International Union of Pharmacology. XXXV. The Glucagon Receptor Family

A role for glucagon-like peptide-1 in the central regulation of feeding

Turton, M. D., O'Shea, D., Gunn, I., Beak, S. A., Edwards, C. M. B., Meeran, K., Choi, S. J., Taylor, G. M., Heath, M. M., Lambert, P. D., et al. (1996) · Nature · doi:10.1038/379069a0 · Cited by 1,950

Preserved incretin activity of glucagon-like peptide 1 [7-36 amide] but not of synthetic human gastric inhibitory polypeptide in patients with type-2 diabetes mellitus

Nauck, M. A., Heimesaat, M. M., Orskov, C., Holst, J. J., Ebert, R., & Creutzfeldt, W. (1993) · Journal of Clinical Investigation · doi:10.1172/jci116186 · Cited by 1,651

Effect of 6-week course of glucagon-like peptide 1 on glycaemic control, insulin sensitivity, and β-cell function in type 2 diabetes: a parallel-group study

Zander, M., Madsbad, S., Madsen, J. L., & Holst, J. J. (2002) · The Lancet · doi:10.1016/s0140-6736(02)07952-7 · Cited by 1,297

Growth Hormone-Releasing Factor from a Human Pancreatic Tumor That Caused Acromegaly

Guillemin, R., Brazeau, P., Bohlen, P., Esch, F., Ling, N., & Wehrenberg, W. B. (1982) · Science · doi:10.1126/science.6812220 · Cited by 1,294

Dipeptidyl‐peptidase IV hydrolyses gastric inhibitory polypeptide, glucagon‐like peptide‐1(7–36)amide, peptide histidine methionine and is responsible for their degradation in human serum

MENTLEIN, R., GALLWITZ, B., & SCHMIDT, W. E. (1993) · European Journal of Biochemistry · doi:10.1111/j.1432-1033.1993.tb17986.x · Cited by 1,161

Degradation of glucose-dependent insulinotropic polypeptide and truncated glucagon-like peptide 1 in vitro and in vivo by dipeptidyl peptidase IV.

Kieffer, T. J., McIntosh, C. H., & Pederson, R. A. (1995) · Endocrinology · doi:10.1210/endo.136.8.7628397 · Cited by 1,124

Pituitary Adenylate Cyclase-Activating Polypeptide and Its Receptors: From Structure to Functions

Vaudry, D., Gonzalez, B. J., Basille, M., Yon, L., Fournier, A., & Vaudry, H. (2000) · Pharmacological Reviews · doi:10.1016/s0031-6997(24)01449-2 · Cited by 1,121

Characterization of a growth hormone-releasing factor from a human pancreatic islet tumour

Rivier, J., Spiess, J., Thorner, M., & Vale, W. (1982) · Nature · doi:10.1038/300276a0 · Cited by 1,104

The Glucagon-Like Peptides

Kieffer, T. J., & Francis Habener, J. (1999) · Endocrine Reviews · doi:10.1210/edrv.20.6.0385 · Cited by 1,062

Inhibition of gastric inhibitory polypeptide signaling prevents obesity

Miyawaki, K., Yamada, Y., Ban, N., Ihara, Y., Tsukiyama, K., Zhou, H., Fujimoto, S., Oku, A., Tsuda, K., Toyokuni, S., et al. (2002) · Nature Medicine · doi:10.1038/nm727 · Cited by 963

Expression cloning of the pancreatic beta cell receptor for the gluco-incretin hormone glucagon-like peptide 1.

Thorens, B. (1992) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.89.18.8641 · Cited by 906

Glucagon-like peptide I stimulates insulin gene expression and increases cyclic AMP levels in a rat islet cell line.

Drucker, D. J., Philippe, J., Mojsov, S., Chick, W. L., & Habener, J. F. (1987) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.84.10.3434 · Cited by 903

Reduced Postprandial Concentrations of Intact Biologically Active Glucagon-Like Peptide 1 in Type 2 Diabetic Patients

Vilsbøll, T., Krarup, T., Deacon, C. F., Madsbad, S., & Holst, J. J. (2001) · Diabetes · doi:10.2337/diabetes.50.3.609 · Cited by 884

Induction of intestinal epithelial proliferation by glucagon-like peptide 2.

Drucker, D. J., Erlich, P., Asa, S. L., & Brubaker, P. L. (1996) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.93.15.7911 · Cited by 880

STIMULATION OF INSULIN SECRETION BY GASTRIC INHIBITORY POLYPEPTIDE IN MAN. 1

Dupre, J., Ross, S. A., Watson, D., & Brown, J. C. (1973) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem-37-5-826 · Cited by 860

Exendin-4 is a high potency agonist and truncated exendin-(9-39)-amide an antagonist at the glucagon-like peptide 1-(7-36)-amide receptor of insulin-secreting beta-cells.

Göke, R., Fehmann, H. C., Linn, T., Schmidt, H., Krause, M., Eng, J., & Göke, B. (1993) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)36565-2 · Cited by 837

The Glucagon-sensitive Adenyl Cyclase System in Plasma Membranes of Rat Liver

Rodbell, M., Birnbaumer, L., Pohl, S. L., & Krans, H. M. J. (1971) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)62390-7 · Cited by 812

Glucose intolerance but normal satiety in mice with a null mutation in the glucagon–like peptide 1 receptor gene

Scrocchi, L. A., Brown, T. J., Maclusky, N., Brubaker, P. L., Auerbach, A. B., Joyner, A. L., & Drucker, D. J. (1996) · Nature Medicine · doi:10.1038/nm1196-1254 · Cited by 793

Preproglucagon gene expression in pancreas and intestine diversifies at the level of post-translational processing

Mojsov, S., Heinrich, G., Wilson, I. B., Ravazzola, M., Orci, L., & Habener, J. F. (1986) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)67324-7 · Cited by 724

Distribution of glucagon-like peptide-1 and other preproglucagon-derived peptides in the rat hypothalamus and brainstem

Larsen, P. J., Tang-Christensen, M., Holst, J. J., & Ørskov, C. (1997) · Neuroscience · doi:10.1016/s0306-4522(96)00434-4 · Cited by 663

Hamster preproglucagon contains the sequence of glucagon and two related peptides

Bell, G. I., Santerre, R. F., & Mullenbach, G. T. (1983) · Nature · doi:10.1038/302716a0 · Cited by 649

Tissue distribution of messenger ribonucleic acid encoding the rat glucagon-like peptide-1 receptor

Bullock, B. P., Heller, R. S., & Habener, J. F. (1996) · Endocrinology · doi:10.1210/en.137.7.2968 · Cited by 618

Glucagon-Like Peptides

Drucker, D. J. (1998) · Diabetes · doi:10.2337/diab.47.2.159 · Cited by 601

A Meta-Analysis of the Effect of Glucagon-Like Peptide-1 (7–36) Amide on Ad Libitum Energy Intake in Humans

Verdich, C., Flint, A., Gutzwiller, J.-P., Näslund, E., Beglinger, C., Hellström, P. M., Long, S. J., Morgan, L. M., Holst, J. J., & Astrup, A. (2001) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.86.9.7877 · Cited by 600

Exon duplication and divergence in the human preproglucagon gene

Bell, G. I., Sanchez-Pescador, R., Laybourn, P. J., & Najarian, R. C. (1983) · Nature · doi:10.1038/304368a0 · Cited by 593

Glucagon-like Peptide-1 Receptor Signaling Modulates β Cell Apoptosis

Li, Y., Hansotia, T., Yusta, B., Ris, F., Halban, P. A., & Drucker, D. J. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m209423200 · Cited by 589

Insulinotropic glucagon-like peptide 1 agonists stimulate expression of homeodomain protein IDX-1 and increase islet size in mouse pancreas.

Stoffers, D. A., Kieffer, T. J., Hussain, M. A., Drucker, D. J., Bonner-Weir, S., Habener, J. F., & Egan, J. M. (2000) · Diabetes · doi:10.2337/diabetes.49.5.741 · Cited by 576

Lower blood glucose, hyperglucagonemia, and pancreatic α cell hyperplasia in glucagon receptor knockout mice

Gelling, R. W., Du, X. Q., Dichmann, D. S., Rømer, J., Huang, H., Cui, L., Obici, S., Tang, B., Holst, J. J., Fledelius, C., et al. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0237106100 · Cited by 563

Cloning and Functional Expression of the Human Islet GLP-1 Receptor: Demonstration That Exendin-4 Is an Agonist and Exendin-(9–39) an Antagonist of the Receptor

Thorens, B., Porret, A., Bühler, L., Deng, S.-P., Morel, P., & Widmann, C. (1993) · Diabetes · doi:10.2337/diab.42.11.1678 · Cited by 558

Gastric inhibitory polypeptide receptor, a member of the secretin-vasoactive intestinal peptide receptor family, is widely distributed in peripheral organs and the brain.

Usdin, T. B., Mezey, E., Button, D. C., Brownstein, M. J., & Bonner, T. I. (1993) · Endocrinology · doi:10.1210/endo.133.6.8243312 · Cited by 534

Glucagon-like peptide 2 improves nutrient absorption and nutritional status in short-bowel patients with no colon

Jeppesen, P. B., Hartmann, B., Thulesen, J., Graff, J., Lohmann, J., Hansen, B. S., Tofteng, F., Poulsen, S. S., Madsen, J. L., Holst, J. J., et al. (2001) · Gastroenterology · doi:10.1053/gast.2001.22555 · Cited by 532

Cell and Molecular Biology of the Incretin Hormones Glucagon-Like Peptide-I and Glucose-Dependent Insulin Releasing Polypeptide

FEHMANN, H.-C., GÖKE, R., & GÖKE, B. (1995) · Endocrine Reviews · doi:10.1210/edrv-16-3-390 · Cited by 528

Glucagon-like peptide-1 promotes satiety and reduces food intake in patients with diabetes mellitus type 2

Gutzwiller, J.-P., Drewe, J., Göke, B., Schmidt, H., Rohrer, B., Lareida, J., & Beglinger, C. (1999) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.1999.276.5.r1541 · Cited by 521

The pharmacokinetics, pharmacodynamics, safety and tolerability of NN2211, a new long-acting GLP-1 derivative, in healthy men

Agersø, H., Jensen, L. B., Elbrønd, B., Rolan, P., & Zdravkovic, M. (2002) · Diabetologia · doi:10.1007/s00125-001-0719-z · Cited by 510

Biological actions and therapeutic potential of the glucagon-like peptides

Drucker, D. J. (2002) · Gastroenterology · doi:10.1053/gast.2002.31068 · Cited by 500

Glucagon-Like Peptides: Regulators of Cell Proliferation, Differentiation, and Apoptosis

Drucker, D. J. (2003) · Molecular Endocrinology · doi:10.1210/me.2002-0306 · Cited by 483

Glucagon-Like Peptides GLP-1 and GLP-2, Predicted Products of the Glucagon Gene, Are Secreted Separately from Pig Small Intestine but Not Pancreas*

ØRSKOV, C., HOLST, J. J., KNUHTSEN, S., BALDISSERA, F. G. A., POULSEN, S. S., & NIELSEN, O. V. (1986) · Endocrinology · doi:10.1210/endo-119-4-1467 · Cited by 482

cAMP-GEFII is a direct target of cAMP in regulated exocytosis

Ozaki, N., Shibasaki, T., Kashima, Y., Miki, T., Takahashi, K., Ueno, H., Sunaga, Y., Yano, H., Matsuura, Y., Iwanaga, T., et al. (2000) · Nature Cell Biology · doi:10.1038/35041046 · Cited by 481 · cited 1×

Interactions of Glucagon-Like Peptide-1 (GLP-1) with the Blood-Brain Barrier

Kastin, A. J., Akerstrom, V., & Pan, W. (2002) · Journal of Molecular Neuroscience · doi:10.1385/jmn:18:1-2:07 · Cited by 480

Molecular basis of the little mouse phenotype and Implications for cell type-specific growth

Lin, S.-C., Lin, C. R., Gukovsky, I., Lusis, A. J., Sawchenko, P. E., & Rosenfeld, M. G. (1993) · Nature · doi:10.1038/364208a0 · Cited by 474

Distribution of GLP‐1 Binding Sites in the Rat Brain: Evidence that Exendin‐4 is a Ligand of Brain GLP‐1 Binding Sites

Göke, R., Larsen, P. J., Mikkelsen, J. D., & Sheikh, S. P. (1995) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.1995.tb00650.x · Cited by 474

The Glucagon-sensitive Adenyl Cyclase System in Plasma Membranes of Rat Liver

Rodbell, M., Krans, H. M. J., Pohl, S. L., & Birnbaumer, L. (1971) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)62388-9 · Cited by 473

Glucagon-like peptide-1 receptor stimulation increases blood pressure and heart rate and activates autonomic regulatory neurons

Yamamoto, H., Lee, C. E., Marcus, J., Williams, T. D., Overton, J. M., Lopez, M. E., Hollenberg, A. N., Baggio, L. L., Saper, C. B., Drucker, D. J., et al. (2002) · Journal of Clinical Investigation · doi:10.1172/jci15595 · Cited by 473

Glucose intolerance caused by a defect in the entero-insular axis: A study in gastric inhibitory polypeptide receptor knockout mice

Miyawaki, K., Yamada, Y., Yano, H., Niwa, H., Ban, N., Ihara, Y., Kubota, A., Fujimoto, S., Kajikawa, M., Kuroe, A., et al. (1999) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.96.26.14843 · Cited by 454

CD26, let it cut or cut it down

De Meester, I., Korom, S., Van Damme, J., & Scharpé, S. (1999) · Immunology Today · doi:10.1016/s0167-5699(99)01486-3 · Cited by 451

Tissue-specific expression of the human receptor for glucagon-like peptide-I: Brain, heart and pancreatic forms have the same deduced amino acid sequences

Wei, Y., & Mojsov, S. (1995) · FEBS Letters · doi:10.1016/0014-5793(94)01430-9 · Cited by 450 · cited 4×

Glucagon-like peptide-1 receptor stimulation increases blood pressure and heart rate and activates autonomic regulatory neurons

Yamamoto, H., Lee, C. E., Marcus, J. N., Williams, T. D., Overton, J. M., Lopez, M. E., Hollenberg, A. N., Baggio, L., Saper, C. B., Drucker, D. J., et al. (2002) · Journal of Clinical Investigation · doi:10.1172/jci0215595 · Cited by 429

Growth Hormone-Releasing Hormone*

FROHMAN, L. A., & JANSSON, J.-O. (1986) · Endocrine Reviews · doi:10.1210/edrv-7-3-223 · Cited by 427

Minireview: The Glucagon-Like Peptides

Drucker, D. J. (2001) · Endocrinology · doi:10.1210/en.142.2.521 · Cited by 421

Molecular cloning and expression of a cDNA encoding the secretin receptor.

Ishihara, T., Nakamura, S., Kaziro, Y., Takahashi, T., Takahashi, K., & Nagata, S. (1991) · The EMBO Journal · doi:10.1002/j.1460-2075.1991.tb07686.x · Cited by 407

Expression cloning and signaling properties of the rat glucagon receptor

Jelinek, L., Lok, S., Rosenberg, G., Smith, R., Grant, F., Biggs, S., Bensch, P., Kuijper, J., Sheppard, P., Sprecher, C., et al. (1993) · Science · doi:10.1126/science.8384375 · Cited by 397

GHRH receptor of little mice contains a missense mutation in the extracellular domain that disrupts receptor function

Godfrey, P., Rahal, J. O., Beamer, W. G., Copeland, N. G., Jenkins, N. A., & Mayo, K. E. (1993) · Nature Genetics · doi:10.1038/ng0793-227 · Cited by 397

Somatotroph Hyperplasia

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Activation of two signal-transduction systems in hepatocytes by glucagon

Wakelam, M. J. O., Murphy, G. J., Hruby, V. J., & Houslay, M. D. (1986) · Nature · doi:10.1038/323068a0 · Cited by 388

Critical Role of cAMP-GEFII·Rim2 Complex in Incretin-potentiated Insulin Secretion

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Protection and Reversal of Excitotoxic Neuronal Damage by Glucagon-Like Peptide-1 and Exendin-4

Perry, T., Haughey, N. J., Mattson, M. P., Egan, J. M., & Greig, N. H. (2002) · The Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.102.037481 · Cited by 380

Entero-Insular Axis

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Characterization of rat hypothalamic growth hormone-releasing factor

Spiess, J., Rivier, J., & Vale, W. (1983) · Nature · doi:10.1038/303532a0 · Cited by 371

Molecular cloning and expression of a pituitary-specific receptor for growth hormone-releasing hormone

Mayo, K. E. (1992) · Molecular Endocrinology · doi:10.1210/me.6.10.1734 · Cited by 365

Disruption of PC1/3 expression in mice causes dwarfism and multiple neuroendocrine peptide processing defects

Zhu, X., Zhou, A., Dey, A., Norrbom, C., Carroll, R., Zhang, C., Laurent, V., Lindberg, I., Ugleholdt, R., Holst, J. J., et al. (2002) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.162352599 · Cited by 348

Family-B G-protein-coupled receptors.

Harmar, A. J. (2001) · Genome biology · doi:10.1186/gb-2001-2-12-reviews3013 · Cited by 344

Enteroendocrine localization of GLP-2 receptor expression in humans and rodents

Yusta, B., Huang, L., Munroe, D., Wolff, G., Fantaske, R., Sharma, S., Demchyshyn, L., Asa, S. L., & Drucker, D. J. (2000) · Gastroenterology · doi:10.1053/gast.2000.16489 · Cited by 339

Insulinotropic hormone glucagon-like peptide-I(7-37) stimulation of proinsulin gene expression and proinsulin biosynthesis in insulinoma beta TC-1 cells

Fehmann, H. C. (1992) · Endocrinology · doi:10.1210/en.130.1.159 · Cited by 337

A Meta-Analysis of the Effect of Glucagon-Like Peptide-1 (7-36) Amide on Ad Libitum Energy Intake in Humans

Verdich, C. (2001) · Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.86.9.4382 · Cited by 336

Distribution of glucagonlike peptide I (GLP‐I), glucagon, and glicentin in the rat brain: An immunocytochemical study

Jin, S. ‐. C., Han, V. K. M., Simmons, J. G., Towle, A. C., Lauder, J. M., & Lund, P. K. (1988) · Journal of Comparative Neurology · doi:10.1002/cne.902710405 · Cited by 335

Prototypic G protein-coupled receptor for the intestinotrophic factor glucagon-like peptide 2

Munroe, D. G., Gupta, A. K., Kooshesh, F., Vyas, T. B., Rizkalla, G., Wang, H., Demchyshyn, L., Yang, Z.-J., Kamboj, R. K., Chen, H., et al. (1999) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.96.4.1569 · Cited by 328

Modulation of specific intestinal epithelial progenitors by enteric neurons

Bjerknes, M., & Cheng, H. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.211278098 · Cited by 325

Growth hormone-releasing factor stimulates proliferation of somatotrophs in vitro.

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Pit-1-dependent expression of the receptor for growth hormone releasing factor mediates pituitary cell growth

Lin, C., Lin, S.-C., Chang, C.-P., & Rosenfeld, M. G. (1992) · Nature · doi:10.1038/360765a0 · Cited by 325

Biological Effects and Metabolic Rates of Glucagonlike Peptide-1 7–36 Amide and Glucagonlike Peptide-1 7–37 in Healthy Subjects Are Indistinguishable

Ørskov, C., Wettergren, A., & Holst, J. J. (1993) · Diabetes · doi:10.2337/diab.42.5.658 · Cited by 325

Intestinal growth-promoting properties of glucagon-like peptide-2 in mice

Tsai, C. H., Hill, M., Asa, S. L., Brubaker, P. L., & Drucker, D. J. (1997) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.1997.273.1.e77 · Cited by 319

Nonsense mutation in the human growth hormone-releasing hormone receptor causes growth failure analogous to the little (lit) mouse

Wajnrajch, M. P., Gertner, J. M., Harbison, M. D., Chua, S. C., & Leibel, R. L. (1996) · Nature Genetics · doi:10.1038/ng0196-88 · Cited by 313

Novel Receptor Partners and Function of Receptor Activity-modifying Proteins

Christopoulos, A., Christopoulos, G., Morfis, M., Udawela, M., Laburthe, M., Couvineau, A., Kuwasako, K., Tilakaratne, N., & Sexton, P. M. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.c200629200 · Cited by 309

Transcriptional regulation of growth hormone gene expression by growth hormone-releasing factor

Barinaga, M., Yamonoto, G., Rivier, C., Vale, W., Evans, R., & Rosenfeld, M. G. (1983) · Nature · doi:10.1038/306084a0 · Cited by 308

Dipeptidyl peptidase IV resistant analogues of glucagon-like peptide-1 which have extended metabolic stability and improved biological activity

Deacon, C. F., Knudsen, L. B., Madsen, K., Wiberg, F. C., Jacobsen, O., & Holst, J. J. (1998) · Diabetologia · doi:10.1007/s001250050903 · Cited by 303

A Novel Neurotrophic Property of Glucagon-Like Peptide 1: A Promoter of Nerve Growth Factor-Mediated Differentiation in PC12 Cells

Perry, T., Lahiri, D. K., Chen, D., Zhou, J., Shaw, K. T. Y., Egan, J. M., & Greig, N. H. (2002) · The Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.300.3.958 · Cited by 300

Pancreatic preproglucagon cDNA contains two glucagon-related coding sequences arranged in tandem

Lund, P. K., Goodman, R. H., Dee, P. C., & Habener, J. F. (1982) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.79.2.345 · Cited by 295

Isolation, primary structure, and synthesis of human hypothalamic somatocrinin: growth hormone-releasing factor.

Ling, N., Esch, F., Böhlen, P., Brazeau, P., Wehrenberg, W. B., & Guillemin, R. (1984) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.81.14.4302 · Cited by 291

Oxyntomodulin Inhibits Food Intake in the Rat

Dakin, C. L., Gunn, I., Small, C. J., Edwards, C. M. B., Hay, D. L., Smith, D. M., Ghatei, M. A., & Bloom, S. R. (2001) · Endocrinology · doi:10.1210/endo.142.10.8430 · Cited by 281

Food-Dependent Cushing's Syndrome Mediated by Aberrant Adrenal Sensitivity to Gastric Inhibitory Polypeptide

Reznik, Y., Allali-Zerah, V., Chayvialle, J. A., Leroyer, R., Leymarie, P., Travert, G., Lebrethon, M.-C., Budi, I., Balliere, A.-M., & Mahoudeau, J. (1992) · New England Journal of Medicine · doi:10.1056/nejm199210013271403 · Cited by 278

Glucagon-like peptide-2 enhances intestinal epithelial barrier function of both transcellular and paracellular pathways in the mouse

Benjamin, M. A., McKay, D. M., Yang, P.-C., Cameron, H., & Perdue, M. H. (2000) · Gut · doi:10.1136/gut.47.1.112 · Cited by 277

Regulation of the biological activity of glucagon-like peptide 2 in vivo by dipeptidyl peptidase IV

Drucker, D. J., Shi, Q., Crivici, A., Sumner-Smith, M., Tavares, W., Hill, M., DeForest, L., Cooper, S., & Brubaker, P. L. (1997) · Nature Biotechnology · doi:10.1038/nbt0797-673 · Cited by 276

The proglucagon-derived peptide, glucagon-like peptide-2, is a neurotransmitter involved in the regulation of food intake

Tang-Christensen, M., Larsen, P. J., Thulesen, J., Rømer, J., & Vrang, N. (2000) · Nature Medicine · doi:10.1038/77535 · Cited by 269

GIF biology and fat metabolism

Yip, R. G. C., & Wolfe, M. M. (1999) · Life Sciences · doi:10.1016/s0024-3205(99)00314-8 · Cited by 266

Exendin(9-39)amide is an antagonist of glucagon-like peptide-1(7-36)amide in humans

Schirra, J., Sturm, K., Leicht, P., Arnold, R., Göke, B., & Katschinski, M. (1998) · Journal of Clinical Investigation · doi:10.1172/jci1349 · Cited by 265

Osteoblast-Derived Cells Express Functional Glucose-Dependent Insulinotropic Peptide Receptors1

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Glucagon gene expression in vertebrate brain.

Drucker, D. J., & Asa, S. (1988) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)68261-4 · Cited by 264

Bedtime Administration of NN2211, a Long-Acting GLP-1 Derivative, Substantially Reduces Fasting and Postprandial Glycemia in Type 2 Diabetes

Juhl, C. B., Hollingdal, M., Sturis, J., Jakobsen, G., Agersø, H., Veldhuis, J., Pørksen, N., & Schmitz, O. (2002) · Diabetes · doi:10.2337/diabetes.51.2.424 · Cited by 264

Expression of human growth hormone-releasing factor in transgenic mice results in increased somatic growth

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The Insulinotropic Effect of Acute Exendin-4 Administered to Humans: Comparison of Nondiabetic State to Type 2 Diabetes

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