Cited by 125Cancer, Hypoxia, and MetabolismAngiogenesis and VEGF in CancerBioactive Compounds and Antitumor Agents

The DOI matches its Crossref record; 37 of the 40 references it cites were found in a registry or an index.

Reversing Hypoxic Cell Chemoresistance in Vitro Using Genetic and Small Molecule Approaches Targeting Hypoxia Inducible Factor-1

Brown, Louisa M., Cowen, Rachel L., Debray, Camille, Eustace, Amanda, Erler, Janine T., Sheppard, Freda CD., Parker, Catriona A., Stratford, Ian J., Williams, Kaye J.·2006·Molecular Pharmacology

DOI 10.1124/mol.105.015743

Open this paper in CoChat — free account

Abstract

The resistance of hypoxic cells to conventional chemotherapy is well documented. Using both adenovirus-mediated gene delivery and small molecules targeting hypoxia-inducible factor-1 (HIF-1), we evaluated the impact of HIF-1 inhibition on the sensitivity of hypoxic tumor cells to etoposide. The genetic therapy exploited a truncated HIF-1alpha protein that acts as a dominant-negative HIF-1alpha (HIF-1alpha-no-TAD). Its functionality was validated in six human tumor cell lines using HIF-1 reporter assays. An EGFP-fused protein demonstrated that the dominant-negative HIF-1alpha was nucleus-localized and constitutively expressed irrespective of oxygen tension. The small molecules studied were quinocarmycin monocitrate (KW2152), its analog 7-cyanoquinocarcinol (DX-52-1), and topotecan. DX-52-1 and topotecan have been previously established as HIF-1 inhibitors. HT1080 and HCT116 cells were treated with either AdHIF-1alpha-no-TAD or nontoxic concentrations (0.1 microM; <IC(10)) of KW2152 and DX-52-1 and exposed to etoposide in air or anoxia (<0.01% oxygen). Topotecan inhibited HIF-1 activity only at cytotoxic concentrations and was not used in the combination study. Etoposide IC(50) values in anoxia were 3-fold higher than those in air for HT1080 (2.2 +/- 0.3 versus 0.7 +/- 0.2 microM) and HCT116 (9 +/- 4 versus 3 +/- 2 microM) cells. KW2152 and DX-52-1 significantly reduced the anoxic etoposide IC(50) in HT1080 cells, whereas only KW2152 yielded sensitization in HCT116 cells. In co…

Integrity signals

Registry

Crossref · 10.1124/mol.105.015743

Cites

37 of 37 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Hypoxia-mediated selection of cells with diminished apoptotic potential in solid tumours
Graeber, T. G., Osmanian, C., Jacks, T., Housman, D. E., Koch, C. J., Lowe, S. W., & Giaccia, A. J. (1996) · Nature · doi:10.1038/379088a0 · Cited by 2,300
Untitled work
(1999) · PubMed · Cited by 2,204
HIF‐1α is required for solid tumor formation and embryonic vascularization
Ryan, H. E., Lo, J., & Johnson, R. S. (1998) · The EMBO Journal · doi:10.1093/emboj/17.11.3005 · Cited by 1,579
Hypoxia-inducible expression of tumor-associated carbonic anhydrases.
Wykoff, C. C., Beasley, N. J. P., Watson, P. H., Turner, K., Pastorek, J., Sibtain, A., Wilson, G. D., Turley, H., Talks, K., Maxwell, P. H., et al. (2000) · PubMed · Cited by 1,260
ELECTROMETRIC AND COLORIMETRIC DETERMINATION OF CARBONIC ANHYDRASE
Wilbur, K. M., & Anderson, N. G. (1948) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)51011-5 · Cited by 1,130
Dimerization, DNA Binding, and Transactivation Properties of Hypoxia-inducible Factor 1
Jiang, B.-H., Rue, E., Wang, G. L., Roe, R., & Semenza, G. L. (1996) · Journal of Biological Chemistry · doi:10.1074/jbc.271.30.17771 · Cited by 1,106 · cited 1×
“1/Zeo expressing a truncated HIF-1 construct lacking the transactivation domains (TAD) was based on a published strategy (Jiang et al., 1996).”
Method
Hypoxia-inducible factor-1 modulates gene expression in solid tumors and influences both angiogenesis and tumor growth
Maxwell, P. H., Dachs, G. U., Gleadle, J. M., Nicholls, L. G., Harris, A. L., Stratford, I. J., Hankinson, O., Pugh, C. W., & Ratcliffe, P. J. (1997) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.94.15.8104 · Cited by 1,084
Self-citation
Untitled work
(2002) · PubMed · Cited by 840
2ME2 inhibits tumor growth and angiogenesis by disrupting microtubules and dysregulating HIF
Mabjeesh, N. J., Escuin, D., LaVallee, T. M., Pribluda, V. S., Swartz, G. M., Johnson, M. S., Willard, M. T., Zhong, H., Simons, J. W., & Giannakakou, P. (2003) · Cancer Cell · doi:10.1016/s1535-6108(03)00077-1 · Cited by 730
Untitled work
(2000) · PubMed · Cited by 614

Show all 40 references

Sorted by citations

Hypoxia-inducible factors: mediators of cancer progression and targets for cancer therapy
Semenza, G. L. (2012) · Trends in Pharmacological Sciences · doi:10.1016/j.tips.2012.01.005 · Cited by 1,514
Therapeutic targeting of hypoxia and hypoxia-inducible factors in cancer
Wigerup, C., Påhlman, S., & Bexell, D. (2016) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2016.04.009 · Cited by 687
“…these data on the role of HIFs in therapeutic resistance suggest that HIF1/2 inhibitors might be effective in combination with conventional chemotherapy (Unruh et al., 2003; Erler et al., 2004; Brown et al., 2006; Nardinocchi et al., 2009; Roberts et al., 2009; He et al., 2012; Zhao et al., 2014).”
Background
Hypoxia-mediated drug resistance: Novel insights on the functional interaction of HIFs and cell death pathways
Rohwer, N., & Cramer, T. (2011) · Drug Resistance Updates · doi:10.1016/j.drup.2011.03.001 · Cited by 628
Hypoxia-induced resistance to anticancer drugs is associated with decreased senescence and requires hypoxia-inducible factor-1 activity
Sullivan, R., Paré, G. C., Frederiksen, L. J., Semenza, G. L., & Graham, C. H. (2008) · Molecular Cancer Therapeutics · doi:10.1158/1535-7163.mct-08-0198 · Cited by 243
Targeting hypoxia cell signaling for cancer therapy
Melillo, G. (2007) · Cancer and Metastasis Reviews · doi:10.1007/s10555-007-9059-x · Cited by 230
Hypoxia-inducible factor-1α regulates β cell function in mouse and human islets
Cheng, K., Ho, K., Stokes, R., Scott, C., Lau, S. M., Hawthorne, W. J., O’Connell, P. J., Loudovaris, T., Kay, T. W., Kulkarni, R. N., et al. (2010) · Journal of Clinical Investigation · doi:10.1172/jci35846 · Cited by 230
HIF-1 and NF-κB-mediated upregulation of CXCR1 and CXCR2 expression promotes cell survival in hypoxic prostate cancer cells
Maxwell, P., Gallagher, R., Seaton, A., Wilson, C., Scullin, P., Pettigrew, J., Stratford, I. J., Williams, K. J., Johnston, P. G., & Waugh, D. J. J. (2007) · Oncogene · doi:10.1038/sj.onc.1210536 · Cited by 211
Self-citation
Hypoxia-induced autophagy mediates cisplatin resistance in lung cancer cells
Wu, H., Jiang, Z., Ding, P., Shao, L., & Liu, R. (2015) · Scientific Reports · doi:10.1038/srep12291 · Cited by 184
Bioreductive Drugs: from Concept to Clinic
McKeown, S. R., Cowen, R. L., & Williams, K. J. (2007) · Clinical Oncology · doi:10.1016/j.clon.2007.03.006 · Cited by 174
Self-citation
Inhibiting Hypoxia-Inducible Factor 1 for Cancer Therapy
Melillo, G. (2006) · Molecular Cancer Research · doi:10.1158/1541-7786.mcr-06-0235 · Cited by 168
NADPH oxidase-mediated reactive oxygen species production activates hypoxia-inducible factor-1 (HIF-1) via the ERK pathway after hyperthermia treatment
Moon, E. J., Sonveaux, P., Porporato, P. E., Danhier, P., Gallez, B., Batinic̈‐Haberle, I., Nien, Y.-C., Schroeder, T., & Dewhirst, M. W. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1006646107 · Cited by 158
HIF-1α Inhibition Reverses Multidrug Resistance in Colon Cancer Cells via Downregulation of MDR1/P-Glycoprotein
Chen, J., Ding, Z., Peng, Y., Pan, F., Li, J., Zou, L., Zhang, Y., & Liang, H. (2014) · PLoS ONE · doi:10.1371/journal.pone.0098882 · Cited by 167
Hypoxia-Inducible Factor 1α Determines Gastric Cancer Chemosensitivity via Modulation of p53 and NF-κB
Rohwer, N., Dame, C., Haugstetter, A., Wiedenmann, B., Detjen, K. M., Schmitt, C. A., & Cramer, T. (2010) · PLoS ONE · doi:10.1371/journal.pone.0012038 · Cited by 152
Review: Implications of In Vitro Research on the Effect of Radiotherapy and Chemotherapy Under Hypoxic Conditions
Wouters, A., Pauwels, B., Lardon, F., & Vermorken, J. B. (2007) · The Oncologist · doi:10.1634/theoncologist.12-6-690 · Cited by 152
Role of the hypoxic tumor microenvironment in the resistance to anti-angiogenic therapies
Rapisarda, A., & Melillo, G. (2009) · Drug Resistance Updates · doi:10.1016/j.drup.2009.03.002 · Cited by 142
Hypoxia Inducible Factor Pathway Inhibitors as Anticancer Therapeutics
Burroughs, S. K., Kaluz, S., Wang, D., Wang, K., Van Meir, E. G., & Wang, B. (2013) · Future Medicinal Chemistry · doi:10.4155/fmc.13.17 · Cited by 140
Chemosensitization of Cancer In vitro and In vivo by Nitric Oxide Signaling
Frederiksen, L. J., Sullivan, R., Maxwell, L., Macdonald-Goodfellow, S. K., ADAMS, M. A., Bennett, B. M., Siemens, D. R., & Graham, C. H. (2007) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-06-1807 · Cited by 134
Anti-angiogenic effects of resveratrol mediated by decreased VEGF and increased TSP1 expression in melanoma-endothelial cell co-culture
Trapp, V., Parmakhtiar, B., Papazian, V., Willmott, L. J., & Fruehauf, J. P. (2010) · Angiogenesis · doi:10.1007/s10456-010-9187-8 · Cited by 121
Hypoxia-induced chemoresistance in cancer cells: The role of not only HIF-1
Doktorová, H., Hraběta, J., Khalil, M. A., & Eckschlager, T. (2015) · Biomedical Papers · doi:10.5507/bp.2015.025 · Cited by 122
Hypoxia-inducible factor-1α induces multidrug resistance protein in colon cancer
Lv, Y., Zhao, S., Han, J., Zheng, L., Yang, Z., & Zhao, L. (2015) · OncoTargets and Therapy · doi:10.2147/ott.s82835 · Cited by 116
Expression of hypoxia-inducible factor 1α in thyroid carcinomas
Burrows, N., Resch, J., Cowen, R. L., von Wasielewski, R., Hoang‐Vu, C., West, C., Williams, K. J., & Brabant, G. E. (2009) · Endocrine Related Cancer · doi:10.1677/erc-08-0251 · Cited by 107
Self-citation
Selective Killing of Hypoxia-Inducible Factor-1–Active Cells Improves Survival in a Mouse Model of Invasive and Metastatic Pancreatic Cancer
Kizaka‐Kondoh, S., Itasaka, S., Zeng, L., Tanaka, S., Zhao, T., Takahashi, Y., Shibuya, K., Hirota, K., Semenza, G. L., & Hiraoka, M. (2009) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-08-2267 · Cited by 92
Review of high‐dose intravenous vitamin C as an anticancer agent
Wilson, M. K., Baguley, B. C., Wall, C. R., Jameson, M. B., & Findlay, M. P. N. (2014) · Asia-Pacific Journal of Clinical Oncology · doi:10.1111/ajco.12173 · Cited by 93
Gene expression and hypoxia in breast cancer
Favaro, E., Lord, S., Harris, A. L., & Buffa, F. M. (2011) · Genome Medicine · doi:10.1186/gm271 · Cited by 91
Angiogenesis in Colorectal Cancer: Prognostic and Therapeutic Implications
Giatromanolaki, A. N., Sivridis, E., & Koukourakis, M. I. (2006) · American Journal of Clinical Oncology · doi:10.1097/01.coc.0000221317.56731.4e · Cited by 85
Alteration of Cellular Behavior and Response to PI3K Pathway Inhibition by Culture in 3D Collagen Gels
Fallica, B., Maffei, J. S., Villa, S., Makin, G., & Zaman, M. (2012) · PLoS ONE · doi:10.1371/journal.pone.0048024 · Cited by 84
Angiogenesis and antiangiogenic agents in cervical cancer
Tomao, F., Tomao, F., Rossi, L., Zaccarelli, E., Caruso, D., Zoratto, F., Panici, P. B., & Papa, A. (2014) · OncoTargets and Therapy · doi:10.2147/ott.s68286 · Cited by 83
Potentiation of Inflammatory CXCL8 Signalling Sustains Cell Survival in PTEN-deficient Prostate Carcinoma
Maxwell, P. J., Coulter, J. A., Walker, S. M., McKechnie, M., Neisen, J., McCabe, N., Kennedy, R. D., Salto‐Tellez, M., Albanese, C., & Waugh, D. J. J. (2012) · European Urology · doi:10.1016/j.eururo.2012.08.032 · Cited by 82
Glut-1 as a therapeutic target: increased chemoresistance and HIF-1-independent link with cell turnover is revealed through COMPARE analysis and metabolomic studies
Evans, A. R., Bates, V., Troy, H., Hewitt, S. M., Holbeck, S. L., Chung, Y., Phillips, R. M., Stubbs, M., Griffiths, J. R., & Airley, R. E. (2007) · Cancer Chemotherapy and Pharmacology · doi:10.1007/s00280-007-0480-1 · Cited by 82
Chronic hypoxia promotes hypoxia-inducible factor-1α–dependent resistance to etoposide and vincristine in neuroblastoma cells
Hussein, D., Estlin, E. J., Dive, C., & Makin, G. W. J. (2006) · Molecular Cancer Therapeutics · doi:10.1158/1535-7163.mct-06-0145 · Cited by 80
Anti-angiogenesis agents in metastatic or recurrent cervical cancer
Monk, B. J., Willmott, L. J., & Sumner, D. A. (2009) · Gynecologic Oncology · doi:10.1016/j.ygyno.2009.09.033 · Cited by 76
Targeting Tumor Adaption to Chronic Hypoxia: Implications for Drug Resistance, and How It Can Be Overcome
Kim, J., & Lee, J. (2017) · International Journal of Molecular Sciences · doi:10.3390/ijms18091854 · Cited by 80
Hypoxia–Induced Cytotoxic Drug Resistance in Osteosarcoma Is Independent of HIF-1Alpha
Adamski, J., Price, A., Dive, C., & Makin, G. (2013) · PLoS ONE · doi:10.1371/journal.pone.0065304 · Cited by 76
Emerging Nano-Based Strategies Against Drug Resistance in Tumor Chemotherapy
Cao, L., Zhu, Y., Wang, W., Wang, G., Zhang, S., & Cheng, H. (2021) · Frontiers in Bioengineering and Biotechnology · doi:10.3389/fbioe.2021.798882 · Cited by 75
Lentivirus-Mediated Overexpression of MicroRNA-199a Inhibits Cell Proliferation of Human Hepatocellular Carcinoma
Jia, X. Q., Cheng, H., Qian, X., Bian, C.-X., Shi, Z. M., Zhang, J. P., Jiang, B., & Feng, Z. Q. (2011) · Cell Biochemistry and Biophysics · doi:10.1007/s12013-011-9263-8 · Cited by 73
Se-methylselenocysteine sensitizes hypoxic tumor cells to irinotecan by targeting hypoxia-inducible factor 1α
Chintala, S., Tóth, K., Cao, S., Durrani, F. A., Vaughan, M. M., Jensen, R. L., & Rustum, Y. M. (2010) · Cancer Chemotherapy and Pharmacology · doi:10.1007/s00280-009-1238-8 · Cited by 70
Dichloroacetate attenuates hypoxia-induced resistance to 5-fluorouracil in gastric cancer through the regulation of glucose metabolism
Yi, X., Hur, H., Ham, I., Yun, J., Lee, J.-Y., Shim, W., Kim, Y. B., Lee, G., Han, S., & Cho, Y. K. (2013) · Experimental Cell Research · doi:10.1016/j.yexcr.2013.12.009 · Cited by 68
Hypoxia prevents etoposide-induced DNA damage in cancer cells through a mechanism involving hypoxia-inducible factor 1
Sullivan, R., & Graham, C. H. (2009) · Molecular Cancer Therapeutics · doi:10.1158/1535-7163.mct-08-1090 · Cited by 65
Oroxylin A reverses hypoxia-induced cisplatin resistance through inhibiting HIF-1α mediated XPC transcription
Liu, Y., Wang, X., Li, W., Xu, Y., Zhuo, Y., Li, M., He, Y. Z., Wang, X., Guo, Q., Zhao, L., et al. (2020) · Oncogene · doi:10.1038/s41388-020-01474-x · Cited by 64
Hypoxia-Inducible Factor in Thyroid Carcinoma
Burrows, N., Babur, M., Resch, J., Williams, K. J., & Brabant, G. E. (2011) · Journal of Thyroid Research · doi:10.4061/2011/762905 · Cited by 66
Self-citation
GDC-0941 Inhibits Metastatic Characteristics of Thyroid Carcinomas by Targeting both the Phosphoinositide-3 Kinase (PI3K) and Hypoxia-Inducible Factor-1α (HIF-1α) Pathways
Burrows, N., Babur, M., Resch, J., Ridsdale, S., Mejin, M., Rowling, E. J., Brabant, G. E., & Williams, K. J. (2011) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2011-1426 · Cited by 62
Self-citation
Effects of proton pump inhibitors on reversing multidrug resistance via downregulating V-ATPases/PI3K/Akt/mTOR/HIF-1α signaling pathway through TSC1/2 complex and Rheb in human gastric adenocarcinoma cells in vitro and in vivo
Chen, M., Lu, J., Wei, W., Lv, Y., Zhang, X., Yao, Y., Wang, L., Ling, T., & Zou, X. (2018) · OncoTargets and Therapy · doi:10.2147/ott.s161198 · Cited by 61
The emerging role of hypoxia-inducible factor-2 involved in chemo/radioresistance in solid tumors
Zhao, J., Du, F., Luo, Y., Shen, G., Zheng, F., & Xu, B. (2015) · Cancer Treatment Reviews · doi:10.1016/j.ctrv.2015.05.004 · Cited by 59
Effects of lentivirus-mediated HIF-1α knockdown on hypoxia-related cisplatin resistance and their dependence on p53 status in fibrosarcoma cells
Hao, J., Song, X., Song, B., Liu, Y., Wei, L., Wang, X., & Yu, J. (2008) · Cancer Gene Therapy · doi:10.1038/cgt.2008.4 · Cited by 58
Contribution of HIF-1 and drug penetrance to oxaliplatin resistance in hypoxic colorectal cancer cells
Roberts, D. L., Williams, K. J., Cowen, R. L., Baráthová, M., Eustace, A. J., Brittain-Dissont, S., Tilby, M. J., Pearson, D. G., Ottley, C. J., Stratford, I. J., et al. (2009) · British Journal of Cancer · doi:10.1038/sj.bjc.6605311 · Cited by 55
Self-citation
The Mitogen-Activated Protein/Extracellular Signal-Regulated Kinase Kinase 1/2 Inhibitor AZD6244 (ARRY-142886) Enhances the Radiation Responsiveness of Lung and Colorectal Tumor Xenografts
Shannon, A. M., Telfer, B. A., Smith, P. D., Babur, M., Logié, A., Wilkinson, R. W., Debray, C., Stratford, I. J., Williams, K. J., & Wedge, S. R. (2009) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-08-2958 · Cited by 53
Self-citation
Impaired DNA double-strand break repair contributes to chemoresistance in HIF-1 -deficient mouse embryonic fibroblasts
Wirthner, R., Wrann, S., Balamurugan, K., Wenger, R. H., & Stiehl, D. P. (2008) · Carcinogenesis · doi:10.1093/carcin/bgn231 · Cited by 51
Hypoxic human cancer cells are sensitized to BH-3 mimetic–induced apoptosis via downregulation of the Bcl-2 protein Mcl-1
Harrison, L., Micha, D., Brandenburg, M., Simpson, K., Morrow, C. J., Denneny, O., Hodgkinson, C. L., Yunus, Z., Dempsey, C. E., Roberts, D. L., et al. (2011) · Journal of Clinical Investigation · doi:10.1172/jci43505 · Cited by 50
Role of HIF-1α in the Responses of Tumors to Radiotherapy and Chemotherapy
Song, C. W., Kim, H., Kim, M.-S., Park, H. J., Paek, S.-H., Terezakis, S. A., & Cho, L. C. (2024) · Cancer Research and Treatment · doi:10.4143/crt.2024.255 · Cited by 58
Elevated SP-1 Transcription Factor Expression and Activity Drives Basal and Hypoxia-induced Vascular Endothelial Growth Factor (VEGF) Expression in Non-Small Cell Lung Cancer
Deacon, K., Onion, D., Kumari, R., Watson, S. A., & Knox, A. J. (2012) · Journal of Biological Chemistry · doi:10.1074/jbc.m112.397042 · Cited by 48
Cervical cancer therapy: current, future and anti-angiogensis targeted treatment
Willmott, L. J., & Monk, B. J. (2009) · Expert Review of Anticancer Therapy · doi:10.1586/era.09.58 · Cited by 46
Validation of the type 1 insulin-like growth factor receptor as a therapeutic target in renal cancer
Yuen, J. S. P., Akkaya, E., Wang, Y., Takiguchi, M., Peak, S., Sullivan, M., Protheroe, A. S., & Macaulay, V. M. (2009) · Molecular Cancer Therapeutics · doi:10.1158/1535-7163.mct-09-0101 · Cited by 42
Reactive oxygen species produced by the knockdown of manganese-superoxide dismutase up-regulate hypoxia-inducible factor-1α expression in oral squamous cell carcinoma cells
Sasabe, E., Yang, Z., Ohno, S., & Yamamoto, T. (2010) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2010.02.013 · Cited by 45
Hypoxia inducible factor (HIF1α and HIF2α) and carbonic anhydrase 9 (CA9) expression and response of head-neck cancer to hypofractionated and accelerated radiotherapy
Koukourakis, M. I., Giatromanolaki, A. N., Danielidis, V., & Sivridis, E. (2007) · International Journal of Radiation Biology · doi:10.1080/09553000701616114 · Cited by 42
HIF mediated and DNA damage independent histone H2AX phosphorylation in chronic hypoxia
Wrann, S., Kaufmann, M. R., Wirthner, R., Stiehl, D. P., & Wenger, R. H. (2012) · Biological Chemistry · doi:10.1515/hsz-2012-0311 · Cited by 41
Targeting NF-κB and HIF-1 Pathways for the Treatment of Cancer: Part II
Wilczynski, J., Duechler, M., & Czyz, M. (2011) · Archivum Immunologiae et Therapiae Experimentalis · doi:10.1007/s00005-011-0132-3 · Cited by 41
Hypoxia inducible factor‐1 influences sensitivity to paclitaxel of human lung cancer cell lines under normoxic conditions
Zeng, L., Kizaka‐Kondoh, S., Itasaka, S., Xie, X., Inoue, M., Tanimoto, K., Shibuya, K., & Hiraoka, M. (2007) · Cancer Science · doi:10.1111/j.1349-7006.2007.00537.x · Cited by 41
Hypoxia promotes drug resistance in osteosarcoma cells via activating AMP-activated protein kinase (AMPK) signaling
Zhao, C., Zhang, Q., Tao, Y., Sun, S., Wang, W., & Liu, G. (2016) · Journal of bone oncology · doi:10.1016/j.jbo.2016.01.002 · Cited by 40
Hemin, an iron‐binding porphyrin, inhibits HIF‐1α induction through its binding with heat shock protein 90
Lee, J. M., Lee, W. H., Kay, H. Y., Kim, E., Moon, A., & Kim, S. G. (2011) · International Journal of Cancer · doi:10.1002/ijc.26075 · Cited by 40
Helicobacter pylori Induced Phosphatidylinositol-3-OH Kinase/mTOR Activation Increases Hypoxia Inducible Factor-1α to Promote Loss of Cyclin D1 and G0/G1 Cell Cycle Arrest in Human Gastric Cells
Canales, J., Valenzuela, M., Bravo, J., Cerda-Opazo, P., Jorquera‐Cordero, C., Toledo, H., Bravo, D., & Quest, A. F. G. (2017) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2017.00092 · Cited by 41
Cacalol, a natural sesquiterpene, induces apoptosis in breast cancer cells by modulating Akt-SREBP-FAS signaling pathway
Liu, W., Furuta, E., Shindo, K., Watabe, M., Xing, F., Pandey, P. R., Okuda, H., Pai, S. K., Murphy, L. L., Cao, D., et al. (2010) · Breast Cancer Research and Treatment · doi:10.1007/s10549-010-1076-8 · Cited by 38
Effect of HIF-1 modulation on the response of two- and three-dimensional cultures of human colon cancer cells to 5-fluorouracil
Ravizza, R., Molteni, R., Gariboldi, M. B., Marras, E., Perletti, G., & Monti, E. (2009) · European Journal of Cancer · doi:10.1016/j.ejca.2008.12.021 · Cited by 38
Hypoxia-Induced Autophagy Enhances Cisplatin Resistance in Human Bladder Cancer Cells by Targeting Hypoxia-Inducible Factor-1α
Mao, X.-W., Nanzhang, Xiao, J., Wu, H., & Ding, K. (2021) · Journal of Immunology Research · doi:10.1155/2021/8887437 · Cited by 39
Polyphenols in Health and Disease
Zhang, P.-Y. (2015) · Cell Biochemistry and Biophysics · doi:10.1007/s12013-015-0558-z · Cited by 37
Role of hypoxia-inducible transcription factor 1α for progression and chemosensitivity of murine hepatocellular carcinoma
Daskalow, K., Rohwer, N., Raskopf, E., Dupuy, É., Kühl, A. A., Loddenkemper, C., Wiedenmann, B., Schmitz, V., & Cramer, T. (2010) · Journal of Molecular Medicine · doi:10.1007/s00109-010-0623-4 · Cited by 36
STAT3 but Not HIF-1α Is Important in Mediating Hypoxia-Induced Chemoresistance in MDA-MB-231, a Triple Negative Breast Cancer Cell Line
Abyaneh, H. S., Gupta, N., Radziwon‐Balicka, A., Jurasz, P., Seubert, J. M., Lai, R. L., & Lavasanifar, A. (2017) · Cancers · doi:10.3390/cancers9100137 · Cited by 36
Oltipraz and dithiolethione congeners inhibit hypoxia-inducible factor-1α activity through p70 ribosomal S6 kinase-1 inhibition and H2O2-scavenging effect
Lee, W. H., Kim, Y., Choi, J. H., Brooks, S. C., Lee, M., & Kim, S. G. (2009) · Molecular Cancer Therapeutics · doi:10.1158/1535-7163.mct-09-0420 · Cited by 35
Metabolic profiling reveals potential metabolic markers associated with Hypoxia Inducible Factor-mediated signalling in hypoxic cancer cells
Armitage, E. G., Kotze, H. L., Allwood, J. W., Dunn, W. B., Goodacre, R., & Williams, K. J. (2015) · Scientific Reports · doi:10.1038/srep15649 · Cited by 35
Self-citation
Phosphorylated VEGFR2/KDR receptors are widely expressed in B‐cell non‐Hodgkin's lymphomas and correlate with hypoxia inducible factor activation
Giatromanolaki, A. N., Koukourakis, M. I., Pezzella, F., Sivridis, E., Turley, H., Harris, A. L., & Gatter, K. C. (2008) · Hematological Oncology · doi:10.1002/hon.861 · Cited by 34
p53 Ser15 phosphorylation disrupts the p53–RPA70 complex and induces RPA70-mediated DNA repair in hypoxia
Madan, E., Gogna, R., & Pati, U. (2012) · Biochemical Journal · doi:10.1042/bj20111627 · Cited by 35
Hypoxia-inducible factor-1α inhibition by a pyrrolopyrazine metabolite of oltipraz as a consequence of microRNAs 199a-5p and 20a induction
Kang, S. G., Lee, W. H., Lee, Y. H., Lee, Y. S., & Kim, S. G. (2012) · Carcinogenesis · doi:10.1093/carcin/bgr320 · Cited by 33
Targeted Therapy in Ovarian Cancer
Willmott, L. J., & Fruehauf, J. P. (2010) · Journal of Oncology · doi:10.1155/2010/740472 · Cited by 33
Targeting hypoxia in the treatment of small cell lung cancer
Bryant, J., Meredith, S. L., Williams, K. J., & White, A. E. (2014) · Lung Cancer · doi:10.1016/j.lungcan.2014.08.003 · Cited by 32
Self-citation
Increased expression of HIF-1A and its implication in the hypoxia pathway in primary advanced uterine cervical carcinoma
Łuczak, M. W. (2011) · Oncology Reports · doi:10.3892/or.2011.1397 · Cited by 32
Targeting the Loss of the von Hippel-Lindau Tumor Suppressor Gene in Renal Cell Carcinoma Cells
Sutphin, P. D., Chan, D. A., Li, J. M., Turcotte, S., Krieg, A. J., & Giaccia, A. J. (2007) · Cancer Research · doi:10.1158/0008-5472.can-07-0604 · Cited by 32
Modulation of Glucose Metabolism Inhibits Hypoxic Accumulation of Hypoxia-Inducible Factor-1α (HIF-1α)
Staab, A., Löffler, J., Said, H. M., Katzer, A., Beyer, M., Polat, B., Einsele, H., Flentje, M. P., & Vordermark, D. (2007) · Strahlentherapie und Onkologie · doi:10.1007/s00066-007-1649-6 · Cited by 32
The Novel Bcl-2 Inhibitor ABT-737 Is More Effective in Hypoxia and Is Able to Reverse Hypoxia-Induced Drug Resistance in Neuroblastoma Cells
Klymenko, T., Brandenburg, M., Morrow, C. J., Dive, C., & Makin, G. (2011) · Molecular Cancer Therapeutics · doi:10.1158/1535-7163.mct-11-0326 · Cited by 29
Bioengineering approaches to study multidrug resistance in tumor cells
Fallica, B., Makin, G., & Zaman, M. H. (2011) · Integrative Biology · doi:10.1039/c0ib00142b · Cited by 24
A two-phase strategy for treatment of oxidant-dependent cancers
McCarty, M. F., Barroso-Aranda, J., & Contreras, F. (2007) · Medical Hypotheses · doi:10.1016/j.mehy.2006.12.065 · Cited by 24
Evaluation of Copper Oxide-Based Interconnecting Materials
Yasuda, Y., Ide, E., & Morita, T. (2010) · The Open Surface Science Journal · doi:10.2174/1876531901103010123 · Cited by 23
Near-infrared dye loaded polymeric nanoparticles for cancer imaging and therapy and cellular response after laser-induced heating
Lei, T., Fernandez-Fernandez, A., Manchanda, R., Huang, Y., & McGoron, A. J. (2014) · Beilstein Journal of Nanotechnology · doi:10.3762/bjnano.5.35 · Cited by 23
Functional Interaction of Hypoxia-Inducible Factor 2-Alpha and Autophagy Mediates Drug Resistance in Colon Cancer Cells
Saint-Martin, A., Martínez-Ríos, J., Castañeda‐Patlán, M. C., Sarabia-Sánchez, M. Á., Tejeda‐Muñoz, N., Chinney-Herrera, A., Soldevila, G., Benelli, R., Santoyo‐Ramos, P., Poggi, A. D., et al. (2019) · Cancers · doi:10.3390/cancers11060755 · Cited by 21
A Truncated Ah Receptor Blocks the Hypoxia and Estrogen Receptor Signaling Pathways: A Viable Approach for Breast Cancer Treatment
Jensen, K. A., Luu, T. C., & Chan, W. K. (2006) · Molecular Pharmaceutics · doi:10.1021/mp0600438 · Cited by 21
Anticancer therapeutics: A surge of new developments increasingly target tumor and stroma
Broxterman, H. J., & Georgopapadakou, N. H. (2007) · Drug Resistance Updates · doi:10.1016/j.drup.2007.07.001 · Cited by 21
Practical strategies for suppressing hypoxia-inducible factor activity in cancer therapy
McCarty, M. F., Barroso-Aranda, J., & Contreras, F. (2010) · Medical Hypotheses · doi:10.1016/j.mehy.2009.12.022 · Cited by 21
Anti-Tumor Effect of the Mammalian Target of Rapamycin Inhibitor Everolimus in Oral Squamous Cell Carcinoma
Naruse, T., Yanamoto, S., Yamada, S., Rokutanda, S., Kawakita, A., Kawasaki, G., & Umeda, M. (2015) · Pathology & Oncology Research · doi:10.1007/s12253-014-9888-1 · Cited by 18
The relationships between hypoxia-dependent markers: HIF-1alpha, EPO and EPOR in colorectal cancer
Baltaziak, M., Wincewicz, A., Koda, M., Łotowska, J. M., Koda, M., Sulkowska, U., Baltaziak, M., Podbielski, M., Sobaniec-Lotowska, M. E., & Sulkowski, S. (2014) · Folia Histochemica et Cytobiologica · doi:10.5603/fhc.2013.0043 · Cited by 18
Tumor Angiogenesis Genotyping and Efficacy of First-line Chemotherapy in Metastatic Gastric Cancer Patients
Scartozzi, M., Giampieri, R., Loretelli, C., Bittoni, A., Mandolesi, A., Faloppi, L., Bianconi, M., Prete, M. D., Andrikou, K., Bearzi, I., et al. (2013) · Pharmacogenomics · doi:10.2217/pgs.13.185 · Cited by 16
Caveolin-1-Mediated Tumor Suppression Is Linked to Reduced HIF1α S-Nitrosylation and Transcriptional Activity in Hypoxia
Sanhueza, C., Bennett, J. C., Valenzuela, M., Contreras, P., Lobos‐González, L., Campos, A. V., Wehinger, S., Lladser, Á., Kiessling, R. W., Leyton, L., et al. (2020) · Cancers · doi:10.3390/cancers12092349 · Cited by 16
Increased chemoresistance induced by inhibition of HIF‐prolyl‐hydroxylase domain enzymes
Brökers, N., Le-Huu, S. K.-A., Vogel, S., Hagos, Y., Katschinski, D. M., & Kleinschmidt, M. (2009) · Cancer Science · doi:10.1111/j.1349-7006.2009.01367.x · Cited by 16
In Vitro Effects of Hypoxia-Inducible Factor 1a on the Biological Characteristics of the SiHa Uterine Cervix Cancer Cell Line
Tang, B., Qu, Y., Zhao, F., Mao, M., Tang, J., Li, X., Ferriero, D. M., & Mu, D. (2009) · International Journal of Gynecological Cancer · doi:10.1111/igc.0b013e3181a14f9a · Cited by 12
Creating Chemotherapeutic-Resistant Breast Cancer Cell Lines: Advances and Future Perspectives
Steding, C. E. (2016) · Future Oncology · doi:10.2217/fon-2016-0059 · Cited by 13
The cellular adaptations to hypoxia as novel therapeutic targets in childhood cancer
Adamski, J., Estlin, E., & Makin, G. (2008) · Cancer Treatment Reviews · doi:10.1016/j.ctrv.2007.11.005 · Cited by 11
Tumor Hypoxia and Targeted Gene Therapy
Greco, O., & Scott, S. D. (2007) · International review of cytology · doi:10.1016/s0074-7696(07)57005-1 · Cited by 11
Biological characteristics of prostate cancer cells are regulated by hypoxia-inducible factor 1α
Huang, X., Zhou, J., LIU, J., Tang, B., Zhao, F., & Qu, Y. (2014) · Oncology Letters · doi:10.3892/ol.2014.2259 · Cited by 9
Application of two‐dimensional gel‐based mass spectrometry to functionally dissect resistance to targeted cancer therapy
Klein, O., Rohwer, N., de Molina, K. F., Mergler, S., Wessendorf, P., Herrmann, M., Klose, J., & Cramer, T. (2013) · PROTEOMICS - CLINICAL APPLICATIONS · doi:10.1002/prca.201300056 · Cited by 8
Biomarkers in Thyroid Tumor Research: New Diagnostic Tools and Potential Targets of Molecular-Based Therapy
Gimm, O., Castellone, M. D., Hoang‐Vu, C., & Kebebew, E. (2011) · Journal of Thyroid Research · doi:10.4061/2011/631593 · Cited by 9
Photosensitized Oxidation of Hypoxanthine and Xanthine by Aluminum Phthalocyanine Tetrasulfonate. Role of the Alkylating Quinone 2,5‐Dichloro‐diaziridinyl‐1,4‐benzoquinone
Alegrı́a, A. E., Inostroza‐Nieves, Y., & Kumar, A. (2008) · Photochemistry and Photobiology · doi:10.1111/j.1751-1097.2008.00389.x · Cited by 8
Hypoxia-inducible factor as a transcriptional factor regulating gene expression in cancer cells
Dondajewska, E., & Suchorska, W. M. (2011) · Współczesna Onkologia · doi:10.5114/wo.2011.24320 · Cited by 8
Angiogenic activities are increased via upregulation of HIF‑1α expression in gefitinib‑resistant non‑small cell lung carcinoma cells
Cha, J., Bae, W., Choi, J., Lee, S., & Jeong, J. (2021) · Oncology Letters · doi:10.3892/ol.2021.12932 · Cited by 8

Authors: Brown, L. M., Cowen, R. L., Debray, C., Eustace, A., Erler, J. T., Sheppard, F. C., Parker, C. A., Stratford, I. J., & Williams, K. J.
Affiliations: University of Manchester (GB)
ORCID: Cowen, Rachel L.
Erler, Janine T.
Parker, Catriona A.
Stratford, Ian J.
Williams, Kaye J.
Venue: Molecular Pharmacology
Publisher: Elsevier BV
Published: 2006-02
Volume: 69
Issue: 2
Pages: 411-418
ISSN: 0026-895X (ISSN-L)
DOI: 10.1124/mol.105.015743
OpenAlex: W2148419067
Cited by: 125
References: 40
Citations by year: 2026: 1 · 2025: 1 · 2024: 1 · 2023: 6 · 2021: 3 · 2020: 2 · 2019: 2 · 2018: 3 · 2017: 3 · 2016: 4 · 2015: 8 · 2014: 9 · 2013: 9 · 2012: 9
FWCI: 2.76
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/legal/tdmrep-license (tdm)
Locations: Molecular Pharmacology (publishedVersion)
PubMed (publishedVersion)
Research Explorer (The University of Manchester) (publishedVersion)
Funders: National Cancer Institute (T32CA009151)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Cancer, Hypoxia, and Metabolism
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Angiogenesis and VEGF in Cancer
Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Toxicology › Bioactive Compounds and Antitumor Agents
Keywords: HIF-1, HIF-1α, etoposide sensitivity, topotecan, HIF-1 inhibitors, adenoviral gene transfer, tumor hypoxia, anoxia
MeSH terms: Adenoviridae, Antineoplastic Agents, Phytogenic, Cell Nucleus, Etoposide, Genetic Vectors, Humans, Isoquinolines, Neoplasms, Oxygen, Transcriptional Activation, Cell Hypoxia, Sequence Deletion, Drug Resistance, Neoplasm, Topotecan, Cell Line, Tumor, Green Fluorescent Proteins, Hypoxia-Inducible Factor 1, Hypoxia-Inducible Factor 1, alpha Subunit

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Reversing Hypoxic Cell Chemoresistance in Vitro Using Genetic and Small Molecule Approaches Targeting Hypoxia Inducible Factor-1

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Citations

Cites

Cited by

Related

Metadata

Record

About these checks