The DOI matches its Crossref record; 40 of the 40 references it cites were found in a registry or an index.
Activity-Dependent Neuroprotective Protein Snippet NAP Reduces Tau Hyperphosphorylation and Enhances Learning in a Novel Transgenic Mouse Model
Abstract
Activity-dependent neuroprotective protein (ADNP) differentially interacts with chromatin to regulate essential genes. Because complete ADNP deficiency is embryonic lethal, the outcome of partial ADNP deficiency was examined. ADNP(+/-) mice exhibited cognitive deficits, significant increases in phosphorylated tau, tangle-like structures, and neurodegeneration compared with ADNP(+/+) mice. Increased tau hyperphosphorylation is known to cause memory impairments in neurodegenerative diseases associated with tauopathies, including the most prevalent Alzheimer's disease. The current results suggest that ADNP is an essential protein for brain function and plays a role in normal cognitive performance. ADNP-deficient mice offer an ideal paradigm for evaluation of cognitive enhancers. NAP (NAPVSIPQ) is a peptide derived from ADNP that interacts with microtubules and provides potent neuroprotection. NAP treatment partially ameliorated cognitive deficits and reduced tau hyperphosphorylation in the ADNP(+/-) mice. NAP is currently in phase II clinical trials assessing effects on mild cognitive impairment.
Overview
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“while ADNP+/- mice show tauopathy, neuronal cell death and abnormalities in social behaviour and cognitive functioning18,34.”
From A SWI/SNF-related autism syndrome caused by de novo mutations in ADNP (2014) · cites this paper as [18]
In the citing paper
“Of the other genes reported as differentially expressed in Adnp-/-23 and Adnp+/-18 mice (down: CCNC, TMPO, PLAGL2; up: ABCF3), only PLAGL2 was found to be differentially regulated in our patients (Supplementary Fig. 3e).”
From A SWI/SNF-related autism syndrome caused by de novo mutations in ADNP (2014) · cites this paper as [18]
Citations
Cites
Grundman, M. (2004) · Archives of Neurology · doi:10.1001/archneur.61.1.59 · Cited by 972
Roles of Pax-genes in developing and adult brain as suggested by expression patterns
Stoykova, A., & Gruss, P. (1994) · Journal of Neuroscience · doi:10.1523/jneurosci.14-03-01395.1994 · Cited by 577
Kinases and phosphatases and tau sites involved in Alzheimer neurofibrillary degeneration
Wang, J., Grundke, I., & Iqbal, K. (2007) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2006.05226.x · Cited by 569
Abnormal bundling and accumulation of F-actin mediates tau-induced neuronal degeneration in vivo
Fulga, T. A., Elson-Schwab, I., Khurana, V., Steinhilb, M. L., Spires, T. L., Hyman, B. T., & Feany, M. B. (2007) · Nature Cell Biology · doi:10.1038/ncb1528 · Cited by 452
Clogging of axons by tau, inhibition of axonal traffic and starvation of synapses
Mandelkow�, E. (2003) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2003.04.007 · Cited by 412
Bassan, M., Zamostiano, R., Davidson, A., Pinhasov, A., Giladi, E., Perl, O., Bassan, H., Blat, C., Gibney, G., Glazner, G. W., et al. (1999) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.1999.0721283.x · Cited by 394
Self-citationThe Roles of Cyclin-dependent Kinase 5 and Glycogen Synthase Kinase 3 in Tau Hyperphosphorylation
Plattner, F., Angelo, M., & Giese, K. P. (2006) · Journal of Biological Chemistry · doi:10.1074/jbc.m603469200 · Cited by 340
New roles for astrocytes (stars at last)
Ransom, B. R., Behar, T. N., & Nedergaard, M. (2003) · Trends in Neurosciences · doi:10.1016/j.tins.2003.08.006 · Cited by 335
Cloning and Characterization of the Human Activity-dependent Neuroprotective Protein
Zamostiano, R., Pinhasov, A., Gelber, E., Steingart, R. A., Seroussi, E., Giladi, E., Bassan, M., Wollman, Y., Eyre, H. J., Mulley, J. C., et al. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m007416200 · Cited by 251
Self-citationActivity-dependent neuroprotective protein: a novel gene essential for brain formation
Pinhasov, A., Mandel, S., Torchinsky, A., Giladi, E., Pittel, Z., Goldsweig, A. M., Servoss, S. J., Brenneman, D. E., & Gozes, I. (2003) · Developmental Brain Research · doi:10.1016/s0165-3806(03)00162-7 · Cited by 239
Self-citationREVIEW: tau protein pathology in Alzheimer’s disease and related disorders
Tolnay, M., & Probst (1999) · Neuropathology and Applied Neurobiology · doi:10.1046/j.1365-2990.1999.00182.x · Cited by 214
Neuronal injury and loss after traumatic brain injury: time course and regional variability
Sato, M., Chang, E. F., Igarashi, T., & Noble‐Haeusslein, L. J. (2001) · Brain Research · doi:10.1016/s0006-8993(01)02905-5 · Cited by 202
Clodfelder‐Miller, B., Zmijewska, A. A., Johnson, G. V. W., & Jope, R. S. (2006) · Diabetes · doi:10.2337/db06-0485 · Cited by 187
Mandel, S., Rechavi, G., & Gozes, I. (2007) · Developmental Biology · doi:10.1016/j.ydbio.2006.11.039 · Cited by 167
Self-citationRegional distribution of Fluoro-Jade B staining in the hippocampus following traumatic brain injury
Anderson, K. J., Miller, K. M., Fugaccia, I., & Scheff, S. W. (2005) · Experimental Neurology · doi:10.1016/j.expneurol.2004.11.025 · Cited by 165
Matsuoka, Y., Gray, A. J., Hirata‐Fukae, C., Minami, S., Waterhouse, E. G., Mattson, M. P., LaFerla, F. M., Gozes, I., & Aisen, P. S. S. (2007) · Journal of Molecular Neuroscience · doi:10.1385/jmn/31:02:165 · Cited by 164
Self-citationGozes, I., Giladi, E., Pinhasov, A., Bardea, A., & Brenneman, D. E. (2000) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(24)39336-x · Cited by 157
Self-citationSignature Tau Neuropathology in Gray and White Matter of Corticobasal Degeneration
Forman, M. S., Zhukareva, V. A., Bergeron, C., Chin, S. S., Grossman, M., Clark, C. M., Lee, V. M. ‐., & Trojanowski, J. Q. (2002) · American Journal Of Pathology · doi:10.1016/s0002-9440(10)61154-6 · Cited by 149
Gozes, I., Morimoto, B. H., Tiong, J., Fox, A. W., Sutherland, K., Dangoor, D., Holser-Cochav, M., Vered, K., Newton, P. E., Aisen, P. S. S., et al. (2006) · CNS Drug Reviews · doi:10.1111/j.1527-3458.2005.tb00053.x · Cited by 144
Self-citationImpaired Glutamate Transport in a Mouse Model of Tau Pathology in Astrocytes
Dabir, D. V., Robinson, M. B., Swanson, E., Zhang, B., Trojanowski, J. Q., Lee, V. M. ‐., & Forman, M. S. (2006) · Journal of Neuroscience · doi:10.1523/jneurosci.3861-05.2006 · Cited by 138
Divinski, I., Mittelman, L. A., & Gozes, I. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m403197200 · Cited by 136
Self-citationMultiple tubulin forms are expressed by a single neurone
Gozes, I., & Sweadner, K. J. (1981) · Nature · doi:10.1038/294477a0 · Cited by 130
Self-citationTogo, T., & Dickson, D. W. (2002) · Acta Neuropathologica · doi:10.1007/s00401-002-0569-x · Cited by 116
Šimić, G., Lucassen, P. J., Krsnik, Ž., Krušlin, B., Kostović, I., Winblad, B. G., & Bogdanović, N. (2000) · Experimental Neurology · doi:10.1006/exnr.2000.7448 · Cited by 116
Peptide neuroprotection through specific interaction with brain tubulin
Divinski, I., Holtser‐Cochav, M., Vulih, I., Steingart, R. A., & Gozes, I. (2006) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2006.03936.x · Cited by 108
Self-citationModrego, P. J. (2006) · Current Alzheimer Research · doi:10.2174/156720506776383103 · Cited by 105
Further evidence for a susceptibility locus for type 2 diabetes on chromosome 20q13.1-q13.2.
Klupa, T., Malecki, M. T., Pezzolesi, M. G., Ji, L., Curtis, S., Langefeld, C. D., Rich, S. S., Warram, J. H., & Królewski, A. S. (2000) · Diabetes · doi:10.2337/diabetes.49.12.2212 · Cited by 101
Subcellular localization and secretion of activity-dependent neuroprotective protein in astrocytes
Furman, S., Steingart, R. A., Mandel, S., Hauser, J. M., Brenneman, D. E., & Gozes, I. (2004) · Neuron Glia Biology · doi:10.1017/s1740925x05000013 · Cited by 94
Self-citationPascual, M., & Guerri, C. (2007) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2007.04761.x · Cited by 93
Alcalay, R. N., Giladi, E., Pick, C. G., & Gozes, I. (2004) · Neuroscience Letters · doi:10.1016/j.neulet.2003.12.005 · Cited by 83
Self-citationCdk5 and MAPK are associated with complexes of cytoskeletal proteins in rat brain
Veeranna, G. J., Shetty, K. T., Takahashi, M., Grant, P. G., & Pant, H. C. (2000) · Molecular Brain Research · doi:10.1016/s0169-328x(00)00003-6 · Cited by 83
The femtomolar-acting NAP interacts with microtubules: Novel aspects of astrocyte protection
Gozes, I., & Divinski, I. (2005) · Journal of Alzheimer s Disease · doi:10.3233/jad-2004-6s605 · Cited by 77
Self-citationSmith‐Swintosky, V. L., Gozes, I., Brenneman, D. E., D’Andrea, M. R., & Plata‐Saláman, C. R. (2005) · Journal of Molecular Neuroscience · doi:10.1385/jmn:25:3:225 · Cited by 67
Self-citationBorozdin, W., Graham, J. M., Böhm, D., Bamshad, M. J., Spranger, S., Burke, L. W., Leipoldt, M., & Kohlhase, J. (2007) · Human Mutation · doi:10.1002/humu.9502 · Cited by 60
Sexual dimorphism of activity-dependent neuroprotective protein in the mouse arcuate nucleus
Furman, S., Hill, J. M., Vulih, I., Zaltzman, R., Hauser, J. M., Brenneman, D. E., & Gozes, I. (2004) · Neuroscience Letters · doi:10.1016/j.neulet.2004.09.077 · Cited by 59
Self-citationVink, J., Auth, J., Abebe, D. T., Brenneman, D. E., & Spong, C. Y. (2005) · American Journal of Obstetrics and Gynecology · doi:10.1016/j.ajog.2005.02.101 · Cited by 55
Gozes, I., Zaltzman, R., Hauser, J. M., Brenneman, D. E., Shohami, E., & Hill, J. (2005) · Current Alzheimer Research · doi:10.2174/1567205053585873 · Cited by 53
Self-citationRecombinant activity-dependent neuroprotective protein protects cells against oxidative stress
Steingart, R. A., & Gozes, I. (2006) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2006.03.029 · Cited by 48
Self-citationBrain Injury-Dependent Expression of Activity-Dependent Neuroprotective Protein
Zaltzman, R., Alexandrovich, A. G., Beni, S. M., Trembovler, V., Shohami, E., & Gozes, I. (2004) · Journal of Molecular Neuroscience · doi:10.1385/jmn:24:2:181 · Cited by 31
Self-citationHill, J. M., Hauser, J. M., Sheppard, L. M., Abebe, D. T., Spivak-Pohis, I., Kushnir, M., Deitch, I., & Gozes, I. (2007) · Journal of Molecular Neuroscience · doi:10.1385/jmn:31:03:185 · Cited by 31
Self-citation
Cited by
Sorted by citations
Alzheimer Mechanisms and Therapeutic Strategies
Huang, Y., & Mucke, L. (2012) · Cell · doi:10.1016/j.cell.2012.02.040 · Cited by 1,758
Morris, M., Maeda, S., Vossel, K., & Mucke, L. (2011) · Neuron · doi:10.1016/j.neuron.2011.04.009 · Cited by 899
“The peptide NAP stabilizes microtubules (Divinski et al., 2006) and reduces tau hyperphosphorylation (Vulih-Shultzman et al., 2007), suggesting that microtubule-stabilizing compounds can have more than one mechanism of action.”
BackgroundA SWI/SNF-related autism syndrome caused by de novo mutations in ADNP
Helsmoortel, C., Vulto-van Silfhout, A. T., Coe, B. P., Vandeweyer, G., Rooms, L., van den Ende, J., Schuurs-Hoeijmakers, J. H. M., Marcelis, C. L., Willemsen, M. H., Vissers, L. E. L. M., et al. (2014) · Nature Genetics · doi:10.1038/ng.2899 · Cited by 354
Autophagy has a key role in the pathophysiology of schizophrenia
Wagner, A. M., Malishkevich, A., Shemer, Z., Udawela, M., Gibbons, A. S., Scarr, E., Dean, B., Levine, J., Agam, G., & Gozes, I. (2013) · Molecular Psychiatry · doi:10.1038/mp.2013.174 · Cited by 239
Self-citationGenetics and genomics of autism spectrum disorder: embracing complexity
De Rubeis, S., & Buxbaum, J. D. (2015) · Human Molecular Genetics · doi:10.1093/hmg/ddv273 · Cited by 208
“show deficits in spatial learning and memory (65) and sex-specific deficits in novel object recognition, social recognition and social memory (66).”
Background
Metadata
- Authors
- Vulih-Shultzman, I., Pinhasov, A., Mandel, S., Grigoriadis, N., Touloumi, O., Pittel, Z., & Gozes, I.
- Venue
- The Journal of Pharmacology and Experimental Therapeutics
- Publisher
- Elsevier BV
- Published
- 2007-11
- Volume
- 323
- Issue
- 2
- Pages
- 438-449
- ISSN
- 0022-3565 (ISSN-L)
- OpenAlex
- W2136172091
- Cited by
- 219
- References
- 40
- Citations by year
- 2026: 10 · 2025: 12 · 2024: 12 · 2023: 9 · 2022: 14 · 2021: 9 · 2020: 19 · 2019: 18 · 2018: 7 · 2017: 11 · 2016: 15 · 2015: 13 · 2014: 14 · 2013: 11 · 2012: 13
- FWCI
- 5.79
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of Pharmacology and Experimental Therapeutics (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Alzheimer's disease research and treatments
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
- Keywords
- ADNP, NAP peptide, tau hyperphosphorylation, cognitive impairment, learning, neurodegeneration, tauopathy, Alzheimer's disease, mild cognitive impairment, neuroprotection, microtubule binding
- MeSH terms
- Animals, Astrocytes, Cognition Disorders, Female, Learning, Male, Mice, Inbred ICR, Mice, Transgenic, Nerve Tissue Proteins, Oligopeptides, Phosphorylation, tau Proteins, Homeodomain Proteins, Mice
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review