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Rat Hepatocyte Suspensions as a Suitable In Vitro Model for Studying the Biotransformation of Histone Deacetylase Inhibitors

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In vitro multipotency of human bone marrow (mesenchymal) stem cells

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In Vitro Differentiation of Embryonic and Adult Stem Cells into Hepatocytes: State of the Art

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HDAC inhibitors in experimental liver and kidney fibrosis

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Histone Deacetylase Inhibitors through Click Chemistry

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Identification of a Key Lysine Residue in Heat Shock Protein 90 Required for Azole and Echinocandin Resistance in Aspergillus fumigatus

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Engineering EMT using 3D micro-scaffold to promote hepatic functions for drug hepatotoxicity evaluation

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PTG-0861: A novel HDAC6-selective inhibitor as a therapeutic strategy in acute myeloid leukaemia

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Overview of class I HDAC modulators: Inhibitors and degraders

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Hydroxamic Acids Constitute a Novel Class of Autotaxin Inhibitors that Exhibit in Vivo Efficacy in a Pulmonary Fibrosis Model

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The histone deacetylase inhibitor, trichostatin A, inhibits the development of 2,4-dinitrofluorobenzene-induced dermatitis in NC/Nga mice

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Histone deacetylases and repression of the gonadotropin genes

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Synthesis and Biological Evaluation of Novel Thiazolyl-Coumarin Derivatives as Potent Histone Deacetylase Inhibitors with Antifibrotic Activity

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A phase I pharmacokinetic study of belinostat in patients with advanced cancers and varying degrees of liver dysfunction

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Comparison of genotoxicant-modified transcriptomic responses in conventional and epigenetically stabilized primary rat hepatocytes with in vivo rat liver data

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Differential effects of hydroxamate histone deacetylase inhibitors on cellular functionality and gap junctions in primary cultures of mitogen-stimulated hepatocytes

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Preservation of hepatocellular functionality in cultures of primary rat hepatocytes upon exposure to 4-Me2N-BAVAH, a hydroxamate-based HDAC-inhibitor

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Histone deacetylase inhibitors: opening a new field of research in the development of alternative methods ?

Rogiers, V., Vinken, M., Snykers, S., Henkens, T., Fraczek, J., Rop, E. D., Kock, J. D., Doktorova, T. Y., Lukaszuk, A., Tourwé, D. A., et al. (2008) · VUBIR (Vrije Universiteit Brussel)

BindingDB Entry 6266: Kinetic and thermodynamic rationale for suberoylanilide hydroxamic acid being a preferential human histone deacetylase 8 inhibitor as compared to the structurally similar ligand, trichostatin a.

BindingDB (2014) · UC San Diego · doi:10.7270/q2tm78t0

BindingDB Entry 50027635: Histone deacetylase inhibitors through click chemistry.

BindingDB (2010) · UC San Diego · doi:10.7270/q20p0zv9

BindingDB Entry 50012231: PTG-0861: A novel HDAC6-selective inhibitor as a therapeutic strategy in acute myeloid leukaemia.

BindingDB (2022) · UC San Diego · doi:10.7270/q2jh3qvs

BindingDB Entry 50000915: Hydroxamic Acids Constitute a Novel Class of Autotaxin Inhibitors that Exhibit in Vivo Efficacy in a Pulmonary Fibrosis Model.

BindingDB (2020) · UC San Diego · doi:10.7270/q2q52s3g

2007a) A metabolic screening study of Trichostatin A (TSA) and TSA-like histone deacetylase inhibitors in rat and human primary hepatocyte cultures

Elaut, G., Laus, G., Alex, E., Richert, L., Bachellier, P., Rogiers, V., & Vanhaecke, T. (2016)

Major Phase I Biotransformation Pathways of Trichostatin A in Rat Hepatocytes and in Rat and Human Liver Microsomes

Elaut, G., Török, G., Vinken, M., Laus, G., Papeleu, P., Tourwé, D. A., & Rogiers, V. (2002) · Drug Metabolism and Disposition · doi:10.1124/dmd.30.12.1320 · Cited by 47 · see citing works

Structurally Simple Trichostatin A-Like Straight Chain Hydroxamates as Potent Histone Deacetylase Inhibitors

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Rat Hepatocyte Suspensions as a Suitable In Vitro Model for Studying the Biotransformation of Histone Deacetylase Inhibitors

Elaut, G., Török, G., Papeleu, P., Vanhaecke, T., Laus, G., Tourwé, D. A., & Rogiers, V. (2004) · Alternatives to Laboratory Animals · doi:10.1177/026119290403201s16 · Cited by 8 · see citing works

Trichostatin A - like Hydroxamate Histone Deacetylase Inhibitors as Therapeutic Agents: Toxicological Point of View

Vanhaecke, T., Papeleu, P., Elaut, G., & Rogiers, V. (2004) · Current Medicinal Chemistry · doi:10.2174/0929867043365099 · Cited by 256 · see citing works