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Ameliorating the hallmarks of cellular senescence in skeletal muscle myogenic progenitors in vitro and in vivo
Abstract
The embryonic factor NANOG reverses aging hallmarks and rejuvenates senescent skeletal muscle progenitors.
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NANOG alone has a pivotal role in ameliorating senescence hallmarks and inducing rejuvenation in myogenic progenitor cells both in vitro and in vivo.
“Shahini et al. showed that NANOG alone has a pivotal role in ameliorating of senescence hallmarks and inducing rejuvenation in myogenic progenitor cells both in vitro and in vivo 61 .”
From Mechanisms, pathways and strategies for rejuvenation through epigenetic reprogramming (2023) · cites this paper as [61]
Other transcription factors might represent a safer alternative to induce epigenetic rejuvenation.
“further supporting the idea that other transcription factors might represent a safer alternative to induce epigenetic rejuvenation as also reported by other groups 61,118 .”
From Mechanisms, pathways and strategies for rejuvenation through epigenetic reprogramming (2023) · cites this paper as [61]
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Sorted by citations
Mechanisms, pathways and strategies for rejuvenation through epigenetic reprogramming
Cipriano, A., Moqri, M., Maybury-Lewis, S. Y., Rogers-Hammond, R., de Jong, T. A., Parker, A., Rasouli, S., Schöler, H. R., Sinclair, D. A., & Sebastiano, V. (2023) · Nature Aging · doi:10.1038/s43587-023-00539-2 · Cited by 66
Cellular plasticity in reprogramming, rejuvenation and tumorigenesis: a pioneer TF perspective
Huyghe, A., Trajkova, A., & Lavial, F. (2024) · Trends in Cell Biology · doi:10.1016/j.tcb.2023.07.013 · Cited by 56
Metadata
- Authors
- Shahini, A., Rajabian, N., Choudhury, D., Shahini, S., Vydiam, K., Nguyen, T., Kulczyk, J., Santarelli, T., Ikhapoh, I., Zhang, Y., Wang, J., Liu, S., Stablewski, A., Thiyagarajan, R., Seldeen, K., Troen, B. R., Peirick, J., Lei, P., & Andreadis, S. T.
- Venue
- Science Advances
- Published
- 2021-09-03
- Volume
- 7
- Issue
- 36
- ISSN
- 2375-2548
- PMC
- PMC8442867
- Cited by
- 38
- References
- 11
- Language
- en
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