Mouse models of ageing and their relevance to disease

Interleukin-10-deficient mice develop chronic enterocolitis

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Chronic Inflammation (Inflammaging) and Its Potential Contribution to Age-Associated Diseases

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Mutation of the mouse klotho gene leads to a syndrome resembling ageing

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One-step generation of mice carrying mutations in multiple genes by CRISPR/Cas-mediated genome engineering

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Extending Healthy Life Span—From Yeast to Humans

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IL-10 inhibits cytokine production by activated macrophages

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Premature ageing in mice expressing defective mitochondrial DNA polymerase

Trifunovic, A., Wredenberg, A., Falkenberg, M., Spelbrink, J. N., Rovio, A. T., Bruder, C. E., Bohlooly-Y, M., Gidlöf, S., Oldfors, A., Wibom, R., et al. (2004) · Nature · doi:10.1038/nature02517 · Cited by 2,734 · see citing works

Arterial and Cardiac Aging: Major Shareholders in Cardiovascular Disease Enterprises: Part I: Aging Arteries: A “Set Up” for Vascular Disease

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Recurrent de novo point mutations in lamin A cause Hutchinson–Gilford progeria syndrome

Eriksson, M., Brown, W. T., Gordon, L. B., Glynn, M. W., Singer, J. I., Scott, L. J., Erdos, M. R., Robbins, C. M., Moses, T. Y., Berglund, P., et al. (2003) · Nature · doi:10.1038/nature01629 · Cited by 2,217 · see citing works

Mitochondrial DNA mutations, oxidative stress, and apoptosis in mammalian aging

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Telomere Shortening and Tumor Formation by Mouse Cells Lacking Telomerase RNA

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Time-restricted feeding without reducing caloric intake prevents metabolic diseases in mice fed a high-fat diet

Hatori, M., Vollmers, C., Zarrinpar, A., DiTacchio, L., Bushong, E. A., Gill, S., Leblanc, M., Chaix, A., Joens, M., Fitzpatrick, J. A. J., et al. (2012) · Cell Metabolism · doi:10.1016/j.cmet.2012.04.019 · Cited by 1,986 · see citing works

Suppression of Aging in Mice by the Hormone Klotho

Kurosu, H., Yamamoto, M., Clark, J. D., Pastor, J. V., Nandi, A., Gurnani, P., McGuinness, O. P., Chikuda, H., Yamaguchi, M., Kawaguchi, H., et al. (2005) · Science · doi:10.1126/science.1112766 · Cited by 1,935 · see citing works

IL-10 acts on the antigen-presenting cell to inhibit cytokine production by Th1 cells

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Lamin A Truncation in Hutchinson-Gilford Progeria

Sandre‐Giovannoli, A. D., Bernard, R., Cau, P., Navarro, C. L., Amiel, J., Boccaccio, I., Lyonnet, S., Stewart, C. L., Münnich, A., Merrer, M. F. L., et al. (2003) · Science · doi:10.1126/science.1084125 · Cited by 1,472 · see citing works

The mitochondrial basis of aging

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Essential role of mouse telomerase in highly proliferative organs

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Dwarf locus mutants lacking three pituitary cell types result from mutations in the POU-domain gene pit-1

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Impact of caloric restriction on health and survival in rhesus monkeys from the NIA study

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Enterocolitis and colon cancer in interleukin-10-deficient mice are associated with aberrant cytokine production and CD4(+) TH1-like responses.

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The Collaborative Cross, a community resource for the genetic analysis of complex traits

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Dwarf mice and the ageing process

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Biochemical Adaptations to Endurance Exercise in Muscle

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The Retardation of Aging in Mice by Dietary Restriction: Longevity, Cancer, Immunity and Lifetime Energy Intake

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Time-restricted feeding is a preventative and therapeutic intervention against diverse nutritional challenges

Chaix, A., Zarrinpar, A., Miu, P., & Panda, S. (2014) · Cell Metabolism · doi:10.1016/j.cmet.2014.11.001 · Cited by 956 · see citing works

Rapamycin, But Not Resveratrol or Simvastatin, Extends Life Span of Genetically Heterogeneous Mice

Miller, R. A., Harrison, D. E., Astle, C. M., Baur, J. A., Boyd, A. R., de Cabo, R., Fernandez, E., Flurkey, K., Javors, M. A., Nelson, J. F., et al. (2011) · The Journals of Gerontology: Series A · doi:10.1093/gerona/glq178 · Cited by 896 · see citing works

Hypothalamic programming of systemic ageing involving IKK-β, NF-κB and GnRH

Zhang, G., Li, J., Purkayastha, S., Tang, Y., Zhang, H., Yin, Y., Li, B., Liu, G., & Cai, D. (2013) · Nature · doi:10.1038/nature12143 · Cited by 834 · cited 4× · see citing works

Lifespan extension and delayed immune and collagen aging in mutant mice with defects in growth hormone production

Flurkey, K., Papaconstantinou, J., Miller, R. A., & Harrison, D. E. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.111158898 · Cited by 826 · see citing works

Chronic inflammation induces telomere dysfunction and accelerates ageing in mice

Jurk, D., Wilson, C., Passos, J. F., Oakley, F., Correia-Melo, C., Greaves, L., Saretzki, G., Fox, C., Lawless, C., Anderson, R., et al. (2014) · Nature Communications · doi:10.1038/ncomms5172 · Cited by 814 · see citing works

Detection of a specific mitochondrial DNA deletion in tissues of older humans

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Caloric restriction

Speakman, J. R., & Mitchell, S. E. (2011) · Molecular Aspects of Medicine · doi:10.1016/j.mam.2011.07.001 · Cited by 769 · see citing works

Linking functional decline of telomeres, mitochondria and stem cells during ageing

Sahin, E., & DePinho, R. A. (2010) · Nature · doi:10.1038/nature08982 · Cited by 759 · see citing works

Aging-Dependent Large Accumulation of Point Mutations in the Human mtDNA Control Region for Replication

Michikawa, Y., Mazzucchelli, F., Bresolin, N., Scarlato, G., & Attardi, G. M. (1999) · Science · doi:10.1126/science.286.5440.774 · Cited by 725 · see citing works

Caloric restriction reduces age-related and all-cause mortality in rhesus monkeys

Colman, R. J., Beasley, T. M., Kemnitz, J. W., Johnson, S. C., Weindruch, R., & Anderson, R. M. (2014) · Nature Communications · doi:10.1038/ncomms4557 · Cited by 711 · see citing works

Growth Curves and Survival Characteristics of the Animals Used in the Biomarkers of Aging Program

Turturro, A., Witt, W. W., Lewis, S. M., Hass, B. S., Lipman, R. D., & Hart, R. W. (1999) · The Journals of Gerontology Series A · doi:10.1093/gerona/54.11.b492 · Cited by 668 · see citing works

A pattern of accumulation of a somatic deletion of mitochondrial DNA in aging human tissues.

Cortopassi, G. A., Shibata, D. K., Soong, N.-W., & Arnheim, N. (1992) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.89.16.7370 · Cited by 639 · see citing works

Genetic variability in adult bone density among inbred strains of mice

Beamer, W. G., Donahue, L. R., Rosen, C. J., & Baylink, D. J. (1996) · Bone · doi:10.1016/8756-3282(96)00047-6 · Cited by 630 · see citing works

Rapamycin‐mediated lifespan increase in mice is dose and sex dependent and metabolically distinct from dietary restriction

Miller, R. A., Harrison, D. E., Astle, C. M., Fernández, E., Flurkey, K., Han, M. L., Javors, M. A., Li, X., Nadon, N. L., Nelson, J. F., et al. (2013) · Aging Cell · doi:10.1111/acel.12194 · Cited by 624 · see citing works

Intermittent fasting and caloric restriction ameliorate age-related behavioral deficits in the triple-transgenic mouse model of Alzheimer's disease

Halagappa, V. K. M., Guo, Z., Pearson, M., Matsuoka, Y., Cutler, R. G., LaFerla, F. M., & Mattson, M. P. (2007) · Neurobiology of Disease · doi:10.1016/j.nbd.2006.12.019 · Cited by 580 · see citing works

Mutations in PROP1 cause familial combined pituitary hormone deficiency

Wu, W., Cogan, J. D., Pfäffle, R. W., Dasen, J. S., Frisch, H., O’Connell, S. M., Flynn, S. E., Brown, M. R., Mullis, P. E., Parks, J. S., et al. (1998) · Nature Genetics · doi:10.1038/ng0298-147 · Cited by 562 · see citing works

Defective prelamin A processing and muscular and adipocyte alterations in Zmpste24 metalloproteinase–deficient mice

Pendás, A. M., Zhou, Z., Cadiñanos, J., Freije, J. M. P., Wang, J., Hultenby, K., Astudillo, A., Wernerson, A., Rodríguez, F., Tryggvason, K., et al. (2002) · Nature Genetics · doi:10.1038/ng871 · Cited by 554 · see citing works

Premature Aging in Mice Deficient in DNA Repair and Transcription

de Boer, J., Andressoo, J. O., de Wit, J., Huijmans, J., Beems, R. B., van Steeg, H., Weeda, G., van der Horst, G. T. J., van Leeuwen, W., Themmen, A. P. N., et al. (2002) · Science · doi:10.1126/science.1070174 · Cited by 545 · see citing works

Aging, adiposity, and calorie restriction

Fontana, L. (2007) · JAMA · doi:10.1001/jama.297.9.986 · Cited by 526 · see citing works

Genome-wide generation and systematic phenotyping of knockout mice reveals new roles for many genes.

White, J. K., Gerdin, A.-K., Karp, N. A., Ryder, E., Buljan, M., Bussell, J. N., Salisbury, J., Clare, S., Ingham, N. J., Podrini, C., et al. (2013) · Cell · doi:10.1016/j.cell.2013.06.022 · Cited by 509 · see citing works

A comparative phenotypic and genomic analysis of C57BL/6J and C57BL/6N mouse strains

Simon, M. M., Greenaway, S., White, J. K., Fuchs, H., Gailus-Durner, V., Wells, S., Sorg, T., Wong, K., Bedu, E., Cartwright, E. J., et al. (2013) · Genome Biology · doi:10.1186/gb-2013-14-7-r82 · Cited by 507 · see citing works

Genetic variation in the murine lifespan response to dietary restriction: from life extension to life shortening

Liao, C., Rikke, B. A., Johnson, T. E., Diaz, V., & Nelson, J. F. (2010) · Aging Cell · doi:10.1111/j.1474-9726.2009.00533.x · Cited by 501 · see citing works

Association of human aging with a functional variant of klotho

Arking, D. E., Krebsová, A., Maçek, M., Maçek, M., Arking, A., Mian, S. I., Fried, L. F., Hamosh, A., Dey, S., McIntosh, I., et al. (2002) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.022484299 · Cited by 481 · see citing works

High-Resolution Genetic Mapping Using the Mouse Diversity Outbred Population

Svenson, K. L., Gatti, D. M., Valdar, W. S. J., Welsh, C. E., Cheng, R., Chesler, E. J., Palmer, A. A., McMillan, L., & Churchill, G. A. (2012) · Genetics · doi:10.1534/genetics.111.132597 · Cited by 466 · see citing works

Essential role of limiting telomeres in the pathogenesis of Werner syndrome

Chang, S., Multani, A. S., Cabrera, N. G., Naylor, M. L., Laud, P., Lombard, D., Pathak, S., Guarente, L., & DePinho, R. A. (2004) · Nature Genetics · doi:10.1038/ng1389 · Cited by 462 · see citing works

The diversity outbred mouse population

Churchill, G. A., Gatti, D. M., Munger, S. C., & Svenson, K. L. (2012) · Mammalian Genome · doi:10.1007/s00335-012-9414-2 · Cited by 458 · see citing works

Zmpste24 deficiency in mice causes spontaneous bone fractures, muscle weakness, and a prelamin A processing defect

Bergö, M. O., Gavino, B. J., Ross, J., Schmidt, W. K., Hong, C., Kendall, L. V., Mohr, A., Meta, M. D., Genant, H. K., Jiang, Y., et al. (2002) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.192460799 · Cited by 443 · see citing works

A genetic and physiological study of impaired glucose homeostasis control in C57BL/6J mice

Toye, A. A., Lippiat, J. D., Proks, P., Shimomura, K., Bentley, L., Hugill, A., Mijat, V., Goldsworthy, M. E., Moir, L., Haynes, A. R., et al. (2005) · Diabetologia · doi:10.1007/s00125-005-1680-z · Cited by 438 · see citing works

Splicing-directed therapy in a new mouse model of human accelerated aging

Osorio, F. G., Navarro, C. L., Cadiñanos, J., López-Mejía, I. C., Quirós, P. M., Bartoli, C., Rivera, J., Tazi, J., Guzmán, G., Varela, I., et al. (2011) · Science Translational Medicine · doi:10.1126/scitranslmed.3002847 · Cited by 432 · see citing works

Dietary restriction normalizes glucose metabolism and BDNF levels, slows disease progression, and increases survival in huntingtin mutant mice

Duan, W., Guo, Z., Jiang, H., Ware, M., Li, X.-J., & Mattson, M. P. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0536856100 · Cited by 428 · see citing works

Aging in inbred strains of mice: study design and interim report on median lifespans and circulating IGF1 levels

Yuan, R., Tsaih, S., Petkova, S. B., de Evsikova, C. M., Xing, S., Marion, M. A., Bogue, M. A., Mills, K. D., Peters, L. L., Bult, C. J., et al. (2009) · Aging Cell · doi:10.1111/j.1474-9726.2009.00478.x · Cited by 414 · see citing works

Mitochondrial point mutations do not limit the natural lifespan of mice

Vermulst, M., Bielas, J. H., Kujoth, G. C., Ladiges, W. C., Rabinovitch, P. S., Prolla, T. A., & Loeb, L. A. (2007) · Nature Genetics · doi:10.1038/ng1988 · Cited by 404 · see citing works

Progeria syndromes and ageing: what is the connection?

Burtner, C. R., & Kennedy, B. K. (2010) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm2944 · Cited by 386 · see citing works

Disruption of mouse ERCC1 results in a novel repair syndrome with growth failure, nuclear abnormalities and senescence

Weeda, G., Donker, I., de Wit, J., Morreau, H., Janssens, R. C., Vissers, C. J., Nigg, A. L., STEEG, H. V., Bootsma, D., & Hoeijmakers, J. H. J. (1997) · Current Biology · doi:10.1016/s0960-9822(06)00190-4 · Cited by 380 · see citing works

Ultra-sensitive sequencing reveals an age-related increase in somatic mitochondrial mutations that are inconsistent with oxidative damage

Kennedy, S. R., Salk, J. J., Schmitt, M. W., & Loeb, L. A. (2013) · PLoS Genetics · doi:10.1371/journal.pgen.1003794 · Cited by 363 · see citing works

DIABETES MELLITUS AND SIMPLE OPTIC ATROPHY AMONG SIBLINGS: REPORT OF FOUR CASES

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Caloric restriction attenuates Aβ-deposition in Alzheimer transgenic models

Patel, N. V., Gordon, M. N., Connor, K. E., Good, R. A., Engelman, R. W., Mason, J., Morgan, D. G., Morgan, T. E., & Finch, C. E. (2005) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2004.09.014 · Cited by 329 · see citing works

Deletion of Nicotinamide Nucleotide Transhydrogenase

Freeman, H. C., Hugill, A. J., Dear, N. T., Ashcroft, F. M., & Cox, R. (2006) · Diabetes · doi:10.2337/db06-0358 · Cited by 321 · see citing works

Caloric restriction attenuates β‐amyloid neuropathology in a mouse model of Alzheimer's disease

Wang, J., Ho, L., Qin, W., Rocher, A. B., Seror, I., Humala, N., Maniar, K. P., Dolios, G., Wang, R., Hof, P. R., et al. (2005) · The FASEB Journal · doi:10.1096/fj.04-3182fje · Cited by 317 · see citing works

Blocking protein farnesyltransferase improves nuclear blebbing in mouse fibroblasts with a targeted Hutchinson–Gilford progeria syndrome mutation

Yang, S. H., Bergö, M. O., Toth, J. I., Qiao, X., Hu, Y., Sandoval, S., Meta, M. D., Bendale, P. M., Gelb, M. H., Young, S. G., et al. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0504641102 · Cited by 311 · see citing works

T Cell–specific Inactivation of the Interleukin 10 Gene in Mice Results in Enhanced T Cell Responses but Normal Innate Responses to Lipopolysaccharide or Skin Irritation

Roers, A., Siewe, L., Strittmatter, E., Deckert, M., Schlüter, D., Stenzel, W., Gruber, A. D., Krieg, T. M., Rajewsky, K., & Müller, W. (2004) · The Journal of Experimental Medicine · doi:10.1084/jem.20041789 · Cited by 309 · see citing works

A deletion within the murine Werner syndrome helicase induces sensitivity to inhibitors of topoisomerase and loss of cellular proliferative capacity

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Cisd2 deficiency drives premature aging and causes mitochondria-mediated defects in micePreprint

Chen, Y., Kao, C., Chen, Y.-T., Wang, C., Wu, C.-Y., Tsai, C., Liu, F.-C., Yang, C.-W., Wei, Y., Hsu, M., et al. (2009) · Genes & Development · doi:10.1101/gad.1779509 · Cited by 304 · see citing works

Metabolic reprogramming, caloric restriction and aging

Anderson, R. M., & Weindruch, R. H. (2009) · Trends in Endocrinology and Metabolism · doi:10.1016/j.tem.2009.11.005 · Cited by 300 · see citing works

Calorie restriction and prevention of age‐associated chronic disease

Omodei, D., & Fontana, L. (2011) · FEBS Letters · doi:10.1016/j.febslet.2011.03.015 · Cited by 293 · see citing works

Meal size and frequency affect neuronal plasticity and vulnerability to disease: cellular and molecular mechanisms

Mattson, M. P., Duan, W., & Guo, Z. (2003) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.2003.01586.x · Cited by 288 · see citing works

Ath-1, a gene determining atherosclerosis susceptibility and high density lipoprotein levels in mice.

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A Homozygous Mutation in a Novel Zinc-Finger Protein, ERIS, Is Responsible for Wolfram Syndrome 2

Amr, S. S., Heisey, C., Zhang, M., Xia, X.-J., Shows, K. H., Ajlouni, K. M., Pandya, A., Satin, L. S., El‐Shanti, H., & Shiang, R. (2007) · The American Journal of Human Genetics · doi:10.1086/520961 · Cited by 284 · see citing works

The International Mouse Phenotyping Consortium: past and future perspectives on mouse phenotyping

Brown, S. D. M., & Moore, M. W. (2012) · Mammalian Genome · doi:10.1007/s00335-012-9427-x · Cited by 282 · see citing works

Age-dependent cardiomyopathy in mitochondrial mutator mice is attenuated by overexpression of catalase targeted to mitochondria

Dai, D., Chen, T., Wanagat, J., Laflamme, M., Marcinek, D. J., Emond, M. J., Ngo, C. P., Prolla, T. A., & Rabinovitch, P. S. (2010) · Aging Cell · doi:10.1111/j.1474-9726.2010.00581.x · Cited by 280 · see citing works

Genotypic Differences in Behavioral, Physiological and Anatomical Expressions of Age-Related Hearing Loss in the Laboratory Mouse: Original Papers Travaux originaux

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Mitochondrial DNA Mutations Induce Mitochondrial Dysfunction, Apoptosis and Sarcopenia in Skeletal Muscle of Mitochondrial DNA Mutator Mice

Hiona, A., Sanz, A., Kujoth, G. C., Pamplona, R., Seo, A. Y., Hofer, T., Someya, S., Miyakawa, T., Chie, N., Samhan-Arias, A. K., et al. (2010) · PLoS ONE · doi:10.1371/journal.pone.0011468 · Cited by 269 · see citing works

Impact of age and caloric restriction on neurogenesis in the dentate gyrus of C57BL/6 mice

Bondolfi, L., Ermini, F., Long, J. M., Ingram, D. K., & Jucker, M. (2003) · Neurobiology of Aging · doi:10.1016/s0197-4580(03)00083-6 · Cited by 264 · see citing works

Disruption of the WFS1 gene in mice causes progressive -cell loss and impaired stimulus-secretion coupling in insulin secretion

Ishihara, H. (2004) · Human Molecular Genetics · doi:10.1093/hmg/ddh125 · Cited by 258 · see citing works

Accumulating Mitochondrial DNA Mutations Drive Premature Hematopoietic Aging Phenotypes Distinct from Physiological Stem Cell Aging

Norddahl, G. L., Pronk, C. J., Wahlestedt, M., Sten, G., Nygren, J. M., Ugale, A., Sigvardsson, M., & Bryder, D. (2011) · Cell Stem Cell · doi:10.1016/j.stem.2011.03.009 · Cited by 249 · see citing works

Genotype and age influence the effect of caloric intake on mortality in mice

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Mice conditionally lacking the Wolfram gene in pancreatic islet beta cells exhibit diabetes as a result of enhanced endoplasmic reticulum stress and apoptosis

Riggs, A. C., Bernal‐Mizrachi, E., Ohsugi, M., Wasson, J., Fátrai, S., Welling, C. M., Murray, J., Schmidt, R. E., Herrera, P. L., & Permutt, M. A. (2005) · Diabetologia · doi:10.1007/s00125-005-1947-4 · Cited by 228 · see citing works

Defective Extracellular Pyrophosphate Metabolism Promotes Vascular Calcification in a Mouse Model of Hutchinson-Gilford Progeria Syndrome That Is Ameliorated on Pyrophosphate Treatment

Villa‐Bellosta, R., Rivera, J., Osorio, F. G., Acín‐Pérez, R., Enrı́quez, J. A., López-Otı́n, C., & Andrés, V. (2013) · Circulation · doi:10.1161/circulationaha.112.000571 · Cited by 219 · see citing works

The Snell dwarf mutation Pit1dw can increase life span in mice

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Impaired Remodeling of White Adipose Tissue in Obesity and Aging: From Defective Adipogenesis to Adipose Organ Dysfunction

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Changes in the biochemical taste of cytoplasmic and cell-free DNA are major fuels for inflamm-aging

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Secreted Protein Acidic and Rich in Cysteine (Sparc) KO Leads to an Accelerated Ageing Phenotype Which Is Improved by Exercise Whereas SPARC Overexpression Mimics Exercise Effects in Mice

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Vascular Aging in Rodent Models: Contrasting Mechanisms Driving the Female and Male Vascular Senescence

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Premature aging and reduced cancer incidence associated with near-complete body-wide Myc inactivation

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CRISPR-Cas9 Mediated Telomere Removal Leads to Mitochondrial Stress and Protein Aggregation

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A young testicular microenvironment protects Leydig cells against age‐related dysfunction in a mouse model of premature aging

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An Appraisal on the Value of Using Nutraceutical Based Senolytics and Senostatics in Aging

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Frailty index and phenotype frailty score: Sex- and age-related differences in 5XFAD transgenic mouse model of Alzheimer’s disease

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Loss of Chondroitin Sulfate Modification Causes Inflammation and Neurodegeneration in skt Mice

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The effects of dietary fatty acids on bone, hematopoietic marrow and marrow adipose tissue in a murine model of senile osteoporosis

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Peptide location fingerprinting identifies species- and tissue-conserved structural remodelling of proteins as a consequence of ageing and disease

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Aging-Related Changes in the Ultrastructure of Hepatocytes and Cardiomyocytes of Elderly Mice Are Enhanced in ApoE-Deficient Animals

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Bone Tissue and the Nervous System: What Do They Have in Common?

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High-salt diet augments systolic blood pressure and induces arterial dysfunction in outbred, genetically diverse mice

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Constitutive Dicer1 phosphorylation accelerates metabolism and aging in vivo

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Genetic context modulates aging and degeneration in the murine retina

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Lessons in aging from Myc knockout mouse models

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A researcher's guide to studying sex differences in immune aging

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Quantitative proteomics to study aging in rabbit liver

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Progress in precision drug delivery systems for neurodegenerative diseases with muscle atrophy

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Phosphatidylethanolamine N-Methyltransferase Knockout Modulates Metabolic Changes in Aging Mice

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Identification of the Potential Gene Regulatory Networks and Therapeutics in Aged Mice With Postoperative Neurocognitive Disorder

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Targeted Therapeutics Delivery by Exploiting Biophysical Properties of Senescent Cells

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Dicer1 deficient mice exhibit premature aging and metabolic perturbations in adipocytes

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Aging, Parkinson’s Disease, and Models: What Are the Challenges?

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Intermittent Fasting Ameliorates Age-Induced Morphological Changes in Aged Albino Rat Kidney via Autophagy Activation and Reduction of Apoptosis and Inflammation

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Accelerated Aging in Cyclophilin B–Deficient Mice Downstream of p21‐Cip1 /Waf1

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Modelling Osteoporosis in Pre-Clinical Research—Challenges, Trends and New Approaches

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From Elixirs to Geroscience: A Historical and Molecular Perspective on Anti-Aging Medicine

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Restoring the youthful state of striatal plasticity in aged mice re-enables cognitive control of action

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Chemical Characterization and Beneficial Effects of Walnut Oil on a Drosophila melanogaster Model of Parkinson’s Disease

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Plausible Links Between Metabolic Networks, Stem Cells, and Longevity

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More than a number: Incorporating the aged phenotype to improve in vitro and in vivo modeling of neurodegenerative disease

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Metabolic shifts in ratio of ucOcn to cOcn toward bone resorption contribute to age-dependent bone loss in male mice

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Alterations in biogenic amines levels associated with age-related muscular tissue impairment in Drosophila melanogaster

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Back to the Basics: Usefulness of Naturally Aged Mouse Models and Immunohistochemical and Quantitative Morphologic Methods in Studying Mechanisms of Lung Aging and Associated Diseases

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The analysis of fatty acids and their derivatives in the liver of C57BL/6 mice with long-term caloric restrictions

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Using Computational Models to Study Aging

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Reproductive toxicology: keeping up with our changing world

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The African turquoise killifish (Nothobranchius furzeri): A model of age-related diseases and declining regenerative capability across multiple organs

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Age-induced P-bodies become detrimental and shorten the lifespan of yeastPreprint

Choi, J., Wang, S., Li, Y., Hao, N., & Zid, B. M. (2021) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2021.11.05.467477 · Cited by 4 · see citing works

The Converging Roles of Nucleases and Helicases in Genome Maintenance and the Aging Process

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The role of gut microbiota on skeletal muscle strength in LDLR knockdown aging mice

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Potential impact of underlying diseases influencing ADME in nonclinical safety assessment

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Low birth weight and reduced postnatal nutrition lead to cardiac dysfunction in piglets

McPeek, A. C., Patton, B., Columbus, D. A., Olver, T. D., Rodrigues, L. A., Sands, J., Weber, L. P., & Ferguson, D. P. (2023) · Journal of Animal Science · doi:10.1093/jas/skad364 · Cited by 3 · see citing works

RNase 2/EDN cleaves tRNA anticodon loops to generate immunoactive RNAsPreprint

Shigematsu, M., Minami, A., Kawamura, T., Shah, S. D., Ogawa, T., Deshpande, D. A., & Kirino, Y. (2019) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/815803 · Cited by 3 · see citing works

The aging lung mucosa: A proteomics studyPreprint

Garcia‐Vilanova, A., Olmo-Fontánez, A. M., Moliva, J. I., Allué‐Guardia, A., Singh, H., Merrit, R. E., Caceres, D. M., Peters, J. I., Wang, Y., Schlesinger, L. S., et al. (2021) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2021.09.14.460375 · Cited by 3 · see citing works

Age-related diseases as a testbed for anti-aging therapeutics: the case of idiopathic pulmonary fibrosis

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Distinct transcriptomic effects of intermittent and chronic caloric restriction in mammary fat pad of a breast cancer mouse model

Tuna, B. G., Keles, N. A., Cicekdal, M. B., Doğan, S., & Kõks, S. (2025) · PLoS ONE · doi:10.1371/journal.pone.0331898 · Cited by 1 · see citing works

Content of Fatty Acid and Eicosanoids in Muscle and Intestinal Tissue of C57BL/6 Mice Subjected to Long-Term Caloric Restriction

Palma, J., Skonieczna‐Żydecka, K., Maciejewska, D., Zgutka, K., Piotrowska, K., & Stachowska, E. (2026) · Nutrients · doi:10.3390/nu18030518 · Cited by 2 · see citing works

Experimental model systems to study vascular aging

Tuna, B. G., Rey, A. B. A., Julve, J., Borrell-Pagés, M., Praet, M. V., Riches‐Suman, K., Roks, A. J. M., Rochfort, K. D., Keles, N. A., Tura-Ceide, O., et al. (2026) · Ageing Research Reviews · doi:10.1016/j.arr.2026.103256 · Cited by 2 · see citing works

Hesperidin Supplementation During Alternate Day Fasting Provides Synergistic Effect in Conferring Neuroprotection to Aging Rats

Bhoumik, S., Kesherwani, R., & Rizvi, S. I. (2024) · Indian Journal of Clinical Biochemistry · doi:10.1007/s12291-024-01220-0 · Cited by 2 · see citing works

Age-related differences in retinal function and structure in C57BL/6J and Thy1-YFPh mice

Lee, P. Y., & Bui, B. V. (2024) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2024.06.005 · Cited by 2 · see citing works

Generation and Identification of Mutations Resulting in Chronic and Age‐Related Phenotypes in Mice

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Premature Aging and Reduced Cancer Incidence Associated with Near-Complete Body-Wide Myc InactivationPreprint

Wang, H., Lu, J. L., Stevens, T., Roberts, A., Mandel, J. A., Avula, R., Ma, B., Wu, Y. L., Wang, J., Land, C. V., et al. (2023) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2023.01.30.526354 · Cited by 2 · see citing works

Age-Related RPE changes in Wildtype C57BL/6J Mice between 2 and 32 MonthsPreprint

Shelton, D. A., Gefke, I., Summers, V. R., Kim, Y., Yu, H., Getz, Y., Ferdous, S., Donaldson, K. J., Liao, K., Papania, J. T., et al. (2024) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2024.01.30.574142 · Cited by 2 · see citing works

Intrinsic capacity evolution during aging in mouse and fish: Longitudinal perspectives from a narrative review

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Aging in Rodents

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(Re)modeling high-salt diet-induced hypertension in mice

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Fluorescence-Guided Spatial Mapping of p21-Expressing Senescent Cells in Aged Liver at Single-Cell Resolution

Hsu, J.-E., Wang, B., Hwang, Y., Cheng, W., Zhao, Q., Si, Y., Xu, M., Kang, H.-M., & Lee, J. H. (2026) · Biomolecules · doi:10.3390/biom16040579

On the molecular mechanisms of hematopoietic stem cell aging

Lazare, S. (2018) · University of Groningen research database (University of Groningen / Centre for Information Technology)

Models of Immune Aging

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With mouse age comes wisdom: A review and suggestions of relevant mouse models for age-related conditions

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Induction of Accelerated Aging in a Mouse Model

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The mouse as a model organism in aging research: Usefulness, pitfalls and possibilities

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Energy Metabolism and Ageing in the Mouse: A Mini-Review

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The Accelerated Aging Mouse Serves as a Model for Basic Research

Liu, Y., & Zhang, Y. (2024) · International Journal of Clinical and Experimental Medicine Research · doi:10.26855/ijcemr.2024.01.028