Microglia become hypofunctional and release metalloproteases and tau seeds when phagocytosing live neurons with P301S tau aggregates
Brelstaff, Jack H., Mason, Matthew, Katsinelos, Taxiarchis, McEwan, William A., Ghetti, Bernardino, Tolkovsky, Aviva M., Spillantini, Maria Grazia·2021·Science Advances
Cited by (142)
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- Meeting Summary of The NYO3 5th NO-Age/AD Meeting and the 1st Norway–UK Joint Meeting on Aging and Dementia: Recent Progress on the Mechanisms and Interventional StrategiesHeling Wang, Richard C. M. Siow, Tomas Schmauck‐Medina, Jianying Zhang, Per Morten Sandset, Clare Filshie, Øystein Lund, Linda Partridge, Linda Hildegard Bergersen, Lene Juel Rasmussen et al. · 2024 · The Journals of Gerontology Series A
- Pathological Characterisation of Posterior Cortical Atrophy in Comparison With Amnestic Alzheimer's DiseaseZeinab Abdi, Keir X. X. Yong, Jonathan M. Schott, Ariana P. Gatt, Tamás Révész, Sebastian James Crutch, Tammaryn Lashley · 2025 · Neuropathology and Applied Neurobiology
- Cell autonomous microglia defects in a stem cell model of frontotemporal dementiaAbhirami Kannan Iyer, Lisa Vermunt, Farzaneh Sadat Mirfakhar, Miguel Minaya, Mariana Acquarone, Rama K. Koppisetti, Arun Renganathan, Shih‐Feng You, Emma Danhash, Anthony C. Verbeck et al. · 2024 · medRxiv
- Age-Related Differences in Lipopolysaccharide-Induced Delirium-like Behavior Implicate the Distinct Microglial Composition in the HippocampusCongli Sun, Xiaomin Kang, Xirui Jia, Yuwei Wang, Lijia Zhao, Xinyu Sun, Anaerguli Abula, Lijie Liu · 2025 · International Journal of Molecular Sciences
- Microglial senescence and epigenetic reprogramming in alzheimer's disease: An immunometabolic perspectiveJinye Ma, Baiqi Yang, Xuefan Jiang, Luping Wang, Wei Wei, Yu Cao, Hao Li · 2026 · Experimental Gerontology
- Glycoengineered Host-Guest Nanoparticles Potentiate Alzheimer’s Disease Therapy via Lesion-Specific Modulation of Tau PathologyYi Lai, Jiaxing Pan, Yuejiao Gu, Chuan Zhou, Wenfang Yang, Qian Zhao, Zifan Zhu, Yanhong Duan, Li Lei, Ying Fu et al. · 2026 · Journal of the American Chemical Society
- Soluble TREM2 mediates earliest amyloid-associated p-tau increases and cerebral glucose hypermetabolism in Alzheimer’s diseaseDavina Biel, Marc Suárez‐Calvet, Paul Hager, Anna Rubinski, Anna Dewenter, Anna Steward, Sebastian Niclas Roemer, Michael Ewers, Christian Haass, Matthias Brendel et al. · 2022 · medRxiv
- Silmitasertib, an FDA-designated orphan CK2 inhibitor, ameliorates neuropathology and motor dysfunction in a Huntington's disease mouse modelRoss J. Pelzel, Miaya Herbst, Nicholas B Rozema, Melissa A. Solem, Rocío Gómez‐Pastor · 2026 · Neurotherapeutics
- Timing of microglial ablation determines protection from tau-mediated neurodegeneration and cognitive declinePaula Trigo-Alonso, Enrique Luengo, Cristina Fernández‐Mendívil, Lucía Viqueira, Nuria García‐Magro, Eric del Sastre, Juan Antonio Bernal, Pilar Negredo, Manuela García López · 2026 · Acta Neuropathologica Communications
- A Missing Origin of the Tau Protein Aggregation Pathway Triggered by Thermal and Biological ForcesHong Peter Lu · 2023 · Journal of Integrative Neuroscience
- Roles in Innate ImmunityKaira A. Church, Astrid E. Cardona, Sarah C. Hopp · 2024 · Advances in neurobiology
- The Glial Aging & Senescence Hypothesis of Late-onset Alzheimer’sVictor Z. Lau, Leanne M. Ramer, Marie‐Ève Tremblay · 2022 · Preprints.org
- Engulfment of viable neurons by reactive microglia in prion diseasesNatallia Makarava, Tarek Safadi, Olga Mychko, Narayan Prasad Pandit, Kara Molesworth, Simone Baiardi, Li Zhang, Piero Parchi, Ilia V. Baskakov · 2024 · bioRxiv (Cold Spring Harbor Laboratory)
- Regulatory Network Inference of Induced Senescent Midbrain Cell Types Reveals Cell Type-Specific Senescence-Associated Transcriptional RegulatorsTaylor Russo, Jonathan Plessis‐Belair, Roger B. Sher, Markus Rießland · 2025 · bioRxiv (Cold Spring Harbor Laboratory)
- Youth-associated protein TIMP2 alters microglial state and function in the context of agingBrittany M. Hemmer, Ana Catarina Ferreira, Sarah M. Philippi, Samuele F Petridis, Annie Phan, Joseph M. Castellano · 2025 · bioRxiv (Cold Spring Harbor Laboratory)
- Templated seeding induces the formation of Alzheimer paired helical tau filaments in human brain organoidsMehtap Bacioglu, Panagiotis Katsinelos, Manuel Schweighauser, Filomena Gallo, Karin Mueller, Rafailia Christou, Janine Brandes, Sofia Lövestam, Sally A. Cowley, William A. McEwan et al. · 2026 · bioRxiv (Cold Spring Harbor Laboratory)
- Mechanisms of white matter injuryGary A. Rosenberg · 2022 · Elsevier eBooks
- Future directionsGary A. Rosenberg · 2022 · Elsevier eBooks
- Effective immunotherapy occurs in neuronsRebecca M. Nisbet · 2023 · Science
- Additional file 2 of PI3K-AKT activation resculpts integrin signaling to drive filamentous tau-induced proinflammatory astrogliosisPeng Wang, Darrell E. Anderson, Yihong Ye · 2023 · Figshare
- Additional file 8 of PI3K-AKT activation resculpts integrin signaling to drive filamentous tau-induced proinflammatory astrogliosisWang, Peng, Darrell E. Anderson, Yihong Ye · 2023 · Figshare
- Additional file 5 of PI3K-AKT activation resculpts integrin signaling to drive filamentous tau-induced proinflammatory astrogliosisWang, Peng, Darrell E. Anderson, Yihong Ye · 2023 · Figshare
- Additional file 4 of PI3K-AKT activation resculpts integrin signaling to drive filamentous tau-induced proinflammatory astrogliosisWang, Peng, Darrell E. Anderson, Yihong Ye · 2023 · Figshare
- Additional file 1 of PI3K-AKT activation resculpts integrin signaling to drive filamentous tau-induced proinflammatory astrogliosisWang, Peng, Darrell E. Anderson, Yihong Ye · 2023 · Figshare
- Additional file 3 of PI3K-AKT activation resculpts integrin signaling to drive filamentous tau-induced proinflammatory astrogliosisWang, Peng, Darrell E. Anderson, Yihong Ye · 2023 · Figshare
- Additional file 7 of PI3K-AKT activation resculpts integrin signaling to drive filamentous tau-induced proinflammatory astrogliosisWang, Peng, Darrell E. Anderson, Yihong Ye · 2023 · Figshare
- Additional file 6 of PI3K-AKT activation resculpts integrin signaling to drive filamentous tau-induced proinflammatory astrogliosisWang, Peng, Darrell E. Anderson, Yihong Ye · 2023 · Figshare
- Additional file 1 of A 3D human co-culture to model neuron-astrocyte interactions in tauopathiesKevin Llewelyn Batenburg, Claudia Sestito, Paulien Cornelissen‐Steijger, van Weering, Jan R. T., Leo Price, Vivi Majella Heine, Wiep Scheper · 2024 · Figshare
- Additional file 2 of A 3D human co-culture to model neuron-astrocyte interactions in tauopathiesKevin Llewelyn Batenburg, Claudia Sestito, Paulien Cornelissen‐Steijger, van Weering, Jan R. T., Leo Price, Vivi Majella Heine, Wiep Scheper · 2024 · Figshare
- Caractérisation du récepteur Smoothened en tant que régulateur majeur des états fonctionnels des cellules microglialesAdil El Mesaoudi · 2024 · theses.fr (ABES)
- Role of T-cell immunity in the pathophysiology of Alzheimer’s disease and other TauopathiesKaren Matta · 2024 · theses.fr (ABES)
- Atypical involvement of Alzheimer’s tau proteins in diseases beyond tauopathiesJie Meng, Zijie Deng, Jing Zhang, Wenxin Yu, Xiaolei Wu, Peng Lei · 2026 · Life Medicine
- Metal ion dyshomeostasis in neurological disorders: from pathological mechanisms to targeted neuroprotective and regenerative strategiesMengqiang Yao, Chunlei Xing, Xin Li, Xiaochen Sun, Chenxi Zhang, Xingji You, Su Li · 2026 · Frontiers in Pharmacology
- Youth-associated protein TIMP2 regulates microglial state and function in healthy and aged miceBrittany M. Hemmer, Sarah M. Philippi, Ana Catarina Ferreira, Samuele F Petridis, Annie Phan, Joseph M. Castellano · 2026 · Nature Communications
- Carbon-12 and Gamma-Rays Combined Irradiation Ameliorates Behavioral and Biochemical Alterations in Tau P301S Homozygous Transgenic MiceViktor S. Kokhan, Kseniia V. Belokopytova, Vladimir A. Pikalov, Т. Н. Федорова, Агельдинов Руслан Андреевич, Kirill Chaprov · 2026 · Molecular Neurobiology
- Cellular senescence in ageing and neurodegenerative disorders: Molecular mechanisms, biomarkers, and therapeutic strategiesAanchal Verma, Ahsas Goyal, Neetu Agrawal, Harlokesh Narayan Yadav · 2026 · Progress in Neuro-Psychopharmacology and Biological Psychiatry