CCAAT/Enhancer-Binding Protein β (Nuclear Factor for Interleukin 6) Transactivates the Human MDR1 Gene by Interaction with an Inverted CCAAT Box in Human Cancer Cells

Accurate transcription initiation by RNA polymerase II in a soluble extract from isolated mammalian nuclei

Dignam, J. D., Lebovitz, R. M., & Roeder, R. G. (1983) · Nucleic Acids Research · doi:10.1093/nar/11.5.1475 · Cited by 11,262 · see citing works

A rapid micrqpreparation technique for extraction of DNA-binding proteins from limiting numbers of mammalian cells

Andrews, N. C., & Faller, D. V. (1991) · Nucleic Acids Research · doi:10.1093/nar/19.9.2499 · Cited by 2,337 · see citing works

pEF-BOS, a powerful mammalian expression vector

Mizushima, S., & Nagata, S. (1990) · Nucleic Acids Research · doi:10.1093/nar/18.17.5322 · Cited by 1,632 · see citing works

A nuclear factor for IL‐6 expression (NF‐IL6) is a member of a C/EBP family.

Akira, S., Isshiki, H., Sugita, T., Tanabe, O., Kinoshita, S. M., Nishio, Y., Nakajima, T., Hirano, T., & Kishimoto, T. (1990) · The EMBO Journal · doi:10.1002/j.1460-2075.1990.tb08316.x · Cited by 1,446 · see citing works

A liver-enriched transcriptional activator protein, LAP, and a transcriptional inhibitory protein, LIP, are translated from the sam mRNA

Descombes, P., & Schibler, U. (1991) · Cell · doi:10.1016/0092-8674(91)90531-3 · Cited by 973 · see citing works

Phosphorylation at threonine-235 by a ras-dependent mitogen-activated protein kinase cascade is essential for transcription factor NF-IL6.

Nakajima, T., Kinoshita, S. M., Sasagawa, T., Sasaki, K., Naruto, M., Kishimoto, T., & Akira, S. (1993) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.90.6.2207 · Cited by 578 · see citing works

A survey of 178 NF-Y binding CCAAT boxes

Mantovani, R. (1998) · Nucleic Acids Research · doi:10.1093/nar/26.5.1135 · Cited by 513 · see citing works

Mapping chromosomal proteins in vivo by formaldehyde-crosslinked-chromatin immunoprecipitation

Orlando, V. (2000) · Trends in Biochemical Sciences · doi:10.1016/s0968-0004(99)01535-2 · Cited by 506 · see citing works

Nuclear localization and increased levels of transcription factor YB-1 in primary human breast cancers are associated with intrinsic MDR1 gene expression

Bargou, R. C., Jürchott, K., Wagener, C., Bergmann, S., Metzner, S., Bommert, K., Mapara, M. Y., Winzer, K., Dietel, M., Dörken, B., et al. (1997) · Nature Medicine · doi:10.1038/nm0497-447 · Cited by 423 · see citing works

The human multidrug resistance (mdr1) gene. cDNA cloning and transcription initiation.

Ueda, K., Clark, D. P., Chen, C. J., et al. (1987) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)75806-2 · Cited by 391 · see citing works

Histone Acetyltransferase Complexes Stabilize SWI/SNF Binding to Promoter Nucleosomes

Hassan, A. H., Neely, K. E., & Workman, J. L. (2001) · Cell · doi:10.1016/s0092-8674(01)00279-3 · Cited by 365 · see citing works

How cancer cells evade chemotherapy: sixteenth Richard and Hinda Rosenthal Foundation Award Lecture.

Gottesman, M. M. (1993) · PubMed · Cited by 353 · see citing works

Transactivation by NF-IL6/LAP is enhanced by phosphorylation of its activation domain

Trautwein, C., Caelles, C., van der Geer, P., Hunter, T. R., Karin, M., & Chojkier, M. (1993) · Nature · doi:10.1038/364544a0 · Cited by 340 · see citing works

A C/EBPβ Isoform Recruits the SWI/SNF Complex to Activate Myeloid Genes

Kowenz‐Leutz, E., & Leutz, A. (1999) · Molecular Cell · doi:10.1016/s1097-2765(00)80384-6 · Cited by 301 · see citing works

Isolation of amplified and overexpressed DNA sequences from adriamycin-resistant human breast cancer cells.

Fairchild, C. R., Ivy, S. P., Kao-Shan, C. S., et al. (1987) · PubMed · Cited by 297 · see citing works

Transcriptional Regulation of the MDR1 Gene by Histone Acetyltransferase and Deacetylase Is Mediated by NF-Y

Jin, S. V., & Scotto, K. W. (1998) · Molecular and Cellular Biology · doi:10.1128/mcb.18.7.4377 · Cited by 289 · see citing works

Autocrine production of interleukin 6 causes multidrug resistance in breast cancer cells.

Conze, D. B., Weiss, L., Regen, P. S., Bhushan, A., Weaver, D. L., Johnson, P. F., & Rincón, M. (2001) · PubMed · Cited by 282 · see citing works

Direct Involvement of the Y-box Binding Protein YB-1 in Genotoxic Stress-induced Activation of the Human Multidrug Resistance 1 Gene

Ohga, T., Uchiumi, T., Makino, Y., et al. (1998) · Journal of Biological Chemistry · doi:10.1074/jbc.273.11.5997 · Cited by 236 · see citing works

Clinical significance of P-glycoprotein in multidrug resistance malignancies [editorial] [see comments]

Arceci, R. J. (1993) · Blood · doi:10.1182/blood.v81.9.2215.2215 · Cited by 226 · see citing works

Fos and Jun repress transcription activation by NF-IL6 through association at the basic zipper region

Hsu, W., Kerppola, T. K., Chen, P., Curran, T., & Chen‐Kiang, S. (1994) · Molecular and Cellular Biology · doi:10.1128/mcb.14.1.268 · Cited by 199 · see citing works

Modulation of multidrug resistance: at the threshold.

Sikic, B. I. (1993) · Journal of Clinical Oncology · doi:10.1200/jco.1993.11.9.1629 · Cited by 186 · see citing works

Selective regulation of expression of protein kinase C (PKC) isoenzymes in multidrug-resistant MCF-7 cells. Functional significance of enhanced expression of PKC alpha.

Blobe, G. C., Sachs, C. W., Khan, W. A., et al. (1993) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)54202-2 · Cited by 166 · see citing works

Coexamination of Site-Specific Transcription Factor Binding and Promoter Activity in Living Cells

Boyd, K. E., & Farnham, P. (1999) · Molecular and Cellular Biology · doi:10.1128/mcb.19.12.8393 · Cited by 165 · see citing works

Clinical significance of P-glycoprotein in multidrug resistance malignancies [editorial] [see comments]

Arceci, R. J. (1993) · Blood · doi:10.1182/blood.v81.9.2215.bloodjournal8192215 · Cited by 165 · see citing works

Transcriptional Repression by p53 through Direct Binding to a Novel DNA Element

Johnson, R. A., Ince, T. A., & Scotto, K. W. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.c100121200 · Cited by 158 · see citing works

Transcriptional Activation of the MDR1 Gene by UV Irradiation

Hu, Z., Jin, S. V., & Scotto, K. W. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.275.4.2979 · Cited by 147 · see citing works

Transfection with Protein Kinase Cα Confers Increased Multidrug Resistance to MCF-7 Cells Expressing P-Glycoprotein

Yu, G., Ahmad, S., Aquino, A., et al. (1991) · Cancer Communications · doi:10.3727/095535491820873263 · Cited by 145 · see citing works

SP1 activates the MDR1 promoter through one of two distinct G-rich regions that modulate promoter activity.

Cornwell, M. M., & Smith, D. E. (1993) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)36544-5 · Cited by 138 · see citing works

LAP (NF‐IL‐6), a tissue‐specific transcriptional activator, is an inhibitor of hepatoma cell proliferation.

Buck, M., Turler, H., & Chojkier, M. (1994) · The EMBO Journal · doi:10.1002/j.1460-2075.1994.tb06328.x · Cited by 133 · see citing works

The Ability of C/EBPβ but Not C/EBPα To Synergize with an Sp1 Protein Is Specified by the Leucine Zipper and Activation Domain

Lee, Y., Williams, S. C., Baer, M., Sterneck, E., Gonzalez, F. J., & Johnson, P. F. (1997) · Molecular and Cellular Biology · doi:10.1128/mcb.17.4.2038 · Cited by 131 · see citing works

A Y-box consensus sequence is required for basal expression of the human multidrug resistance (mdr1) gene.

Goldsmith, M. E., Madden, M., Morrow, C. S., et al. (1993) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)53398-6 · Cited by 122 · see citing works

An optimized electroporation protocol applicable to a wide range of cell lines.

Baum, C., Forster, P., Hegewisch-Becker, S., et al. (1994) · PubMed · Cited by 112 · see citing works

A signal transduction pathway for activation of the mdr1 promoter involves the proto-oncogene c-raf kinase

Cornwell, M. M., & Smith, D. E. (1993) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)82262-1 · Cited by 107 · see citing works

Nuclear export of phosphorylated C/EBPβ mediates the inhibition of albumin expression by TNF‐α

Buck, M., Zhang, L., Halasz, N. A., Hunter, T., & Chojkier, M. (2001) · The EMBO Journal · doi:10.1093/emboj/20.23.6712 · Cited by 103 · see citing works

NF-IL6, a member of the C/EBP family of transcription factors, binds and trans-activates the human MDR1 gene promoter.

Combates, N. J., Rzepka, R. W., Chen, Y. N., & Cohen, D. (1994) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)43939-7 · Cited by 96 · see citing works

Identification of 5‘ and 3‘ sequences involved in the regulation of transcription of the human mdr1 gene in vivo.

Madden, M., Morrow, C. S., Nakagawa, M., et al. (1993) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)53095-7 · Cited by 96 · see citing works

Negative Regulation of MDR1 Promoter Activity in MCF-7, but Not in Multidrug Resistant MCF-7/Adr, Cells by Cross-Coupled NF-κB/p65 and c-Fos Transcription Factors and Their Interaction with the CAAT Region

Öğretmen, B., & Safa, A. R. (1999) · Biochemistry · doi:10.1021/bi982236+ · Cited by 85 · see citing works

12-O-Tetradecanoylphorbol-13-Acetate Activation of the MDR1 promoter Is Mediated by EGR1

McCoy, C., Smith, D. E., & Cornwell, M. M. (1995) · Molecular and Cellular Biology · doi:10.1128/mcb.15.11.6100 · Cited by 85 · see citing works

Prevalence of multidrug resistance related to activation of the mdr1 gene in human sarcoma mutants derived by single-step doxorubicin selection.

Chen, K. G., Jaffrézou, J. P., Fleming, W. H., et al. (1994) · PubMed · Cited by 85 · see citing works

DNA Elements Recognizing NF-Y and Sp1 Regulate the Human Multidrug-Resistance Gene Promoter

Sundseth, R., MacDonald, G. H., Ting, J. P. ‐., et al. (1997) · Molecular Pharmacology · doi:10.1124/mol.51.6.963 · Cited by 71 · see citing works

Reversal of Multidrug Resistance by Transduction of Cytokine Genes Into Human Colon Carcinoma Cells

Stein, U., Walther, W., & Shoemaker, R. H. (1996) · JNCI Journal of the National Cancer Institute · doi:10.1093/jnci/88.19.1383 · Cited by 68 · see citing works

Coordination of transcription factors, NF-Y and C/EBP beta, in the regulation of the mdr1b promoter.

Yu, L., Wu, Q., Yang, C. H., et al. (1995) · PubMed · Cited by 40 · see citing works

Purification and characterization of NF-R1 that regulates the expression of the human multidrug resistance (MDR1) gene

Ogura, M., Takatori, T., & Tsuruo, T. (1992) · Nucleic Acids Research · doi:10.1093/nar/20.21.5811 · Cited by 34 · see citing works

Phorbol ester induced MDR1 expression in K562 cells occurs independently of mitogen-activated protein kinase signaling pathways

Osborn, M. T., Berry, A., Ruberu, M. S., et al. (1999) · Oncogene · doi:10.1038/sj.onc.1202943 · Cited by 32 · see citing works

Transcriptional activity of the SHP-1 gene in MCF7 cells is differentially regulated by binding of NF-Y factor to two distinct CCAAT-elements

Xu, Y., Banville, D., Zhao, H., et al. (2001) · Gene · doi:10.1016/s0378-1119(01)00445-0 · Cited by 30 · see citing works

Construction of pYGK, an Actinobacillus actinomycetemcomitans-Escherichia coli shuttle vector

Brogan, J. M., Lally, E. T., & Demuth, D. R. (1996) · Gene · doi:10.1016/0378-1119(95)00792-x · Cited by 27 · see citing works

Molecular Pathways: Regulation and Therapeutic Implications of Multidrug Resistance

Chen, K. G., & Sikic, B. I. (2012) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-11-1590 · Cited by 197 · see citing works

The drug efflux pump MDR1 promotes intrinsic and acquired resistance to PROTACs in cancer cells

Kurimchak, A. M., Herrera-Montávez, C., Montserrat-Sangrà, S., Araiza-Olivera, D., Hu, J., Neumann-Domer, R., Kuruvilla, M., Bellacosa, A., Testa, J. R., Jin, J., et al. (2022) · Science Signaling · doi:10.1126/scisignal.abn2707 · Cited by 136 · see citing works

EBNA3C Directs Recruitment of RBPJ (CBF1) to Chromatin during the Process of Gene Repression in EBV Infected B Cells

Kalchschmidt, J., Gillman, A. C. T., Paschos, K., et al. (2016) · PLoS Pathogens · doi:10.1371/journal.ppat.1005383 · Cited by 32 · see citing works

DNA binding of NF‐Y: the effect of HMGI proteins depends upon the CCAAT box

Liberati, C., Sgarra, R., Manfioletti, G., et al. (1998) · FEBS Letters · doi:10.1016/s0014-5793(98)00905-3 · Cited by 14 · see citing works

Several distinct "CCAAT" box binding proteins coexist in eukaryotic cells.

Raymondjean, M., Cereghini, S., & Yaniv, M. (1988) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.85.3.757 · Cited by 206 · see citing works

Several distinct "CCAAT" box binding proteins coexist in eukaryotic cells (albumin/transcription factors/tissue specificity)

Raymondjean, M., Cereghini, S., & Yaniv, M. (2016)

A Role for CCAAT/Enhancer-Binding Protein β in the Basal Regulation of the Distal-Less 3 Gene Promoter in Placental Cells

Holland, M. P., Bliss, S. P., Berghorn, K. A., & Roberson, M. S. (2003) · Endocrinology · doi:10.1210/en.2003-0777 · Cited by 21 · see citing works