International Union of Pharmacology. XXXV. The Glucagon Receptor Family

Different domains in the third intracellular loop of the GLP-1 receptor are responsible for Gαs and Gαi/Gαo activation

Hällbrink, M., Holmqvist, T. G., Olsson, M., Östenson, C., Efendić, S., & Langel, Ü. (2001) · Biochimica et Biophysica Acta (BBA) - Protein Structure and Molecular Enzymology · doi:10.1016/s0167-4838(00)00270-3 · Cited by 92

Glucagon-like Peptide-2 Receptor Activation Engages Bad and Glycogen Synthase Kinase-3 in a Protein Kinase A-dependent Manner and Prevents Apoptosis following Inhibition of Phosphatidylinositol 3-Kinase

Yusta, B., Estall, J. L., & Drucker, D. J. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m201358200 · Cited by 92

Characterization of Deletion and Truncation Mutants of the Rat Glucagon Receptor

Unson, C. G., Cypess, A. M., Kim, H. N., Goldsmith, P. K., Carruthers, C. J. L., Merrifield, R. B., & Sakmar, T. P. (1995) · Journal of Biological Chemistry · doi:10.1074/jbc.270.46.27720 · Cited by 91

The Effect of the Hyperglycemic Factor of the Pancreas and of Epinephrine on Glycogenolysis

Sutherland, E. W. (1950) · Elsevier eBooks · doi:10.1016/b978-0-12-571105-0.50016-2 · Cited by 91

Identification of glucagon-producing cells (A cells) in dog gastric mucosa

Baetens, D. (1976) · The Journal of Cell Biology · doi:10.1083/jcb.69.2.455 · Cited by 90

The truncated metabolite GLP-2 (3–33) interacts with the GLP-2 receptor as a partial agonist

Thulesen, J., Knudsen, L. B., Hartmann, B., Hastrup, S., Kissow, H., Jeppesen, P. B., Ørskov, C., Holst, J. J., & Poulsen, S. S. (2002) · Regulatory Peptides · doi:10.1016/s0167-0115(01)00316-0 · Cited by 90

Glucose-Dependent Insulinotropic Polypeptide Is a Growth Factor for (INS-1) Cells by Pleiotropic Signaling

Trumper, A. (2001) · Molecular Endocrinology · doi:10.1210/me.15.9.1559 · Cited by 90

A glucagon fragment is responsible for the inhibition of the liver Ca2+ pump by glucagon

Mallat, A., Pavoine, C., Dufour, M., Lotersztajn, S., BATAILLE, D., & Pecker, F. (1987) · Nature · doi:10.1038/325620a0 · Cited by 89

Secretin: structure of the precursor and tissue distribution of the mRNA.

Kopin, A. S., Wheeler, M. B., & Leiter, A. B. (1990) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.87.6.2299 · Cited by 89

The expression of growth hormone-releasing hormone (GHRH) and splice variants of its receptor in human gastroenteropancreatic carcinomas

Busto, R., Schally, A. V., Varga, J. L., Garcia-Fernandez, M. O., Groot, K., Armatis, P. E., & Szepesházi, K. (2002) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.182433099 · Cited by 86

Identification of alternatively spliced messenger ribonucleic acid encoding truncated growth hormone-releasing hormone receptor in human pituitary adenomas

Hashimoto, K., Koga, M., Motomura, T., Kasayama, S., Kouhara, H., Ohnishi, T., Arita, N., Hayakawa, T., Sato, B., & Kishimoto, T. (1995) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.80.10.2933 · Cited by 86

Novel signal transduction and peptide specificity of glucagon-like peptide receptor in 3T3-L1 adipocytes

Montrose‐Rafizadeh, C., Yang, H. M., Wang, Y., Roth, J., Montrose, M. H., & Adams, L. G. (1997) · Journal of Cellular Physiology · doi:10.1002/(sici)1097-4652(199709)172:3<275::aid-jcp1>3.0.co;2-l · Cited by 84

Identification of a bioactive domain in the amino-terminus of glucose-dependent insulinotropic polypeptide (GIP)

Hinke, S. A., Manhart, S., Pamir, N., Demuth, H.-U., Gelling, R. W., Pederson, R. A., & McIntosh, C. H. S. (2001) · Biochimica et Biophysica Acta (BBA) - Protein Structure and Molecular Enzymology · doi:10.1016/s0167-4838(01)00181-9 · Cited by 84

In Vivo and in Vitro Degradation of Glucagon-Like Peptide-2 in Humans

Hartmann, B. (2000) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.85.8.2884 · Cited by 84

Biological activity of GLP-1-analogues with N-terminal modifications

Siegel, E. G., Gallwitz, B., Scharf, G., Mentlein, R., Morys‐Wortmann, C., Fölsch, U. R., Schrezenmeir, J., Drescher, K., & Schmidt, W. E. (1999) · Regulatory Peptides · doi:10.1016/s0167-0115(98)00155-4 · Cited by 83

Structure and Regulation of the Human Growth Hormone-Releasing Hormone Receptor Gene

Petersenn, S., Rasch, A. C., Heyens, M., & Schulte, H. M. (1998) · Molecular Endocrinology · doi:10.1210/me.12.2.233 · Cited by 83

Ion channels and the signal transduction pathways in the regulation of growth hormone secretion

Chen, C., Vincent, J., & Clarke, I. J. (1994) · Trends in Endocrinology and Metabolism · doi:10.1016/1043-2760(94)p3080-q · Cited by 82

Glucagon-Like Peptide 1 Elevates Cytosolic Calcium in Pancreatic -Cells Independently of Protein Kinase A

Bode, H., Moormann, B., Dabew, R., & Göke, B. (1999) · Endocrinology · doi:10.1210/endo.140.9.6947 · Cited by 82

Glucocorticoids Regulate Pituitary Growth Hormone-Releasing Hormone Receptor Messenger Ribonucleic Acid Expression

Miller, T., & Mayo, K. E. (1997) · Endocrinology · doi:10.1210/endo.138.6.5184 · Cited by 81

The Rat Growth Hormone-Releasing Hormone Receptor Gene: Structure, Regulation, and Generation of Receptor Isoforms with Different Signaling Properties1

Miller, T., Godfrey, P. A., DeAlmeida, V. I., & Mayo, K. E. (1999) · Endocrinology · doi:10.1210/endo.140.9.6977 · Cited by 81

Growth Hormone-Releasing Hormone Stimulates Mitogen-Activated Protein Kinase

Pombo, C. M., Zalvide, J. B., Gaylinn, B. D., & Diéguez, C. (2000) · Endocrinology · doi:10.1210/endo.141.6.7513 · Cited by 79

Secretin stimulates cyclic AMP and inositol trisphosphate production in rat pancreatic acinar tissue by two fully independent mechanisms.

Trimble, E. R., Bruzzone, R., Biden, T. J., Meehan, C. J., Andreu, D., & Merrifield, R. B. (1987) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.84.10.3146 · Cited by 79

Role of Receptor Phosphorylation in Desensitization and Internalization of the Secretin Receptor

Holtmann, M. H., Roettger, B. F., Pinon, D. I., & Miller, L. J. (1996) · Journal of Biological Chemistry · doi:10.1074/jbc.271.38.23566 · Cited by 79

A Small Molecule Ligand of the Glucagon-like Peptide 1 Receptor Targets Its Amino-terminal Hormone Binding Domain

Tibaduiza, E. C., Chen, C., & Beinborn, M. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m106692200 · Cited by 78

Synthesis and expression of a gene for the rat glucagon receptor. Replacement of an aspartic acid in the extracellular domain prevents glucagon binding.

Carruthers, C. J. L., Unson, C. G., Kim, H. N., & Sakmar, T. P. (1994) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)62047-8 · Cited by 78

Cloning and sequence analysis of the murine glucagon receptor-encoding gene

Burcelin, R., Li, J., & Charron, M. J. (1995) · Gene · doi:10.1016/0378-1119(95)00472-i · Cited by 78

Ontogeny of the Glucagon-Like Peptide-2 Receptor Axis in the Developing Rat Intestine

Lovshin, J. A., Yusta, B., Iliopoulos, I. D., Migirdicyan, A., Dableh, L. J., Brubaker, P. L., & Drucker, D. J. (2000) · Endocrinology · doi:10.1210/endo.141.11.7773 · Cited by 78

Internalization and Homologous Desensitization of the GLP-1 Receptor Depend on Phosphorylation of the Receptor Carboxyl Tail at the Same Three Sites

Widmann, C., Dolci, W., & Thorens, B. (1997) · Molecular Endocrinology · doi:10.1210/mend.11.8.9959 · Cited by 77

Properties of Chimeric Secretin and VIP Receptor Proteins Indicate the Importance of the N-Terminal Domain for Ligand Discrimination

Vilardaga, J., DENEEF, P., Dipaolo, E., Bollen, A., Waelbroeck, M., & Robberecht, P. (1995) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.1995.1895 · Cited by 77

Human Glucagon-Like Peptide-1 Receptor Gene: Localization to Chromosome Band 6p21 by Fluorescence In Situ Hybridization and Linkage of a Highly Polymorphic Simple Tandem Repeat DNA Polymorphism to Other Markers on Chromosome 6

Stoffel, M., Espinosa, R., Beau, M. M. L., & Bell, G. I. (1993) · Diabetes · doi:10.2337/diab.42.8.1215 · Cited by 77

Cloning and Expression of a Human Glucagon Receptor

Macneil, D. J., Occi, J., Hey, P. J., Strader, C. D., & Graziano, M. P. (1994) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.1994.1046 · Cited by 75

The Mutant Growth Hormone-Releasing Hormone (GHRH) Receptor of the Little Mouse Does Not Bind GHRH1

Gaylinn, B. D., DeAlmeida, V. I., Lyons, C. E., Wu, K. C., Mayo, K. E., & Thorner, M. O. (1999) · Endocrinology · doi:10.1210/endo.140.11.7092 · Cited by 74

Glucose-Dependent Insulinotropic Polypeptide Stimulation of Lipolysis in Differentiated 3T3-L1 Cells: Wortmannin-Sensitive Inhibition by Insulin**This work was supported by grants from Zymogenetics Inc. (Seattle, WA), the Medical Research Council of Canada (5–90007-RAP/CHSM) and the Canadian Diabetes Association (CHSM/RAP).

McIntosh, C. H. S., Bremsak, I., Lynn, F. C., Gill, R., Hinke, S. A., Gelling, R., Nian, C., McKnight, G., Jaspers, S., & Pederson, R. A. (1999) · Endocrinology · doi:10.1210/endo.140.1.6464 · Cited by 73

Homologous Down-Regulation of Growth Hormone-Releasing Hormone Receptor Messenger Ribonucleic Acid Levels

Aleppo, G., Moskal, S. F., Grandis, P. A. D., Kineman, R. D., & Frohman, L. A. (1997) · Endocrinology · doi:10.1210/endo.138.3.5029 · Cited by 72

Glucose-dependent insulinotropic peptide: structure of the precursor and tissue-specific expression in rat.

Tseng, C., Jarboe, L. A., Landau, S. B., Williams, E. K., & Wolfe, M. M. (1993) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.90.5.1992 · Cited by 72

Naturally occurring products of proglucagon 111-160 in the porcine and human small intestine.

Buhl, T., Thim, L., Kofod, H., Ørskov, C., Harling, H., & Holst, J. J. (1988) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)68350-4 · Cited by 71

Glucose-dependent insulinotropic peptide signaling pathways in endothelial cells

Zhong, Q., Bollag, R. J., Dransfield, D. T., Gasalla-Herraiz, J., Ding, K.-H., Min, L., & Isales, C. M. (2000) · Peptides · doi:10.1016/s0196-9781(00)00287-4 · Cited by 71

Glucagon-like peptide-1 (GLP-1) releases thyrotropin (TSH): characterization of binding sites for GLP-1 on alpha-TSH cells

Beak, S. A., Small, C. J., Иловайская, И. А., Hurley, J. D., Ghatei, M. A., Bloom, S. R., & Smith, D. M. (1996) · Endocrinology · doi:10.1210/endo.137.10.8828468 · Cited by 71

Discovery of amino acid variants in the human glucose-dependent insulinotropic polypeptide (GIP) receptor: the impact on the pancreatic beta cell responses and functional expression studies in Chinese hamster fibroblast cells

Almind, K., Ambye, L., Urhammer, S. A., Hansen, T. F., Echwald, S. M., Holst, J. J., Gromada, J., Thorens, B., & Pedersen, O. B. (1998) · Diabetologia · doi:10.1007/s001250051051 · Cited by 68

Gene Expression of the Receptor for Growth-Hormone-Releasing Hormone Is Physiologically Regulated by Glucocorticoids and Estrogen

Lam, K. S. L., Lee, M. F., Tam, S. P., & Srivastava, G. (2008) · Neuroendocrinology · doi:10.1159/000127075 · Cited by 68

Free Intracellular Ca2+Concentration ([Ca2+]i) and Growth Hormone Release from Purified Rat Somatotrophs. I. GH-Releasing Factor-Induced Ca2+Influx Raises [Ca2+]i*

Lussier, B., French, M. B., Moor, B. C., & Kraicer, J. (1991) · Endocrinology · doi:10.1210/endo-128-1-570 · Cited by 68

The Effects of Glucagon-like Peptide-I (GLP-I) on Hormone Secretion from Isolated Human Pancreatic Islets

Fehmann, H. C., Hering, B. J., Wolf, M.-J., Brandhorst, H., Brandhorst, D., Bretzel, R. G., Federlin, K., & Göke, B. (1995) · Pancreas · doi:10.1097/00006676-199508000-00014 · Cited by 67

Immunoneutralization of endogenous glucagon-like peptide-2 reduces adaptive intestinal growth in diabetic rats

Hartmann, B., Thulesen, J., Hare, K. J., Kissow, H., Ørskov, C., Poulsen, S. S., & Holst, J. J. (2002) · Regulatory Peptides · doi:10.1016/s0167-0115(02)00013-7 · Cited by 66

NH2-terminally modified gastric inhibitory polypeptide exhibits amino-peptidase resistance and enhanced antihyperglycemic activity.

O'Harte, F. P. M., Mooney, M. H., & Flatt, P. R. (1999) · Diabetes · doi:10.2337/diabetes.48.4.758 · Cited by 66

Oxyntomodulin Inhibits Food Intake in the Rat

Cl, D. (2001) · Endocrinology · doi:10.1210/en.142.10.4244 · Cited by 66

Cloning and Functional Expression of a Human Glucagon-like Peptide-1 Receptor

Graziano, M. P., Hey, P. J., Borkowski, D., Chicchi, G. G., & Strader, C. D. (1993) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.1993.2226 · Cited by 65

Characterization of glucagon-like peptide-1 receptor-binding determinants

Xiao, Q. F., Jeng, W., & Wheeler, M. B. (2000) · Journal of Molecular Endocrinology · doi:10.1677/jme.0.0250321 · Cited by 65

A New Pathway for Glucose-dependent Insulinotropic Polypeptide (GIP) Receptor Signaling

Ehses, J. A., Lee, S. S. T., Pederson, R. A., & McIntosh, C. H. S. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m103023200 · Cited by 64

Characterization of high‐affinity receptors for truncated glucagon‐like peptide‐1 in rat gastric glands

UTTENTHAL, L. O., & Blázquez, E. (1990) · FEBS Letters · doi:10.1016/0014-5793(90)80173-g · Cited by 64

A randomized, double-blind, placebo-controlled trial of single-dose intravenous secretin as treatment for children with autism

Coniglio, S. J., Lewis, J. D., Lang, C. B., Burns, T. G., Subhani-Siddique, R., Weintraub, A. H., Schub, H. S., & Holden, E. W. (2001) · The Journal of Pediatrics · doi:10.1067/mpd.2001.112474 · Cited by 63

Osteoblast-Derived Cells Express Functional Glucose-Dependent Insulinotropic Peptide Receptors

Bollag, R. J. (2000) · Endocrinology · doi:10.1210/en.141.3.1228 · Cited by 63

Identification of Two Missense Mutations in the GIP Receptor Gene: A Functional Study and Association Analysis with NIDDM: No Evidence of Association with Japanese NIDDM Subjects

Kubota, A., Yamada, Y., HAYAMI, T., Yasuda, K., Someya, Y., Ihara, Y., Kagimoto, S., Watanabe, R., Taminato, T., Tsuda, K., et al. (1996) · Diabetes · doi:10.2337/diab.45.12.1701 · Cited by 62

A synthetic glucagon-like peptide-1 analog with improved plasma stability

Ritzel, U., Leonhardt, U., Ottleben, M., Rühmann, A., Eckart, K., Spiess, J., & Ramadori, G. P. (1998) · Journal of Endocrinology · doi:10.1677/joe.0.1590093 · Cited by 61

Glucagon-mediated Ca2+signaling in BHK cells expressing cloned human glucagon receptors

Hansen, L., Gromada, J., Bouchelouche, P. N., Whitmore, T., Jelinek, L., Kindsvogel, W., & Nishimura, E. (1998) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.1998.274.6.c1552 · Cited by 61

Silencing of secretin receptor function by dimerization with a misspliced variant secretin receptor in ductal pancreatic adenocarcinoma.

Ding, W.-Q., Cheng, Z. J., McElhiney, J., Kuntz, S. M., & Miller, L. J. (2002) · PubMed · Cited by 61

Elimination of glucagon-like peptide 1R signaling does not modify weight gain and islet adaptation in mice with combined disruption of leptin and GLP-1 action.

Scrocchi, L. A., Hill, M. E., Saleh, J., Perkins, B. A., & Drucker, D. J. (2000) · Diabetes · doi:10.2337/diabetes.49.9.1552 · Cited by 60

Production of a growth hormone-releasing hormone-like peptide and its mRNA by human lymphocytes.

Stephanou, A., Knight, R. A., & Lightman, S. L. (1991) · PubMed · Cited by 59

Glucagonlike peptide-2 analogue enhances intestinal mucosal mass after ischemia and reperfusion

Prasad, R., Alavi, K., & Schwartz, M. Z. (2000) · Journal of Pediatric Surgery · doi:10.1016/s0022-3468(00)90040-x · Cited by 59

The Growth-Hormone-Releasing Hormone Receptor: Signal Transduction, Gene Expression, and Physiological Function in Growth Regulationa

Mayo, K. E., Miller, T., DeAlmeida, V. I., Zheng, J., & Godfrey, P. A. (2006) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.1996.tb17483.x · Cited by 59

Identification of an essential serine residue in glucagon: implication for an active site triad.

Unson, C. G., & Merrifield, R. B. (1994) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.91.2.454 · Cited by 58

Developmental regulation of pituitary growth hormone-releasing hormone receptor gene expression in the rat

Korytko, A. I., Zeitler, P. S., & Cuttler, L. (1996) · Endocrinology · doi:10.1210/endo.137.4.8625907 · Cited by 58

Signal transduction of the GLP‐1‐receptor cloned from a human insulinoma

Eyll, B. V., Lankat–Buttgereit, B., Bode, H., Göke, R., & Göke, B. (1994) · FEBS Letters · doi:10.1016/0014-5793(94)00553-2 · Cited by 58

Regulation of Glucagon Receptor mRNA in Cultured Primary Rat Hepatocytes by Glucose and cAMP

Abrahamsen, N., Lundgren, K., & Nishimura, E. (1995) · Journal of Biological Chemistry · doi:10.1074/jbc.270.26.15853 · Cited by 57

GIP6–30amide contains the high affinity binding region of GIP and is a potent inhibitor of GIP1–42action in vitro

Gelling, R. W., Coy, D. H., Pederson, R. A., Wheeler, M. B., Hinke, S. A., Kwan, T., & McIntosh, C. H. S. (1997) · Regulatory Peptides · doi:10.1016/s0167-0115(97)00009-8 · Cited by 57

Regulation of glucagon and glucagon-like peptide-1 receptor messenger ribonucleic acid expression in cultured rat pancreatic islets by glucose, cyclic adenosine 3',5'-monophosphate, and glucocorticoids

Abrahamsen, N., & Nishimura, E. (1995) · Endocrinology · doi:10.1210/endo.136.4.7534705 · Cited by 56

Identification of human growth hormone-releasing hormone receptor splicing variants

Tang, J., Lagacé, G., Castagné, J., & COLLU, R. (1995) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.80.8.7629234 · Cited by 55

Structure and functional expression of a complementary DNA for porcine growth hormone-releasing hormone receptor

Hsiung, H. M., Smith, D. P., Zhang, X.-Y., Bennett, T., Rosteck, P. R., & Lai, M. (1993) · Neuropeptides · doi:10.1016/0143-4179(93)90062-f · Cited by 55

Two Cytoplasmic Loops of the Glucagon Receptor Are Required to Elevate cAMP or Intracellular Calcium

Cypess, A. M., Unson, C. G., Wu, C.-R., & Sakmar, T. P. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.27.19455 · Cited by 54

Investigation of Growth Hormone Releasing Hormone Receptor Structure and Activity Using Yeast Expression Technologies

Kajkowski, E. M., Price, L. A., Pausch, M. H., Young, K. H., & Ozenberger, B. A. (1997) · Journal of Receptors and Signal Transduction · doi:10.3109/10799899709036610 · Cited by 54

Signal transmission after GLP-1(7-36)amide binding in RINm5F cells

Göke, R., Trautmann, M., Haus, E., Richter, G., Fehmann, H. C., Arnold, R., & Göke, B. (1989) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.1989.257.3.g397 · Cited by 54

Rat parietal cell receptors for GLP-1-(7-36) amide: northern blot, cross-linking, and radioligand binding

Schmidtler, J., Dehne, K., Allescher, H. D., SCHUSDZIARRA, V., Claßen, M., Holst, J. J., Polack, A., & Schepp, W. (1994) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.1994.267.3.g423 · Cited by 54

Molecular cloning of a cDNA encoding for the GLP-1 receptor expressed in rat lung

Lankat–Buttgereit, B., Göke, R., Fehmann, H.-C., Richter, G., & Göke, B. (2009) · Experimental and Clinical Endocrinology & Diabetes · doi:10.1055/s-0029-1211301 · Cited by 52

Glucagon receptors along the nephron: [125I]glucagon binding in rat tubules

Butlen, D., & Morel, F. (1985) · Pflügers Archiv - European Journal of Physiology · doi:10.1007/bf00585347 · Cited by 52

Tissue-Specific and Glucose-Dependent Expression of Receptor Genes for Glucagon and Glucagon-Like Peptide-1 (GLP-1)

Yamato, E., Ikegami, H., Takekawa, K., Fujisawa, T., Nakagawa, Y., Hamada, Y., Uedo, H., & Ogihara, T. (1997) · Hormone and Metabolic Research · doi:10.1055/s-2007-978985 · Cited by 52

Localization of the Domains Involved in Ligand Binding and Activation of the Glucose-Dependent Insulinotropic Polypeptide Receptor

Gelling, R. W., Wheeler, M. B., Xue, J., Gyomorey, S., Nian, C., Pederson, R. A., & McIntosh, C. H. S. (1997) · Endocrinology · doi:10.1210/endo.138.6.9104 · Cited by 51

Gastric Inhibitory Polypeptide Activates MAP Kinase through the Wortmannin-Sensitive and -Insensitive Pathways

Kubota, A., Yamada, Y., Yasuda, K., Someya, Y., Ihara, Y., Kagimoto, S., Watanabe, R., Kuroe, A., Ishida, H., & Seino, Y. (1997) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.1997.6743 · Cited by 50

Characterization of GIP(1–30) and GIP(1–42) as stimulators of proinsulin gene transcription

Fehmann, H. C., & Göke, B. (1995) · Peptides · doi:10.1016/0196-9781(95)00090-7 · Cited by 50

Characterization of the receptor for glucagon-like peptide-1(7–36)amide on plasma membranes from rat insulinoma-derived cells by covalent cross-linking

Göke, R., Cole, T. S., & Conlon, J. M. (1989) · Journal of Molecular Endocrinology · doi:10.1677/jme.0.0020093 · Cited by 50

Improved glycaemic control in obese diabetic ob/ob mice using N-terminally modified gastric inhibitory polypeptide

O'Harte, F. P. M., Mooney, M., Kelly, C. M., & Flatt, P. R. (2000) · Journal of Endocrinology · doi:10.1677/joe.0.1650639 · Cited by 50

A Role for Receptor Kinases in the Regulation of Class II G Protein-coupled Receptors

Shetzline, M. A., Premont, R. T., Walker, J. K. L., Vigna, S. R., & Caron, M. G. (1998) · Journal of Biological Chemistry · doi:10.1074/jbc.273.12.6756 · Cited by 49

Cloning and Characterization of the 5′-Flanking Region of the Human Growth Hormone-releasing Hormone Receptor Gene

Iguchi, G., Okimura, Y., Takahashi, T., Mizuno, I., Fumoto, M., Takahashi, Y., Kaji, H., Abe, H., & Chihara, K. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.17.12108 · Cited by 48

Growth Hormone (GH)-Releasing Factor Differentially Activates Cyclic Adenosine 3',5'-Monophosphate- and Inositol Phosphate-Dependent Pathways to Stimulate GH Release in Two Porcine Somatotrope Subpopulations

Ramírez, J. L., Castano, J. P., Torronteras, R., Martínez‐Fuentes, A. J., Frawley, L. S., García‐Navarro, S., & Gracia‐Navarro, F. (1999) · Endocrinology · doi:10.1210/endo.140.4.6613 · Cited by 47

Roles of Specific Extracellular Domains of the Glucagon Receptor in Ligand Binding and Signaling

Unson, C. G., Wu, C.-R., Jiang, Y., Yoo, B., Cheung, C. P., Sakmar, T. P., & Merrifield, R. B. (2002) · Biochemistry · doi:10.1021/bi025711j · Cited by 46

Thyroid hormone and glucocorticoid regulation of pituitary growth hormone-releasing hormone receptor gene expression

Korytko, A. I., & Cuttler, L. (1997) · Journal of Endocrinology · doi:10.1677/joe.0.152r013 · Cited by 46

Hamster Gastric Inhibitory Polypeptide Receptor Expressed in Pancreatic Islets and Clonal Insulin-Secreting Cells: Its Structure and Functional Properties

Yasuda, K., Inagaki, N., Yamada, Y., Kubota, A., Seino, S., & Seino, Y. (1994) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.1994.2844 · Cited by 46

Specific binding of synthetic human pancreatic growth hormone releasing factor (1–40-OH) to bovine anterior pituitaries

Veliçelebi, G., Santacroce, T. M., & Harpold, M. M. (1985) · Biochemical and Biophysical Research Communications · doi:10.1016/0006-291x(85)90567-4 · Cited by 45

Five Out of Six Tryptophan Residues in the N -Terminal Extracellular Domain of the Rat GLP-1 Receptor Are Essential for its Ability to Bind GLP-1

Wilmen, A., Eyll, B. V., Göke, B., & Göke, R. (1997) · Peptides · doi:10.1016/s0196-9781(96)00321-x · Cited by 45

The Growth Hormone (GH)-Axis of GH Receptor/Binding Protein Gene-Disrupted and Metallothionein-Human GH-Releasing Hormone Transgenic Mice: Hypothalamic Neuropeptide and Pituitary Receptor Expression in the Absence and Presence of GH Feedback

Peng, X.-D., Park, S., Gadelha, M. R., Coschigano, K. T., Kopchick, J. J., Frohman, L. A., & Kineman, R. D. (2001) · Endocrinology · doi:10.1210/endo.142.3.8005 · Cited by 45

Sexually Dimorphic Expression of Pituitary Growth Hormone-Releasing Factor Receptor in the Rat

Ono, M., Miki, N., Murata, Y., et al. (1995) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.1995.2728 · Cited by 44

AQUEOUS EXTRACTS OF PANCREAS

Piper, H. A., Allen, R. S., & Murlin, J. R. (1923) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)85473-4 · Cited by 44

Identification of Alkylidene Hydrazides as Glucagon Receptor Antagonists

Ling, A. L., Hong, Y., González, J., Gregor, V. E., Polinsky, A., Kuki, A., Shi, S., Teston, K., Murphy, D. E., Porter, J. W., et al. (2001) · Journal of Medicinal Chemistry · doi:10.1021/jm000547o · Cited by 42

Characterization of receptors for glucagon‐like peptide‐1(7–36) amide on rat lung membranes

Richter, G., Göke, R., Göke, B., & Arnold, R. (1990) · FEBS Letters · doi:10.1016/0014-5793(90)80292-q · Cited by 42

Effect of truncated glucagon‐like peptide 1 on cAMP in rat gastric glands and HGT‐1 human gastric cancer cells

Hansen, Å., Gespach, C. P., Rosselin, G., & Holst, J. J. (1988) · FEBS Letters · doi:10.1016/0014-5793(88)80297-7 · Cited by 41

Assessment of the Role of Interstitial Glucagon in the Acute Glucose Secretory Responsiveness of In Situ Pancreatic β-Cells

Moens, K., Berger, V., Ahn, J., Schravendijk, C. V., Hruby, V. J., PIPELEERS, D. G., & Schuit, F. C. (2002) · Diabetes · doi:10.2337/diabetes.51.3.669 · Cited by 41

Regional distribution of growth hormone-releasing hormone (GHRH) receptor mRNA in the rat brain.

Takahashi, T., Okimura, Y., Yoshimura, K., Shigeyoshi, Y., Kaji, H., Abe, H., & Chihara, K. (1995) · Endocrinology · doi:10.1210/endo.136.10.7664697 · Cited by 40

Structure‐function analysis of a series of glucagon‐like peptide‐1 analogs

Parker, J. C., Andrews, K. M., Rescek, D. M., Massefski, W. W., Andrews, G. C., Contillo, L. G., Stevenson, R. W., Singleton, D. H., & SULESKE, R. T. (1998) · Journal of Peptide Research · doi:10.1111/j.1399-3011.1998.tb00664.x · Cited by 40

Human glucagon receptor antagonists based on alkylidene hydrazides

Ling, A. L., Plewe, M. B., González, J., Madsen, P., Sams, C. K., Lau, J. F., Gregor, V. E., Murphy, D., Teston, K., Kuki, A., et al. (2002) · Bioorganic & Medicinal Chemistry Letters · doi:10.1016/s0960-894x(01)00819-8 · Cited by 40

Human Studies with Glucagon-like-peptide-1: Potential of the Gut Hormone for Clinical Use

Byrne, M. M., & Göke, B. (1996) · Diabetic Medicine · Cited by 39

Potential targets for glucagon-like peptide 2 (GLP-2) in the rat: distribution and binding of i.v. injected 125I-GLP-2

Thulesen, J., Hartmann, B., Ørskov, C., Jeppesen, P. B., Holst, J. J., & Poulsen, S. S. (2000) · Peptides · doi:10.1016/s0196-9781(00)00305-3 · Cited by 39

Glycosylation of the GLP-1 receptor is a prerequisite for regular receptor function

Göke, R., Just, R., Lankat–Buttgereit, B., & Göke, B. (1994) · Peptides · doi:10.1016/0196-9781(94)90095-7 · Cited by 38

Miniglucagon (Glucagon 19–29), a Potent and Efficient Inhibitor of Secretagogue-induced Insulin Release through a Ca2+Pathway

Dalle, S., Smith, P. A., Blache, P., Le‐Nguyen, D., Brigand, L. L., Bergeron, F., Ashcroft, F. M., & BATAILLE, D. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.16.10869 · Cited by 37

Discovery of 5-Hydroxyalkyl-4-phenylpyridines as a New Class of Glucagon Receptor Antagonists

Ladouceur, G. H., Cook, J. H., Doherty, E. M., Schoen, W. R., MacDougall, M. L., & Livingston, J. N. (2002) · Bioorganic & Medicinal Chemistry Letters · doi:10.1016/s0960-894x(01)00766-1 · Cited by 37

Maintaining Gut Integrity During Parenteral Nutrition of Tumor-Bearing Rats: Effects of Glucagon-Like Peptide 2

Chance, W. T., Sheriff, S., Foley‐Nelson, T., Thomas, I., & Balasubramaniam, A. (2000) · Nutrition and Cancer · doi:10.1207/s15327914nc372_15 · Cited by 37

Glucagon and Liver Glycogen Metabolism

Stalmans, W. (1983) · Handbook of experimental pharmacology · doi:10.1007/978-3-642-68866-9_14 · Cited by 36

Characterization of the Carboxyl-terminal Domain of the Rat Glucose-dependent Insulinotropic Polypeptide (GIP) Receptor

Wheeler, M. B., Gelling, R. W., Hinke, S. A., Tu, B., Pederson, R. A., Lynn, F. C., Ehses, J. A., & McIntosh, C. H. S. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.35.24593 · Cited by 36

Miniglucagon (Glucagon 19-29)

Dalle, S., Fontès, G., Lajoix, A., Brigand, L. L., Gross, R., Ribes, G., Dufour, M., Barry, L., Le‐Nguyen, D., & BATAILLE, D. (2002) · Diabetes · doi:10.2337/diabetes.51.2.406 · Cited by 36

Role of the Glucagon Receptor COOH-Terminal Domain in Glucagon-Mediated Signaling and Receptor Internalization

Buggy, J. J., Heurich, R. O., MacDougall, M. L., et al. (1997) · Diabetes · doi:10.2337/diab.46.9.1400 · Cited by 35

Characterization of glucagon‐like peptide‐I(7–36)amide receptors of rat lung membranes by covalent cross‐linking

Richter, G., Göke, R., Göke, B., Schmidt, H., & Arnold, R. (1991) · FEBS Letters · doi:10.1016/0014-5793(91)80303-k · Cited by 35

Glucagon-like peptide-1 receptor stimulation increases blood pressure and heart rate and activates autonomic regulatory neurons

Yamamoto, H., Lee, C. E., Marcus, J., Williams, T. D., Overton, J. M., Lopez, M. E., Hollenberg, A. N., Baggio, L. L., Saper, C. B., Drucker, D. J., et al. (2002) · Journal of Clinical Investigation · doi:10.1172/jci200215595 · Cited by 35

Encapsulated, Genetically Engineered Cells, Secreting Glucagon‐like Peptide‐1 for the Treatment of Non‐insulin‐dependent Diabetes Mellitus

Burcelin, R., ROLLAND, E., Dolci, W., GERMAIN, S., CARREL, V., & Thorens, B. (1999) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.1999.tb08510.x · Cited by 34

Identification of a Glucose Response Element in the Promoter of the Rat Glucagon Receptor Gene

Portois, L., Maget, B., Tastenoy, M., Perret, J., & Svoboda, M. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.12.8181 · Cited by 34

Neuroendocrine Function and Response to Stress in Mice with Complete Disruption of Glucagon-Like Peptide-1 Receptor Signaling

MacLusky, N. J. (2000) · Endocrinology · doi:10.1210/en.141.2.752 · Cited by 34

Gene Expression of the Human Glucagon-Like Peptide-1 Receptor Is Regulated by Sp1 and Sp3

Wildhage, I., Trusheim, H., Göke, B., & Lankat–Buttgereit, B. (1999) · Endocrinology · doi:10.1210/endo.140.2.6512 · Cited by 33

Differential in Vivo Regulation of the Pituitary Growth Hormone-Releasing Hormone (GHRH) Receptor by GHRH in Young and Aged Rats

Girard, N., Boulanger, L., Denis, S., & Gaudreau, P. (1999) · Endocrinology · doi:10.1210/en.140.6.2836 · Cited by 33

Solubilization of active GLP‐1 (7–36)amide receptors from RINm5F plasma membranes

Göke, R., Oltmer, B., Sheikh, S. P., & Göke, B. (1992) · FEBS Letters · doi:10.1016/0014-5793(92)80852-8 · Cited by 32

Glucagon and Its Receptor in Various Tissues

Christophe, J. (2006) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.1996.tb17471.x · Cited by 32

Glucagon-Like Peptide 2

Drucker, D. J. (2001) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.86.4.1759 · Cited by 32

Insertion of an N-Terminal 6-Aminohexanoic Acid after the 7 Amino Acid Position of Glucagon-Like Peptide-1 Produces a Long-Acting Hypoglycemic Agent

Doyle, M. E., Greig, N. H., Holloway, H. W., Betkey, J. A., Bernier, M., & Egan, J. M. (2001) · Endocrinology · doi:10.1210/endo.142.10.8410 · Cited by 31

Human pancreatic GRF stimulates phosphatidylinositol labeling in cultured anterior pituitary cells

Canonico, P. L., Cronin, M. J., Thorner, M. O., et al. (1983) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.1983.245.6.e587 · Cited by 31

A novel peptide from the growth hormone releasing hormone gene stimulates Sertoli cell activity.

Breyer, P. R., Rothrock, J. K., Beaudry, N., et al. (1996) · Endocrinology · doi:10.1210/endo.137.5.8612561 · Cited by 30

Gastric inhibitory polypeptide stimulates glucocorticoid secretion in rats, acting through specific receptors coupled with the adenylate cyclase-dependent signaling pathway

Mazzocchi, G., Rebuffat, P., Meneghelli, V., Malendowicz, L. K., Tortorella, C., Gottardo, G., & Nussdorfer, G. G. (1999) · Peptides · doi:10.1016/s0196-9781(99)00011-x · Cited by 29

Cloning and Characterization of the 5′ Flanking Sequences (Promoter Region) of the Human GLP-1 Receptor Gene

Lankat–Buttgereit, B., & Göke, B. (1997) · Peptides · doi:10.1016/s0196-9781(97)00001-6 · Cited by 28

A Point Mutation in the Glucose-Dependent Insulinotropic Peptide Receptor Confers Constitutive Activity

Tseng, C., & Lin, L. (1997) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.1997.6231 · Cited by 28

Selective Stabilization of the High Affinity Binding Conformation of Glucagon Receptor by the Long Splice Variant of Gαs

Unson, C. G., Wu, C.-R., Sakmar, T. P., & Merrifield, R. B. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.m002093200 · Cited by 28

Inhibition of signal transduction by a splice variant of the growth hormone—releasing hormone receptor expressed in human pituitary adenomas

Motomura, T., Hashimoto, K., Koga, M., Arita, N., Hayakawa, T., Kishimoto, T., & Kasayama, S. (1998) · Metabolism · doi:10.1016/s0026-0495(98)90116-0 · Cited by 27

Biologic Properties and Therapeutic Potential of Glucagon‐like Peptide‐2

Drucker, D. J., Boushey, R. P., Wang, F., Hill, M. E., Brubaker, P. L., & Yusta, B. (1999) · Journal of Parenteral and Enteral Nutrition · doi:10.1177/014860719902300524 · Cited by 26

A Composite Hormone Response Element Regulates Transcription of the Rat GHRH Receptor Gene

Nogami, H., Hiraoka, Y., Matsubara, M., Nonobe, E., Harigaya, T., Katayama, M., Hemmi, N., Kobayashi, S., Mogi, K., Aiso, S., et al. (2002) · Endocrinology · doi:10.1210/endo.143.4.8710 · Cited by 26

Structure of the rat glucose-dependent insulinotropic polypeptide receptor gene

Boylan, M. O., Jepeal, L. I., & Wolfe, M. M. (1999) · Peptides · doi:10.1016/s0196-9781(98)00176-4 · Cited by 24

Functional studies of a glucagon receptor isolated from frog Rana tigrina rugulosa: implications on the molecular evolution of glucagon receptors in vertebrates

Ngan, E., Chow, L. S. N., Tse, D. L. Y., Du, X., Wei, Y., Mojsov, S., & Chow, B. (1999) · FEBS Letters · doi:10.1016/s0014-5793(99)01112-6 · Cited by 24

Glicentin and Oxyntomodulin Modulate Both the Phosphoinositide and Cyclic Adenosine Monophosphate Signaling Pathways in Gastric Myocytes**This work was supported by La Fondation pour la Recherche Medicale.

Rodier, G., Magous, R., Mochizuki, T., et al. (1999) · Endocrinology · doi:10.1210/endo.140.1.6424 · Cited by 23

Glucagon and the Heart

FARAH, A. E. (1983) · Handbook of experimental pharmacology · doi:10.1007/978-3-642-69019-8_31 · Cited by 22

Glucagon-Like Peptide 1 Elevates Cytosolic Calcium in Pancreatic -Cells Independently of Protein Kinase A

Bode, H. (1999) · Endocrinology · doi:10.1210/en.140.9.3919 · Cited by 22

Glucagon and Gluconeogenesis

Claus, T. H., Park, C. R., & Pilkis, S. J. (1983) · Handbook of experimental pharmacology · doi:10.1007/978-3-642-68866-9_15 · Cited by 21

The cysteine of the cytoplasmic tail of glucose-dependent insulinotropic peptide receptor mediates its chronic desensitization and down-regulation

Tseng, C., & Zhang, X. (1998) · Molecular and Cellular Endocrinology · doi:10.1016/s0303-7207(98)00061-6 · Cited by 21

Over-expression of the glucagon-like peptide-1 receptor on INS-1 cells confers autocrine stimulation of insulin gene promoter activity: a strategy for production of pancreatic β-cell lines for use in transplantation

Chepurny, O. G., & Holz, G. G. (2002) · Cell and Tissue Research · doi:10.1007/s00441-001-0494-7 · Cited by 20

Differential GH-releasing hormone regulation of GHRH receptor mRNA expression in the rat pituitary

Lasko, C. M., Korytko, A. I., Wehrenberg, W. B., & Cuttler, L. (2001) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.2001.280.4.e626 · Cited by 17

Posttranslational Processing of Progrowth Hormone-Releasing Hormone

Nillni, E. A., Steinmetz, R. W., & Pescovitz, O. H. (1999) · Endocrinology · doi:10.1210/en.140.12.5817 · Cited by 14

HYPOTHESIS: GLUCAGON RECEPTOR GLYCINE TO SERINE MISSENSE MUTATION CONTRIBUTES TO ONE IN 20 CASES OF ESSENTIAL HYPERTENSION*

Morris, B. J., & Chambers, S. M. (1996) · Clinical and Experimental Pharmacology and Physiology · doi:10.1111/j.1440-1681.1996.tb01164.x · Cited by 14

Preproglucagon and Its Processing

BATAILLE, D. (1996) · Handbook of experimental pharmacology · doi:10.1007/978-3-642-61150-6_3 · Cited by 12

Structural Simplification of Potent Growth Hormone-Releasing Hormone Analogs: Implications for Other Members of the VIP/GHRH/PACAP Familya

Coy, D. H., Jiang, N.-Y., Fuselier, J. A., & Murphy, W. A. (2006) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.1996.tb17480.x · Cited by 11

Gene Expression of the Human Glucagon-Like Peptide-1 Receptor Is Regulated by Sp1 and Sp3

Wildhage, I. (1999) · Endocrinology · doi:10.1210/en.140.2.624 · Cited by 11

Oxyntomodulin and Its Related Peptides

BATAILLE, D. (1996) · Handbook of experimental pharmacology · doi:10.1007/978-3-642-61150-6_19 · Cited by 10

FIVE pS ANION CHANNELS IN HUMAN AIRWAY EPITHELIAL CELLS

Wilk-Blaszczak, M. A., French, A. S., & Man, S. F. P. (1992) · Biomedical Research · doi:10.2220/biomedres.13.143 · Cited by 10

Fluorescein-Trp 25 -Exendin-4, a Biologically Active Fluorescent Probe for the Human GLP-1 Receptor

Chicchi, G. G., Cascieri, M. A., Graziano, M. P., Calahan, T., & Tota, M. R. (1997) · Peptides · doi:10.1016/s0196-9781(96)00320-8 · Cited by 9

Structure and Function of the Glucagon-Like Peptide-1 Receptor

Thorens, B., & Widmann, C. (1996) · Handbook of experimental pharmacology · doi:10.1007/978-3-642-61150-6_16 · Cited by 8

Contribution of a PS1‐like element to the tissue‐ and cell‐specific expression of the human GLP‐1 receptor gene

Galehshahi, F. S., Göke, B., & Lankat–Buttgereit, B. (1998) · FEBS Letters · doi:10.1016/s0014-5793(98)01116-8 · Cited by 8

Role of the Gly40Ser Mutation in the Glucagon Receptor Gene in Brazilian Patients With Type 2 Diabetes Mellitus

Shiota, D., Kasamatsu, T. S., Dib, S. A., Chacra, A. R., & Moisés, R. S. (2002) · Pancreas · doi:10.1097/00006676-200205000-00010 · Cited by 8

Glucagon and Lipoprotein Regulation in Man

Eaton, R. P. (1977) · Springer eBooks · doi:10.1007/978-1-4612-6366-1_34 · Cited by 7

Editorial: Targeted Gene Disruption in Endocrine Research--The Case of Glucagon-Like Peptide-1 and Neuroendocrine Function

Seeley, R. J., Woods, S. C., & D’Alessio, D. A. (2000) · Endocrinology · doi:10.1210/endo.141.2.7372 · Cited by 7

Gene Regulation of Growth Hormone-Releasing Hormone and Its Receptor.

Sato, M., & Takahara, J. (1997) · Endocrine Journal · doi:10.1507/endocrj.44.765 · Cited by 6

Untitled work

Merchenthaler (1999) · doi:10.1002/(sici)1096-9861(19990111)403:2<261::aid-cne8>3.0.co;2-5

Biology of Incretins: GLP-1 and GIP

Baggio, L. L., & Drucker, D. J. (2007) · Gastroenterology · doi:10.1053/j.gastro.2007.03.054 · Cited by 3,639

The Physiology of Glucagon-like Peptide 1

Holst, J. J. (2007) · Physiological Reviews · doi:10.1152/physrev.00034.2006 · Cited by 3,371

Mechanisms of Action and Therapeutic Application of Glucagon-like Peptide-1

Drucker, D. J. (2018) · Cell Metabolism · doi:10.1016/j.cmet.2018.03.001 · Cited by 2,170

Glucagon-like peptide 1 (GLP-1)

Müller, T. D., Finan, B., Bloom, S. R., D'Alessio, D., Drucker, D. J., Flatt, P. R., Fritsche, A., Gribble, F., Grill, H. J., Habener, J. F., et al. (2019) · Molecular Metabolism · doi:10.1016/j.molmet.2019.09.010 · Cited by 1,868

Cardioprotective and Vasodilatory Actions of Glucagon-Like Peptide 1 Receptor Are Mediated Through Both Glucagon-Like Peptide 1 Receptor–Dependent and –Independent Pathways

Ban, K., Noyan-Ashraf, M. H., Hoefer, J., Bolz, S.-S., Drucker, D. J., & Husain, M. (2008) · Circulation · doi:10.1161/circulationaha.107.739938 · Cited by 1,057