Unraveling the link between neuropathy target esterase NTE/SWS, lysosomal storage diseases, inflammation, abnormal fatty acid metabolism, and leaky brain barrier
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Abstract
Mutations in Drosophila Swiss cheese (SWS) gene or its vertebrate orthologue neuropathy target esterase (NTE) lead to progressive neuronal degeneration in flies and humans. Despite its enzymatic function as a phospholipase is well established, the molecular mechanism responsible for maintaining nervous system integrity remains unclear. In this study, we found that NTE/SWS is present in surface glia that forms the blood-brain barrier (BBB) and that NTE/SWS is important to maintain its structure and permeability. Importantly, BBB glia-specific expression of Drosophila NTE/SWS or human NTE in the sws mutant background fully rescues surface glial organization and partially restores BBB integrity, suggesting a conserved function of NTE/SWS. Interestingly, sws mutant glia showed abnormal organization of plasma membrane domains and tight junction rafts accompanied by the accumulation of lipid droplets, lysosomes, and multilamellar bodies. Since the observed cellular phenotypes closely resemble the characteristics described in a group of metabolic disorders known as lysosomal storage diseases (LSDs), our data established a novel connection between NTE/SWS and these conditions. We found that mutants with defective BBB exhibit elevated levels of fatty acids, which are precursors of eicosanoids and are involved in the inflammatory response. Also, as a consequence of a permeable BBB, several innate immunity factors are upregulated in an age-dependent manner, while BBB glia-specific expression of NTE/SWS normalizes inflammatory response. Treatment with anti-inflammatory agents prevents the abnormal architecture of the BBB, suggesting that inflammation contributes to the maintenance of a healthy brain barrier. Considering the link between a malfunctioning BBB and various neurodegenerative diseases, gaining a deeper understanding of the molecular mechanisms causing inflammation due to a defective BBB could help to promote the use of anti-inflammatory therapies for age-related neurodegeneration.
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Self-citationAn anti-inflammatory transcriptional cascade conserved from flies to humans
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Self-citationCorrection to: Preserving Lysosomal Function in the Aging Brain: Insights from Neurodegeneration
Peng, W., Minakaki, G., Nguyen, M. N., & Krainc, D. (2019) · Neurotherapeutics · doi:10.1007/s13311-019-00756-x · Cited by 2 · see citing works
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Tsap, M. I., & Shcherbata, H. R. (2025) · Progress in Lipid Research · doi:10.1016/j.plipres.2025.101341 · Cited by 11 · see citing works
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Invertebrate glial barriers as a model for understanding blood–brain barrier evolution
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Tsikas, D. (2025) · Journal of Chromatography B · doi:10.1016/j.jchromb.2025.124578 · Cited by 4 · see citing works
Self-citationVoronina, P. A., Belinskaia, D. A., Samodurova, K. V., & Goncharov, N. V. (2025) · Journal of Evolutionary Biochemistry and Physiology · doi:10.1134/s0022093025060225
Drosophila as a model in organophosphate toxicology
Tkachuk, M., & Matiytsiv, N. P. (2026) · Fly · doi:10.1080/19336934.2026.2695497
Neuroprotective Potential of Spermidine in Drosophila sws Neurodegenerative Model
Raspopina, A., Tkachuk, M., & Matiytsiv, N. P. (2026) · Archives of Insect Biochemistry and Physiology · doi:10.1002/arch.70201
Esterase Profile: Functional Features and Diagnostic Potential
Belinskaia, D. A., Voronina, P. A., Samodurova, K. V., & Goncharov, N. V. (2026) · Journal of Evolutionary Biochemistry and Physiology · doi:10.1134/s0022093026040034
- Authors
- Tsap, M. I., Yatsenko, A. S., Hegermann, J., Beckmann, B., Tsikas, D., & Shcherbata, H. R.
- Affiliations
- Medizinische Hochschule Hannover (DE)
- Mount Desert Island Biological Laboratory (US)
- Corresponding author
- Shcherbata, Halyna R
- Venue
- eLife
- Publisher
- eLife Sciences Publications, Ltd
- Published
- 2024-04-25
- Volume
- 13
- ISSN
- 2050-084X (ISSN-L)
- PMC
- PMC11090517
- OpenAlex
- W4395454199
- Cited by
- 8
- References
- 161
- Citations by year
- 2026: 3 · 2025: 5
- FWCI
- 1.24
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- eLife (publishedVersion, cc-by)
- bioRxiv (Cold Spring Harbor Laboratory) (acceptedVersion, cc-by-nc-nd)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Funders
- Volkswagen Foundation (90218, 97750)
- Deutsche Forschungsgemeinschaft (521749003, INST 192/574-1 FUGG)
- European Molecular Biology Organization (Young Investigator Programme)
- Topics
- Life Sciences › Neuroscience › Neurology › Barrier Structure and Function Studies
- Health Sciences › Medicine › Physiology › Lysosomal Storage Disorders Research
- Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
- Keywords
- neuropathy target esterase, blood-brain barrier, lysosomal storage disease, fatty acid metabolism, eicosanoids, neuroinflammation, innate immunity, lipid droplets, multilamellar bodies, plasma membrane domains, age-related neurodegeneration, anti-inflammatory therapy, Drosophila
- MeSH terms
- Animals, Blood-Brain Barrier, Carboxylic Ester Hydrolases, Drosophila melanogaster, Fatty Acids, Humans, Inflammation, Neuroglia, Lysosomal Storage Diseases, Drosophila Proteins
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
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