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Cited by 16Neurobiology and Insect Physiology ResearchNeurotransmitter Receptor Influence on BehaviorNeuroscience and Neuropharmacology Research

A neurogenetic mechanism of experience-dependent suppression of aggression

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Ishii, Kenichi, Cortese, Matteo, Leng, Xubo, Shokhirev, Maxim N., Asahina, Kenta·2022·Science Advances
DOI 10.1126/sciadv.abg3203PMC PMC9451153

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Abstract

Aggression is an ethologically important social behavior, but excessive aggression can be detrimental to fitness. Social experiences among conspecific individuals reduce aggression in many species, the mechanism of which is largely unknown. We found that loss-of-function mutation of nervy ( nvy ), a Drosophila homolog of vertebrate myeloid translocation genes (MTGs), increased aggressiveness only in socially experienced flies and that this could be reversed by neuronal expression of human MTGs. A subpopulation of octopaminergic/tyraminergic neurons labeled by nvy was specifically required for such social experience–dependent suppression of aggression, in both males and females. Cell type–specific transcriptomic analysis of these neurons revealed aggression-controlling genes that are likely downstream of nvy . Our results illustrate both genetic and neuronal mechanisms by which the nervous system suppresses aggression in a social experience–dependent manner, a poorly understood process that is considered important for maintaining the fitness of animals.

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Cited by

Sorted by citations

Authors
Ishii, K., Cortese, M., Leng, X., Shokhirev, M. N., & Asahina, K.
Affiliations
Salk Institute for Biological Studies (US)
Corresponding author
Asahina, Kenta
ORCID
Venue
Science Advances
Publisher
American Association for the Advancement of Science (AAAS)
Published
2022-09-09
Volume
8
Issue
36
Pages
eabg3203-eabg3203
ISSN
2375-2548 (ISSN-L)
DOI
10.1126/sciadv.abg3203
PMC
PMC9451153
OpenAlex
W4294884840
Cited by
16
References
12
Citations by year
2026: 6 · 2025: 6 · 2024: 2 · 2023: 2
FWCI
1.11
Type
journal article
Language
en
Open access
Licence
cc-by-nc
Locations
  • Science Advances (publishedVersion, cc-by-nc)
  • bioRxiv (Cold Spring Harbor Laboratory) (acceptedVersion, cc-by-nc-nd)
  • PubMed Central (publishedVersion, cc-by-nc)
  • PubMed (publishedVersion)
Funders
  • National Institutes of Health (P40OD018537)
  • Japan Society for the Promotion of Science (22K06309)
  • National Institute of General Medical Sciences (R35GM119844)
Topics
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurobiology and Insect Physiology Research
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
Keywords
aggression, social experience, Drosophila, octopaminergic neurons, loss-of-function mutations, cell type-specific transcriptomics, social behavior
MeSH terms
Aggression, Animals, Drosophila, Female, Humans, Male, Neurosciences, Social Behavior, Drosophila Proteins

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