The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.
R406, an Orally Available Spleen Tyrosine Kinase Inhibitor Blocks Fc Receptor Signaling and Reduces Immune Complex-Mediated Inflammation
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Citations
Cites
Janeway, C. A., & Medzhitov, R. (2002) · Annual Review of Immunology · doi:10.1146/annurev.immunol.20.083001.084359 · Cited by 8,394
Monitoring human basophil activation via CD63 monoclonal antibody 435
Knol, E. F., Mul, F. P. J., Jansen, H., Calafat, J., & Roos, D. (1991) · Journal of Allergy and Clinical Immunology · doi:10.1016/0091-6749(91)90094-5 · Cited by 421 · cited 1×
“To test the effects of R406 on basophil activation, heparinized blood from volunteers was stimulated ex vivo with antiIgE, and degranulation was measured as CD63 cell-surface up-regulation on basophils by flow cytometry (Knol et al., 1991; Ebo et al., 2002).”
Method
Cited by
The SYK tyrosine kinase: A crucial player in diverse biological functions
Mócsai, A., Ruland, J., & Tybulewicz, V. L. J. (2010) · Nature Reviews Immunology · doi:10.1038/nri2765 · Cited by 1,368
Singh, A., Greninger, P., Rhodes, D., Koopman, L., Violette, S., Bardeesy, N., & Settleman, J. (2009) · Cancer Cell · doi:10.1016/j.ccr.2009.03.022 · Cited by 841
Syk kinase signalling couples to the Nlrp3 inflammasome for anti-fungal host defence
Gross, O., Poeck, H., Bscheider, M., Dostert, C., Hannesschläger, N., Endres, S., Hartmann, G., Tardivel, A., Schweighoffer, E., Tybulewicz, V., et al. (2009) · Nature · doi:10.1038/nature07965 · Cited by 819
Neutrophil cell surface receptors and their intracellular signal transduction pathways
Futosi, K., Fodor, S., & Mócsai, A. (2013) · International Immunopharmacology · doi:10.1016/j.intimp.2013.06.034 · Cited by 642
Properties of FDA-approved small molecule protein kinase inhibitors
Roskoski, R. (2019) · Pharmacological Research · doi:10.1016/j.phrs.2019.03.006 · Cited by 554
Metadata
- Authors
- Braselmann, S., Taylor, V., Zhao, H., Wang, S., Sylvain, C., Baluom, M., Qu, K., Herlaar, E., Lau, A., Young, C., Wong, B. R., Lovell, S., Sun, T., Park, G., Argade, A., Jurcevic, S., Pine, P., Singh, R., Grossbard, E. B., Payan, D. G., & Masuda, E. S.
- Venue
- The Journal of Pharmacology and Experimental Therapeutics
- Publisher
- Elsevier BV
- Published
- 2006-12
- Volume
- 319
- Issue
- 3
- Pages
- 998-1008
- ISSN
- 0022-3565 (ISSN-L)
- OpenAlex
- W2095726706
- Cited by
- 508
- References
- 2
- FWCI
- 14.86
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: R406, an Orally Available Spleen Tyrosine Kinase Inhibitor Blocks Fc Receptor Signaling and Reduces Immune Complex-Mediated Inflammation. https://app.cochat.ai/papers/10.1124/jpet.106.109058
- The paper
- Braselmann, S., Taylor, V., Zhao, H., Wang, S., Sylvain, C., Baluom, M., Qu, K., Herlaar, E., Lau, A., Young, C., Wong, B. R., Lovell, S., Sun, T., Park, G., Argade, A., Jurcevic, S., Pine, P., Singh, R., Grossbard, E. B., . . . Masuda, E. S. (2006). R406, an Orally Available Spleen Tyrosine Kinase Inhibitor Blocks Fc Receptor Signaling and Reduces Immune Complex-Mediated Inflammation. The Journal of Pharmacology and Experimental Therapeutics. https://doi.org/10.1124/jpet.106.109058
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
