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Cited by 53Invertebrate Immune Response MechanismsNeurobiology and Insect Physiology ResearchNeuroinflammation and Neurodegeneration Mechanisms

Brain inflammation triggers macrophage invasion across the blood-brain barrier in Drosophila during pupal stages

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Winkler, Bente, Funke, Dominik, Benmimoun, Billel, Spéder, Pauline, Rey, Simone, Logan, Mary A., Klämbt, Christian·2021·Science Advances
DOI 10.1126/sciadv.abh0050PMC PMC8550232
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Abstract

Macrophages can invade the fly brain triggered by inflammation and show phagocytotic responses reducing longevity.

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  • Macrophages derived from peripheral blood invaded across the blood-brain barrier mediated via BBB-forming glial cells and promoted neuronal injury following brain inflammation.

    “Bente Winkler et al. found that macrophages, derived from the peripheral blood, invaded across the BBB mediated via BBB-forming glial cells and promoted neuronal injury following brain inflammation (26).”

    From Nociplastic pain: the prominent role of non-neuronal cells in central and peripheral sensitization (2026) · cites this paper as [26]

    The Introduction and Discussion identify the invading macrophages as originating in Drosophila hemolymph, and the Results section on glial cell types finds that immune activation in BBB-forming glia is particularly important for their recruitment. In “Macrophage invasion reduces longevity and causes brain damage” (page unavailable), macrophages contain neuronal and synaptic material, but the authors say their role in causing the observed deficits is suggested and requires further experiments. The claim overstates that proposed contribution as established neuronal injury. (LLM, conf=0.86)

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Authors
Winkler, B., Funke, D., Benmimoun, B., Spéder, P., Rey, S., Logan, M. A., & Klämbt, C.
Affiliations
  • University of Münster (DE)
  • Centre National de la Recherche Scientifique (FR)
  • Oregon Health & Science University (US)
Corresponding author
Klämbt, Christian
ORCID
Venue
Science Advances
Publisher
American Association for the Advancement of Science (AAAS)
Published
2021-10-29
Volume
7
Issue
44
Pages
eabh0050-eabh0050
ISSN
2375-2548 (ISSN-L)
DOI
10.1126/sciadv.abh0050
PMC
PMC8550232
OpenAlex
W3209441523
Cited by
53
References
2
Citations by year
2026: 8 · 2025: 17 · 2024: 8 · 2023: 10 · 2022: 10
FWCI
2.61
Type
journal article
Language
en
Open access
Licence
cc-by-nc
Locations
  • Science Advances (publishedVersion, cc-by-nc)
  • Europe PMC (PubMed Central) (publishedVersion, other-oa)
  • PubMed Central (publishedVersion, cc-by-nc)
  • PubMed (publishedVersion)
  • HAL (submittedVersion, cc-by-nc)
Funders
Agence Nationale de la Recherche (ANR-17-CE13-0018, ANR-17-CE13-0010, ANR-10-LABX-0073)
Topics
  • Life Sciences › Immunology and Microbiology › Immunology › Invertebrate Immune Response Mechanisms
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurobiology and Insect Physiology Research
  • Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
Keywords
neuroinflammation, macrophage infiltration, blood-brain barrier, Drosophila, pupal stage, Imd pathway, innate immunity, macrophage recruitment

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

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