d -α-Tocopheryl polyethylene glycol 1000 succinate conjugated folic acid nanomicelles: towards enhanced bioavailability, stability, safety, prolonged drug release and synergized anticancer effect of plumbagin
Abstract
Plumbagin (PLB) loaded d -α-tocopheryl polyethylene glycol 1000 succinate (TPGS) with folic acid (FOL) conjugated nanomicelles achieved controlled and targeted delivery with synergized anticancer potency and reduced PLB toxicity.
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Polymeric nanomicelles (PNMs) employ passive targeting, folate, pH-sensitive, and thermosensitive DDSs to beat drug resistance through perfect targeting.
“PNMs employ passive targeting, folate, pH-sensitive, and thermosensitive DDSs to beat drug resistance through perfect targeting (Figure 4) [101,102,103,104].”
From Recent Advances in Nanomicelles Delivery Systems. (2020) · cites this paper as [104]
Cites
Cancer chemoprevention with dietary phytochemicals
Surh, Y.-J. (2003) · Nature reviews. Cancer · doi:10.1038/nrc1189 · Cited by 2,955 · see citing works
Polymeric Micelles in Anticancer Therapy: Targeting, Imaging and Triggered Release
Oerlemans, C., Bult, W., Bos, M. A., Storm, G., Nijsen, J. F. W., & Hennink, W. E. (2010) · Pharmaceutical Research · doi:10.1007/s11095-010-0233-4 · Cited by 951 · see citing works
Gupta, S. C., Kim, J. H., Prasad, S., & Aggarwal, B. B. (2010) · Cancer and Metastasis Reviews · doi:10.1007/s10555-010-9235-2 · Cited by 806 · see citing works
Advances in polymeric micelles for drug delivery and tumor targeting
Kedar, U., Phutane, P., Shidhaye, S., & Kadam, V. (2010) · Nanomedicine: Nanotechnology, Biology and Medicine · doi:10.1016/j.nano.2010.05.005 · Cited by 791 · see citing works
Kim, S., Shi, Y., Kim, J. Y., Park, K., & Cheng, J. (2009) · Expert Opinion on Drug Delivery · doi:10.1517/17425240903380446 · Cited by 549 · see citing works
Paclitaxel: a review of adverse toxicities and novel delivery strategies
Marupudi, N. I., Han, J. E., Li, K. W., Renard, V. M., Tyler, B., & Brem, H. (2007) · Expert Opinion on Drug Safety · doi:10.1517/14740338.6.5.609 · Cited by 509 · see citing works
Liu, Y., Li, K., Pan, J., Liu, B., & Feng, S. (2009) · Biomaterials · doi:10.1016/j.biomaterials.2009.09.036 · Cited by 341 · see citing works
Sandur, S. K., Ichikawa, H., Sethi, G., Ahn, K. S., & Aggarwal, B. B. (2006) · Journal of Biological Chemistry · doi:10.1074/jbc.m601595200 · Cited by 322 · see citing works
van Schooneveld, M. M., Vucic, E., Koole, R., et al. (2008) · Nano Letters · doi:10.1021/nl801596a · Cited by 256 · see citing works
Improving Penetration in Tumors With Nanoassemblies of Phospholipids and Doxorubicin
Tang, N., Du, G., Wang, N., Liu, C., Hang, H., & Liang, W. P. (2007) · JNCI Journal of the National Cancer Institute · doi:10.1093/jnci/djm027 · Cited by 240 · see citing works
Folate-decorated poly(lactide-co-glycolide)-vitamin E TPGS nanoparticles for targeted drug delivery
Zhang, Z., Lee, S. H., & Feng, S. (2007) · Biomaterials · doi:10.1016/j.biomaterials.2006.12.018 · Cited by 239 · see citing works
Lymphatic targeting with nanoparticulate system
Nishioka, Y., & Yoshino, H. (2001) · Advanced Drug Delivery Reviews · doi:10.1016/s0169-409x(00)00121-6 · Cited by 224 · see citing works
Collnot, E.-M., Baldes, C., Schaefer, U. F., Edgar, K. J., Wempe, M. F., & Lehr, C. (2010) · Molecular Pharmaceutics · doi:10.1021/mp900191s · Cited by 219 · see citing works
Hsu, Y., Cho, C.-Y., Kuo, P., Huang, Y., & Lin, C. (2006) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.105.098863 · Cited by 209 · see citing works
Wang, C. C. C., Chiang, Y., Sung, S., et al. (2007) · Cancer Letters · doi:10.1016/j.canlet.2007.10.005 · Cited by 204 · see citing works
Muthu, M. S., Kulkarni, S. A., Xiong, J., et al. (2011) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2011.09.045 · Cited by 197 · see citing works
Muthu, M. S., Kutty, R. V., Luo, Z., Xie, J., & Feng, S. (2014) · Biomaterials · doi:10.1016/j.biomaterials.2014.11.008 · Cited by 193 · see citing works
Plumbagin induces reactive oxygen species, which mediate apoptosis in human cervical cancer cells
Srinivas, P., Gopinath, G., Banerji, A., Dinakar, A., & Gopala, S. (2004) · Molecular Carcinogenesis · doi:10.1002/mc.20031 · Cited by 186 · see citing works
Kulthe, S. S., Inamdar, N., Choudhari, Y. M., Shirolikar, S. M., Borde, L. C., & Mourya, V. K. (2011) · Colloids and Surfaces B Biointerfaces · doi:10.1016/j.colsurfb.2011.08.002 · Cited by 169 · see citing works
Hussain, M. D., & Saxena, . (2012) · International Journal of Nanomedicine · doi:10.2147/ijn.s28745 · Cited by 166 · see citing works
Ahmad, A., Banerjee, S., Wang, Z. P., Kong, D., & Sarkar, F. H. (2008) · Journal of Cellular Biochemistry · doi:10.1002/jcb.21966 · Cited by 151 · see citing works
Preparation and characterization of Pluronic/TPGS mixed micelles for solubilization of camptothecin
Gao, Y., Li, L. B., & Zhai, G. (2008) · Colloids and Surfaces B Biointerfaces · doi:10.1016/j.colsurfb.2008.01.021 · Cited by 133 · see citing works
Powolny, A. A., & Singh, S. V. (2008) · Pharmaceutical Research · doi:10.1007/s11095-008-9533-3 · Cited by 130 · see citing works
Neužil, J., Dyason, J. C., Freeman, R., Dong, L., Procházka, L., Wang, X., Scheffler, I. E., & Ralph, S. J. (2007) · Journal of Bioenergetics and Biomembranes · doi:10.1007/s10863-006-9060-z · Cited by 124 · see citing works
A novel size-tunable nanocarrier system for targeted anticancer drug delivery
Li, Y., Xiao, K., Luo, J., Lee, J., Pan, S., & Lam, K. S. (2010) · Journal of Controlled Release · doi:10.1016/j.jconrel.2010.02.027 · Cited by 123 · see citing works
Muthu, M. S., Kulkarni, S. A., Liu, Y., & Feng, S. (2012) · Nanomedicine · doi:10.2217/nnm.11.111 · Cited by 120 · see citing works
Dou, J., Zhang, H., Liu, X., Zhang, M., & Zhai, G. (2013) · Colloids and Surfaces B Biointerfaces · doi:10.1016/j.colsurfb.2013.09.010 · Cited by 116 · see citing works
Performance evaluation of PAMAM dendrimer based simvastatin formulations
Kulhari, H., Pooja, D., Prajapati, S. K., & Chauhan, A. S. (2010) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2010.12.002 · Cited by 113 · see citing works
Plumbagin induces ROS-mediated apoptosis in human promyelocytic leukemia cells in vivo
Xu, K., & Lu, D.-P. (2009) · Leukemia Research · doi:10.1016/j.leukres.2009.08.017 · Cited by 113 · see citing works
Bothiraja, C., Yojana, B. D., Pawar, A., Shaikh, K. S., & Thorat, U. H. (2013) · Expert Opinion on Drug Delivery · doi:10.1517/17425247.2013.860131 · Cited by 108 · see citing works
Self-citationZhao, J., Mi, Y., & Feng, S. (2013) · Biomaterials · doi:10.1016/j.biomaterials.2013.01.009 · Cited by 92 · see citing works
Kawiak, A., Piosik, J., Stasiłojć, G., Gwizdek‐Wiśniewska, A., Marczak, Ł., Stobiecki, M., Bigda, J., & Łojkowska, E. (2007) · Toxicology and Applied Pharmacology · doi:10.1016/j.taap.2007.05.018 · Cited by 89 · see citing works
Wang, G., Yu, B., Wu, Y., Huang, B., Yuan, Y., & Liu, C. S. (2013) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2013.02.004 · Cited by 84 · see citing works
Dendrimer–TPGS mixed micelles for enhanced solubility and cellular toxicity of taxanes
Pooja, D., Kulhari, H., Singh, M. K., Mukherjee, S., Rachamalla, S. S., & Sistla, R. (2014) · Colloids and Surfaces B Biointerfaces · doi:10.1016/j.colsurfb.2014.06.059 · Cited by 84 · see citing works
Li, X., Zhang, Y., Fan, Y., Zhou, Y., Wang, X., Fan, C., Liu, Y., & Zhang, Q. (2011) · Nanoscale Research Letters · doi:10.1186/1556-276x-6-275 · Cited by 83 · see citing works
Nair, S., Nair, R. R. K., Srinivas, P., Gopala, S., & Pillai, M. R. (2007) · Molecular Carcinogenesis · doi:10.1002/mc.20359 · Cited by 79 · see citing works
Improved bioavailability of orally administered andrographolide from pH-sensitive nanoparticles
Bothiraja, C., & Pawar, A. (2010) · European Journal of Drug Metabolism and Pharmacokinetics · doi:10.1007/s13318-010-0016-7 · Cited by 77 · see citing works
Self-citationKaredath, T., Rakesh, S., Rojini, G., et al. (2008) · Annals of Oncology · doi:10.1093/annonc/mdm557 · Cited by 76 · see citing works
HSIEH, Y., LIN, L., & Tsai, T. (2006) · Journal of Chromatography B · doi:10.1016/j.jchromb.2006.06.024 · Cited by 74 · see citing works
Bothiraja, C., Shinde, M. B., Rajalakshmi, S., et al. (2009) · Journal of Pharmacy and Pharmacology · doi:10.1211/jpp.61.11.0005 · Cited by 74 · see citing works
Self-citationZhao, L., Shi, Y., Zou, S., et al. (2011) · Journal of Biomedical Nanotechnology · doi:10.1166/jbn.2011.1298 · Cited by 66 · see citing works
Bothiraja, C., Shinde, M. B., Rajalakshmi, S., et al. (2009) · Journal of Pharmacy and Pharmacology · doi:10.1211/jpp/61.11.0005 · Cited by 59 · see citing works
Self-citationNiosomal Plumbagin with Reduced Toxicity and Improved Anticancer Activity in BALB/C Mice
Naresh, R. A. R., Udupa, N., & Devi, P. U. (1996) · Journal of Pharmacy and Pharmacology · doi:10.1111/j.2042-7158.1996.tb03907.x · Cited by 59 · see citing works
Different Tissue Distribution of Paclitaxel With Intravenous and Intraperitoneal Administration
Soma, D., Kitayama, J., Ishigami, H., et al. (2008) · Journal of Surgical Research · doi:10.1016/j.jss.2008.06.049 · Cited by 56 · see citing works
Love, S. A., Thompson, J. W., & Haynes, C. L. (2012) · Nanomedicine · doi:10.2217/nnm.12.17 · Cited by 56 · see citing works
Mu, L., Teo, M. Y. B., Ning, H.-Z., et al. (2005) · Journal of Controlled Release · doi:10.1016/j.jconrel.2004.12.023 · Cited by 55 · see citing works
Kumar, M. R. S., Aithal, B. K., Udupa, N., et al. (2011) · Drug Delivery · doi:10.3109/10717544.2011.595840 · Cited by 49 · see citing works
Vitamin E Succinate Decreases Lung Cancer Tumor Growth in Mice
Quin, J. A., Engle, D. L., Litwiller, A. R., Peralta, E. A., Grasch, A. L., Boley, T. M., & Hazelrigg, S. R. (2005) · Journal of Surgical Research · doi:10.1016/j.jss.2005.01.014 · Cited by 48 · see citing works
Bothiraja, C., Kapare, H. S., Pawar, A., et al. (2013) · Therapeutic Delivery · doi:10.4155/tde.13.92 · Cited by 46 · see citing works
Self-citationToxic effects of crude root extract of Plumbago rosea (Rakta chitraka) on mice and rats
Solomon, F. E., Sharada, A. C., & Devi, P. U. (1993) · Journal of Ethnopharmacology · doi:10.1016/0378-8741(93)90081-f · Cited by 46 · see citing works
Antitumor and antifertility activities of plumbagin controlled release formulations.
Kini, D. D., Pandey, S., Shenoy, B., et al. (1997) · PubMed · Cited by 43 · see citing works
Bothiraja, C., Thorat, U. H., Pawar, A., et al. (2014) · Materials Technology · doi:10.1179/1753555714y.0000000174 · Cited by 42 · see citing works
Self-citationVitamin E analogues as mitochondria‐targeting compounds: From the bench to the bedside?
Zhao, Y., Neužil, J., & Wu, K. (2008) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.200800045 · Cited by 42 · see citing works
Rapid method for isolation of plumbagin, an alternative medicine from roots of Plumbago zeylanica
Bothiraja, C., Joshi, P. P., Dama, G., et al. (2011) · European Journal of Integrative Medicine · doi:10.1016/j.eujim.2011.02.008 · Cited by 39 · see citing works
Self-citationBothiraja, C., Pawar, A., Dama, G., et al. (2012) · Journal of Pharmacological and Toxicological Methods · doi:10.1016/j.vascn.2012.05.007 · Cited by 35 · see citing works
Self-citationPlumbago zeylanica action on blood coagulation profile with and without blood volume reduction
Vijayakumar, R., Senthilvelan, M., Ravindran, R., et al. (2006) · Vascular Pharmacology · doi:10.1016/j.vph.2006.02.001 · Cited by 35 · see citing works
Rayabandla, S. K. M., Aithal, K. B., Anandam, A., et al. (2010) · Drug Delivery · doi:10.3109/10717540903548447 · Cited by 34 · see citing works
Tiwari, S. B., Pai, R. M., & Udupa, N. (2002) · Journal of drug targeting · doi:10.1080/1061186021000054924 · Cited by 29 · see citing works
Srinivas, P., Patra, Bhattacharya, et al. (2011) · International Journal of Nanomedicine · doi:10.2147/ijn.s24074 · Cited by 25 · see citing works
Eudragit® EPO Based Nanoparticle Suspension of Andrographolide: In Vitro and In Vivo
Bothiraja, C., Pawar, A., Shaikh, K. S., et al. (2009) · Nanoscience and Nanotechnology Letters · doi:10.1166/nnl.2009.1029 · Cited by 21 · see citing works
Self-citationBothiraja, C., & Pawar, A. (2011) · International Journal of Nanotechnology · doi:10.1504/ijnt.2011.041444 · Cited by 19 · see citing works
Self-citationImproved pharmaceutical properties of surface modified bioactive plumbagin crystals
Bothiraja, C., Pawar, A., Mali, A., et al. (2013) · International Journal of Surface Science and Engineering · doi:10.1504/ijsurfse.2013.053708 · Cited by 19 · see citing works
Self-citationKılçar, A. Y., Tekin, V., Müftüler, F. Z. B., et al. (2015) · Journal of Radioanalytical and Nuclear Chemistry · doi:10.1007/s10967-015-4284-1 · Cited by 13 · see citing works
Rajalakshmi, S., Pawar, A., Mali, A., et al. (2014) · Materials Research Express · doi:10.1088/2053-1591/1/2/025405 · Cited by 13 · see citing works
Self-citationThermosensitive Liposomes for the Delivery of Cancer Therapeutics
Koning, G. A., Li, L., & ten Hagen, T. L. M. (2010) · Therapeutic Delivery · doi:10.4155/tde.10.65 · Cited by 7 · see citing works
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Recent Advances in Nanomicelles Delivery Systems.
Tawfik, S. M., Azizov, S., Elmasry, M. R., Sharipov, M., & Lee, Y.-I. (2020) · Nanomaterials · doi:10.3390/nano11010070 · Cited by 156 · see citing works
- Authors
- Pawar, A., Patel, R., Arulmozhi, S., & Bothiraja, C.
- Affiliations
- Savitribai Phule Pune University (IN)
- Corresponding author
- Bothiraja, C.
- Venue
- RSC Advances
- Publisher
- Royal Society of Chemistry (RSC)
- Published
- 2016
- Volume
- 6
- Issue
- 81
- Pages
- 78106-78121
- ISSN
- 2046-2069 (ISSN-L)
- OpenAlex
- W2513212960
- Cited by
- 30
- References
- 65
- Citations by year
- 2025: 3 · 2024: 4 · 2023: 4 · 2022: 1 · 2021: 2 · 2020: 3 · 2019: 4 · 2018: 5 · 2017: 2 · 2016: 1
- FWCI
- 1.64
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- RSC Advances (publishedVersion)
- Topics
- Physical Sciences › Materials Science › Biomaterials › Nanoparticle-Based Drug Delivery
- Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmaceutical Science › Advanced Drug Delivery Systems
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › RNA Interference and Gene Delivery
- Keywords
- plumbagin, TPGS, folic acid, nanomicelles, drug delivery, bioavailability, controlled drug release, targeted delivery, anticancer activity, drug toxicity reduction, synergistic antitumor effect
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