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Cited by 206Inflammasome and immune disordersReproductive Biology and FertilityOvarian function and disorders

Inhibition of the NLRP3 inflammasome prevents ovarian aging

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Navarro-Pando, José M., Alcocer-Gómez, Elísabet, Castejón-Vega, Beatriz, Navarro-Villarán, Elena, Condés-Hervás, Mónica, Mundi-Roldan, María, Muntané, Jordi, Pérez-Pulido, Antonio J. +7 more·2021·Science Advances
DOI 10.1126/sciadv.abc7409PMC PMC7775749

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Abstract

The inhibition of NLRP3 delays ovarian aging and extends fertility during reproductive aging.

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Authors
Navarro-Pando, J. M., Alcocer-Gómez, E., Castejón-Vega, B., Navarro-Villarán, E., Condés-Hervás, M., Mundi-Roldan, M., Muntané, J., Pérez-Pulido, A. J., Bullon, P., Wang, C., Hoffman, H. M., Sanz, A., Mbalaviele, G., Ryffel, B., & Cordero, M. D.
Affiliations
  • Universidad Europea del Atlántico (ES)
  • Departamento de Psicología Experimental, Facultad de Psicología, Universidad de Sevilla, Seville, Spain.
  • Institute of Molecular, Cell and Systems Biology, University of Glasgow, Glasgow G12 8QQ, UK.
  • Institute of Biomedicine of Seville (IBiS), Hospital University Virgen del Rocío/CSIC/University of Seville, Seville, Spain.
  • Instituto de Salud Carlos III (ES)
  • Centro Andaluz de Biologia del Desarrollo (CABD, UPO-CSIC-JA), Facultad de Ciencias Experimentales (Área de Genética), Universidad Pablo de Olavide, 41013 Seville, Spain.
  • Washington University in St. Louis (US)
  • University of California San Diego (US)
  • University of Glasgow (GB)
  • Université d'Orléans (FR)
  • Biomedical Research and Innovation Institute of Cadiz (ES)
Corresponding author
Cordero, Mario D.
ORCID
Venue
Science Advances
Publisher
American Association for the Advancement of Science (AAAS)
Published
2021-01
Volume
7
Issue
1
ISSN
2375-2548 (ISSN-L)
DOI
10.1126/sciadv.abc7409
PMC
PMC7775749
OpenAlex
W3120028415
Cited by
206
References
5
Citations by year
2026: 53 · 2025: 45 · 2024: 36 · 2023: 38 · 2022: 23 · 2021: 10 · 2020: 1
FWCI
8.40
Type
journal article
Language
en
Open access
Licence
Locations
  • Science Advances (publishedVersion, cc-by-nc)
  • bioRxiv (Cold Spring Harbor Laboratory) (acceptedVersion)
  • Europe PMC (PubMed Central) (publishedVersion, cc-by-nc)
  • PubMed Central (publishedVersion, cc-by-nc)
  • PubMed (publishedVersion)
  • ENLIGHTEN (Jurnal Bimbingan dan Konseling Islam) (acceptedVersion, cc-by-sa)
  • RISalud Institutional Health Repository of Andalucía (submittedVersion, cc-by-nc)
  • Digital Commons@Becker (Washington University School of Medicine) (submittedVersion, cc-by-nc)
  • DIGITAL.CSIC (Spanish National Research Council (CSIC)) (submittedVersion, cc-by-nc-nd)
  • Deposito de Investigacion Universidad de Sevilla (University of Seville) (submittedVersion, cc-by-nc)
Funders
  • NIH Office of the Director (NIH/NIAMS AR068972, AR076758)
  • European Commission Directorate-General for Research and Innovation (2016-00110366 BIO-TARGET, EX005756 BIO-TARGET II)
  • Consejera Economa, Innovacin, Ciencia y Empleo, Junta de Andalucia (PI-0036-2014)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Inflammasome and immune disorders
  • Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Reproductive Biology and Fertility
  • Health Sciences › Medicine › Reproductive Medicine › Ovarian function and disorders
Keywords
NLRP3 inflammasome, ovarian aging, female fertility, inflammation, therapeutic target, mouse model

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