypertension in infancy: diagnosis, management and outcome
Dionne, J. M., Abitbol, C. L., & Flynn, J. T. (2011) · Pediatric Nephrology · doi:10.1007/s00467-010-1755-z · Cited by 279
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Metadata
- Authors
- Rieg, T., Steigele, H., Schnermann, J., Richter, K., Osswald, H., & Vallon, V.
- Affiliations
- University of Tübingen (DE)
- Venue
- The Journal of Pharmacology and Experimental Therapeutics
- Publisher
- Elsevier BV
- Published
- 2005-04
- Volume
- 313
- Issue
- 1
- Pages
- 403-409
- ISSN
- 0022-3565 (ISSN-L)
- OpenAlex
- W2134391819
- Cited by
- 133
- References
- 43
- Citations by year
- 2025: 9 · 2024: 4 · 2023: 5 · 2022: 5 · 2021: 7 · 2020: 19 · 2019: 7 · 2018: 7 · 2017: 5 · 2016: 5 · 2015: 6 · 2014: 7 · 2013: 3 · 2012: 4
- FWCI
- 4.20
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of Pharmacology and Experimental Therapeutics (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Physiology › Adenosine and Purinergic Signaling
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Ion Transport and Channel Regulation
- Health Sciences › Medicine › Pharmacology (medical) › Coffee research and impacts
- Keywords
- adenosine A1 receptor, theophylline, caffeine, methylxanthines, diuresis, sodium excretion, tubular reabsorption, phosphodiesterase inhibition, urinary excretion
- MeSH terms
- Anesthesia, Animals, Caffeine, Diuretics, Genotype, Glomerular Filtration Rate, Mice, Inbred C57BL, Natriuresis, Potassium, Sodium, Theophylline, Urodynamics, Mice, Knockout, Receptor, Adenosine A1, Mice
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