The DOI matches its Crossref record; 4 of the 4 references it cites were found in a registry or an index.
Plumbagin (5-Hydroxy-2-methyl-1,4-naphthoquinone) Induces Apoptosis and Cell Cycle Arrest in A549 Cells through p53 Accumulation via c-Jun NH2-Terminal Kinase-Mediated Phosphorylation at Serine 15 in Vitro and in Vivo
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Citations
Cites
SP600125, an anthrapyrazolone inhibitor of Jun N-terminal kinase
Bennett, B. L., Sasaki, D. T., Murray, B. W., O'Leary, E. C., Sakata, S. T., Xu, W., Leisten, J. C., Motiwala, A., Pierce, S., Satoh, Y., et al. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.251194298 · Cited by 2,558 · cited 3×
“Although SP600125 was described as an inhibitor of the JNK pathway for the treatment of autoimmune, inflammatory, and neurodegenerative diseases and shown to be selective for JNK1/2 (Bennett et al., 2001), it has also been reported to exhibit nonspecific inhibition on several cell cycle and apoptosis-related enzymes,…”
BackgroundInfluentialThe p53 pathway: positive and negative feedback loops
Harris, S. L., & Levine, A. J. (2005) · Oncogene · doi:10.1038/sj.onc.1208615 · Cited by 1,967
The specificities of protein kinase inhibitors: an update
BAIN, J., McLAUCHLAN, H., ELLIOTT, M., & COHEN, P. (2003) · Biochemical Journal · doi:10.1042/bj20021535 · Cited by 1,369 · cited 1×
“, 2001), it has also been reported to exhibit nonspecific inhibition on several cell cycle and apoptosis-related enzymes, including serum- and glucocorticoid-induced kinase, p70 ribosomal protein S6 kinase, AMP-activated protein kinase, Cdk2, and dual-specificity, tyrosine-phosphorylated and regulated kinase 1A (Bain…”
BackgroundPost-translational modification of p53 in tumorigenesis
Bode, A. M., & Dong, Z. (2004) · Nature Reviews Cancer · doi:10.1038/nrc1455 · Cited by 1,270
Cited by
The Chemical Biology of Naphthoquinones and Its Environmental Implications
Kumagai, Y., Shinkai, Y., Miura, T., & Cho, A. K. (2012) · Annual Review of Pharmacology and Toxicology · doi:10.1146/annurev-pharmtox-010611-134517 · Cited by 332
Perspectives on medicinal properties of plumbagin and its analogs
Padhye, S., Dandawate, P., Yusufi, M., Ahmad, A., & Sarkar, F. H. (2012) · Medicinal Research Reviews · doi:10.1002/med.20235 · Cited by 324
Babula, P., Adam, V., Havel, L., & Kizek, R. (2009) · Current Pharmaceutical Analysis · doi:10.2174/157341209787314936 · Cited by 268
Pawar, A., Patel, R., Arulmozhi, S., & Bothiraja, C. (2016) · RSC Advances · doi:10.1039/c6ra12714b · Cited by 30
Metadata
- Authors
- Hsu, Y.-L., Cho, C.-Y., Kuo, P.-L., Huang, Y.-T., & Lin, C.-C.
- Venue
- The Journal of Pharmacology and Experimental Therapeutics
- Publisher
- Elsevier BV
- Published
- 2006-08
- Volume
- 318
- Issue
- 2
- Pages
- 484-494
- ISSN
- 0022-3565 (ISSN-L)
- OpenAlex
- W1982258251
- Cited by
- 209
- References
- 4
- FWCI
- 18.93
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: Plumbagin (5-Hydroxy-2-methyl-1,4-naphthoquinone) Induces Apoptosis and Cell Cycle Arrest in A549 Cells through p53 Accumulation via c-Jun NH2-Terminal Kinase-Mediated Phosphorylation at Serine 15 in Vitro and in Vivo. https://app.cochat.ai/papers/10.1124/jpet.105.098863
- The paper
- Hsu, Y.-L., Cho, C.-Y., Kuo, P.-L., Huang, Y.-T., & Lin, C.-C. (2006). Plumbagin (5-Hydroxy-2-methyl-1,4-naphthoquinone) Induces Apoptosis and Cell Cycle Arrest in A549 Cells through p53 Accumulation via c-Jun NH2-Terminal Kinase-Mediated Phosphorylation at Serine 15 in Vitro and in Vivo. The Journal of Pharmacology and Experimental Therapeutics. https://doi.org/10.1124/jpet.105.098863
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
