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Tetrandrine ameliorates cognitive deficits and mitigates tau aggregation in cell and animal models of tauopathies

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Microglia in Alzheimer's Disease: a Key Player in the Transition Between Homeostasis and Pathogenesis

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Pharmacological Targeting of Senescence with Senolytics as a New Therapeutic Strategy for Neurodegeneration

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Quantitative super-resolution imaging of pathological aggregates reveals distinct toxicity profiles in different synucleinopathies

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Alzheimer’s genes in microglia: a risk worth investigating

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Limitations of human tau-expressing mouse models and novel approaches of mouse modeling for tauopathy

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The chaperone Clusterin in neurodegeneration−friend or foe?

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Alzheimer’s Amyloid‐ β Accelerates Cell Senescence and Suppresses the SIRT1/NRF2 Pathway in Human Microglial Cells

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Microglial phagocytosis in Alzheimer disease

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Dysfunctional microglia and tau pathology in Alzheimer’s disease

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Senolytic therapy preserves blood-brain barrier integrity and promotes microglia homeostasis in a tauopathy model

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Characterizing microglial senescence: Tau as a key player

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Taming microglia: the promise of engineered microglia in treating neurological diseases

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Modulation of Oxidative Stress and Neuroinflammation by Cannabidiol (CBD): Promising Targets for the Treatment of Alzheimer’s Disease

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Single domain antibodies targeting pathological tau protein: Influence of four IgG subclasses on efficacy and toxicity

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A Combined Panel of Salivary Biomarkers in de novo Parkinson's Disease

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The role of adenosine A2A receptors in Alzheimer's disease and tauopathies

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Friend or foe: role of pathological tau in neuronal death

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Ketone body metabolism and the NLRP3 inflammasome in Alzheimer's disease

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Reactive microglia partially envelop viable neurons in prion diseases

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Senescent brain cell types in Alzheimer's disease: Pathological mechanisms and therapeutic opportunities

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S100A8 ‐enriched microglia populate the brain of tau‐seeded and accelerated aging mice

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p16-expressing microglia and endothelial cells promote tauopathy and neurovascular abnormalities in PS19 mice

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Phosphorylated tau exhibits antimicrobial activity capable of neutralizing herpes simplex virus 1 infectivity in human neurons

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Molecular Insights into Cell Type-specific Roles in Alzheimer’s Disease: Human Induced Pluripotent Stem Cell-based Disease Modelling

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Microglial senescence in neurodegeneration: Insights, implications, and therapeutic opportunities

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Amyloid beta and tau are associated with the dual effect of neuroinflammation on neurodegeneration

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Zinc utilization by microglia in Alzheimer’s disease

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Hunting for the cause: Evidence for prion-like mechanisms in Huntington’s disease

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Alzheimer’s disease is an inherent, natural part of human brain aging: an integrated perspective

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Exploring the link between dystrophic microglia and the spread of Alzheimer's neuropathology

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The innate immune response in tauopathies

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Molecular Regulation Mechanism of Microglial Autophagy in the Pathology of Alzheimer's Disease

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A 3D human co-culture to model neuron-astrocyte interactions in tauopathies

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sTREM2 is associated with attenuated tau aggregate accumulation in the presence of amyloid-β pathology

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The crosstalk between extracellular matrix proteins and Tau

Chinnathambi, S., & Desale, S. E. (2024) · Advances in protein chemistry and structural biology · doi:10.1016/bs.apcsb.2024.04.002 · Cited by 19 · see citing works

Extracellular vesicles in TDP-43 proteinopathies: pathogenesis and biomarker potential

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Emerging roles for innate and adaptive immunity in tauopathies

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Signalling Pathways Involved in Microglial Activation in Alzheimer’s Disease and Potential Neuroprotective Role of Phytoconstituents

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PI3K-AKT activation resculpts integrin signaling to drive filamentous tau-induced proinflammatory astrogliosis

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Positron Emission Tomography in Animal Models of Tauopathies

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A hypothesis explaining Alzheimer's disease, Parkinson's disease, and dementia with Lewy bodies overlap

Lau, V. Z., Awogbindin, I. O., Frenkel, D., Whitehead, S. N., & Tremblay, M. (2025) · Alzheimer s & Dementia · doi:10.1002/alz.70363 · Cited by 15 · see citing works

Phosphatidylserine in the Nervous System: Cytoplasmic Regulator of the AKT and PKC Signaling Pathways and Extracellular “Eat-Me” Signal in Microglial Phagocytosis

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Endoplasmic reticulum stress: A possible connection between intestinal inflammation and neurodegenerative disorders

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Complement receptor 4 mediates the clearance of extracellular tau fibrils by microglia

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Microglial modulation as a therapeutic strategy in Alzheimer's disease: Focus on microglial preconditioning approaches

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The microglial P2Y6 receptor as a therapeutic target for neurodegenerative diseases

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High levels of HDAC expression correlate with microglial aging

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Female sex is linked to a stronger association between sTREM2 and CSF p-tau in Alzheimer’s disease

Biel, D., Suárez‐Calvet, M., Dewenter, A., Steward, A., Roemer, S. N., Dehsarvi, A., Zhu, Z., Pescoller, J., Frontzkowski, L. K., Kreuzer, A., et al. (2025) · EMBO Molecular Medicine · doi:10.1038/s44321-024-00190-3 · Cited by 14 · see citing works

Extracellular tau clearance is governed by its aggregation state and independent of microglial activation by LPS and IFN-γ

Shultz, A., Vincze, A., Yau, T. T., Poirier, E. L., Demanche, H., & Rauch, J. N. (2025) · Neurobiology of Disease · doi:10.1016/j.nbd.2025.107058 · Cited by 12 · see citing works

Noradrenergic therapies in neurodegenerative disease: from symptomatic to disease modifying therapy?

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The Inflammation-Induced Dysregulation of Reelin Homeostasis Hypothesis of Alzheimer’s Disease

Reive, B. S., Lau, V. Z., Sánchez-Lafuente, C. L., Henri‐Bhargava, A., Kalynchuk, L. E., Tremblay, M., & Caruncho, H. J. (2024) · Journal of Alzheimer s Disease · doi:10.3233/jad-240088 · Cited by 15 · see citing works

Excessive Alcohol Use as a Risk Factor for Alzheimer’s Disease: Epidemiological and Preclinical Evidence

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Glial phagocytosis for synapse and toxic proteins in neurodegenerative diseases

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Apolipoprotein E isoform does not influence trans-synaptic spread of tau pathology in a mouse model

Davies, C., Tulloch, J., Yip, E., Currie, L., Colom‐Cadena, M., Wegmann, S., Hyman, B. T., Wilkins, L., Hooley, M., Tzioras, M., et al. (2023) · Brain and Neuroscience Advances · doi:10.1177/23982128231191046 · Cited by 11 · see citing works

Basic Microglial Functions and How They Go Awry in Neurodegenerative Disease

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The putative contribution of cellular senescence to driving tauopathies

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The role of microglia in the prion-like transmission of protein aggregates in neurodegeneration

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Cell autonomous microglia defects in a stem cell model of frontotemporal dementia tau

Iyer, A. K., Vermunt, L., Mirfakhar, F. S., Minaya, M., Acquarone, M., Koppisetti, R. K., Renganathan, A., You, S., Danhash, E., Schache, K. J., et al. (2025) · Molecular Psychiatry · doi:10.1038/s41380-025-03073-2 · Cited by 13 · see citing works

Tau aggregation and its relation to selected forms of neuronal cell death

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Insulin Mediates Lipopolysaccharide-Induced Inflammatory Responses and Oxidative Stress in BV2 Microglia

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Systematic profiling reveals distinct senescence signatures and regulators across human brain cell types

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Targeting tau in Alzheimer’s Disease: rationale, approach and challenges

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Alzheimer's disease: from molecular pathways to therapies

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Tau aggregation and its relation to selected forms of neuronal cell death.

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Willis Lecture: Biomarkers for Inflammatory White Matter Injury in Binswanger Disease Provide Pathways to Precision Medicine

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Distinct factors drive the progression of tau pathology in Alzheimer’s disease

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Dynamic neuroinflammatory profiles predict Alzheimer’s disease pathology in microglia-containing cerebral organoidsPreprint

Kuhn, M. K., Kang, R. Y., Kim, C., Tagay, Y., Morris, N., Tabdanov, E. D., Elcheva, I. A., & Proctor, E. A. (2023) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2023.11.16.567220 · Cited by 8 · see citing works

Impairment of the Glial Phagolysosomal System Drives Prion-Like Propagation in a Drosophila Model of Huntington's Disease

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Enhanced Microglial Engulfment of Dopaminergic Synapses Induces Parkinson's Disease‐Related Executive Dysfunction in an Acute LPC Infusion Targeting the mPFC

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Dietary modulation of the gut–immune–brain axis: nutritional immunoepigenomics for immune regulation in autoimmunity, cancer, and infection

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Unraveling the molecular mechanisms of aluminium chloride-induced Alzheimer’s disease

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Tau Protein Modulates Perineuronal Extracellular Matrix Expression in the TauP301L-acan Mouse Model

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A Need for Refined Senescence Biomarkers and Measures of Senolytics in the Brain

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Suppressing phagocyte activation by overexpressing the phosphatidylserine lipase ABHD12 preserves sarmopathic nerves

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Microglia as a Possible Alternative Therapeutic for Dementia

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Microglial Drivers of Alzheimer's Disease Pathology: An Evolution of Diverse Participating States

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The Mitochondrial Guardian α‐Amyrin Mitigates Alzheimer's Disease Pathology via Modulation of the DLK‐SARM1‐ULK1 Axis

Cao, S., Jiménez‐Loygorri, J. I., Qiu, Y., Kang, Y. J., Do, K. V., Smith, A. E., Huang, J., Pan, J., Mao, L., Li, A., et al. (2026) · Advanced Science · doi:10.1002/advs.202512374 · Cited by 5 · see citing works

Microglia become hypofunctional and release metalloproteases and tau seeds after phagocytosing live neurons with P301S tau aggregatesPreprint

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P4‐257: NEURONS WITH TAU AGGREGATES EXPOSE PHOSPHATIDYLSERINE AND ARE PHAGOCYTOSED LIVE BY MICROGLIA

Brelstaff, J., Tolkovsky, A. M., Ghetti, B. F., Goedert, M., & Spillantini, M. G. (2018) · Alzheimer s & Dementia · doi:10.1016/j.jalz.2018.07.079

Microglial activation arises after aggregation of phosphorylated-tau in a neuron-specific P301S tauopathy mouse model

van Olst, L., Verhaege, D., Franssen, M., Kamermans, A., Roucourt, B., Carmans, S., Ytebrouck, E., van der Pol, S. M. A., Wever, D. D., Popovic, M. A., et al. (2020) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2020.01.003 · Cited by 75 · see citing works

Living Neurons with Tau Filaments Aberrantly Expose Phosphatidylserine and Are Phagocytosed by Microglia

Brelstaff, J., Tolkovsky, A. M., Ghetti, B., Goedert, M., & Spillantini, M. G. (2018) · Cell Reports · doi:10.1016/j.celrep.2018.07.072 · Cited by 195 · see citing works

Extracellular tau induces microglial phagocytosis of living neurons in cell cultures

Pampuščenko, K., Morkūnienė, R., Šneideris, T., Smirnovas, V., Budvytytė, R., Valinčius, G., Brown, G. C., & Borutaitė, V. (2019) · Journal of Neurochemistry · doi:10.1111/jnc.14940 · Cited by 62 · see citing works