Microbiota and SCFA in lean and overweight healthy subjects
Abstract
Obesity has recently been linked to the composition of human microbiota and the production of short chain fatty acids (SCFAs). However, these findings rely on experimental studies carried out using rather small and defined groups of volunteers or model animals. Our aim was to evaluate differences within the human intestinal microbiota and fecal SCFA concentration of lean and obese subjects. A total of 98 subjects volunteered to take part in this study. The BMI in kg/m(2) of 30 volunteers was within the lean range, 35 were overweight and 33 were obese. The fecal microbiota was characterized by real-time PCR analyses. With the primers used herein we were able to cover 82.3% (interquartile range of 68.3-91.4%) of the total microbiota detectable with a universal primer. In addition, the concentration of SCFA was evaluated. The total amount of SCFA was higher in the obese subject group (P = 0.024) than in the lean subject group. The proportion of individual SCFA changed in favor of propionate in overweight (P = 0.019) and obese subjects (P = 0.028). The most abundant bacterial groups in faeces of lean and obese subjects belonged to the phyla Firmicutes and Bacteroidetes. The ratio of Firmicutes to Bacteroidetes changed in favor of the Bacteroidetes in overweight (P = 0.001) and obese subjects (P = 0.005). Our results are in line with previous reports suggesting that SCFA metabolism might play a considerable role in obesity. However, our results contradict previous reports with regard to the contribution of various bacterial groups to the development of obesity and this issue remains controversial.
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Other studies did not confirm that the Firmicutes/Bacteroidetes ratio is increased in obesity, or even showed that the relative abundance of Firmicutes was reduced in obese subjects.
“However, others did not confirm these observations [40], or even show that the relative abundance of Firmicutes was reduced in obese subjects [41].”
From Intestinal Microbiota Is Influenced by Gender and Body Mass Index (2016) · cites this paper as [41]
Obesity is associated with an increase in total levels of short-chain fatty acids.
“obesity has been associated with an increase in total levels of SCFAs [10]”
From Gut microbiota and glucometabolic alterations in response to recurrent partial sleep deprivation in normal-weight young individuals (2016) · cites this paper as [10]
An increase in the Firmicutes:Bacteroidetes ratio has been found to be associated with obesity in humans and in genetically or diet-induced obese mice in some but not all studies.
“An increase in this ratio in some [40], but not all [10] studies, has been found to be associated with obesity in humans as well as in genetically or diet-induced obese mice [40], [46], [47]”
From Gut microbiota and glucometabolic alterations in response to recurrent partial sleep deprivation in normal-weight young individuals (2016) · cites this paper as [10]
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- Authors
- Schwiertz, A., Taras, D., Schäfer, K., Beijer, S., Bos, N. A., Donus, C., & Hardt, P. D.
- Affiliations
- Institut für Mikroökologie (DE)
- Freie Universität Berlin (DE)
- University Medical Center Groningen (NL)
- Universitätsklinikum Gießen und Marburg (DE)
- Corresponding author
- Schwiertz, Andreas
- Venue
- Obesity
- Publisher
- Wiley
- Published
- 2010-01
- Volume
- 18
- Issue
- 1
- Pages
- 190-195
- ISSN
- 1930-7381 (ISSN-L)
- 1930-739X
- OpenAlex
- W2136500114
- Cited by
- 2,457
- References
- 48
- Citations by year
- 2026: 59 · 2025: 127 · 2024: 135 · 2023: 185 · 2022: 247 · 2021: 223 · 2020: 234 · 2019: 188 · 2018: 181 · 2017: 153 · 2016: 174 · 2015: 144 · 2014: 129 · 2013: 109 · 2012: 91
- FWCI
- 22.36
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Obesity (publishedVersion)
- PubMed (publishedVersion)
- University of Groningen research database (University of Groningen / Centre for Information Technology) (submittedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
- Health Sciences › Medicine › Epidemiology › Adipokines, Inflammation, and Metabolic Diseases
- Health Sciences › Medicine › Gastroenterology › Gastrointestinal motility and disorders
- Keywords
- gut microbiota, short-chain fatty acids, overweight, lean subjects, Firmicutes, Bacteroidetes, Firmicutes/Bacteroidetes ratio, propionate, fecal microbiota
- MeSH terms
- Adolescent, Adult, Aged, Analysis of Variance, Bacteroides, Clostridium, Fatty Acids, Volatile, Feces, Female, Humans, Intestinal Mucosa, Intestines, Male, Middle Aged, Obesity, RNA, Bacterial, Reverse Transcriptase Polymerase Chain Reaction, Overweight, Metagenome
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