The metabolic regulation of aging

Aging: a theory based on free radical and radiation chemistry

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Resveratrol Improves Mitochondrial Function and Protects against Metabolic Disease by Activating SIRT1 and PGC-1α

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Small molecule activators of sirtuins extend Saccharomyces cerevisiae lifespan

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Rapamycin fed late in life extends lifespan in genetically heterogeneous mice

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Premature ageing in mice expressing defective mitochondrial DNA polymerase

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Genes that act downstream of DAF-16 to influence the lifespan of Caenorhabditis elegans

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Caloric Restriction Delays Disease Onset and Mortality in Rhesus Monkeys

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daf-2 , an Insulin Receptor-Like Gene That Regulates Longevity and Diapause in Caenorhabditis elegans

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The ketone metabolite β-hydroxybutyrate blocks NLRP3 inflammasome-mediated inflammatory disease

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Mitochondrial DNA mutations, oxidative stress, and apoptosis in mammalian aging

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IGF-1 receptor regulates lifespan and resistance to oxidative stress in mice

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Calorie restriction promotes mammalian cell survival by inducing the SIRT1 deacetylase

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Requirement of NAD and <i>SIR2</i> for Life-Span Extension by Calorie Restriction in <i>Saccharomyces cerevisiae</i>

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SIRT3 regulates mitochondrial fatty-acid oxidation by reversible enzyme deacetylation

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Induction of autophagy by spermidine promotes longevity

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mTOR is a key modulator of ageing and age-related disease

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NAD+ Metabolism and the Control of Energy Homeostasis: A Balancing Act between Mitochondria and the Nucleus

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A Mutant Drosophila Insulin Receptor Homolog That Extends Life-Span and Impairs Neuroendocrine Function

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Declining NAD+ Induces a Pseudohypoxic State Disrupting Nuclear-Mitochondrial Communication during Aging

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NAD+ and sirtuins in aging and disease

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A role for the NAD-dependent deacetylase Sirt1 in the regulation of autophagy

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Metformin improves healthspan and lifespan in mice

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Sir2 mediates longevity in the fly through a pathway related to calorie restriction

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Nicotinamide Mononucleotide, a Key NAD+ Intermediate, Treats the Pathophysiology of Diet- and Age-Induced Diabetes in Mice

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Decline in skeletal muscle mitochondrial function with aging in humans

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Calorie Restriction-like Effects of 30 Days of Resveratrol Supplementation on Energy Metabolism and Metabolic Profile in Obese Humans

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Calorie restriction reduces oxidative stress by SIRT3-mediated SOD2 activation

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Regulation of lifespan in Drosophila by modulation of genes in the TOR signaling pathway

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Regulation of Yeast Replicative Life Span by TOR and Sch9 in Response to Nutrients

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A role for the mitochondrial deacetylase Sirt3 in regulating energy homeostasis

Ahn, B.-H., Kim, H.-S., Song, S., Lee, I. H., Liu, J., Vassilopoulos, A., Deng, C.-X., & Finkel, T. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0803790105 · Cited by 1,291 · see citing works

Autophagy Genes Are Essential for Dauer Development and Life-Span Extension in <i>C. elegans</i>

Meléndez, A., Tallóczy, Z., Seaman, M., Eskelinen, E.-L., Hall, D. H., & Levine, B. (2003) · Science · doi:10.1126/science.1087782 · Cited by 1,270 · see citing works

Promoting Health and Longevity through Diet: From Model Organisms to Humans

Fontana, L., & Partridge, L. (2015) · Cell · doi:10.1016/j.cell.2015.02.020 · Cited by 1,245 · see citing works

The NAD+ Precursor Nicotinamide Riboside Enhances Oxidative Metabolism and Protects against High-Fat Diet-Induced Obesity

Cantó, C., Houtkooper, R. H., Pirinen, E., Youn, D. Y., Oosterveer, M. H., Cen, Y., Fernandez-Marcos, P. J., Yamamoto, H., Andreux, P. A., Cettour-Rose, P., et al. (2012) · Cell Metabolism · doi:10.1016/j.cmet.2012.04.022 · Cited by 1,238 · see citing works

The NAD+/Sirtuin Pathway Modulates Longevity through Activation of Mitochondrial UPR and FOXO Signaling

Mouchiroud, L., Houtkooper, R. H., Moullan, N., Katsyuba, E., Ryu, D., Cantó, C., Mottis, A., Jo, Y.-S., Viswanathan, M., Schoonjans, K., et al. (2013) · Cell · doi:10.1016/j.cell.2013.06.016 · Cited by 1,210 · see citing works

Glucose restriction extends Caenorhabditis elegans life span by inducing mitochondrial respiration and increasing oxidative stress

Schulz, T. J., Zarse, K., Voigt, A., Urban, N., Birringer, M., & Ristow, M. (2007) · Cell Metabolism · doi:10.1016/j.cmet.2007.08.011 · Cited by 1,209 · see citing works

Rapamycin-Induced Insulin Resistance Is Mediated by mTORC2 Loss and Uncoupled from Longevity

Lamming, D. W., Ye, L., Katajisto, P., Goncalves, M. D., Saitoh, M., Stevens, D. M., Davis, J. G., Salmon, A. B., Richardson, A., Ahima, R. S., et al. (2012) · Science · doi:10.1126/science.1215135 · Cited by 1,199 · see citing works

Resveratrol delays age-related deterioration and mimics transcriptional aspects of dietary restriction without extending life span

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Sirt3 mediates reduction of oxidative damage and prevention of age-related hearing loss under caloric restriction

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Impact of caloric restriction on health and survival in rhesus monkeys from the NIA study

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Rates of Behavior and Aging Specified by Mitochondrial Function During Development

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Dwarf mice and the ageing process

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The sirtuin SIRT6 regulates lifespan in male mice

Kanfi, Y., Naiman, S., Amir, G., Peshti, V., Zinman, G., Nahum, L., Bar-Joseph, Z., & Cohen, H. Y. (2012) · Nature · doi:10.1038/nature10815 · Cited by 1,059 · see citing works

The Cell Non-Autonomous Nature of Electron Transport Chain-Mediated Longevity

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Influence of TOR kinase on lifespan in C. elegans

Vellai, T., Takacs-Vellai, K., Zhang, Y., Kovacs, A. L., Orosz, L., & Müller, F. (2003) · Nature · doi:10.1038/426620a · Cited by 1,057 · see citing works

Overview of caloric restriction and ageing

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Mitonuclear protein imbalance as a conserved longevity mechanism

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Mitochondrial Import Efficiency of ATFS-1 Regulates Mitochondrial UPR Activation

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Effect of 6-Month Calorie Restriction on Biomarkers of Longevity, Metabolic Adaptation, and Oxidative Stress in Overweight Individuals: A Randomized Controlled Trial

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A systematic RNAi screen identifies a critical role for mitochondria in C. elegans longevity

Lee, S. S., Lee, R. Y. N., Fraser, A. G., Kamath, R. S., Ahringer, J., & Ruvkun, G. (2003) · Nature Genetics · doi:10.1038/ng1056 · Cited by 969 · see citing works

Lifespan extension by conditions that inhibit translation in Caenorhabditis elegans

Hansen, M., Taubert, S., Crawford, D., Libina, N., Lee, S.-J., & Kenyon, C. (2007) · Aging Cell · doi:10.1111/j.1474-9726.2006.00267.x · Cited by 918 · see citing works

Sirt3-mediated deacetylation of evolutionarily conserved lysine 122 regulates MnSOD activity in response to stress

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Hypothalamic programming of systemic ageing involving IKK-β, NF-κB and GnRH

Zhang, G., Li, J., Purkayastha, S., Tang, Y., Zhang, H., Yin, Y., Li, B., Liu, G., & Cai, D. (2013) · Nature · doi:10.1038/nature12143 · Cited by 834 · see citing works

Oxidative stress response and Nrf2 signaling in aging

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An AMPK-FOXO pathway mediates longevity induced by a novel method of dietary restriction in C. elegans

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Autophagy and aging: The importance of maintaining "clean" cells

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Coordination of mitophagy and mitochondrial biogenesis during ageing in C. elegans

Palikaras, K., Lionaki, E., & Tavernarakis, N. (2015) · Nature · doi:10.1038/nature14300 · Cited by 770 · see citing works

Caloric restriction

Speakman, J. R., & Mitchell, S. E. (2011) · Molecular Aspects of Medicine · doi:10.1016/j.mam.2011.07.001 · Cited by 769 · see citing works

mTORC1 in the Paneth cell niche couples intestinal stem-cell function to calorie intake

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Sirt1 Extends Life Span and Delays Aging in Mice through the Regulation of Nk2 Homeobox 1 in the DMH and LH

Satoh, A., Brace, C. S., Rensing, N., Cliften, P. F., Wozniak, D. F., Herzog, E. D., Yamada, K. A., & Imai, S. (2013) · Cell Metabolism · doi:10.1016/j.cmet.2013.07.013 · Cited by 734 · see citing works

Overexpression of Atg5 in mice activates autophagy and extends lifespan

Pyo, J.-O., Yoo, S.-M., Ahn, H.-H., Nah, J., Hong, S.-H., Kam, T.-I., Jung, S., & Jung, Y.-K. (2013) · Nature Communications · doi:10.1038/ncomms3300 · Cited by 721 · see citing works

Functionally significant insulin-like growth factor I receptor mutations in centenarians

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Calorie restriction induces mitochondrial biogenesis and bioenergetic efficiency

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Nutrient Availability Regulates SIRT1 Through a Forkhead-Dependent Pathway

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Skeletal Muscle-Specific Ablation of raptor, but Not of rictor, Causes Metabolic Changes and Results in Muscle Dystrophy

Bentzinger, C. F., Romanino, K., Cloëtta, D., Lin, S., Mascarenhas, J. B., Oliveri, F., Xia, J., Casanova, E., Costa, C. F., Brink, M., et al. (2008) · Cell Metabolism · doi:10.1016/j.cmet.2008.10.002 · Cited by 640 · see citing works

Calorie restriction and SIRT3 trigger global reprogramming of the mitochondrial protein acetylome

Hebert, A. S., Dittenhafer-Reed, K. E., Yu, W., Bailey, D. J., Selen, E. S., Boersma, M. D., Carson, J. J., Tonelli, M., Balloon, A. J., Higbee, A. J., et al. (2013) · Molecular Cell · doi:10.1016/j.molcel.2012.10.024 · Cited by 636 · see citing works

Mitohormesis

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The Mammalian Target of Rapamycin (mTOR) Pathway Regulates Mitochondrial Oxygen Consumption and Oxidative Capacity

Schieke, S. M., Phillips, D., McCoy, J. P., Aponte, A. M., Shen, R.-F., Balaban, R. S., & Finkel, T. (2006) · Journal of Biological Chemistry · doi:10.1074/jbc.m603536200 · Cited by 623 · see citing works

Caloric restriction and resveratrol promote longevity through the Sirtuin-1-dependent induction of autophagy

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Tissue-specific regulation of SIRT1 by calorie restriction

Chen, D., Bruno, J., Easlon, E., Lin, S.-J., Cheng, H.-L., Alt, F. W., & Guarente, L. (2008) · Genes &amp; Development · doi:10.1101/gad.1650608 · Cited by 567 · see citing works

Mitohormesis: Promoting Health and Lifespan by Increased Levels of Reactive Oxygen Species (ROS)

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The TFEB orthologue HLH-30 regulates autophagy and modulates longevity in Caenorhabditis elegans

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Brain IRS2 Signaling Coordinates Life Span and Nutrient Homeostasis

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Genetic variation in the murine lifespan response to dietary restriction: from life extension to life shortening

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Inhibition of Respiration Extends C. elegans Life Span via Reactive Oxygen Species that Increase HIF-1 Activity

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A 2-year randomized controlled trial of human caloric restriction: Feasibility and effects on predictors of health span and longevity

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AMPK: positive and negative regulation, and its role in whole-body energy homeostasis

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AMPK at the Nexus of Energetics and Aging

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Adipose-Specific Knockout of raptor Results in Lean Mice with Enhanced Mitochondrial Respiration

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Essential role for autophagy in life span extension

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Sir2-Independent Life Span Extension by Calorie Restriction in Yeast

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Metabolic Regulation by Lysine Malonylation, Succinylation, and Glutarylation

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Extending the Lifespan of Long-Lived Mice

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Reduced TOR Signaling Extends Chronological Life Span via Increased Respiration and Upregulation of Mitochondrial Gene Expression

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