Fenofibrate Treatment of Diabetic Rats Reduces Nitrosative Stress, Renal Cyclooxygenase-2 Expression, and Enhanced Renal Prostaglandin Release
Abstract
Renal cyclooxygenase (COX)-2 expression is increased in the diabetic rat and has been linked to increased glomerular filtration rate (GFR) and renal injury. Our studies indicate that oxidative stress in the form of peroxynitrite (ONOO) may be the stimulus for induction of COX-2. In this study, we addressed the effects of a peroxisome proliferator-activated receptor alpha agonist on renal COX-2 expression as fibrates exert renal protective effects. Forty-eight hours after the induction of diabetes with streptozotocin in male Wistar rats, fenofibrate treatment (100 mg/kg/day) was started, and the effects were compared with untreated diabetic rats and treated and untreated age-matched control rats (n = 5 per group). After 12 to 14 weeks of treatment, the right kidney was perfused to determine prostaglandin release in response to arachidonic acid (AA), and the left kidney was used to examine the expression of COX-2 and nitrotyrosine, an index of ONOO formation. Release of prostaglandin (PG) E(2) in response to AA was enhanced in the diabetic rat kidney compared with control (4.8 +/- 0.7 versus 1.9 +/- 0.7 ng/min) and reduced by fenofibrate to 0.6 +/- 0.2 ng/min. A similar pattern was obtained for AA-stimulated release of 6-ketoPGF(1alpha). The effects of fenofibrate were associated with reduced renal expression of COX-2 and nitrotyrosine in diabetic rats. We used creatinine clearance as an index of GFR, which was increased in the diabetic rat, 3.09 +/- 0.4 versus 1.15 +/- 0.1 ml/…
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
The investigators of the experimental study concluded that fenofibrate may attenuate diabetes-induced hyperfiltration by preventing the upregulation of renal cyclooxygenase-2 expression that accompanies diabetes.
“The investigators concluded that fenofibrate may attenuate diabetes-induced hyperfiltration by preventing the upregulation of renal cyclooxygenase-2 expression that accompanies diabetes.26”
From Associations of Fenofibrate Therapy With Incidence and Progression of CKD in Patients With Type 2 Diabetes (2019) · cites this paper as [26]
Cites
Nitric Oxide and Peroxynitrite in Health and Disease
Pacher, P., Beckman, J. S., & Liaudet, L. (2007) · Physiological Reviews · doi:10.1152/physrev.00029.2006 · Cited by 6,390 · see citing works
Normalizing mitochondrial superoxide production blocks three pathways of hyperglycaemic damage
Nishikawa, T., Edelstein, D., Du, X. L., Yamagishi, S.-I., Matsumura, T., Kaneda, Y., Yorek, M. A., Beebe, D., Oates, P. J., Hammes, H.-P., et al. (2000) · Nature · doi:10.1038/35008121 · Cited by 4,277 · see citing works
The mechanisms of action of PPARs
Berger, J., & Moller, D. E. (2002) · Annual Review of Medicine · doi:10.1146/annurev.med.53.082901.104018 · Cited by 2,659 · see citing works
Cosentino, F., Eto, M., Paolis, P. D., van der Loo, B., Bachschmid, M. M., Ullrich, V., Kouroedov, A., Gatti, C., Joch, H., Volpe, M., et al. (2003) · Circulation · doi:10.1161/01.cir.0000051367.92927.07 · Cited by 419 · see citing works
Oxidative stress and nitric oxide synthase in rat diabetic nephropathy: Effects of ACEI and ARB
Onozato, M. L., Tojo, A., Goto, A., Fujita, T., & Wilcox, C. S. (2002) · Kidney International · doi:10.1046/j.1523-1755.2002.00123.x · Cited by 374 · see citing works
Kiritoshi, S., Nishikawa, T., Sonoda, K., Kukidome, D., Senokuchi, T., Matsuo, T., Matsumura, T., Tokunaga, H., Brownlee, M., & Araki, E. (2003) · Diabetes · doi:10.2337/diabetes.52.10.2570 · Cited by 345 · see citing works
Inoue, I., Goto, S.-I., Matsunaga, T., Nakajima, T., Awata, T., Hokari, S., Komoda, T., & Katayama, S. (2001) · Metabolism · doi:10.1053/meta.2001.19415 · Cited by 283 · see citing works
van Raalte, D. H., Li, M., Pritchard, P. H., & Wasan, K. M. (2004) · Pharmaceutical Research · doi:10.1023/b:pham.0000041444.06122.8d · Cited by 269 · see citing works
Etoh, T., Inoguchi, T., Kakimoto, M., Sonoda, N., Kobayashi, K., Kuroda, J., Sumimoto, H., & Nawata, H. (2003) · Diabetologia · doi:10.1007/s00125-003-1205-6 · Cited by 253 · see citing works
PPARα agonist fenofibrate improves diabetic nephropathy in db/db mice
Park, C. W., Zhang, Y., Zhang, X., Wu, J., Chen, L., Cha, D. R., Su, D., Hwang, M.-T., Fan, X., Davis, L., et al. (2006) · Kidney International · doi:10.1038/sj.ki.5000209 · Cited by 202 · see citing works
Cheng, H., Wang, C. J., Moeckel, G. W., Zhang, M., McKanna, J. A., & Harris, R. C. (2002) · Kidney International · doi:10.1046/j.1523-1755.2002.00520.x · Cited by 192 · see citing works
Immunohistochemical and functional correlations of renal cyclooxygenase-2 in experimental diabetes
Komers, R., Lindsley, J. N., Oyama, T., Schutzer, W. E., Reed, J. F., Mader, S. L., & Anderson, S. (2001) · Journal of Clinical Investigation · doi:10.1172/jci10228 · Cited by 187 · see citing works
Nitric Oxide Synthase Isoforms and Glomerular Hyperfiltration in Early Diabetic Nephropathy
Veelken, R. A., Hilgers, K. F., Hartner, A., HAAS, A., DiaeresisHMER, K. P. B., & Sterzel, R. B. (2000) · Journal of the American Society of Nephrology · doi:10.1681/asn.v11171 · Cited by 181 · see citing works
Szabó, C., Zanchi, A., Komjáti, K., Pacher, P., Królewski, A. S., Quist, W. C., LoGerfo, F. W., Horton, E. S., & Veves, A. (2002) · Circulation · doi:10.1161/01.cir.0000038365.78031.9c · Cited by 171 · see citing works
Schambelan, M., Blake, S., Sraer, J., Bens, M., Nivez, M.-P., & Wahbe, F. (1985) · Journal of Clinical Investigation · doi:10.1172/jci111714 · Cited by 170 · see citing works
Glucose-induced oxidative stress in mesangial cells
Catherwood, M. A., Powell, L. A., Anderson, P., McMaster, D., Sharpe, P. C., & Trimble, E. R. (2002) · Kidney International · doi:10.1046/j.1523-1755.2002.00168.x · Cited by 170 · see citing works
Craven, P. A., Caines, M. A., & DeRubertis, F. R. (1987) · Metabolism · doi:10.1016/0026-0495(87)90070-9 · Cited by 166 · see citing works
Rosenson, R. S., Wolff, D. A., Huskin, A. L., Helenowski, I. B., & Rademaker, A. W. (2007) · Diabetes Care · doi:10.2337/dc07-0015 · Cited by 117 · see citing works
Increased nitrotyrosine staining in kidneys from patients with diabetic nephropathy
Thuraisingham, R. C., Nott, C. A., Dodd, S., & Yaqoob, M. (2000) · Kidney International · doi:10.1046/j.1523-1755.2000.00046.x · Cited by 112 · see citing works
Inoue, I., Noji, S., Awata, T., Takahashi, K., Nakajima, T., Sonoda, M., Komoda, T., & Katayama, S. (1998) · Life Sciences · doi:10.1016/s0024-3205(98)00249-5 · Cited by 101 · see citing works
Kreisberg, J. I., & Patel, P. Y. (1983) · Prostaglandins Leukotrienes and Medicine · doi:10.1016/0262-1746(83)90097-5 · Cited by 79 · see citing works
Ding, H., Hashem, M., & Triggle, C. R. (2007) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2006.12.034 · Cited by 72 · see citing works
PPAR Agonists Amplify iNOS Expression While Inhibiting NF-κB
Cernuda‐Morollón, E., Rodríguez‐Pascual, F., Klatt, P., Lamas, S., & Pérez‐Sala, D. (2002) · Journal of the American Society of Nephrology · doi:10.1097/01.asn.0000025786.87646.b1 · Cited by 67 · see citing works
Kanie, N., Matsumoto, T., Kobayashi, T., & Kamata, K. (2003) · British Journal of Pharmacology · doi:10.1038/sj.bjp.0705414 · Cited by 65 · see citing works
Creatinine concentration in plasma from dog, rat, and mouse: a comparison of 3 different methods
Palm, M., & Lundblad, A. (2005) · Veterinary Clinical Pathology · doi:10.1111/j.1939-165x.2005.tb00046.x · Cited by 57 · see citing works
Role of COX-2 in the Enhanced Vasoconstrictor Effect of Arachidonic Acid in the Diabetic Rat Kidney
Quilley, J., & Chen, Y.-J. (2003) · Hypertension · doi:10.1161/01.hyp.0000085650.29823.f2 · Cited by 53 · see citing works
Self-citationQuilley, J., McGiff, J. C., & Nasjletti, A. (1989) · British Journal of Pharmacology · doi:10.1111/j.1476-5381.1989.tb11790.x · Cited by 49 · see citing works
Self-citationEffect of aspirin on experimental diabetic nephropathy.
Moel, D. I., Safirstein, R. L., McEvoy, R. C., & Hsueh, W. (1987) · PubMed · Cited by 45 · see citing works
Quilley, J., & McGiff, J. C. (1985) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(25)23316-x · Cited by 43 · see citing works
Self-citationEligini, S., Habib, A., Lebret, M., Créminon, C., Levy-Toledano, S., & Maclouf, J. (2001) · British Journal of Pharmacology · doi:10.1038/sj.bjp.0704163 · Cited by 38 · see citing works
Ito, A., Uriu, K., Inada, Y., Qie, Y.-L., Takagi, I., Ikeda, M., Hashimoto, O., Suzuka, K., Eto, S., Tanaka, Y., et al. (2001) · Journal of Laboratory and Clinical Medicine · doi:10.1067/mlc.2001.116843 · Cited by 34 · see citing works
Effect of Tempol on Renal Cyclooxygenase Expression and Activity in Experimental Diabetes in the Rat
Li, J., Chen, Y.-J., & Quilley, J. (2005) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.104.076927 · Cited by 33 · see citing works
Self-citationEarly effects of diabetes on inducible nitric oxide synthase in the kidney
Cosenzi, A., Bernobich, E., Bonavita, M., Trevisan, R., Bellini, G., & Campanacci, L. (2002) · Acta Diabetologica · doi:10.1007/s005920200019 · Cited by 29 · see citing works
High glucose increases B1-kinin receptor expression and signaling in endothelial cells
Rodriguez, A. I., Pereira‐Flores, K., Hernández, R., Borić, M. P., & Velarde, V. (2006) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2006.04.127 · Cited by 19 · see citing works
Zager, R. A. (1987) · American Journal of Kidney Diseases · doi:10.1016/s0272-6386(87)80188-9 · Cited by 16 · see citing works
Effect of inhibition of nitric oxide synthase on renal cyclooxygenase in the diabetic rat
Chen, Y.-J., Li, J., & Quilley, J. (2006) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2006.05.004 · Cited by 12 · see citing works
Self-citationKlinger, W., Lupp, A., Karge, E., Oelschläger, H., Rothley, D., Danz, M., Linss, W., Löbel, S., Deufel, T., Müller, M., et al. (1998) · Experimental and Toxicologic Pathology · doi:10.1016/s0940-2993(98)80010-9 · Cited by 3 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
Oxidative stress and human health
Rahman, T., Hosen, M. I., Islam, M. M., & Shekhar, H. U. (2012) · Advances in Bioscience and Biotechnology · doi:10.4236/abb.2012.327123 · Cited by 494 · see citing works
Induction of Oxidative Stress in Kidney
Özbek, E. (2012) · International Journal of Nephrology · doi:10.1155/2012/465897 · Cited by 377 · see citing works
Mechanistic insight of diabetic nephropathy and its pharmacotherapeutic targets: An update
Bhattacharjee, N., Barma, S., Konwar, N., Dewanjee, S., & Manna, P. (2016) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2016.08.022 · Cited by 271 · see citing works
Molecular mechanisms in the pathogenesis of diabetic nephropathy: An update
Arora, M. K., & Singh, U. K. (2013) · Vascular Pharmacology · doi:10.1016/j.vph.2013.01.001 · Cited by 241 · see citing works
Ishibashi, S., Arai, H., Yokote, K., Araki, E., Suganami, H., & Yamashita, S. (2018) · Journal of Clinical Lipidology · doi:10.1016/j.jacl.2017.10.006 · Cited by 184 · see citing works
Obstructive Sleep Apnea and Diabetic Nephropathy
Tahrani, A. A., Ali, A., Raymond, N. T., Begum, S., Dubb, K., Altaf, Q., Piya, M. K., Barnett, A. H., & Stevens, M. J. (2013) · Diabetes Care · doi:10.2337/dc13-0450 · Cited by 127 · see citing works
Vincent, A. M., Kato, K., McLean, L. L., Soules, M. E., & Feldman, E. L. (2008) · Antioxidants and Redox Signaling · doi:10.1089/ars.2008.2235 · Cited by 120 · see citing works
Munusamy, S., & MacMillan-Crow, L. A. (2009) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2009.01.022 · Cited by 106 · see citing works
Shaikh, R. U., Pund, M., & Gacche, R. N. (2015) · Journal of Traditional and Complementary Medicine · doi:10.1016/j.jtcme.2015.07.001 · Cited by 104 · see citing works
PPARα: an emerging therapeutic target in diabetic microvascular damage
Hiukka, A., Maranghi, M., Matikainen, N., & Taskinen, M.-R. (2010) · Nature Reviews Endocrinology · doi:10.1038/nrendo.2010.89 · Cited by 103 · see citing works
Chung, H. W., Lim, J. H., Kim, M. Y., Shin, S. J., Chung, S., Choi, B. S., Kim, H. W., Kim, Y., Park, C. W., & Chang, Y. S. (2011) · Nephrology Dialysis Transplantation · doi:10.1093/ndt/gfr613 · Cited by 82 · see citing works
Li, L., Emmett, N. L., Mann, D. R., & Zhao, X. (2010) · Experimental Biology and Medicine · doi:10.1258/ebm.2009.009218 · Cited by 72 · see citing works
Fenofibrate and the kidney: an overview
Kostapanos, M. S., Florentin, M., & Elisaf, M. (2013) · European Journal of Clinical Investigation · doi:10.1111/eci.12068 · Cited by 66 · see citing works
El-Haleim, E. A. A., Bahgat, A. K., & Saleh, S. (2016) · World Journal of Gastroenterology · doi:10.3748/wjg.v22.i10.2931 · Cited by 65 · see citing works
Frazier, R., Mehta, R., Cai, X., Lee, J., Napoli, S., Craven, T., Tuazon, J., Safdi, A., Scialla, J., Susztak, K., et al. (2019) · Kidney International Reports · doi:10.1016/j.ekir.2018.09.006 · Cited by 63 · see citing works
“The investigators concluded that fenofibrate may attenuate diabetesinduced hyperfiltration by preventing the upregulation of renal cyclooxygenase-2 expression that accompanies diabetes.(26) Other studies suggest that fenofibrate has antiinflammatory effects with reduction of inflammatory cytokines, which may also have…”
BackgroundArora, M. K., Reddy, K., & Balakumar, P. (2010) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2010.03.002 · Cited by 57 · see citing works
Nuclear receptors in the kidney during health and disease
Libby, A. E., Jones, B. A., Santiago, I. L., Rowland, E., & Levi, M. (2020) · Molecular Aspects of Medicine · doi:10.1016/j.mam.2020.100935 · Cited by 50 · see citing works
Fibrates: Therapeutic potential for diabetic nephropathy?
Kouroumichakis, I., Παπάνας, Ν., Zarogoulidis, P., Liakopoulos, V., Maltezos, E. S., & Mikhailidis, D. P. (2012) · European Journal of Internal Medicine · doi:10.1016/j.ejim.2011.12.007 · Cited by 42 · see citing works
Renal protective effect of chronic inhibition of COX-2 with SC-58236 in streptozotocin-diabetic rats
Quilley, J., Santos, M., & Pedraza, P. L. (2011) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.01259.2010 · Cited by 39 · see citing works
Self-citationDai, X., Su, S., Cai, H.-D., Wei, D., Yan, H., Zheng, T., Zhu, Z., Shang, E., Guo, S., Qian, D., et al. (2018) · Frontiers in Pharmacology · doi:10.3389/fphar.2018.01012 · Cited by 38 · see citing works
Nuclear hormone receptors in diabetic nephropathy
Wang, X. X., Jiang, T., & Levi, M. (2010) · Nature Reviews Nephrology · doi:10.1038/nrneph.2010.56 · Cited by 38 · see citing works
El-Haleim, E. A. A., Bahgat, A. K., & Saleh, S. (2016) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2016.01.011 · Cited by 35 · see citing works
Nuclear receptors in renal disease
Levi, M. (2011) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2011.04.003 · Cited by 34 · see citing works
Fenofibrate‐induced decrease of expression of CYP2C11 and CYP2C6 in rat
Večeřa, R., Zachařová, A., Orolin, J., Strojil, J., Škottová, N., & Anzenbacher, P. (2011) · Biopharmaceutics & Drug Disposition · doi:10.1002/bdd.774 · Cited by 31 · see citing works
Chen, W., Fan, S., Xie, X., Xue, N., Jin, X., & Wang, L. (2014) · PLoS ONE · doi:10.1371/journal.pone.0096056 · Cited by 29 · see citing works
Fenofibrate-induced renal dysfunction, yes or no?
Nematbakhsh, M., Emami, F., Hariri, A., & Matinfar, M. (2020) · Journal of Research in Medical Sciences · doi:10.4103/jrms.jrms_772_19 · Cited by 25 · see citing works
Al‐Rasheed, N. M., Al-Rasheed, N. M., Attia, H., Alamin, M. A., Al‐Ajmi, H. N., Hasan, I. H., Mohamad, R. A., & Sinjilawi, N. A.-A. (2015) · Pharmacology · doi:10.1159/000381190 · Cited by 25 · see citing works
Li, Y., Qi, J., Liu, K., Li, B., Wang, H., & Jia, J. (2010) · Molecular Medicine · doi:10.2119/molmed.2010.00034 · Cited by 25 · see citing works
Al-Rasheed, N. M., Al‐Rasheed, N. M., Alamin, M. A., Hasan, I. H., Al‐Ajmi, H. N., Ahmed, M., & Attia, H. (2016) · Archives of Physiology and Biochemistry · doi:10.3109/13813455.2016.1164186 · Cited by 25 · see citing works
Fenofibrate in cancer: mechanisms involved in anticancer activity
Koltai, T. (2015) · F1000Research · doi:10.12688/f1000research.6153.1 · Cited by 24 · see citing works
Sugimoto, R., Iwasa, M., Eguchi, A., Tamai, Y., Shigefuku, R., Fujiwara, N., Tanaka, H., Kobayashi, Y., Ikoma, J., Kaito, M., et al. (2023) · Frontiers in Medicine · doi:10.3389/fmed.2023.1073025 · Cited by 23 · see citing works
Attridge, R. L., Linn, W. D., Ryan, L., Koeller, J. M., & Frei, C. R. (2011) · Journal of clinical lipidology · doi:10.1016/j.jacl.2011.08.008 · Cited by 23 · see citing works
Prasad, G. S., Govardhan, P., Deepika, G., Vakdevi, V., & Sashidhar, R. B. (2017) · Inflammopharmacology · doi:10.1007/s10787-017-0428-y · Cited by 20 · see citing works
Hamrén, B., Öhman, K. P., Svensson, M. K. E., & Karlsson, M. O. (2011) · The Journal of Clinical Pharmacology · doi:10.1177/0091270011416937 · Cited by 19 · see citing works
Malur, P., Menezes, A. R., DiNicolantonio, J. J., O’Keefe, J. H., & Lavie, C. J. (2017) · Europe PMC (PubMed Central) · Cited by 16 · see citing works
Effect of Fenofibrate on the Expression of Inflammatory Mediators in a Diabetic Rat Model
Yeh, P., Wang, L., Chang, S., Yang, W., Yang, C., & Yang, C.-H. (2019) · Current Eye Research · doi:10.1080/02713683.2019.1622020 · Cited by 15 · see citing works
Farag, M. M., Ashour, E. H., & El-Hadidy, W. F. (2020) · Dubai Medical Journal · doi:10.1159/000506899 · Cited by 15 · see citing works
Yamashita, S., Hirano, T., Shimano, H., Tsukamoto, K., Yoshida, M., & Yoshida, H. (2024) · European Journal of Clinical Investigation · doi:10.1111/eci.14227 · Cited by 14 · see citing works
Cervantes-Pérez, L. G., Ibarra-Lara, L., Escalante, B., del Valle‐Mondragón, L., Vargas‐Robles, H., Pérez‐Severiano, F., Pastelı́n, G., & Sánchez-Mendoza, A. (2012) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2012.04.006 · Cited by 12 · see citing works
Izumihara, R., Nomoto, H., Kito, K., Yamauchi, Y., Omori, K., Shibayama, Y., Yanagiya, S., Miya, A., Kameda, H., Cho, K. Y., et al. (2024) · Diabetes & Metabolism Journal · doi:10.4093/dmj.2023.0370 · Cited by 11 · see citing works
Hahm, J. R., Ahn, J.-S., Noh, H.-S., Baek, S.-M., Ha, J., Jung, T. S., An, Y., Kim, D.-K., & Kim, D. R. (2010) · BMB Reports · doi:10.3858/bmbrep.2010.43.5.337 · Cited by 8 · see citing works
Ahmad, N., Ansari, K. A., Alamoudi, M. K., Ullah, Z., Haque, A., & Ibrahim, H. O. (2024) · Journal of Drug Delivery Science and Technology · doi:10.1016/j.jddst.2024.106096 · Cited by 7 · see citing works
Devil’s Triangle in Kidney Diseases: Oxidative Stress, Mediators, and Inflammation
Balat, A., Resić, H., Bellinghieri, G., & Anarat, A. (2012) · International Journal of Nephrology · doi:10.1155/2012/156286 · Cited by 7 · see citing works
Chen, Y.-J., Santos, M., & Quilley, J. (2011) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00768.2010 · Cited by 7 · see citing works
Self-citationFenofibrate and renal disease: clinical effects in diabetes
Ting, R.-D., & KEECH, A. C. (2013) · Clinical Lipidology · doi:10.2217/clp.13.69 · Cited by 5 · see citing works
Ibrahim, M. A., Ela, A. E. S. F. A. E., Al-Rasheed, N. M., & Alamin, M. A. (2019) · Pharmaceutical Development and Technology · doi:10.1080/10837450.2019.1616300 · Cited by 5 · see citing works
Falfushynska, H., Sokolov, E. P., & Sokolova, I. M. (2025) · Aquatic Toxicology · doi:10.1016/j.aquatox.2024.107233 · Cited by 4 · see citing works
Mézešová, L., Javorková, V., Vlkovičová, J., Kyseľová, Z., Navarová, J., Bezek, Š., & Vrbjar, N. (2012) · Molecular and Cellular Biochemistry · doi:10.1007/s11010-012-1281-3 · Cited by 4 · see citing works
Arora, M. K. (2013) · Journal of Diabetes & Metabolism · doi:10.4172/2155-6156.1000320 · Cited by 4 · see citing works
Safety and efficacy modelling in anti-diabetic drug development.
Hamrén, B. (2008) · KTH Publication Database DiVA (KTH Royal Institute of Technology) · Cited by 3 · see citing works
Zhao, L. D., Liu, Z., Zhang, R., Li, Y., & Zhang, X. (2025) · Renal Failure · doi:10.1080/0886022x.2025.2569086 · Cited by 2 · see citing works
Nuclear receptors as therapeutic targets in metabolic and cardiovascular disorders
Li, F., Chen, Q., Dai, Y., & Lu, L. (2025) · iScience · doi:10.1016/j.isci.2025.114042 · Cited by 1 · see citing works
Allah, O. M. A., El‐Din, A. A. I. S., & Debakey, F. E. (2014) · American Journal of Pharmacology and Toxicology · doi:10.3844/ajptsp.2014.206.222 · Cited by 1 · see citing works
Andrographolide: A Renoprotective Diterpene from Andrographis Paniculata (Burm. f.) Nees
Singh, P., Srivastava, M. M., Hazra, D. K., & Khemani, L. D. (2011) · Springer eBooks · doi:10.1007/978-3-642-23394-4_7 · Cited by 1 · see citing works
Zghair, A. N., & Jabir, F. A. (2015) · International Journal of Pharma and Bio Sciences
Nano-formulation of Tabernaemontana divericata extract for the management of inflammation
Nawale, S., Tarana, K., Kedar, K. A., & Raju, M. G. (2023) · Medicinal Plants - International Journal of Phytomedicines and Related Industries · doi:10.5958/0975-6892.2023.00041.2
Kinguchi, S., Tamura, K., Yano, Y., Nangaku, M., Isaka, Y., Maruyama, S., Kanegae, H., Heerspink, H. J. L., Nakagawa, N., Nishio, S., et al. (2026) · Clinical Kidney Journal · doi:10.1093/ckj/sfag053
Naim, M. A. A. Z., Thomas, F., Streja, E., Davis, R. L., Kalantar‐Zadeh, K., Sumida, K., & Kovesdy, C. P. (2026) · Clinical Journal of the American Society of Nephrology · doi:10.2215/cjn.0000001188
Oxidative Stress in Immunotoxicity: A Biochemical Foe or a Friend?
Okopi, A., Isaac, O. T., & Agi, A. B. (2021) · International Journal of Innovative Science and Research Technology (IJISRT) · doi:10.38124/ijisrt/21mar405
- Authors
- Chen, Y.-J., & Quilley, J.
- Affiliations
- New York Medical College (US)
- ORCID
- Chen, Yu-Jung
- Venue
- The Journal of Pharmacology and Experimental Therapeutics
- Publisher
- Elsevier BV
- Published
- 2008-02
- Volume
- 324
- Issue
- 2
- Pages
- 658-663
- ISSN
- 0022-3565 (ISSN-L)
- OpenAlex
- W2075372190
- Cited by
- 59
- References
- 37
- Citations by year
- 2026: 2 · 2025: 3 · 2024: 3 · 2023: 2 · 2021: 1 · 2020: 3 · 2019: 2 · 2018: 2 · 2017: 3 · 2016: 4 · 2015: 4 · 2014: 2 · 2013: 5 · 2012: 6
- FWCI
- 1.99
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of Pharmacology and Experimental Therapeutics (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Heart, Lung, and Blood Institute (R01HL069061)
- Topics
- Health Sciences › Medicine › Pharmacology › Inflammatory mediators and NSAID effects
- Health Sciences › Medicine › Nephrology › Chronic Kidney Disease and Diabetes
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Peroxisome Proliferator-Activated Receptors
- Keywords
- fenofibrate, diabetic nephropathy, cyclooxygenase-2, nitrosative stress, peroxynitrite, nitrotyrosine, arachidonic acid, glomerular filtration rate, PPARα, fibrates, streptozotocin-induced diabetes, kidney injury
- MeSH terms
- Animals, Diabetes Mellitus, Experimental, Kidney, Male, Fenofibrate, Prostaglandins, Tyrosine, Gene Expression Regulation, Enzymologic, Rats, Wistar, Rats, Cyclooxygenase 2
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review