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High frequency of intestinal T H 17 cells correlates with microbiota alterations and disease activity in multiple sclerosis
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The headquarter of our immune system resides in the gut and modulates autoimmune disease activation in multiple sclerosis.
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“In therapeutic interventions the inhibitor of IL-12+23, ustekinumab, showed no efficacy in relapsing remitting MS (RRMS) [146].”
From TH17 cell heterogeneity and its role in tissue inflammation (2023) · cites this paper as [146]
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Cites
Naive Bayesian Classifier for Rapid Assignment of rRNA Sequences into the New Bacterial Taxonomy
Wang, Q., Garrity, G. M., Tiedje, J. M., & Cole, J. R. (2007) · Applied and Environmental Microbiology · doi:10.1128/aem.00062-07 · Cited by 20,145
De Filippo, C., Cavalieri, D., Di Paola, M., Ramazzotti, M., Poullet, J. B., Massart, S., Collini, S., Pieraccini, G., & Lionetti, P. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1005963107 · Cited by 5,579
Induction of Intestinal Th17 Cells by Segmented Filamentous Bacteria
Ivanov, I. I., Atarashi, K., Manel, N., Brodie, E. L., Shima, T., Karaoz, U., Wei, D., Goldfarb, K. C., Santee, C. A., Lynch, S. V., et al. (2009) · Cell · doi:10.1016/j.cell.2009.09.033 · Cited by 4,554
The Effect of Infections on Susceptibility to Autoimmune and Allergic Diseases
Bach, J. (2002) · New England Journal of Medicine · doi:10.1056/nejmra020100 · Cited by 2,723
Microbiota and SCFA in lean and overweight healthy subjects
Schwiertz, A., Taras, D., Schäfer, K., Beijer, S., Bos, N. A., Donus, C., & Hardt, P. D. (2010) · Obesity · doi:10.1038/oby.2009.167 · Cited by 2,457
Ivanov, I. I., Frutos, R. D. L., Manel, N., Yoshinaga, K., Rifkin, D. B., Sartor, R. B., Finlay, B. B., & Littman, D. R. (2008) · Cell Host & Microbe · doi:10.1016/j.chom.2008.09.009 · Cited by 1,770
Kebir, H., Kreymborg, K., Ifergan, I., Dodelet-Devillers, A., Cayrol, R., Bernard, M., Giuliani, F., Arbour, N., Becher, B., & Prat, A. (2007) · Nature Medicine · doi:10.1038/nm1651 · Cited by 1,759
Lock, C., Hermans, G., Pedotti, R., Brendolan, A., Schadt, E. E., Garren, H., Langer-Gould, A. M., Strober, S., Cannella, B., Allard, J. D., et al. (2002) · Nature Medicine · doi:10.1038/nm0502-500 · Cited by 1,659
Gaboriau-Routhiau, V., Rakotobe, S., Lécuyer, E., Mulder, I., Lan, A., Bridonneau, C., Rochet, V., Pisi, A., De Paepe, M., Brandi, G., et al. (2009) · Immunity · doi:10.1016/j.immuni.2009.08.020 · Cited by 1,452
Sodium chloride drives autoimmune disease by the induction of pathogenic TH17 cells
Kleinewietfeld, M., Manzel, A., Titze, J., Kvakan, H., Yosef, N., Linker, R. A., Muller, D. N., & Hafler, D. A. (2013) · Nature · doi:10.1038/nature11868 · Cited by 1,394
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Microbiome and multiple sclerosis
Durán, M. J. O., Rodríguez, T., López‐Nevot, M. Á., & Cobo, F. (2023) · Elsevier eBooks · doi:10.1016/b978-0-443-18578-6.00005-2
Ma, J., Lu, Q., Zhao, Y., Liu, X., Ding, G., Wang, Y., Wang, X., Chen, Y., Zhang, T., & Cheng, X. (2023) · Research Square · doi:10.21203/rs.3.rs-3350930/v1
Generalov, V. O., Obodzinskaya, I. E., Русланович, С. Т., Меликсович, Ю. А., Aleksandrenkova, A. A., Larionov, G. V., & Niculina, L. V. (2023) · Psikhiatriya · doi:10.30629/2618-6667-2023-21-5-17-24 · Cited by 2
Microbiome in multiple sclerosis
Baranzini, S. E. (2024) · Elsevier eBooks · doi:10.1016/b978-0-12-823848-6.00012-9
Lu, Q., & Xin, Y. (2024) · Elsevier eBooks · doi:10.1016/b978-0-443-23947-2.00008-4
Western Diet Impact on Multiple Sclerosis
Al-Ali, H., Zubedi, S., Rabeh, N., Aljoudi, S., Dimassi, Z., & Hamdan, H. (2024) · Nutritional neurosciences · doi:10.1007/978-981-97-4673-6_4
Th17-Mediated Immune Responses in Pathogenesis of Neuroinflammatory Disorders
Pourgholaminejad, A., & Tahmasebinia, F. (2024) · Springer eBooks · doi:10.1007/978-3-031-24297-7_3-1
Otoimmün Hastalıklarda Probiyotikler Bir Tedavi Yöntemi Olabilir mi?
Şeker, E., & Özdemır, Ö. (2024) · JOURNAL OF BIOTECHNOLOGY AND STRATEGIC HEALTH RESEARCH · doi:10.34084/bshr.1542051
Cencicchio, M. A., & Falcone, M. (2025) · The microbiomes of humans, animals, plants, and the environment · doi:10.1007/978-3-031-84065-4_7
Self-citationAsnicar, F., & Manara, S. (2025) · The microbiomes of humans, animals, plants, and the environment · doi:10.1007/978-3-031-84065-4_6
Montgomery, T. L., Eckstrom, K. M., Lile, K. H., Caldwell, S. K., Heney, E. R., Lahue, K. G., D’Alessandro, A., Wargo, M. J., & Krementsov, D. N. (2022) · Figshare · doi:10.6084/m9.figshare.21622034
Lin, X., Liu, Y., Ma, L., Ma, X., Shen, L., Ma, X., Chen, Z., Chen, H., Li, D., Su, Z., et al. (2021) · Figshare · doi:10.6084/m9.figshare.15047571
Montgomery, T. L., Eckstrom, K. M., Lile, K. H., Caldwell, S. K., Heney, E. R., Lahue, K. G., D’Alessandro, A., Wargo, M. J., & Krementsov, D. N. (2022) · Figshare · doi:10.6084/m9.figshare.21622055
Montgomery, T. L., Eckstrom, K. M., Lile, K. H., Caldwell, S. K., Heney, E. R., Lahue, K. G., D’Alessandro, A., Wargo, M. J., & Krementsov, D. N. (2022) · Figshare · doi:10.6084/m9.figshare.21622037
Montgomery, T. L., Eckstrom, K. M., Lile, K. H., Caldwell, S. K., Heney, E. R., Lahue, K. G., D’Alessandro, A., Wargo, M. J., & Krementsov, D. N. (2022) · Figshare · doi:10.6084/m9.figshare.21622043
Montgomery, T. L., Eckstrom, K. M., Lile, K. H., Caldwell, S. K., Heney, E. R., Lahue, K. G., D’Alessandro, A., Wargo, M. J., & Krementsov, D. N. (2022) · Figshare · doi:10.6084/m9.figshare.21622031
Montgomery, T. L., Eckstrom, K. M., Lile, K. H., Caldwell, S. K., Heney, E. R., Lahue, K. G., D’Alessandro, A., Wargo, M. J., & Krementsov, D. N. (2022) · Figshare · doi:10.6084/m9.figshare.21622052
Montgomery, T. L., Eckstrom, K. M., Lile, K. H., Caldwell, S. K., Heney, E. R., Lahue, K. G., D’Alessandro, A., Wargo, M. J., & Krementsov, D. N. (2022) · Figshare · doi:10.6084/m9.figshare.21622046
Montgomery, T. L., Eckstrom, K. M., Lile, K. H., Caldwell, S. K., Heney, E. R., Lahue, K. G., D’Alessandro, A., Wargo, M. J., & Krementsov, D. N. (2022) · Figshare · doi:10.6084/m9.figshare.21622049
Montgomery, T. L., Eckstrom, K. M., Lile, K. H., Caldwell, S. K., Heney, E. R., Lahue, K. G., D’Alessandro, A., Wargo, M. J., & Krementsov, D. N. (2022) · Figshare · doi:10.6084/m9.figshare.21622040
Aznar, M. D. G., Villanueva Guerrero, M. D., Cordero-Ramos, J., Eichau Madueño, S., Bravo, M. M., Ruiz, R. L., & García, M. B. (2022) · Figshare · doi:10.6084/m9.figshare.21376285
Montgomery, T. L., Nelson, E. A., Downs, L. A., Heney, E. R., Lee, M. F. J., Martino, C., McDonald, D. T., Rahman, G., Knight, R. D., & Krementsov, D. N. (2026) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.64898/2026.01.08.698420
Raveney, B. J. E., Okamoto, T., Kimura, A., Lin, Y., Araki, M., Kimura, Y., Sato, N., Shimizu, Y., Nishida, Y., Yokota, T., et al. (2026) · medRxiv · doi:10.64898/2026.02.04.26345323
Khodve, G., Raval, S., & Banerjee, S. (2026) · International review of neurobiology · doi:10.1016/bs.irn.2026.05.015
Preventing MALT1-mediated CYLD cleavage induces intestinal dysbiosis and reduces EAE severity
Skordos, I., Gilis, E., Callewaert, C., Aidarova, A., Haegman, M., Driege, Y., Kreike, M., Afonina, I. S., Staal, J., Demeyer, A., et al. (2026) · EMBO Reports · doi:10.1038/s44319-026-00814-4
Chen, K., Zou, Q., & Yao, Y. (2026) · Genes · doi:10.3390/genes17070810
Hong, J. S., Shamim, A., Atta, H. M., Merl, S., Park, H., Eliby, D., Tillman, A. M., Tekal, M., Patwardhan, S., Chauhan, I., et al. (2026) · American Journal of Transplantation · doi:10.1016/j.ajt.2026.07.007
Gut microbiota and brain health: Disease-specific pathways and emerging therapeutic strategies
Oriquat, G., Rizaev, J., Abdulqader, A. F., Kadhim, A. A., Jamuna, K. V., Singhal, D. K., Bainsal, N., & Mansurova, N. (2026) · Multiple Sclerosis and Related Disorders · doi:10.1016/j.msard.2026.107407
Chen, M., Yuan, Y., Zhao, Y., Wu, S., Yang, H., Xiong, D., & Xia, S. (2026) · Health Science Reports · doi:10.1002/hsr2.72895
Montgomery, T. L., Nelson, E. A., Downs, L. A., Heney, E. R., Lee, M. F. J., Martino, C., McDonald, D. T., Rahman, G., Knight, R. D., & Krementsov, D. N. (2026) · mSystems · doi:10.1128/msystems.00002-26
The therapeutic potential of saponins for neurological diseases via the gut-brain axis
Wang, X., Li, S., Zhong, G., Zhang, T., Chen, Q., Jing, S., Liu, S., Liu, J., & Wang, Q. (2026) · Chinese Journal of Natural Medicines · doi:10.1016/s1875-5364(26)61203-4
The gut microbiota–miRNA axis in multiple sclerosis: Mechanisms and therapeutic potentials
Sedaghat, F. R., Hasani, A., Poortahmasebi, V., Hosseini, S., Kafil, H. S., Heydarlou, M. M., Ahmadi, S., Mehdizadehfar, E., Sadeghpour, Y., Hasani, R., et al. (2026) · Folia Microbiologica · doi:10.1007/s12223-026-01574-3
Chasov, V. V., Mukhametshin, S. A., Valiullina, A., Skibo, Y. V., Zhumabekova, M., Zharlyganova, D., Keyer, V. V., Kydyrbayeva, A., Shustov, A. V., & Bulatov, E. (2026) · Current Issues in Molecular Biology · doi:10.3390/cimb48090958
Dulębska, J., Sabat, Z., Kukla, I., Szcześniak, A., Jasińska, E., & Adamus-Białek, W. (2026) · Antonie van Leeuwenhoek · doi:10.1007/s10482-026-02429-0
Montini, F., Pittock, S. J., Cacciaguerra, L., Weiner, H. L., & Schwerdtfeger, L. (2026) · Annals of Neurology · doi:10.1002/ana.78380
Wang, J., Zheng, F., Zhang, Y., & Lu, Z. (2026) · Multiple Sclerosis and Related Disorders · doi:10.1016/j.msard.2026.107948
Multiple sclerosis occurrence with gut microbial metabolites and sex hormones
Sefat, M. P., Bahar, A., Mashhadi, M. J., Yosefi, S., Khazaei, M., & Tahmasebi, H. (2026) · Multiple Sclerosis and Related Disorders · doi:10.1016/j.msard.2026.107973
Metadata
- Authors
- Cosorich, I., Dalla-Costa, G., Sorini, C., Ferrarese, R., Messina, M. J., Dolpady, J., Radice, E., Mariani, A., Testoni, P. A., Canducci, F., Comi, G., Martinelli, V., & Falcone, M.
- Affiliations
- Vita-Salute San Raffaele University (IT)
- Clinical Neurology Unit, IRCCS San Raffaele Scientific Institute, 20132 Milan, Italy.
- IRCCS Ospedale San Raffaele (IT)
- University of Insubria (IT)
- Corresponding author
- Cosorich, Ilaria
- Martinelli, Vittorio
- Falcone, Marika
- ORCID
- Venue
- Science Advances
- Published
- 2017-07-07
- Volume
- 3
- Issue
- 7
- Pages
- e1700492-e1700492
- ISSN
- 2375-2548 (ISSN-L)
- PMC
- PMC5507635
- OpenAlex
- W2734586792
- Cited by
- 338
- References
- 48
- Citations by year
- 2026: 29 · 2025: 34 · 2024: 51 · 2023: 41 · 2022: 48 · 2021: 46 · 2020: 30 · 2019: 31 · 2018: 25 · 2017: 3
- FWCI
- 19.11
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- cc-by-nc
- Locations
- Science Advances (publishedVersion, cc-by-nc)
- PubMed Central (publishedVersion, cc-by-nc)
- PubMed (publishedVersion)
- Archivio Istituzionale della Ricerca - Università Vita-Salute San Raffaele (submittedVersion)
- Funders
- Fondazione Italiana Sclerosi Multipla (award330486)
- Topics
- Health Sciences › Medicine › Clinical Neurology › Multiple Sclerosis Research Studies
- Life Sciences › Immunology and Microbiology › Immunology › Psoriasis: Treatment and Pathogenesis
- Health Sciences › Medicine › Gastroenterology › Inflammatory Bowel Disease
- Keywords
- multiple sclerosis, Th17 cells, intestinal immune cells, gut microbiota, microbiota alterations, disease activity, autoimmune disease, gut-immune axis
- MeSH terms
- Gastrointestinal Microbiome, Adult, Biopsy, Female, Humans, Magnetic Resonance Imaging, Male, Middle Aged, Multiple Sclerosis, Peyer's Patches, Severity of Illness Index, Biomarkers, T-Lymphocyte Subsets, Lymphocyte Count, Immunity, Mucosal, Th17 Cells
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