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Cited by 199Autophagy in Disease and TherapyParkinson's Disease Mechanisms and TreatmentsCellular transport and secretion

RAB7A phosphorylation by TBK1 promotes mitophagy via the PINK-PARKIN pathway

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Heo, J.-M., Ordureau, A., Swarup, S., Paulo, J. A., Shen, K., Sabatini, D. M., Harper, J. W.·2018·Science Advances
DOI 10.1126/sciadv.aav0443PMC PMC6314648
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Abstract

TBK1 phosphorylates RAB7A-S72 to support multiple downstream steps in PARKIN-dependent mitophagy.

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Crossref · 10.1126/sciadv.aav0443

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  • RAB7A is located in the HOPS, Rab proteins involved in autophagosome formation, and mitophagy core sub-groups.

    “Indeed, some genes belong to more than one category due to their multiple role (indicated in red in the Supplementary Table 1): for example, the regulator of vesicular transport “RAB7A” is located in i) the “HOPS” [32], ii) the “Rab proteins involved in autophagosome formation” [33], and iii) the “mitophagy core” [34] sub-groups.”

    From A gene toolbox for monitoring autophagy transcription (2021) · cites this paper as [34]

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Research works printed but not linked: 47

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Cited by

Sorted by citations

  • A gene toolbox for monitoring autophagy transcription

    Bordi, M., De Cegli, R., Testa, B., Nixon, R. A., Ballabio, A., & Cecconi, F. (2021) · Cell Death & Disease · doi:10.1038/s41419-021-04121-9 · Cited by 131 · see citing works

    “Indeed, some genes belong to more than one category due to their multiple role (indicated in red in the Supplementary Table 1): for example, the regulator of vesicular transport “RAB7A” is located in i) the “HOPS” [32], ii) the “Rab proteins involved in autophagosome formation” [33], and iii) the “mitophagy core” [34]…”
    Background

Authors
Heo, J.-M., Ordureau, A., Swarup, S., Paulo, J. A., Shen, K., Sabatini, D. M., & Harper, J. W.
Affiliations
  • Harvard University (US)
  • Broad Institute (US)
Corresponding author
Harper, J. W.
ORCID
Venue
Science Advances
Publisher
American Association for the Advancement of Science (AAAS)
Published
2018-11-02
Volume
4
Issue
11
Pages
eaav0443-eaav0443
ISSN
2375-2548 (ISSN-L)
DOI
10.1126/sciadv.aav0443
PMC
PMC6314648
OpenAlex
W2900687171
Cited by
199
References
4
Citations by year
2026: 20 · 2025: 35 · 2024: 34 · 2023: 23 · 2022: 22 · 2021: 27 · 2020: 24 · 2019: 14
FWCI
12.69
Type
journal article
Language
en
Open access
Locations
  • Science Advances (publishedVersion)
  • Europe PMC (PubMed Central) (publishedVersion, cc-by-nc)
  • PubMed Central (publishedVersion, cc-by-nc)
  • PubMed (publishedVersion)
  • DSpace@MIT (Massachusetts Institute of Technology) (submittedVersion, cc-by-nc)
Funders
  • National Institutes of Health (NS083524, GM095567, CA103866, AI47389, DK098285)
  • Howard Hughes Medical Institute
  • Michael J. Fox Foundation for Parkinson’s Research (15866)
Topics
  • Health Sciences › Medicine › Epidemiology › Autophagy in Disease and Therapy
  • Health Sciences › Medicine › Neurology › Parkinson's Disease Mechanisms and Treatments
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Cellular transport and secretion
Keywords
Rab7, TBK1, mitophagy, PINK1, Parkin, protein phosphorylation, ATG9A, LRRK2, autophagy
MeSH terms
Autophagy-Related Proteins, rab7 GTP-Binding Proteins, PTEN-Induced Putative Kinase, HeLa Cells, Humans, Membrane Proteins, Mitochondria, Phosphorylation, Protein Kinases, Proto-Oncogene Proteins, Protein Serine-Threonine Kinases, rab GTP-Binding Proteins, Tumor Suppressor Proteins, Vesicular Transport Proteins, Ubiquitin-Protein Ligases, Ubiquitination, Mitophagy

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