The DOI matches its Crossref record; 218 of the 219 references it cites were found in a registry or an index.
Organic Anion Transporters and Their Implications in Pharmacotherapy
Abstract
Organic anion transporters play an essential role in the distribution and excretion of numerous endogenous metabolic products and exogenous organic anions, including a host of widely prescribed drugs. The expression and activity of these transporters is influenced by several conditions, including transcriptional regulation, gender-dependent regulation, and genetic variation. In addition, the interaction of these transporters with several drugs and endogenous substrates has been well documented and may play a significant role in drug disposition and development of various disease states, such as nephrotoxicity and familial idiopathic hypouricemia. Members of this family of transporters have been localized mainly to the renal epithelia of various species. Much of the early research in this field has focused on their role in renal drug transport, yet increasing research on this family of transporters has localized them to various other epithelial tissues, including liver, brain, and placenta. Thus, an understanding of the role of these transporters in drug interaction and disposition in the kidney and other tissues may help in the determination of individual drug response, susceptibility to drug toxicity, and chemical carcinogenesis. This review seeks to summarize current knowledge of the molecular function and substrate profile of cloned organic anion transporters and to discuss recent progress in the understanding of the impact of interindividual variability, transcriptional regulation, and tissue distribution on individual drug response.
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“Organic anion transporters are highly expressed in renal epithelia (Emami Riedmaier et al., 2012).”
From Intracrine androgen biosynthesis, metabolism and action revisited (2018) · cites this paper as Emami Riedmaier et al., 2012
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Molecular identification of a renal urate–anion exchanger that regulates blood urate levels
Enomoto, A., Kimura, H. J., Chairoungdua, A., Shigeta, Y., Jutabha, P., Ho, S., Hosoyamada, M., Takeda, M., Sekine, T., Igarashi, T., et al. (2002) · Nature · doi:10.1038/nature742 · Cited by 1,535
PDZ Domains: Structural Modules for Protein Complex Assembly
Hung, A. Y., & Sheng, M. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.r100065200 · Cited by 699
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Expression Cloning and Characterization of a Novel Multispecific Organic Anion Transporter
Sekine, T., Watanabe, N., Hosoyamada, M., Kanai, Y., & Endou, H. (1997) · Journal of Biological Chemistry · doi:10.1074/jbc.272.30.18526 · Cited by 623
Functional pharmacogenetics/genomics of human cytochromes P450 involved in drug biotransformation
Zanger, U. M., Turpeinen, M., Klein, K., & Schwab, M. G. (2008) · Analytical and Bioanalytical Chemistry · doi:10.1007/s00216-008-2291-6 · Cited by 593
Self-citationHilgendorf, C., Ahlin, G., Seithel‐Keuth, A., Artursson, P., Ungell, A.-L. B., & Karlsson, J. E. (2007) · Drug Metabolism and Disposition · doi:10.1124/dmd.107.014902 · Cited by 592
The SLC22 drug transporter family
Koepsell, H., & Endou, H. (2004) · Pflügers Archiv - European Journal of Physiology · doi:10.1007/s00424-003-1089-9 · Cited by 521
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Gene Expression Levels and Immunolocalization of Organic Ion Transporters in the Human Kidney
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1 of the 219 references couldn’t be matched to a known paper.
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Transporters and Drug-Drug Interactions: Important Determinants of Drug Disposition and Effects
König, J., Müller, F., & Fromm, M. F. (2013) · Pharmacological Reviews · doi:10.1124/pr.113.007518 · Cited by 595
What do drug transporters really do?
Nigám, S. K. (2014) · Nature Reviews Drug Discovery · doi:10.1038/nrd4461 · Cited by 547
The Organic Anion Transporter (OAT) Family: A Systems Biology Perspective
Nigám, S. K., Bush, K. T., Martovetsky, G., Ahn, S.-Y., Liu, H. C., Richard, E., Bhatnagar, V., & Wu, W. (2014) · Physiological Reviews · doi:10.1152/physrev.00025.2013 · Cited by 526
Bioaccumulation of Perfluorinated Alkyl Acids: Observations and Models
Ng, C. A., & Hungerbühler, K. (2014) · Environmental Science & Technology · doi:10.1021/es404008g · Cited by 393
Blood Brain Barrier: A Challenge for Effectual Therapy of Brain Tumors
Bhowmik, A., Khan, R., & Ghosh, M. K. (2015) · BioMed Research International · doi:10.1155/2015/320941 · Cited by 303
Metadata
- Authors
- Emami Riedmaier, A., Nies, A. T., Schaeffeler, E., & Schwab, M.
- Affiliations
- Universitätsklinikum Tübingen (DE)
- Venue
- Pharmacological Reviews
- Publisher
- Elsevier BV
- Published
- 2012-07
- Volume
- 64
- Issue
- 3
- Pages
- 421-449
- ISSN
- 0031-6997 (ISSN-L)
- OpenAlex
- W2114622644
- Cited by
- 128
- References
- 219
- Citations by year
- 2026: 4 · 2025: 4 · 2024: 10 · 2023: 9 · 2022: 7 · 2021: 7 · 2020: 7 · 2019: 11 · 2018: 6 · 2017: 13 · 2016: 12 · 2015: 11 · 2014: 18 · 2013: 8 · 2012: 1
- FWCI
- 1.26
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Pharmacological Reviews (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Oncology › Drug Transport and Resistance Mechanisms
- Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmacology › Pharmacogenetics and Drug Metabolism
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Biochemistry › Amino Acid Enzymes and Metabolism
- Keywords
- organic anion transporters, renal drug transport, drug disposition, drug-drug interactions, nephrotoxicity, transcriptional regulation, interindividual variability, genetic variation, tissue distribution, drug toxicity, chemical carcinogenesis, substrate specificity
- MeSH terms
- Animals, Biological Transport, Drug Interactions, Drug Therapy, Pharmaceutical Preparations, Female, Gene Expression Regulation, Humans, Male, Organ Specificity, Sex Characteristics, Substrate Specificity, Tissue Distribution, Xenobiotics, Organic Anion Transporters, Drug-Related Side Effects and Adverse Reactions
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